Navigation Links
First prospective trial shows molecular profiling timely for tailoring therapy
Date:5/15/2013

ns to provide an accurate statistical analysis of response to novel drugs, says Giaccone.

Giaccone led the clinical trial while at the National Cancer Institute where he was the Chief of the Medical Oncology Branch, before he joined Georgetown in January. Researchers at Oregon Health & Science University also participated.

CUSTOM enrolled patients diagnosed with advanced stage non-small cell lung cancer, small cell lung cancer or thymic cancer. Researchers used next-generation sequencing, which was novel at the time, to look at almost 200 genes. From this, patients were assigned to different treatment groups based on genetic mutations or amplification.

Results from the largest group patients with non-small cell lung cancer had either an EGFR or a KRAS mutation, and results showed that those with EGFR mutations had a very high response to the drug erlotinib. "This is nothing new; we essentially confirmed what was already known," Giaccone says. But they also discovered that patients with KRAS mutations did not benefit from the single agent investigational drug selumetinib, which is being studied for use in a number of cancers, including non-small cell lung cancer.

Results for the patients with small cell lung or thymic cancers were inconclusive, primarily because the investigated mutations were rare not enough patients had specific mutations to adequately test response to therapy. "When we started the study, we didn't know how frequently the mutations occurred," Giaccone says. "Now we know that many mutations represent only 1 to 2 percent of patients and to do this right, you need to screen thousands of patients. That is only possible with a global study that involves, potentially, hundreds of institutions.

"The CUSTOM trial demonstrates both the feasibility of the approach for common mutations that it is possible to have a real-time genetic analysis that guides treatment as well as the difficulty of studying treatment for
'/>"/>

Contact: Karen Mallet
km463@georgetown.edu
Georgetown University Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. First targeted nanomedicine to enter human clinical studies
2. First contact: Early intervention key in diagnosis and treatment of serious mental illness
3. Donor Kidney Re-Used in Second Patient After Failing in First
4. Many Who First Misuse Prescription Pills Get Them From Friends, Family: Report
5. First-of-its-kind Menopause Map helps women navigate treatment
6. First recipients of AcademyHealths Presidential Scholarship announced
7. Kessler Foundation researchers present at first International Congress on Cognition in MS
8. Whos the Dad? First-Trimester Blood Test May Tell
9. AGA releases first independently developed ABIM-approved Practice Improvement Module in GI
10. Dr. Yael Mosse will receive first Nachman Award in Pediatric Oncology at national conference
11. First study investigating possible link between sunscreen ingredient and endometriosis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/29/2014)... July 29, 2014 Outsourced coding ... tripling in the number of hospitals contracting for ... 2015 deadline, according to the recently published Black ... leaders, found in the reports “Top Ranked Clinical ... now outsource Clinical documentation audit, review and programming. ...
(Date:7/29/2014)... invested $3.4 million this year to support innovative ... chronic diseases that affect more than 233,000 Canadians. ... research projects across Canada. This diverse research will ... improve our understanding (and potential treatment) of symptoms ... quality of life. , Crohn,s and Colitis ...
(Date:7/29/2014)... CHI-California Healthcare Institute today unveiled a ... C (hep C) epidemic in the U.S., the rise ... reduce human suffering. The report examines key data to ... C, while highlighting the significance of breakthroughs that have ... is a nonprofit, public policy research organization, representing leading ...
(Date:7/29/2014)... Thompson HealthDay Reporter MONDAY, ... virus that continues to rage throughout West Africa poses little ... only spreads through physical touch, and it can,t be spread ... deputy director of the National Center for Emerging & Zoonotic ... Prevention, explained in a Monday afternoon news conference. Those ...
(Date:7/29/2014)... Ill. By studying the injuries and aptitudes of ... the war, scientists are tackling -- and beginning to ... , The researchers found that brain regions that contribute ... intelligence and to emotional intelligence. This finding bolsters the ... social context of one,s life. , The ...
Breaking Medicine News(10 mins):Health News:Clinical Documentation Improvement Heats Up as Half of US Hospitals Make 2015 Preparations for ICD-10, the Rest to Rely on Outsourcers, Black Book Survey Reveals 2Health News:Clinical Documentation Improvement Heats Up as Half of US Hospitals Make 2015 Preparations for ICD-10, the Rest to Rely on Outsourcers, Black Book Survey Reveals 3Health News:Prestigious Crohn's and Colitis Canada grants fund promising Canadian research 2Health News:CHI Releases Report Highlighting Public Impact of Hepatitis C, Opportunities for Action in US 2Health News:CHI Releases Report Highlighting Public Impact of Hepatitis C, Opportunities for Action in US 3Health News:CHI Releases Report Highlighting Public Impact of Hepatitis C, Opportunities for Action in US 4Health News:CDC Downplays Ebola's Threat to the United States 2Health News:CDC Downplays Ebola's Threat to the United States 3Health News:CDC Downplays Ebola's Threat to the United States 4Health News:Team studies the social origins of intelligence in the brain 2Health News:Team studies the social origins of intelligence in the brain 3
... Children,s Research Hospital and Washington University School of Medicine ... identify the genetic changes that give rise to some ... joined forces to decode the genomes of more than ... have contributed tumor samples for this historic effort. ...
... ... look, but do not touch. Mamabears.com, a Web site devoted to providing parents with products ... strangers “Your Germs Are Too Big For Me Please Don’t Touch.” 100 percent of sales ... ...
... ... Jose, provides discounted dental services to local veterans referred through the Palo Alto VA hospital ... San Jose, CA (PRWEB) ... discounted services to American veterans in need of dental care. American veterans who are referred ...
... attempts to get young women pregnant , MONDAY, Jan. 25 ... of teenage girls and young women who engage in physical ... control the women are using. , The study, which appears ... finds that women who experience both birth-control sabotage and violence ...
... 100 fewer calories per meal for their children, study ... When nutritional information is available on fast-food restaurant menus, ... their kids, new research finds. , Often spurred on ... nutrition information about their menu items. But whether this ...
... ... Up Program at three of their Premiere Clubs. , ... (PRWEB) January 25, 2010 -- Diet-to-Go, a national leader in nutritional ... and wellness solutions operating 20 health clubs in California., , , , ,Through this exciting ...
Cached Medicine News:Health News:St. Jude and Washington University team to unravel genetic basis of childhood cancers 2Health News:St. Jude and Washington University team to unravel genetic basis of childhood cancers 3Health News:Mamabears.com Launches Stroller Signs – Finally a Kind Way to Say Do Not Touch 2Health News:Mamabears.com Launches Stroller Signs – Finally a Kind Way to Say Do Not Touch 3Health News:Top San Jose Dentists at Zeidler Dental Group Work with Local VA 2Health News:Male Abusers Often Sabotage Birth Control With Partners 2Health News:Listing Calories on Fast-Food Menus Cuts Kids' Intake 2Health News:Listing Calories on Fast-Food Menus Cuts Kids' Intake 3Health News:Diet-to-Go and Club One Fitness Join Forces For New Wellness Initiative 2
(Date:7/29/2014)... CITY , July 29, 2014  The ... Grand American Hotel in Salt Lake City ... representing some of most respected healthcare organizations in the ... Catalyst , is an industry conference devoted to providing ... analytics,  an essential element of both accountable care initiatives ...
(Date:7/29/2014)... , July 29, 2014  Ambit Biosciences (Nasdaq: ... and development of drugs targeting unmet needs in oncology, ... second quarter operational results after closing of the NASDAQ ... A conference call hosted by Michael Martino ... management will take place on the same day at ...
(Date:7/29/2014)... TRIANGLE PARK, N.C. , July 29, 2014 ... on cloud-based drug design and development, announced today ... grant from the National Science Foundation Small Business ... valued at $150,000. Cloud Pharmaceuticals ... the development process by implementing new, innovative cloud ...
Breaking Medicine Technology:Health Catalyst Adds Keynote Speakers, New Sessions, and Expands Attendee Limit for Healthcare Analytics Summit 2014 2Health Catalyst Adds Keynote Speakers, New Sessions, and Expands Attendee Limit for Healthcare Analytics Summit 2014 3Health Catalyst Adds Keynote Speakers, New Sessions, and Expands Attendee Limit for Healthcare Analytics Summit 2014 4Health Catalyst Adds Keynote Speakers, New Sessions, and Expands Attendee Limit for Healthcare Analytics Summit 2014 5Ambit Biosciences To Announce Second Quarter 2014 Financial Results 2Cloud Pharmaceuticals Receives Phase I NSF SBIR Grant Valued at $150,000 2
... HARLEYSVILLE, Pa. and LUDWIGSHAFEN, Germany, Oct. 20, 2011 ... the development of future film coating systems using Kollicoat® ... Colorcon has developed a pre-formulated additive ... enables efficient preparation and application of this polymer in ...
... Onyx Pharmaceuticals, Inc. (Nasdaq: ONXX ) today ... management to discuss third quarter 2011 financial results, as well ... 2011, at 5:00 p.m. Eastern Time (2:00 p.m. Pacific Time). ... will be released earlier that day. Interested parties ...
Cached Medicine Technology:Colorcon and BASF Announce Collaboration to Develop Film Coating Applications Using Kollicoat® Smartseal 30 D 2
... the finest surgical-quality loupes available ... standard for innovative optical design, combining ... optimum performance with maximum comfort, SheerVision ... medical professionals worldwide. Make both a ...
... Experience the finest surgical-quality loupes ... set the standard for innovative optical ... support. Delivering optimum performance with maximum ... choice for medical professionals worldwide. Make ...
... of award-winning flip-up dental loupes in the ... loupes feature extremely high resolution razor-sharp clarity, ... for anti-glare, anti-fog, and scratch resistance. ... stylish, yet comfortable design with wrap around ...
... & portable FireFly LED light offers superior ... the new FireFly LED you'll get powerful, ... whereever your practice demands. High center-beam brightness ... your procedures, while the rechargeable battery provides ...
Medicine Products: