Navigation Links
First-of-its-kind study creates new tool for targeted cancer drug development
Date:10/30/2011

ent kinases performing numerous functions. And the vast majority of kinase inhibitors will act on more than one kinase, and so have the potential to interfere with both cancer and the normal processes the body needs for health and survival. Not surprisingly, some of the kinase inhibitors approved for use in cancer cause significant side effects, such as cardiovascular problems.

Until the last few years, however, researchers simply didn't have the technology to observe which kinases a specific inhibitor acted upon. Recently, however, the company Reaction Biology Corporation developed a way to observe the suite of effects from one kinase inhibitor.

For the first time, Peterson and his team catalogued the activity of 178 kinase inhibitors against 300 kinases. The experiment was like observing what happens after shooting a scattergun at a wall of balloons, he says. Before, scientists could only tell if you popped one particular balloon now, however, they can see if other balloons were hit, as well. "We're essentially shining a light on the wall of balloons so we have a much better view of the balloons that were popped."

Not surprisingly, the researchers found that kinase inhibitors targeted multiple kinases, even some that appeared to be unrelated to each other. They have deposited this massive library of results on a free website so scientists studying kinases and inhibitors can learn more about their multiple interactions.

The fact that kinase inhibitors target multiple kinases may actually be a good thing, says Peterson. Initially, scientists had hoped to find an inhibitor that targets one specific kinase involved in cancer; now, they realize that cancer rarely results from one kinase. Instead, multiple kinases likely collaborate to produce the disease -- so to stop that process, you may have to hit all of those kinases together. "It may not be possible to develop a successful drug against one kinase," he says. Indeed, some kinase
'/>"/>

Contact: Diana Quattrone
Diana.Quattrone@fccc.edu
215-728-7784
Fox Chase Cancer Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Pediatric personalized medicine takes center stage at first-of-its-kind international conference
2. Mount Sinai Medical Center and ENT & Allergy Associates, LLP Create First-Of-Its-Kind Physician Portal
3. Johns Hopkins scientists begin first-of-its-kind research to create blood platelets from stem cells
4. Despite Treatment, Employees with Depression Generate Higher Absentee Costs, According to Thomson Reuters Study
5. American Council on Exercise (ACE) Study Reveals Kettlebells Provide Powerful Workout in Short Amount of Time
6. TV drama can be more persuasive than news program, study finds
7. Study carried out into biological risks of eating reptiles
8. Neuroimaging study may pave way for effective Alzheimers treatments
9. Study finds racial gaps continue in heart disease awareness
10. Luth Researchs IndicatorEDG(TM) Study Finds Americans Hopes of Achieving Their Dreams Are Fading
11. First blinded study of venous insufficiency prevalence in MS shows promising results
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/29/2014)... Rancho Cucamonga, CA (PRWEB) July 29, 2014 ... “Realistic Ways to Make More Money in 30 Days” E-book. ... that anyone can use to make extra cash. Examples include ... and utilizing unique free websites that help people monetize the ... bedroom, and even unused items they can find in their ...
(Date:7/29/2014)... (PRWEB) July 29, 2014 1Heart ... senior communities with focus on Brain Fitness Education ... in Ventura. Brain Fitness Program Director Tee Barr ... Aegis Memory Care unit and the Assisted Living ... Aegis Life Enrichment Director Christy Rozsa and Aegis ...
(Date:7/29/2014)... Colorado (PRWEB) July 29, 2014 Daily ... as well as all other disturbing symptoms that hemorrhoids ... Hayden, a researcher and natural medicine expert. , ... will lead to the elimination of symptoms such as ... , Learn more about the H Miracle by ...
(Date:7/29/2014)... The One Minute Herpes Cure review indicates ... herbal medicine specialist. Alison Freeman wanted to show her patients ... People interested in finding out more about this method can ... as it is currently available in online format. , In ... and herbal medicine tips that can help them achieve a ...
(Date:7/29/2014)... Daily Gossip indicates in its Natural Cure ... for any sufferer who is looking for an all-natural holistic ... the new program, Sarah Summer, says that her method is ... infection, too. Actually, this is the reason why she was ... , The Natural Cure for Yeast Infection review ...
Breaking Medicine News(10 mins):Health News:Create Indestructible Wealth Launches Innovative E-Book: “Realistic Ways to Make More Money in 30 Days” 2Health News:1Heart Caregiver Services Conducts Brain Fitness Education and Brings Tee Barr to Aegis Ventura 2Health News:1Heart Caregiver Services Conducts Brain Fitness Education and Brings Tee Barr to Aegis Ventura 3Health News:1Heart Caregiver Services Conducts Brain Fitness Education and Brings Tee Barr to Aegis Ventura 4Health News:H Miracle Review Exposes Natural Method to Cure Hemorrhoids 2Health News:One Minute to Herpes Cure Review Reveals Simplest Herpes Treatment 2Health News:Natural Cure for Yeast Infection Review Reveals Sarah Summer’s Healing Method 2
... in French . , Montreal, October 7, ... be regulated to protect consumers, according to Universit de ... Developing World Bioethics argues that Argentinean fertility ... consumers: these clinics offer all-inclusive packages with fixed prices ...
... better and faster services in cardiac care and other ... of the Institute for Operations Research and the Management ... achieve these results, and that average patients actually receive ... Evidence from California Hospitals" is by Diwas KC, Asst ...
... ... company in the emerging medical tourism industry, has formed a relationship with GreenWood International ... ... October 7, 2009 -- Satori World Medical , a global healthcare company in ...
... tied to weight gain, study finds , WEDNESDAY, Oct. 7 ... and depression, may increase a person,s risk of obesity, and ... risk, British researchers say. , In the study, published in ... researchers analyzed data from four medical screenings of 4,363 British ...
... ... tracking capabilities of their shipments - even in most remote regions of the U.S. and ... , ... October 7, 2009 -- Medical device manufacturers can have 100 percent visibility and tracking capabilities ...
... Ensign Group, Inc. (Nasdaq: ENSG ), announced today ... South Valley Care Center in West Jordan, a suburb ... Center in Provo, and Castle Country Care Center in ... , (Logo: http://www.newscom.com/cgi-bin/prnh/20071213/LATH168LOGO ) , "These strategic acquisitions ...
Cached Medicine News:Health News:Study examines ethical dilemmas of medical tourism 2Health News:Specialty hospitals cherry-pick patients, exaggerate success, says INFORMS meeting paper 2Health News:Medical Travel Company Satori World Medical Announces Relationship with Managing General Underwriter GreenWood International Insurance Services (GWI) 2Health News:Medical Travel Company Satori World Medical Announces Relationship with Managing General Underwriter GreenWood International Insurance Services (GWI) 3Health News:Purolator USA Offers Advanced Tracking Capabilities for Medical Device Shipments 2Health News:Purolator USA Offers Advanced Tracking Capabilities for Medical Device Shipments 3Health News:The Ensign Group Acquires Three Utah Skilled Nursing Facilities 2
(Date:7/29/2014)... LINCOLNSHIRE, Ill. , July 29, 2014  Sysmex ... equipment and information systems technology, will feature an exhibit ... (AACC) Annual Meeting and Clinical Lab Expo in ... 31, 2014. "We are extremely excited ... tremendous opportunity to interact with our customers and continue ...
(Date:7/29/2014)... , July 29, 2014 Apex Medical Corporation ... and Pressure Area Care sectors, announces that it is appealing ... in Germany that found ... Apex notes that it has initiated invalidity challenges against various ... efforts in counterattacking against trivial and junk patents. ...
(Date:7/29/2014)... 2014  Drug development for hepatitis C virus ... and the intense need for curative therapy in ... underway as the market moves away from protease ... interferon-free oral therapies. Logo - ... blockbuster Sovaldi is the first of these novel ...
Breaking Medicine Technology:New Product Offerings Highlight Sysmex's Presence at 2014 AACC in Chicago 2New Product Offerings Highlight Sysmex's Presence at 2014 AACC in Chicago 3Apex Continues Fighting Against Patents to Free Up Competition 2A Treatment Revolution is Underway: All-Oral Therapies Transform Global Hepatitis C Antiviral Market 2A Treatment Revolution is Underway: All-Oral Therapies Transform Global Hepatitis C Antiviral Market 3A Treatment Revolution is Underway: All-Oral Therapies Transform Global Hepatitis C Antiviral Market 4
Medtronic Ophthalmics offers a comprehensive selection of corneal trephine,blades and handles. Handcrafted, sharp, uniform blade edges promote a,symetrical and vertical cut of all corneal layers....
Medtronic Ophthalmics offers a comprehensive selection of corneal trephine,blades and handles. Handcrafted, sharp, uniform blade edges promote a,symetrical and vertical cut of all corneal layers....
Medtronic Ophthalmics offers a comprehensive selection of corneal trephine,blades and handles. Handcrafted, sharp, uniform blade edges promote a,symetrical and vertical cut of all corneal layers....
Medtronic Ophthalmics offers a comprehensive selection of corneal trephine,blades and handles. Handcrafted, sharp, uniform blade edges promote a,symetrical and vertical cut of all corneal layers....
Medicine Products: