Navigation Links
First-of-its-kind approach nanomedicine design effectively targets cancer with decreased toxicity
Date:7/10/2012

BOSTON, MAResearchers at Brigham and Women's Hospital (BWH) are the first to report a new approach that integrates rational drug design with supramolecular nanochemistry in cancer treatment.

Supramolecular chemistry is the development of complex chemical systems using molecular building blocks. The researchers utilized such methods to create nanoparticles that significantly enhanced antitumor activity with decreased toxicity in breast and ovarian cancer models.

"This work is effectively moving beyond using nanotechnology as drug 'delivery' vehicles to reengineering drugs themselves so that they become nanomedicines." said Shiladitya Sengupta, PhD, MSc, BWH associate bioengineer, and senior study author.

The study is published in this week's issue of the Proceedings of the National Academy of Sciences (PNAS).

The researchers used cisplatina drug of choice for first and second line chemotherapyas a template.

They designed a cisplatin nanoparticle that incorporated various components, namely a unique platinum (II) tethered to a cholesterol backbone, that helped foster an environment that facilitated efficient nanoparticle assembly.

The researchers found that the innovative nanoparticles they developed were more effective compared to carboplatin or cisplatin in vitro, and remained active in cisplatin-resistant conditions.

"In the last 30 years, there have only been three platins that have been approved for use in almost all cancers," said Sengupta. "A fourth platin that homes preferentially to the tumor, is more potent, but is safer to use at the same time can have major impact on chemotherapy."

Given that platinum-based chemotherapies serve as the frontline therapy for many cancers, the researchers are optimistic that the increased efficacy and toxicity profile demonstrated by their design may lead to the next generation platinum-based agents in the fight against cancer.


'/>"/>
Contact: Marjorie Montemayor-Quellenberg
mmontemayor-quellenberg@partners.org
617-534-2208
Brigham and Women's Hospital
Source:Eurekalert

Related medicine news :

1. First-of-its-kind Menopause Map helps women navigate treatment
2. Unique approach needed to accurately assess health of young adult cancer survivors
3. MU receives national award for using mind-body approach to improve health
4. Global, common approach to pharmaceutical supply chain integrity the focus of workshop
5. Editorial calls for comprehensive approach to cancer screening
6. Rutgers team discovers novel approach to stimulate immune cells
7. National initiative launched to change the way biology departments approach undergraduate education
8. A systems approach to preventing obesity in early life
9. Mount Sinai researchers develop a multi-target approach to treating tumors
10. Moffitt researcher, colleagues find success with new immune approach to fighting some cancers
11. A non-antibiotic approach for treating urinary tract infections
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2016)... Fla. (PRWEB) , ... May 26, 2016 , ... The ... (AHEC) to host a six-week smoking cessation class starting June 6 at their clinic ... website, http://www.gnahec.org . , Additionally, the Lung Institute has created a free downloadable ...
(Date:5/26/2016)... ... ... The MIAMI Institute for Age Management and Intervention celebrates Global Wellness Day ... Dr. Adonis , Wellness Physician of the MIAMI Institute is certified by the American ... Medicine. , He also heads up FITTLab, the comprehensive medical testing lab located in ...
(Date:5/26/2016)... (PRWEB) , ... May 26, 2016 , ... ... information to oncology professionals, has added National Cancer Institute-designated University of Virginia ... , In this new partnership, OncLive’s editorial and marketing teams will publicize and ...
(Date:5/26/2016)... (PRWEB) , ... May 26, 2016 , ... ... organization to provide strategic sales leadership and to further develop their rapidly expanding ... B.S. in Business Administration with a concentration in Marketing and an M.B.A. with ...
(Date:5/26/2016)... ... May 26, 2016 , ... Dr. LeRoy Perry’s recently authored whitepaper, ... mobile devices on the billions of users, hundreds of millions of whom are coming ... life threatening, the frequent and common action of looking down at hand-held technology devices ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... , May 24, 2016 ... den Markt gebracht, die es Ärzten erlaubt, ihre ... zu behandeln: MDLinking kombiniert Live Streaming mit einer ... Umfeld zu kommunizieren. Mediziner in Europa, Afrika, Asien ... sich bereits für die Plattform registriert. ...
(Date:5/24/2016)...  Diana Russell suffers from a form of rheumatoid ... out.  This disease has put her in a wheelchair, ... grandchildren to leave her home.  Because of the size ... the wheelchair.  So if there is a family function, ... left to wait for the bus. Photo ...
(Date:5/24/2016)... , May 24, 2016  Joe Marziani has joined VMS BioMarketing as senior vice ... officer, today. In his new role, Marziani will lead the company,s business development and ... to improve outcomes. Photo - http://photos.prnewswire.com/prnh/20160523/371089 ... ... ...
Breaking Medicine Technology: