Navigation Links
First-of-its-kind approach nanomedicine design effectively targets cancer with decreased toxicity
Date:7/10/2012

BOSTON, MAResearchers at Brigham and Women's Hospital (BWH) are the first to report a new approach that integrates rational drug design with supramolecular nanochemistry in cancer treatment.

Supramolecular chemistry is the development of complex chemical systems using molecular building blocks. The researchers utilized such methods to create nanoparticles that significantly enhanced antitumor activity with decreased toxicity in breast and ovarian cancer models.

"This work is effectively moving beyond using nanotechnology as drug 'delivery' vehicles to reengineering drugs themselves so that they become nanomedicines." said Shiladitya Sengupta, PhD, MSc, BWH associate bioengineer, and senior study author.

The study is published in this week's issue of the Proceedings of the National Academy of Sciences (PNAS).

The researchers used cisplatina drug of choice for first and second line chemotherapyas a template.

They designed a cisplatin nanoparticle that incorporated various components, namely a unique platinum (II) tethered to a cholesterol backbone, that helped foster an environment that facilitated efficient nanoparticle assembly.

The researchers found that the innovative nanoparticles they developed were more effective compared to carboplatin or cisplatin in vitro, and remained active in cisplatin-resistant conditions.

"In the last 30 years, there have only been three platins that have been approved for use in almost all cancers," said Sengupta. "A fourth platin that homes preferentially to the tumor, is more potent, but is safer to use at the same time can have major impact on chemotherapy."

Given that platinum-based chemotherapies serve as the frontline therapy for many cancers, the researchers are optimistic that the increased efficacy and toxicity profile demonstrated by their design may lead to the next generation platinum-based agents in the fight against cancer.'/>"/>

Contact: Marjorie Montemayor-Quellenberg
mmontemayor-quellenberg@partners.org
617-534-2208
Brigham and Women's Hospital
Source:Eurekalert

Page: 1 2

Related medicine news :

1. First-of-its-kind Menopause Map helps women navigate treatment
2. Unique approach needed to accurately assess health of young adult cancer survivors
3. MU receives national award for using mind-body approach to improve health
4. Global, common approach to pharmaceutical supply chain integrity the focus of workshop
5. Editorial calls for comprehensive approach to cancer screening
6. Rutgers team discovers novel approach to stimulate immune cells
7. National initiative launched to change the way biology departments approach undergraduate education
8. A systems approach to preventing obesity in early life
9. Mount Sinai researchers develop a multi-target approach to treating tumors
10. Moffitt researcher, colleagues find success with new immune approach to fighting some cancers
11. A non-antibiotic approach for treating urinary tract infections
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/12/2014)... 12, 2014 The Passenger Information System ... 2013 to $20,341.36 million by 2019, at an expected ... 2019. , The public transport infrastructure in North America ... available in almost every corner of the region. The ... of public transport service providers are driving the North ...
(Date:7/12/2014)... The rise in the number of mobility devices ... architectures to suit the upsurge. Virtualization has become a ... storage technologies. The data traffic has increased by several ... has resulted in larger and more complex networks. These ... SDN market. , The North American (NA) region is ...
(Date:7/12/2014)... Thompson HealthDay Reporter SATURDAY, ... guarantee that a surgical technique used to grind up uterine ... risk of spreading cancer to other parts of a woman,s ... to the Food and Drug Administration also said that women ... -- should sign a written consent stating that they understand ...
(Date:7/12/2014)... 12, 2014 In this ... ‘cognitive assessment and training’ is defined as ... train, or enhance cognitive functions. These solutions ... in dementia screening, clinical trials, driver’s safety, ... self assessment, brain training, and employers’ assessment ...
(Date:7/12/2014)... The Security Analytics market is estimated to grow ... 2019, at an expected CAGR of 9.7% for the ... the increasing number of security breaches, continued line of ... in organizations are enormous. Vendors in the security analytics ... to develop better and more secure systems. , There ...
Breaking Medicine News(10 mins):Health News:North America Passenger Information System (ICT) Market worth $5,486.88 Million by 2019 - New Report by MicroMarket Monitor 2Health News:North America Passenger Information System (ICT) Market worth $5,486.88 Million by 2019 - New Report by MicroMarket Monitor 3Health News:North America Passenger Information System (ICT) Market worth $5,486.88 Million by 2019 - New Report by MicroMarket Monitor 4Health News:North America Software Defined Network (SDN) Market Worth $1,443.8 Million by 2019 - New Report by MicroMarket Monitor 2Health News:North America Software Defined Network (SDN) Market Worth $1,443.8 Million by 2019 - New Report by MicroMarket Monitor 3Health News:North America Software Defined Network (SDN) Market Worth $1,443.8 Million by 2019 - New Report by MicroMarket Monitor 4Health News:North America Software Defined Network (SDN) Market Worth $1,443.8 Million by 2019 - New Report by MicroMarket Monitor 5Health News:FDA Advisers Weigh Risks of Procedure for Removal of Uterine Fibroids 2Health News:FDA Advisers Weigh Risks of Procedure for Removal of Uterine Fibroids 3Health News:Global Cognitive Assessment & Training Market: 27.3% CAGR to 2018 Says a New Research Report Available at LifeScienceIndustryResearch.com 2Health News:Global Cognitive Assessment & Training Market: 27.3% CAGR to 2018 Says a New Research Report Available at LifeScienceIndustryResearch.com 3Health News:Global Cognitive Assessment & Training Market: 27.3% CAGR to 2018 Says a New Research Report Available at LifeScienceIndustryResearch.com 4Health News:Global Cognitive Assessment & Training Market: 27.3% CAGR to 2018 Says a New Research Report Available at LifeScienceIndustryResearch.com 5Health News:North America Security Analytics Market Worth $1,215.2 Million by 2019 - New Report by MicroMarket Monitor 2Health News:North America Security Analytics Market Worth $1,215.2 Million by 2019 - New Report by MicroMarket Monitor 3Health News:North America Security Analytics Market Worth $1,215.2 Million by 2019 - New Report by MicroMarket Monitor 4
... market most aggressively to physicians and patients tend to offer ... phenomenon described as the "inverse benefit law" in a paper ... Published online Thursday, Jan. 13 in the American ... of blockbuster drugs due to safety concerns and finds a ...
... By Amanda Gardner HealthDay Reporter , THURSDAY, Jan. ... heartening medical progress continued to arrive Thursday, five days after ... an assassin,s bullet. Giffords, doctors at University Medical Center ... keep her eyes open for up to 15 minutes at ...
... (HealthDay News) -- Differences in income, gender and race ... prematurely, a federal government report released Thursday shows. ... live healthy lives, disparities persist, according to the U.S. ... low-income people have five to 11 times fewer healthy ...
... from training programs that put them behind the wheelin a ... skills. That,s the conclusion of a new article published in ... the Association for Psychological Science. Older people are ... Some states and provinces test older drivers, hoping to get ...
... AMES, Iowa Advancements in understanding rotational motion in ... causes of deadly diseases, such as Alzheimer,s, according to ... of Energy,s Ames Laboratory and faculty member at Iowa ... article entitled "Resolving Rotational Motions of Nano-objects in Engineered ...
... Virginia Tech-Wake Forest University Center for Injury Biomechanics ( ... from the U.S. Army Medical Research and Materiel Command ... brain and eye injuries in military personnel. Specifically, blast ... computational models. Given improvements in helmet design and body ...
Cached Medicine News:Health News:Inverse benefits due to drug marketing undermine patient safety and public health 2Health News:Inverse benefits due to drug marketing undermine patient safety and public health 3Health News:Rep. Giffords Continues to Recover From Gunshot Wound 2Health News:Rep. Giffords Continues to Recover From Gunshot Wound 3Health News:Health Disparities Persist in U.S., Report Shows 2Health News:Driving simulators help older adults improve their road skills 2Health News:New tool for cell research may help unravel secrets of disease 2Health News:US Department of Defense supports study of brain, eye injuries in military personnel 2
(Date:7/10/2014)... July 10, 2014  BC Technical, the largest nationwide, ... America , Inc., a leading provider of Siemens Nuclear ... long-term agreement naming BC Technical as the authorized provider ... MiE and BC Technical announced today that the ... BC Technical as the service and systems provider for ...
(Date:7/10/2014)... BURLINGTON, Mass. , July 10, 2014 /PRNewswire/ ... three-quarters of surveyed infectious disease (ID) specialists are ... Medicines Company,s Orbactiv (oritavancin) for use as OPAT, ... to prescribe these agents to their hospital inpatients. ... percent) of OPAT patients are initiated on OPAT ...
(Date:7/10/2014)... , July 10, 2014 Decision Resources ... awareness of the U.S. Food and Drug Administration,s (FDA) ... phosphate binder Velphoro, which was approved by the FDA ... chronic kidney disease (CKD) patients on dialysis. ... TreatmentTrends: Nephrology (US) Q2 2014 : ...
Breaking Medicine Technology:BC Technical Partners With MiE America To Be Authorized Provider Of Systems & Service 2Long-Acting Antibiotics Offering Once-Weekly Dosing Will See Favorable Uptake and Use as Outpatient Parenteral Antimicrobial Therapy (OPAT) 2Long-Acting Antibiotics Offering Once-Weekly Dosing Will See Favorable Uptake and Use as Outpatient Parenteral Antimicrobial Therapy (OPAT) 3Half of Surveyed Nephrologists Report Moderate Familiarity with Velphoro, Which Received FDA Approval Late Last Year for the Treatment of Hyperphosphatemia in Dialysis 2Half of Surveyed Nephrologists Report Moderate Familiarity with Velphoro, Which Received FDA Approval Late Last Year for the Treatment of Hyperphosphatemia in Dialysis 3
... STEVENSVILLE, Md., July 13, 2011 Vapotherm, a privately held ... announced today that it has received approval from the Medical ... device which will be launched later this year in the ... Flow Specialty Gas Program. "We are pleased ...
... 2011 The U.S. Food and Drug Administration today ... and patients that surgical placement of mesh through the ... to greater risk than other surgical options. ... communication also says that with the exposure to greater ...
Cached Medicine Technology:Vapotherm Announces Approval in Canada for New High Flow Device Designed for Heliox 2FDA: Surgical Placement of Mesh to Repair Pelvic Organ Prolapse Poses Risks 2FDA: Surgical Placement of Mesh to Repair Pelvic Organ Prolapse Poses Risks 3FDA: Surgical Placement of Mesh to Repair Pelvic Organ Prolapse Poses Risks 4
Ambion's barrier tips prevent cross-contamination of samples by means of an aerosol filter. They are RNase- and DNase-free and are ideal for handling RNA, PCR applications, and for working with radio...
10 L, Bulk Recommended for 5 and 10 L pipettes. Ideal for pipetting into long, narrow tubes or deep well plates....
This extended 10 L tip additionally combats contamination by keeping your pipettor out of 1.5 L and 2.0 L tubes....
1000 L, Bulk Recommended for 500 and 1000 L pipettes....
Medicine Products: