Navigation Links
First observation of a human HAT, key proteins in numerous pathologies
Date:2/11/2014

e and releasing them in the cytoplasm or vice-versa," explains Palacn. "We knew the structure of one of the parts. Now, for the first time, we have the low resolution of the entire complex," he says.

The study, whose first four authors include the post-doctoral researcher Albert Rosell and the PhD student Elena lvarez-Marimon at IRB Barcelona, describes the structure of the 4F2hc/LAT2 complex. "We chose this complex because it shows the highest stability among human HATs and would allow a greater chance of tackling its structure. The next step is to move onto its atomic resolution," explains Rosell. "Resolution at this level, at the highest definition, will help us to study the details of how "the machine" works and to gain a greater knowledge regarding the precise drug targets," add the scientists.

Only some HATs are associated with diseases. The 4F2hc/LAT1 and 4F2hc/xCT complexes are overexpressed in many kinds of cancer. "We have better and more detailed knowledge about the complexes and so we are providing new options by which to deal with cancer," says Manuel Palacn. The lab also focuses on aminoacidurias. Mutation in the 4F2hc/y+LAT1 complex causes lysinuric protein intolerance, a rare disease with 200 known cases. Finally, mutations in the rBAT/b(0,+)AT complex lead to cystinuria, a condition with an estimated incidence of one case per 7,000 births.

Manuel Palacn's basic research into HATs seeks to identify new therapeutic targets and to improve diagnostic tools for all conditions that involve HATs, with a special focus on aminoacidurias.

The study started as part of the European project EDICT (European Drug Initiative on Channels and Transporters), a consortium comprising 21 groups and funded by 11 million euros, which aims to increase the database of membrane protein structures. In 2008, at the beginning of the project, about 100 membrane protein structures were known. Today, this number has tripled, Palacn's group having
'/>"/>

Contact: Sònia Armengou
armengou@irbbarcelona.org
34-934-037-255
Institute for Research in Biomedicine (IRB Barcelona)
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Beaumont Health System first outside of Japan to test new atrial fibrillation technology
2. CONRAD wins USAID Science and Technology Pioneers Prize for development of first vaginal gel proven to reduce HIV
3. Maternal-fetal medicine professionals identify ways to reduce first cesarean
4. A scientific first: Physicists, physicians, engineers photograph radiation beams in the human body through the Cherenkov effect
5. NCCS and Clearbridge Biomedics open the regions first circulating tumor cell center
6. Dr Steven Shoshany to Become First NYC Chiropractor to Accept Bitcoin
7. A Priceless Resolution: Take That First Step Toward Financial Security
8. Dr. Kanani Announces Complimentary Consultations for First Time Patients
9. New NuGo Stronger: First Non-GMO High Protein Bar with rBGH-Free Whey Protein for Serious Athletes
10. PCG Kids Pediatric Care Group Voted in Top 20 Finalist to Win Philly's First Business Award From Firstrust Bank
11. Sarantos Releases First Music Video - "Not Where I Wanna Be"
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
First observation of a human HAT, key proteins in numerous pathologies
(Date:7/23/2014)... CA (PRWEB) July 23, 2014 “Unlike ... will focus on developing your own unique gifts, talents ... techniques and clichéd sales verbiage, “says Ja Marr Brown. ... Your Sales Story?" which chronicles Brown’s transformation from nearly ... Person of The Year, winning every sales contest offered ...
(Date:7/23/2014)... DC (PRWEB) July 23, 2014 ... overwhelming ratified today a robust trial for a ... implications of risk adjusting relevant quality measures for ... to NQF policy.     , Sociodemographic factors can be ... e.g., race, ethnicity, and primary language. Growing ...
(Date:7/23/2014)... Worth, FL (PRWEB) July 23, 2014 ... take place Aug. 10-16, Millennium Treatment Group is providing ... abuse has existed in society ever since man first ... wine. Substance abuse treatment has existed since shortly thereafter. ... recognizing a problem and then developing a way to ...
(Date:7/23/2014)... Steven Reinberg HealthDay Reporter ... obese and overweight American children and teens look in ... U.S. health officials reported Wednesday. "Being overweight or ... high blood pressure, high cholesterol and diabetes," said lead ... Centers for Disease Control and Prevention,s National Center for ...
(Date:7/23/2014)... VA (PRWEB) July 23, 2014 Inventor ... America: From football games to the gas pump – ... guests on Wednesday, July 30 at Noon. , With ... Legislator has more patents than anyone in the General ... football’s superimposed yellow line yard marker as seen on ...
Breaking Medicine News(10 mins):Health News:Using Your Story and Not Technique to Achieve Sales Success 2Health News:NQF Board Approves Trial Period to Test Impact of Risk Adjustment of Performance Measures for Sociodemographic Factors 2Health News:Millennium Treatment Group Offers Tips on Choosing a Reputable Treatment Center 2Health News:Millennium Treatment Group Offers Tips on Choosing a Reputable Treatment Center 3Health News:Many Obese U.S. Kids Think They're Thinner Than They Are 2Health News:Many Obese U.S. Kids Think They're Thinner Than They Are 3Health News:Celebrating Innovation and Invention 2
... woman with dementia, little money and an equally aged caregiver sister who ... woman with Alzheimer,s who cannot be left safely on her own, forcing ... A 78-year-old Los Angeles man with Alzheimer,s ... him if day care services are cut. These ...
... the body,s chemical response to injury , THURSDAY, Oct. 1 ... were injured were more likely to survive than sober trauma ... similar finding. , The latest study of 7,985 trauma patients ... 1 percent of intoxicated patients. All of the patients were ...
... ... media supplements, Zap-CHO and Optiferrin, have been developed to maximize cell culture media performance ... bioprocessing industry, October 12-16 at Raleigh Convention Center in Raleigh, North Carolina. , ... Fort Collins, CO (PRWEB) ...
... , Effort Illustrates Broad Public Support for Addressing ... Oct. 1 Citizens of Delaware ... prevention and wellness with the launch today of "Say ,Yes, ... online video campaign of the Partnership to Fight Chronic Disease ...
... Oct. 1 Cynthia Perkins, M.Ed., publishes new book, ... , to provide alcoholics with the little known facts ... Stay Sober: The Truth About Alcoholism provides an ... and its successful treatment! Despite past decades of unrelenting ...
... 1 Reportlinker.com announces that a new market research ... World Pharmaceutical Packaging , http://www.reportlinker.com/p0127773/World-Pharmaceutical-Packaging.html ... 2013 Global demand for pharmaceutical packaging will rise ... 2013. The developed countries of Western Europe, the US ...
Cached Medicine News:Health News:Half-million low-income elderly affected by sweeping cuts to state safety net 2Health News:Half-million low-income elderly affected by sweeping cuts to state safety net 3Health News:InVitria's Better Ingredients for Better Media to be Showcased at BPI '09 2Health News:Delaware Residents Participate in Launch of National Video Campaign: 'Say 'Yes' to Health Reform' 2Health News:Delaware Residents Participate in Launch of National Video Campaign: 'Say 'Yes' to Health Reform' 3Health News:New Book Provides Alcoholics with Hope for Stable, Long-Term, Craving-Free Sobriety 2Health News:Reportlinker Adds World Pharmaceutical Packaging Report 2Health News:Reportlinker Adds World Pharmaceutical Packaging Report 3Health News:Reportlinker Adds World Pharmaceutical Packaging Report 4Health News:Reportlinker Adds World Pharmaceutical Packaging Report 5Health News:Reportlinker Adds World Pharmaceutical Packaging Report 6Health News:Reportlinker Adds World Pharmaceutical Packaging Report 7Health News:Reportlinker Adds World Pharmaceutical Packaging Report 8Health News:Reportlinker Adds World Pharmaceutical Packaging Report 9Health News:Reportlinker Adds World Pharmaceutical Packaging Report 10
(Date:7/23/2014)... 23, 2014  MiMedx Group, Inc.  (NASDAQ: ... marketer of patent-protected regenerative biomaterials and bioimplants processed ... filed its initial Investigational New Drug ("IND") application ... The IND submission, which was filed ... submission for certain indications of its micronized allografts ...
(Date:7/23/2014)...  Dompe, a leader in R&D for new therapeutic solutions ... Human Nerve Growth Factor) has been designated as an orphan ... The candidate drug, developed by the research of ... treatment of neurotrophic keratitis, a degenerative corneal disease that affects ... currently without a cure. This is the second orphan drug ...
(Date:7/23/2014)... DUBLIN , July 23, 2014 ... addition of the "Prepackaged Medical Kits and ... to their offering. ... worldwide markets for Prepackaged Medical Kits and Trays ... ENT Custom Trays, Ophthalmic Custom Trays, Custom Basin ...
Breaking Medicine Technology:MiMedx Files Its Initial Investigational New Drug Application 2MiMedx Files Its Initial Investigational New Drug Application 3Dompe announces the Food and Drug Administration (FDA) has granted orphan drug designation to its rhNGF-based treatment for neurotrophic keratitis 2Dompe announces the Food and Drug Administration (FDA) has granted orphan drug designation to its rhNGF-based treatment for neurotrophic keratitis 3Dompe announces the Food and Drug Administration (FDA) has granted orphan drug designation to its rhNGF-based treatment for neurotrophic keratitis 4Prepackaged Medical Kits and Trays - Global Strategic Business Report: Updated 2014 Report 2
... The SAP® Customer Relationship Management (SAP CRM) application, configured ... enabled by Freudenberg IT (FIT), is powering the complex sales and ... in stem cell cryopreservation services. , ... SAP CRM 7.0, provided by RunE2E, enables ...
... , VANCOUVER , May 17 Xenon Pharmaceuticals Inc. ... Mansour as Executive Vice President, Research and Development. , ... "We are delighted to welcome Tarek ... CEO. "Tarek is a world-class R&D executive whose experience in discovering products, ...
Cached Medicine Technology:RunE2E and Freudenberg IT Create Customer Value Through Implementation of SAP® CRM in Hosted, Private Cloud 2RunE2E and Freudenberg IT Create Customer Value Through Implementation of SAP® CRM in Hosted, Private Cloud 3RunE2E and Freudenberg IT Create Customer Value Through Implementation of SAP® CRM in Hosted, Private Cloud 4Xenon Announces Appointment of EVP, Research & Development 2
... Direct has been selling replacement ... 1996, and we are extremely ... guarantee. Check out our catalog ... our discount light bulbs specials. ...
... Bulb Direct has been ... Internet since 1996, and we ... 100% satisfaction guarantee. Check out ... and see our discount light ...
... Direct has been selling replacement ... 1996, and we are extremely ... guarantee. Check out our catalog ... our discount light bulbs specials. ...
... Bulb Direct has been selling ... since 1996, and we are ... satisfaction guarantee. Check out our ... see our discount light bulbs ...
Medicine Products: