Navigation Links
First observation of a human HAT, key proteins in numerous pathologies
Date:2/11/2014

e and releasing them in the cytoplasm or vice-versa," explains Palacn. "We knew the structure of one of the parts. Now, for the first time, we have the low resolution of the entire complex," he says.

The study, whose first four authors include the post-doctoral researcher Albert Rosell and the PhD student Elena lvarez-Marimon at IRB Barcelona, describes the structure of the 4F2hc/LAT2 complex. "We chose this complex because it shows the highest stability among human HATs and would allow a greater chance of tackling its structure. The next step is to move onto its atomic resolution," explains Rosell. "Resolution at this level, at the highest definition, will help us to study the details of how "the machine" works and to gain a greater knowledge regarding the precise drug targets," add the scientists.

Only some HATs are associated with diseases. The 4F2hc/LAT1 and 4F2hc/xCT complexes are overexpressed in many kinds of cancer. "We have better and more detailed knowledge about the complexes and so we are providing new options by which to deal with cancer," says Manuel Palacn. The lab also focuses on aminoacidurias. Mutation in the 4F2hc/y+LAT1 complex causes lysinuric protein intolerance, a rare disease with 200 known cases. Finally, mutations in the rBAT/b(0,+)AT complex lead to cystinuria, a condition with an estimated incidence of one case per 7,000 births.

Manuel Palacn's basic research into HATs seeks to identify new therapeutic targets and to improve diagnostic tools for all conditions that involve HATs, with a special focus on aminoacidurias.

The study started as part of the European project EDICT (European Drug Initiative on Channels and Transporters), a consortium comprising 21 groups and funded by 11 million euros, which aims to increase the database of membrane protein structures. In 2008, at the beginning of the project, about 100 membrane protein structures were known. Today, this number has tripled, Palacn's group having
'/>"/>

Contact: Sònia Armengou
armengou@irbbarcelona.org
34-934-037-255
Institute for Research in Biomedicine (IRB Barcelona)
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Beaumont Health System first outside of Japan to test new atrial fibrillation technology
2. CONRAD wins USAID Science and Technology Pioneers Prize for development of first vaginal gel proven to reduce HIV
3. Maternal-fetal medicine professionals identify ways to reduce first cesarean
4. A scientific first: Physicists, physicians, engineers photograph radiation beams in the human body through the Cherenkov effect
5. NCCS and Clearbridge Biomedics open the regions first circulating tumor cell center
6. Dr Steven Shoshany to Become First NYC Chiropractor to Accept Bitcoin
7. A Priceless Resolution: Take That First Step Toward Financial Security
8. Dr. Kanani Announces Complimentary Consultations for First Time Patients
9. New NuGo Stronger: First Non-GMO High Protein Bar with rBGH-Free Whey Protein for Serious Athletes
10. PCG Kids Pediatric Care Group Voted in Top 20 Finalist to Win Philly's First Business Award From Firstrust Bank
11. Sarantos Releases First Music Video - "Not Where I Wanna Be"
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
First observation of a human HAT, key proteins in numerous pathologies
(Date:8/29/2014)... 2014 The Department of Health and ... (file code CMS–0052–P) today allowing healthcare providers to attest ... Certified EHR Technology (CEHRT) or a combination of the ... have not been able to fully implement 2014 Edition ... can continue to use 2011 Edition CEHRT, or a ...
(Date:8/29/2014)... Daily Gossip indicates in its recently published ... perfectly understand what patients have to go through at the ... creator of this new method. Bakker is a naturopathic doctor ... , Bakker claims that during all this time he ... living with the yeast infection can be. , Read ...
(Date:8/29/2014)... 29, 2014 Dr. Mohebi’s lecture on ... talked about introducing these cutting edge techniques at their ... the FUE Research Committee has allowed him the ability ... is possible with modern technology. Dr. Mohebi stated, “We ... FUE devices that facilitate extraction and implantation of hair ...
(Date:8/29/2014)... According to a CNN article, entitled ... (8/25), a new study found that those states who ... a significant decrease in the number of painkiller overdoses ... year period, and comparing various states with and without ... there was about a 25% decrease in painkiller prescription ...
(Date:8/29/2014)... 29, 2014 As reported by GantDaily.com in ... Drug Abuse Trends , Outbreaks (8/20), the National Institute on ... monitor drug abuse trends by turning to social media. As ... trends, it is also working with the University of Maryland ... Early Warning System, which will be funded by the National ...
Breaking Medicine News(10 mins):Health News:Quirk Healthcare Outlook on MU2 Delay Confirmation 2Health News:Candida Crusher Review Reveals a Unique Way to Eliminate Yeast Infection Permanently 2Health News:Parsa Mohebi M.D., Beverly Hills Hair Restoration Surgeon Gives Inspiring Lecture on Groundbreaking Techniques in Follicular Unit Extraction 2Health News:Overdoses on Painkillers Decreased in States With Medical Marijuana 2Health News:Overdoses on Painkillers Decreased in States With Medical Marijuana 3Health News:Social Media Proves to Be Helpful in Fighting Drug Abuse 2Health News:Social Media Proves to Be Helpful in Fighting Drug Abuse 3
... lady love Jenny McCarthy has revealed her plans about getting a ... couple will be spending as much time as possible on the ... sit and do nothing. Stare at the ocean and go 'ohhmmm, ... spending a lot of time with her beau on the beach, ...
... Food Programme (WFP) has warned that continuing security problems are ... the west of the country where food stocks are running ... see critical food supplies curtailed or interrupted. ,"WFP ... of Afghanistan for four weeks due to insecurity. Unless we ...
... expert has organized a three-day workshop on the ancient Indian ... director of Yoga Darshan, India, in his lecture on Yoga, ... said, yoga could help the people of Lahore keep healthy, ... can help Lahoris keep healthy, said Dr Mishra, who holds ...
... New adjuvant treatments for breast cancer are cost-effective ... A peer-reviewed journal of the American Cancer Society, ... for the management of adjuvant therapies for early ... study of estrogen receptor positive breast cancers, switching ...
... revisited across the West. Experts have begun to wonder whether ... commodity prices are skyrocketing . ,For those of ... have gone only one way, and that is down. Sixty ... of its income on food. Today, that figure has dropped ...
... Scotland today [Monday 25 June 2007] published a five point ... highlighted in a new paper published by BMA Scotland ... in Torquay. ,Alcohol kills six people every day ... of young people presenting to the NHS with serious illness ...
Cached Medicine News:Health News:Insecurity Jepardising WFP Initiatives in Western Afghanistan 2Health News:Cost-effective Treatments for Breast Cancer 2Health News:Consume Less, Experts Advise as Malthusian Nightmare Returns to Haunt West 2Health News:Consume Less, Experts Advise as Malthusian Nightmare Returns to Haunt West 3Health News:Consume Less, Experts Advise as Malthusian Nightmare Returns to Haunt West 4Health News:BMA Scotland Publishes Plan to Tackle Scotland's Drink Problem 2Health News:BMA Scotland Publishes Plan to Tackle Scotland's Drink Problem 3
(Date:8/29/2014)... , Aug. 29, 2014 Pomerantz LLP ... S.A. ("EDAP" or the "Company") (NASDAQ: EDAP ) ... in United States District Court, Southern District of ... is on behalf of a class consisting of all ... 1, 2013 and July 30, 2014, inclusive (the "Class ...
(Date:8/29/2014)... , Aug. 29, 2014   Mast ... biopharmaceutical company, announced today that Santosh Vetticaden, Chief ... leaving the Company, for personal reasons, in mid-September.  ... Medical Officer of Aires Pharmaceuticals, which Mast acquired ... responsibilities as the Company,s interim Chief Medical Officer.  ...
(Date:8/29/2014)... PLEASANTON, Calif. , Aug. 29, 2014 ... leader in device-based mechanical circulatory support therapies to save, ... be participating in the 2014 Morgan Stanley Global Healthcare ... F. Burbach , President and Chief Executive Officer, will ... p.m., Eastern Daylight Time (9:55 a.m., Pacific Daylight Time). ...
Breaking Medicine Technology:SHAREHOLDER ALERT: Pomerantz Law Firm Announces the Filing of a Class Action against EDAP TMS S.A. and Certain Officers - EDAP 2SHAREHOLDER ALERT: Pomerantz Law Firm Announces the Filing of a Class Action against EDAP TMS S.A. and Certain Officers - EDAP 3Mast Therapeutics Announces Management Change 2Mast Therapeutics Announces Management Change 3Mast Therapeutics Announces Management Change 4
... 2012  Mylan Inc. (Nasdaq: MYL ) today announced ... from the U.S. Food and Drug Administration (FDA) for its ... mg, 5 mg, 7.5 mg, 10 mg, 15 mg, and ... Lilly and Company,s Zyprexa ® , which is indicated for ...
... April 24, 2012  Insmed Incorporated (Nasdaq CM: INSM), a ... May 8th, 2012, at 8:30 AM ET, to discuss ... Insmed intends to issue its quarterly financial results press ... To participate in the live conference call, ...
Cached Medicine Technology:Mylan Launches Generic Version of Zyprexa® Tablets 2Insmed to Host 2012 First Quarter Earnings Conference Call 2Insmed to Host 2012 First Quarter Earnings Conference Call 3
For the quantitative determination of direct bilirubin in human serum. Linearity: 20 mg/dl...
Intended for the quantitative determination of direct bilirubin in serum. Modified EvelynMalloy Method. Endpoint Reaction. Wavelength: 555 nm. Linearity: 20 mg/dl (340 mol/l)...
... is the first microplate spectrophotometer designed specifically ... days per week. With rugged hardware, proven ... breaks the barrier of traditional spectrophotometry to ... instrument can easily read up to eight, ...
... microplate spectrophotometer designed specifically to run 24 ... With rugged hardware, proven optical performance and ... of traditional spectrophotometry to obtain results quickly, ... read up to eight, 1 cm Biocell ...
Medicine Products: