Navigation Links
First noninvasive technique to accurately predict mutations in human brain tumors
Date:4/20/2009

DENVER Donald O'Rourke, MD, Associate Professor of Neurosurgery at the University of Pennsylvania School of Medicine and colleagues, were able to accurately predict the specific genetic mutation that caused brain cancer in a group of patients studied using magnetic resonance imaging (MRI). The researchers presented their findings this week at the American Association for Cancer Research 100th Annual Meeting 2009.

"The field of cancer research has evolved to the point where the identification of the mutations that cause tumors has changed how we treat patients in a number of cancers," says O'Rourke. "Potentially, we believe we have a method that uses MRI to identify a tumor mutation. Historically tumor mutations have been identified in only one way: take the tissue out and examine it using one of two laboratory tests to see if the mutation is present. In this study we've done this identification noninvasively. To my knowledge this is the first demonstration that an MRI, or any imaging technique, can accurately predict the type of mutation of a human tumor."

A particular MRI technique, called relative cerebral blood volume that measures blood flow to the tumor, very highly correlates with the presence of an important mutation in glioblastoma, a type of brain cancer. The mutation occurs in the epidermal growth factor receptor, EGFR, a well known cancer-related protein that helps tumors form their necessary blood vessels. EGFRvIII, the specific mutation the Penn group studied, is the hallmark of a more aggressive form of glioblastoma.

The research team compared MRI readings to tumor tissue samples from 97 glioblastoma patients. They found that patients with higher relative cerebral blood volume as measured by MRI correlates with the EGFRvIII mutation compared to those who did not have the mutation.

Glioblastoma is a variable disease, and clinicians need help to distinguish one form from another. "All of cancer research is evol
'/>"/>

Contact: Karen Kreeger
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Sitting at the Virtual Poker Table: Results From First Ever Epidemiological Study of Actual Internet Poker Gaming Behavior, in Press
2. IPC The Hospitalist Company, Inc. to Report First Quarter 2009 Financial Results
3. Yashoda Cancer Institute Treats First Patient in India Using RapidArc Radiotherapy Technology
4. Response Biomedical Corporation Delivers Record Preliminary Revenues in First Quarter
5. First Annual World Meningitis Day Gaining National Support
6. Lilly Reports Strong First-Quarter 2009 Results
7. First Woman President of the AVMA to Speak at Ross University School of Veterinary Medicine's 2009 Graduation
8. U.S. Venture Investment Lowest in 11 Years, Down 50% to $3.9 Billion in First Quarter
9. ISTA Pharmaceuticals Announces Conference Call and Webcast of First Quarter 2009 Financial Results
10. Pennsylvania Governors Food Safety Council to Hold First Meeting on April 22
11. Caliper Life Sciences First Quarter 2009 Financial Results Conference Call Notice
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... NJ (PRWEB) September 18, 2014 ... firm, announced today that President and co-founder John ... Journal’s Innovation Award Winners for 2014, recognizing the ... him as an emerging executive of the year. ... care and life sciences that continue to shape ...
(Date:9/18/2014)... Qualis Health, one of the nation’s leading ... paper, “Advancing Primary Care through the Patient-Centered Medical Home ... Authors Jeff Hummel, MD, MPH and Peggy C. Evans, ... in the work of becoming a Patient-Centered Medical Home ... objectives, such as generating and providing useful data that ...
(Date:9/18/2014)... Baltimore, MD (PRWEB) September 18, 2014 ... Award-winning celebrity and wellness advocate, and Frank Davis, ... Activz Whole-food Nutrition, are pleased to announce ... 150+ ways to make delicious, nutrition-packed meals using ... book is the next step in the ...
(Date:9/18/2014)... of international scientists have developed a new method to ... . , The Wildlife Conservation Society (WCS)-led research, published ... , describes the use of fecal samples from wild ... exposed to the virus. This represents a new tool ... change the way Ebola virus is studied and improve ...
(Date:9/18/2014)... expect to pay higher employee contributions for their health ... officers about the impact of the Patient Protection and ... conducted by the Darla Moore School of Business at ... Patrick Wright, a professor in strategic human resource management, ... Officers. The survey is distributed to more than 560 ...
Breaking Medicine News(10 mins):Health News:TayganPoint Executive Receives Prestigious Award from Philadelphia Business Journal 2Health News:Advancing Primary Care Through PCMH and HIT: New White Paper Connects the Dots 2Health News:Montel Williams and Frank Davis Announce New Whole-Food Nutrition Recipe Book, The Simple Scoop, at Natural Products Expo East In Baltimore 2Health News:Montel Williams and Frank Davis Announce New Whole-Food Nutrition Recipe Book, The Simple Scoop, at Natural Products Expo East In Baltimore 3Health News:Research yields a game changer for improving understanding of Ebola and great apes 2Health News:Research yields a game changer for improving understanding of Ebola and great apes 3Health News:Survey: Fortune 500 employees can expect to pay more for health insurance 2Health News:Survey: Fortune 500 employees can expect to pay more for health insurance 3
... regional networks , , FRIDAY, April 24 (HealthDay News) ... laboratory personnel has led to steady improvements in the ... a severe heart attack, new research shows. , The ... ST elevation myocardial infarction (STEMI), the deadliest type of ...
... Though soldiers tend to be healthier, trauma erases the advantage, ... Those serving in the armed forces tend to be in ... experienced combat duty, that initial health advantage is erased. , ... life than do non-combat veterans, according to a study that ...
... N.C. (April 23, 2009) Talecris Biotherapeutics, Inc. ... of life results from the largest clinical trial ... polyneuropathy (CIDP) in the April 14, 2009 issue ... that long-term treatment with Gamunex (Immune Globulin Intravenous ...
... ANGELES , April 24 MMR Information ... its wholly-owned operating subsidiary, MyMedicalRecords, Inc. (collectively, "MMR") ... www.mymedicalrecords.com ) and electronic safe deposit box ... a Webinar on the company,s products for healthcare ...
... ABC,s hit television show Grey,s Anatomy has selected the ... its favorite charities and has listed the AAN Foundation on the Grey,s ... and Dr. Derek "McDreamy" Shepherd. Fans and the public are encouraged ... lieu of gifts. The public can buy a virtual brain for ...
... "Pregnant women need our assistance now so that abortion ... April 24 Cardinal Rigali, chair of the Committee ... Bishops (USCCB), wrote to all U.S. Representatives urging them ... 2035) re-introduced in the House by Rep. Lincoln Davis ...
Cached Medicine News:Health News:Coordination Has Led to Quicker Heart Treatment 2Health News:Combat Duty Harms Long-Term Health of Vets 2Health News:Combat Duty Harms Long-Term Health of Vets 3Health News:Landmark study demonstrates Gamunex improves health-related quality of life in patients with CIDP 2Health News:Landmark study demonstrates Gamunex improves health-related quality of life in patients with CIDP 3Health News:MMR Announces Webinar to Demonstrate MyMedicalRecords PHR Product Line 2Health News:MMR Announces Webinar to Demonstrate MyMedicalRecords PHR Product Line 3Health News:AAN Foundation Benefits from Grey's Anatomy 'Wedding Registry' 2Health News:Cardinal Rigali Praises House Re-Introduction of 'Pregnant Women Support Act,' Urges Co-Sponsorship 2
(Date:9/18/2014)... Mich. , Sept. 18, 2014  A $3 ... will allow the University of Michigan to establish a ... The Glenn Center for Aging Research at U-M ... that drugs can slow the effects of aging and ... mechanisms of aging that can help develop medications that ...
(Date:9/18/2014)... --  3D Systems   (NYSE: DDD ) announced ... a new robotic surgery skills and procedural training simulator, which ... exhibition in Amsterdam, The Netherlands from ... invasive surgery represents a growing portion of overall surgical volume, ... robotic surgery has increased, and it is expected that this ...
(Date:9/18/2014)... , Sept. 18, 2014  Halozyme Therapeutics, Inc. ... the U.S. Food and Drug Administration (FDA) has ... dosing of PEGPH20 in SWOG,s ongoing Phase 1b/2 ... evaluate Halozyme,s investigational drug PEGPH20 (PEGylated Recombinant Human ... in patients with metastatic pancreatic adenocarcinoma.  The study ...
Breaking Medicine Technology:$3 M grant funds Paul F. Glenn Center for Aging Research at the University of Michigan 2$3 M grant funds Paul F. Glenn Center for Aging Research at the University of Michigan 33D Systems Introduces New Simbionix Robotics Training Platform 23D Systems Introduces New Simbionix Robotics Training Platform 3SWOG To Resume Clinical Trial Of Halozyme's PEGPH20 In Combination With Modified FOLFIRINOX For Advanced Pancreatic Cancer 2SWOG To Resume Clinical Trial Of Halozyme's PEGPH20 In Combination With Modified FOLFIRINOX For Advanced Pancreatic Cancer 3SWOG To Resume Clinical Trial Of Halozyme's PEGPH20 In Combination With Modified FOLFIRINOX For Advanced Pancreatic Cancer 4
... Surgical, recently named one of Philadelphia,s 100 Fastest ... the healthcare marketplace with the acquisition of the ... surgical facilities to Millennium Surgical,s resources.  Its acquisition ... company has been undertaking for several years.  Millennium ...
... March 23, 2011 Polar ( ... assessment technology, today announced a partnership with celebrity fitness trainer ... president and CEO of NGR™ / No Gym Required™ ... a new show on the CW network, as a spokesperson ...
Cached Medicine Technology:Millennium Surgical adds "SurgicalInstruments.com" Name 2Polar Partners with 'Shedding for the Wedding' Trainer and NGR™ President and CEO Jennifer Cohen 2Polar Partners with 'Shedding for the Wedding' Trainer and NGR™ President and CEO Jennifer Cohen 3
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: