Navigation Links
First look at an enzyme target for antibacterial and cancer drugs
Date:12/20/2007

The veil has finally been lifted on an enzyme that is critical to the process of DNA transcription and replication, and is a prime target of antibacterial and anticancer drugs. Researchers with the U.S. Department of Energys Lawrence Berkeley National Laboratory (Berkeley Lab) and the University of California (UC) at Berkeley have produced the first three-dimensional structural images of a DNA-bound Type II topoisomerase (topo II) that is responsible for untangling coiled strands of the chromosome during cell division.

Preventing topo II from disentangling a cells DNA is fatal to the cell, which is why drugs that target topo II serve as agents against bacterial infections and some forms of cancer. This first ever structural image of topo II should help in the development of future antibacterial and anticancer drugs that are even more effective and carry fewer potential side effects.

Topo II has been called natures magician because it literally can move one DNA segment through another, said James Berger, a biochemist and structural biologist who led this research. The enzyme cleaves a double-stranded DNA, passes a second duplex through the break, and then immediately repairs the broken strands. This enables topo II to control the topology of DNA for chromosome segregation and disentanglement.

Berger holds a joint appointment with Berkeley Labs Physical Biosciences Division, and UC Berkeleys Department of Molecular and Cell Biology. He and Ken Dong, a graduate student in his research group, co-authored a paper reporting this research in the December 20, 2007 issue of the journal Nature. The paper is titled: Structural basis for Gate-DNA recognition and bending by type IIA topoisomerases.

Using the exceptionally bright and intense beams of x-rays generated at Berkeley Labs Advanced Light Source (ALS), Berger and Dong obtained high resolution, 3-D crystallography images of the DNA binding and cleavage core of a topo II enzym
'/>"/>

Contact: Lynn Yarris
lcyarris@lbl.gov
510-486-5375
DOE/Lawrence Berkeley National Laboratory  
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. First biomarker discovered that predicts prostate cancer outcome
2. FDA Approves First Anti-Psychotic for Kids
3. Single-incision belly-button surgery to remove kidney performed first at UT Southwestern
4. First study examines newly-licensed RN work attitudes and intentions
5. Glades General Hospital First in Palm Beach County to Provide On-Site Electronic Birth Registration
6. UHW Announces: Antelope Valley Hospital Caregivers and Board Vote to Ratify First Union Contract With SEIU UHW-West
7. Father and Daughter From Tanzania Receive Their First Medical Examination in Newport Beach
8. High and mighty: first common height gene identified by researchers behind obesity gene finding
9. APA Comments on FDAs First Approval of Medication to Treat Pediatric Schizophrenia and Bipolar Disorder
10. TriWest Creates First-of-its-Kind Partnership to Offer Military Leaders With Grief Support Program
11. Watson Receives First FDA Approval for Manufacturing Product at Its Goa, India Facility
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
First look at an enzyme target for antibacterial and cancer drugs
(Date:8/27/2014)... August 27, 2014 ANS ... a ground breaking anti-cancer therapy for the treatment of ... to prescribe this new medical therapy and will begin ... starting immediately. , NovoTTF™ Therapy is a portable, non-invasive ... 22 years of age and older. It is a ...
(Date:8/27/2014)... August 27, 2014 Ticket Down is a ... at Sun Life Stadium in Miami. The Brazilian national ... on September 5 at Sun Life Stadium in Miami Gardens, ... a rematch of the World Cup earlier this year when ... to injury. The Brazilian Soccer Federation announced earlier this week ...
(Date:8/27/2014)... New York (PRWEB) August 27, 2014 ... filed in U.S. courts on behalf of women who ... uterine morcellation, Bernstein Liebhard LLP reports. According to court ... on August 18th in the U.S. District Court, Northern ... patient who claims the use of a power morcellator ...
(Date:8/27/2014)... NC. SonaCare Medical, LLC, the global ... sales of 15 HIFU devices over the past twelve ... for the company’s ablation technology. , “It is ... achieved over the past year, especially since we are ... our most active sales period,” says Mike Klein, CEO ...
(Date:8/27/2014)... inherited from our parents shapes many aspects of our ... an epigenome that is set during development, but can ... perhaps by those of our parents and grandparents. , ... and supporting proteins that determine whether genes are expressed ... for our own health, but also that it may ...
Breaking Medicine News(10 mins):Health News:Atlantic NeuroSurgical Specialists (ANS) Announces Availability of New Therapy for Brain Cancer 2Health News:Atlantic NeuroSurgical Specialists (ANS) Announces Availability of New Therapy for Brain Cancer 3Health News:Brazil vs. Colombia Tickets in Miami, FL: Ticket Down Cuts Ticket Prices on World Cup Rematch of Colombia vs. Brazil at Sun Life Stadium in Miami on Sept. 5th 2Health News:Brazil vs. Colombia Tickets in Miami, FL: Ticket Down Cuts Ticket Prices on World Cup Rematch of Colombia vs. Brazil at Sun Life Stadium in Miami on Sept. 5th 3Health News:Power Morcellator Lawsuit Alleges Storz Morcellator Caused Spread of Aggressive Uterine Cancer, Bernstein Liebhard LLP Reports 2Health News:Power Morcellator Lawsuit Alleges Storz Morcellator Caused Spread of Aggressive Uterine Cancer, Bernstein Liebhard LLP Reports 3Health News:Power Morcellator Lawsuit Alleges Storz Morcellator Caused Spread of Aggressive Uterine Cancer, Bernstein Liebhard LLP Reports 4Health News:SonaCare Medical Announces Twelve Months Sales Results of Fifteen HIFU Devices 2Health News:Scientists map the 'editing marks' on fly, worm, human genomes 2Health News:Scientists map the 'editing marks' on fly, worm, human genomes 3Health News:Scientists map the 'editing marks' on fly, worm, human genomes 4
... Office of Naval Research are working on using virtual ... Disorder (PTSD). //, ,In this research, scientists are ... from PTSD to go through the similar experiences they ... the traumatic experience that had left them unable to ...
... the declining numbers of infants in the Middle East ... first six months of their lives.//, ,"Several high-income ... Qatar, Oman, the UAE and Saudi Arabia maintain patterns ... below 35 percent," Unicef said in a statement released ...
... very active leisure time can reduce the chances of having ... from National Public Health Institute in Helsinki, Finland, had reported ... Heart Association., ,Researchers had looked into the data provided ... 25 to 64 years, all of them healthy and without ...
... the University of Arkansas, Worcester Polytechnic Institute //and other ... to examine the fossils of our ancestors’ teeth to ... and why. ,By comparing teeth from two species ... researchers confirm previous evidence that A. africanus ate more ...
... change in the genetic constitution is what makes each ... is unraveled, then health care can be individualized according ... same genetic code, how those genes express themselves at ... medicines and dietary advice. According to a recent study, ...
... Nebraska, was slated for a slow but sure death, weighing in ... or even turn over in bed. , ,Deuel is now ... than 200 kg after undergoing an operation that is becoming increasingly ... opera singer, Deborah Voigt, also lost 50 kg after she underwent ...
Cached Medicine News:Health News:Breastfeeding Decline In Middle East Worries UN 2Health News:Physical Activity During Leisure Can Reduce Risk Of Stroke 2Health News:Scientists Develop New Technology To Find About Human Ancestors’ Teet 2Health News:Learning Just How Different We Are 2Health News:Obesity better handled with gastric bypass surgery 2
(Date:8/27/2014)... 27, 2014   Los Angeles orthodontics expert, ... to patients who want to make their treatment even ... the OrthoSpaceship, all patients have a powerful tool to ... can be used by most patients with all types ... by using the AcceleDent® Aura system for a few ...
(Date:8/27/2014)... 27, 2014 By now, if you haven,t heard ... on this planet. The awareness campaign has brought this devastating ... to raise over $88.5 Million (and counting) for ALS. Every ... companies are starting to as well. One such ... , who actually works with ALS sufferers and helps ...
(Date:8/27/2014)... , August 27, 2014 ResearchMoz ... States  Laparoscopes Market Outlook to 2020. New report, ... market data on the United States Laparoscopes market ... dollars, volume (in units) and average prices (in US ... Laparoscopes and Flexible Tip Video Laparoscopes), Robotic Surgical Systems ...
Breaking Medicine Technology:Los Angeles Orthodontist, Dr. Isaac Hakim, is Now Offering AcceleDent Aura 2Acorn Stairlifts Gives a Lift to the ALS Ice Bucket Challenge 2United States Laparoscopes Market Outlook, Analysis, Size, Share, Growth, Trends And Forecast 2020 2United States Laparoscopes Market Outlook, Analysis, Size, Share, Growth, Trends And Forecast 2020 3United States Laparoscopes Market Outlook, Analysis, Size, Share, Growth, Trends And Forecast 2020 4United States Laparoscopes Market Outlook, Analysis, Size, Share, Growth, Trends And Forecast 2020 5
... BD (Becton, Dickinson and Company) (NYSE: ... announced the completion of its acquisition of Carmel Pharma, ... the leading closed-system drug transfer device for the safe ...  The acquisition expands the scope of BD,s healthcare worker ...
... S.C., Aug. 16, 2011 Femasys Inc. and Norgenix ... rights in the United States as well as US ... This FDA cleared device is used to evaluate a ... HSG. Femasys Inc. is an emerging medical device developer ...
Cached Medicine Technology:BD Completes Acquisition of Carmel Pharma 2BD Completes Acquisition of Carmel Pharma 3Femasys and Norgenix Announce Distribution Agreement for Groundbreaking New Device for Infertility Diagnosis 2
Hartman Mosquito forceps, straight, 3-1/2", German stainless steel...
Straight 20 mm serrated jaws. Ring handle with ratchet lock and dull finish. Overall length 3.9 inches...
Curved 21 mm serrated jaws. Ring handle with ratchet lock. Non-magnetic and dull finish. Overall length 4.7 inches....
Angled 55 degree shafts with 9.5 mm tips. Tongue and groove platform for tying sutures and grasping silicone bonding and buckling material. Serrated handle with polished finish....
Medicine Products: