Navigation Links
First live targeting of tumors with RNA-based technology
Date:11/30/2009

that the RNA molecules that bind to normal cellular elements would be filtered out, and this happened," said Clary, who treats colon cancer patients. "In this way, we found the RNA molecules that went specifically to the tumor."

The researchers removed the tumor, extracted the specific RNA in the tumor, amplified these pieces of RNA to create a greater amount, and reinjected the molecules to learn which bound most tightly to the tumor. They repeated this process 14 times to find a good candidate.

The team found a tumor-targeting RNA aptamer that specifically bound to RNA helicase p68, a nuclear protein produced in colorectal tumors.

"This aptamer not only binds to p68 protein in cell culture, but also preferentially binds to cancer deposits in a living animal," Mi said. "The nice thing about this aptamer approach is that it could be used to discover the molecular signatures of many other diseases."

Clary said the process could be repeated with different types of tumors. For example, a scientist might take a breast cancer line and grow it in the lung as a metastasis model and then perform in vivo selection to identify RNAs specifically binding to the lung tumor.

"This would work, theoretically," Clary said. "The idea of selecting molecules targeting a tumor growing in a body that results in a useful reagent for biologic exploration and therapy delivery in tumors is exciting."

In fact, based on earlier research done with proteins called peptides, the researchers expected that the aptamer process would find proteins in the blood vessels feeding the liver tumor, but instead they found the p68 target inside of tumor cells. "We think this is a valuable target because delivering to the sites inside of cells may make it easier to treat an entire tumor with drugs that are 'escorted' by the aptamer," Clary said.

He said that repeating the selection and amplification process with the same liver tumor could lead to
'/>"/>

Contact: Mary Jane Gore
mary.gore@duke.edu
919-660-1309
Duke University Medical Center
Source:Eurekalert

0

GOOD

Page: 1 2 3

Related medicine news :

1. ShowMyPC Provides First Online Service in the World to Access Personal Computers from Anywhere Using Microsoft Remote Desktop
2. Simbionix First Procedure Rehearsal Studio(TM) Training Workshop
3. First Time-Door is Open for Family Discussion of Bipolar Disorder
4. Implant-based cancer vaccine is first to eliminate tumors in mice
5. Vanderbilt scientists report first effective medical therapy for rare stomach disorder
6. Elluminate's Fire and Ice Project Recognized as First-Ever iNACOL Award Winner for Outstanding and Most Innovative Online Learning Practice
7. MinuteClinic Opens First Retail Clinic in Washington, D.C. at CVS/pharmacy Store in Northeast
8. First-Time Father-to-Be Quits Smoking, Wins $5,000 in The QuitCash Challenge(TM)
9. Nordic Naturals Ultimate Omega(TM) First Fish Oil to Participate in NFL/NFLPA Sports Nutrition Label Certification Program
10. Pivotal study for PSD502 -- the first potential treatment for premature ejaculation
11. Diet Delivery Company Bistro MD Is Giving Away $1,500 in First Ever Creative Writing Contest
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/20/2013)... Heritage Woods of Gurnee , a ... is hosting Breakfast and Bingo at 8:30 a.m. on ... at 3775 Grand Ave. in Gurnee, Illinois, serves older ... need some help to maintain their independence. , "Come ... bingo," says Tammy Temaner-Rosas, Director of Marketing for Heritage ...
(Date:5/20/2013)... (PRWEB) May 21, 2013 This week has ... Bite Prevention Week (May 19th-May 25th) is an awareness campaign ... attacks and by encouraging dog owners to properly train their ... , Michigan dog bite lawyers at Buckfire & ... in cases throughout Michigan. The personal injury law firm is ...
(Date:5/20/2013)... 2013 The automated external defibrillator ... two categories - semi-automated and fully automated defibrillators. ... five categories, namely, hospitals, pre-hospital, public access, alternate ... 2017. Automated external defibrillators play an important role ... victims. Considering the life-saving potential of AEDs, legislations ...
(Date:5/20/2013)... 21, 2013 For the third ... Best of Frederick Award in the Professional Standards ... (USCA). , The USCA "Best of Local Business" ... country. Each year, the USCA identifies companies that ... their local community and business category. These are ...
(Date:5/20/2013)... Minneapolis, MN (PRWEB) May 20, 2013 When ... right bed is only part of the process. Much of ... over the internet involves not knowing what to expect. ... expert advice consumers can use to ensure their purchase proves ... When You Buy a Mattress Online ”, readers find helpful ...
Breaking Medicine News(10 mins):Health News:Heritage Woods of Gurnee Affordable Assisted Living Community to Host Breakfast and Bingo 2Health News:Buckfire & Buckfire, P.C. Dog Bite Lawyers in Michigan Discuss National Dog Bite Prevention Week 2Health News:North America Leads Automated External Defibrillator Market (AED), Says New Research Report at ReportsnReports.com 2Health News:North America Leads Automated External Defibrillator Market (AED), Says New Research Report at ReportsnReports.com 3Health News:A2LA Receives 2013 Best of Frederick Award 2Health News:See What to Expect When You Buy a Mattress Online With Latest Guide From Best Mattress Online 2
... could you do with,$150,000? That,s the sum the ... for Gov. Sarah Palin., Contrast that with ... scrubs,for just $10 for a hospital shift. "The ... Geri Jenkins, RN, co-president of the California,Nurses Association/National ...
... key functionality & improved accountability. , ... West Palm ... released the newest version of Enterprise 101 On-site messaging software. In ... custom priority, pre-defined, or emergency alert message to a defined group ...
... ones at all times with Eyedentity Label. Custom made temporary tattoos provide ... Food allergy sufferers,epilepsy sufferers, Alzheimer,s patients, those living with non-speaking Autism ... have an additional tool for communication and to be returned to the ... ...
... WLP ) announced,that Angela Braly, president and CEO, appeared ... this evening. Ms. Braly focused on how all,aspects of ... to improve,both access to care and the quality of ... have made in the past few years, Ms.,Braly encouraged ...
... Oct. 28 ATS Medical, Inc.,(Nasdaq: ATSI ... and services, today announced that it will release,financial ... 2008 after the,market close on Monday, November 3, ... webcast on Monday, November 3, 2008 at 5:00 ...
... reduce the cost and time required for cancer drug ... online issue of the Journal of the National ... multistep process that involves in vitro tests, animal studiesoften ... designed rodent studies have led to missteps and delays ...
Cached Medicine News:Health News:Nurses Present Palin Clothing Line Website ... and Other Ways the Money Could Have Been Spent 2Health News:InterPage L.P. Announces New Enhancements to Enterprise 101 Messaging Solution 2Health News:A Universal Gift of Peace of Mind 2Health News:A Universal Gift of Peace of Mind 3Health News:WellPoint President and CEO Angela Braly Appears at the Norfolk Forum 2Health News:ATS Medical Announces Third Quarter 2008 Earnings Release Date and Conference Call 2
(Date:5/20/2013)...  Volcano Corporation (NASDAQ: VOLC ) a ... designed to enhance the diagnosis and treatment of coronary ... its efforts to expand research and innovation surrounding its ... iFR ® (Instant Wave-Free Ratio™) 1 technologies, ... EuroPCR 2013 in Paris . ...
(Date:5/20/2013)... 20, 2013  B. Braun Medical Inc. (B.Braun) ... safety with products, services and education focused on ... innovative Outlook® 400ES and Space Infusion Systems, and ... the American Association of Critical-Care Nurses (AACN) National ... Boston Convention Center. ...
(Date:5/20/2013)... 20, 2013 Landauer, Inc. (NYSE: ... radiation measurement and monitoring, outsourced medical physics services and ... Board of Directors declared, at its meeting on May ... per share for the third quarter of fiscal 2013.  ... to shareholders of record on June 7, 2013. ...
Breaking Medicine Technology:Volcano to Highlight its Physiology Expansion Efforts at EuroPCR 2013 2Volcano to Highlight its Physiology Expansion Efforts at EuroPCR 2013 3Volcano to Highlight its Physiology Expansion Efforts at EuroPCR 2013 4B. Braun Committed To Improving Patient Safety 2Landauer, Inc. Declares Regular Cash Dividend 2
... laser is ideal for small clinics and ... system, it combines the advantages of laser ... feel. The Novapulse system delivers short-duration, high ... which tissue is allowed to cool thus ...
The compact size and portability of the Epic system makes it a cost-effective solution for single or multi-office use....
... The Pentacam images the anterior segment of ... measurement. This rotating process supplies pictures in ... is measured very precisely because of this ... less than two seconds and minute eye ...
The Ahmed Glaucoma Valve has been successfully demonstrated to work in all types of glaucoma cases, particularly neovascular, congenital and uvietic glaucoma....
Medicine Products: