Navigation Links
First live targeting of tumors with RNA-based technology
Date:11/30/2009

DURHAM, N.C. Finding and treating a tumor without disturbing normal tissue presents challenges sometimes the most effective therapies can be invasive and harsh.

Researchers at Duke University Medical Center have devised a way they might deliver the right therapy directly to tumors using special molecules, called aptamers, which specifically bind to living tumor tissue.

They screened a large pool of aptamers in a rodent with liver cancer until they found the best molecule to bind to a tumor protein.

"We are already exploring attaching chemicals to the aptamers, so the aptamer molecules could deliver tumor-killing agents where they are needed, which is the next phase of our research," said senior author Bryan Clary, M.D., chief of the Division of Hepatopancreatobiliary and Oncologic Surgery.

The study was published in Nature Chemical Biology online on Nov. 29.

Aptamers are small pieces of RNA that bind to a specific target molecule, usually a protein. They offer ease of use because they can be easily regenerated and modified and therefore have increased stability over some other agents, such as protein-based antibodies. Notably, they have a very low chance of immune-system interference, making them great candidates for tumor diagnosis and therapy.

"Most importantly, it's not necessary to have detailed knowledge of protein changes in the disease before the selection process," said lead author Jing Mi, M.D., Ph.D., assistant professor in the Duke Department of Surgery. "This greatly simplifies the process of molecular probe development. The selected aptamers can be used to discover proteins not previously linked with the disease in question, which could speed up the search for effective therapies."

The researchers used a large pool of RNA strands and applied them to a rodent with a liver tumor, the type of metastatic tumor that often results from a colon cancer tumor.

"We hypothesized
'/>"/>

Contact: Mary Jane Gore
mary.gore@duke.edu
919-660-1309
Duke University Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. ShowMyPC Provides First Online Service in the World to Access Personal Computers from Anywhere Using Microsoft Remote Desktop
2. Simbionix First Procedure Rehearsal Studio(TM) Training Workshop
3. First Time-Door is Open for Family Discussion of Bipolar Disorder
4. Implant-based cancer vaccine is first to eliminate tumors in mice
5. Vanderbilt scientists report first effective medical therapy for rare stomach disorder
6. Elluminate's Fire and Ice Project Recognized as First-Ever iNACOL Award Winner for Outstanding and Most Innovative Online Learning Practice
7. MinuteClinic Opens First Retail Clinic in Washington, D.C. at CVS/pharmacy Store in Northeast
8. First-Time Father-to-Be Quits Smoking, Wins $5,000 in The QuitCash Challenge(TM)
9. Nordic Naturals Ultimate Omega(TM) First Fish Oil to Participate in NFL/NFLPA Sports Nutrition Label Certification Program
10. Pivotal study for PSD502 -- the first potential treatment for premature ejaculation
11. Diet Delivery Company Bistro MD Is Giving Away $1,500 in First Ever Creative Writing Contest
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/5/2015)... May 05, 2015 NCPDP announced today ... Program. The program establishes a three-year commitment of strategic ... of 10 Elite Partners. “AmerisourceBergen has supported our multi-stakeholder ... of NCPDP, “and this is a wonderful continuation and ... We can trace AmerisourceBergen back to our very first ...
(Date:5/5/2015)... Hiliary Critchley, Senior Manager for ... the 24th Annual WEDI National Conference ... Scottsdale, AZ. WEDI, the Workgroup for Electronic Data ... the use of health IT to create efficiencies ... of Telemedicine for UnitedHealthcare will co-present with Critchley ...
(Date:5/5/2015)... 05, 2015 Viverae®, a health ... Inc., a leading multinational developer, manufacturer and marketer ... of vascular, urology, oncology and surgical specialty products, ... The Vanguard Award recognizes outstanding achievement in ... among Viverae’s significant client base. , Viverae reviewed ...
(Date:5/5/2015)... May 05, 2015 Nutritional science and ... prevent a variety of health conditions and illnesses linked ... research to adopt clean eating methods to rid the ... associated with over-consumption of fast and processed foods. Patients ... easy to follow and report feeling better and losing ...
(Date:5/5/2015)... MAP Health Management, LLC, a provider of ... addiction treatment facilities, announced today that Jimmy Mooney has ... Mr. Mooney, who has more than 35 years of ... for developing new strategic partnerships with substance abuse facilities ... new initiatives. , Prior to joining MAP, Mr. Mooney ...
Breaking Medicine News(10 mins):Health News:AmerisourceBergen Joins NCPDP Elite Partner Program 2Health News:AmerisourceBergen Joins NCPDP Elite Partner Program 3Health News:Optimity Advisors’ Hiliary Critchley, Telemedicine Expert, to Speak at WEDI Conference May 20th in Scottsdale, AZ 2Health News:Viverae® Honors C. R. Bard, Inc. with 2015 Vanguard Award 2Health News:Diet Doc Introduces Diet Plans that Teach Patients how to Eat Clean by Getting Back to Basics and Exchanging Processed Foods for Clean, Nutritious Foods 2Health News:Diet Doc Introduces Diet Plans that Teach Patients how to Eat Clean by Getting Back to Basics and Exchanging Processed Foods for Clean, Nutritious Foods 3Health News:Jimmy Mooney, an Addiction Treatment Veteran, Named Vice President of Business Development at MAP Health Management, LLC 2
... than the father’s tend to pose more of a risk ... ,The results of the study have been published ... Medicine. This could help to better guide the treatment of ... as show early signs of the disease themselves. ...
... the Kangaroos is getting known for its severe dearth of ... // Australia is in the throes of a severe GP ... Australia has revealed the current trend of Doctors, gravitating to ... would leave the GP sector lean and totally understaffed. ...
... her boyfriend have been accused of the murder of three ... made her second court appearance. // ,The victims ... son Jacob, 8 and a funeral visitation has been planned ... Tuesday at La Toussaint Church in Sudbury. ,The ...
... released its first-ever international growth standards for infants and ... found that all children are similar in how they ... that the new guidelines were created to help make ... scientific evidence that infants and children from all over ...
... Government plans to hasten patient treatment has included bestowing ... drugs//. ,Under this plan, nurses and pharmacists ... for common illnesses that range from acne to tonsillitis. ... clinics and will soon be able to prescribe drugs ...
... publish a private member's bill for regulating tanning salons in ... of a clampdown against Scotland's rising incidents of skin cancer. ... banned as a part of this proposal. More information ... of tanning and prohibit children under 16 using tanning equipment. ...
Cached Medicine News:Health News:Risk of Heart Disease Greater from Mom than Dad 2Health News:An International Growth Standard For Childs Releases By WHO 2Health News:Bill for Formal Regulation of Tanning Salons 2
(Date:5/5/2015)... 5, 2015  CipherHealth, a leading provider of innovations ... care, sent representatives to the Nepalese American Nursing Association ... their nurses to Nepal to ... last month. In addition to helping fund the travel ... utilized for much-needed medical supplies for the mission.  ...
(Date:5/5/2015)... 5, 2015   InspireMD, Inc. (NYSE MKT: NSPR) ... announced today that it will release its full financial results ... May 11 th before the open, followed by a ... results and business outlook. Participants should call (888) ... (International) and request the InspireMD call. A live webcast of ...
(Date:5/5/2015)... SAN DIEGO, May 5, 2015  Trovagene, Inc. ... today reported its financial results for the three ... "In the first quarter, we presented favorable clinical ... Lung Cancer Conference, demonstrating our Precision Cancer Monitoring ... in pancreatic, colorectal, and lung cancers," said Antonius ...
Breaking Medicine Technology:Five Nurses and Medical Supplies En Route to Nepal With Donation Assistance from CipherHealth 2InspireMD to Report Financial Results for the First Quarter Ended March 31, 2015 on Monday, May 11th 2InspireMD to Report Financial Results for the First Quarter Ended March 31, 2015 on Monday, May 11th 3Trovagene, Inc. Announces First Quarter 2015 Financial Results 2Trovagene, Inc. Announces First Quarter 2015 Financial Results 3Trovagene, Inc. Announces First Quarter 2015 Financial Results 4Trovagene, Inc. Announces First Quarter 2015 Financial Results 5Trovagene, Inc. Announces First Quarter 2015 Financial Results 6
... May 6 Exelixis,Inc. (Nasdaq: EXEL ) ... March 31, 2008., Revenues for the quarter ... $28.1 million for the comparable period in 2007. ... reflect the completion of,revenue recognition associated with our ...
... collaborate with key stakeholders on efforts to ... 6 The Association of,Clinical Research Organizations ... regulators, biopharmaceutical clients,policymakers, and the public in ... role in the recently formed Clinical Trial ...
Cached Medicine Technology:Exelixis Announces First Quarter 2008 Financial Results 2Exelixis Announces First Quarter 2008 Financial Results 3Exelixis Announces First Quarter 2008 Financial Results 4Exelixis Announces First Quarter 2008 Financial Results 5Exelixis Announces First Quarter 2008 Financial Results 6Association of Clinical Research Organizations (ACRO) to Help Lead Clinical Trials Transformation Initiative 2
... auto-expanding foam filled cuff conforms ... each patients trachea. During mechanical ... insure the lowest possible cuff ... pressure throughout the ventilatory cycle. ...
... cost control. , ,Our full range ... of wound dressing components for the effective ... , ,Tray configurations include full trays, ... cannula for both rigid and flexible D.I.C.® ...
Disposable tracheostomy care tray....
... Solution For Your Tracheostomy Care Needs, ... features the latest components for efficient and ... task. Designed by clinicians, these latex-free trays ... patient and caregiver. All of our trays ...
Medicine Products: