Navigation Links
'First-in-human' drug for malignant glioma available in experimental trial
Date:2/15/2012

umor samples obtained during their original surgery prior to enrollment.

Each patient's response to the treatment and overall health will be clinically monitored through blood, urine and imaging tests at regular intervals through the trial. Patients may be involved in the study for about eight months, including a pre-study assessment period and safety follow-up visit.

This is a paradigm shift in the way we look at gliomas, because the ADC model has the potential to revolutionize the way we deliver chemotherapy to cancer cells while sparing the surrounding healthy tissue." adds Rixe.

"Our goal is to improve the benefits-risk ratio of treatment by increasing anti-tumor activity while reducing the side effects of toxicity on healthy tissue."

The clinical trial of AMG 595, the experimental drug being used in the study, is sponsored by Amgen, a biotechnology company based in Thousand Oaks, California.

More than 22,000 people in the United States are diagnosed with a primary malignant brain tumor every year, according to the National Cancer Institute, and the majority of these are malignant gliomas which have a poor prognosis.

In 2011, the UC Cancer Institute partnered with the UC Neuroscience Institute's Brain Tumor Center to launch a translational research program aimed at understanding the biological mechanisms of cancer's spread to the brain and developing more effective ways to treat the condition.

Both programs are part of the Cincinnati Cancer Center, a joint cancer program involving the UC College of Medicine, Cincinnati Children's Hospital Medical Center and UC Health. The collaborative initiative brings together interdisciplinary research teams of caring scientists and health professionals to research and develop new cures, while providing a continuum of care for children, adults and families with cancer.


'/>"/>
Contact: Amanda Harper
amanda.harper@uc.edu
513-558-4657
University of Cincinnati Academic Health Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Cancer-targeting investigational nanoparticle receives FDA IND approval for first-in-human trial
2. Using Viagra to combat malignant melanoma
3. Elusive gene mutations found for malignant brain tumor
4. Agent selectively targets malignant B cells in chronic leukemia, study shows
5. Malignant brain tumors: Benefit of PET and PET/CT in the detection of recurrences is not assessable
6. Huge pelvi-abdominal malignant inflammatory myofibroblastic tumor
7. Novel RNA interference screening technique identifies possible path for malignant glioma treatment
8. CD97 gene expression and function correlate with WT1 protein expression and glioma invasiveness
9. RTOG activates study to determine best treatment strategies for patients with glioma brain tumors
10. Photons vs. protons for treatment of spinal cord gliomas
11. Discordance among commercially-available diagnostics for latent TB infection
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... (PRWEB) August 29, 2014 Cosmetic Town ... knowledge and authenticity of its doctors. Cosmetic Town ... the most renowned doctors in their field are chosen ... assure patients have a direct link to potentially hundreds ... doctors will be able to communicate through the site’s ...
(Date:8/29/2014)... CO (PRWEB) August 29, 2014 Panic ... attack is the feeling of intense stress and fear, ... life of the sufferer, causing insecurity and affecting relationships. ... factors and there are many symptoms that patients can ... are among these symptoms. Overcoming panic attacks is extremely ...
(Date:8/29/2014)... Daily Gossip indicates in its recently published review that ... what patients have to go through at the development of ... this new method. Bakker is a naturopathic doctor who has ... Bakker claims that during all this time he had heard ... the yeast infection can be. , Read more about ...
(Date:8/29/2014)... Developed as a nod to post-war ... Canada Goose products offer the mobility, durability and ... runways. The company’s Canada Goose Chilliwack bombers ... market. Additionally, the firm has unveiled its new bomber ... At present, all high quality Chilliwack bombers are provided ...
(Date:8/29/2014)... August 29, 2014 As reported by CNN.com ... (8/15), the process of admitting that you need help ... The article acknowledges and highlights the fact that if you ... may be very overwhelmed by all of the information that ... impossible to sift through, it is still possible to get ...
Breaking Medicine News(10 mins):Health News:Cosmetic Town Now Advocates for the Rights of Cosmetic Patients Using Novel Approach 2Health News:60 Second Panic Solution Review Exposes Simple Panic Attacks Remedy 2Health News:Candida Crusher Review Reveals a Unique Way to Eliminate Yeast Infection Permanently 2Health News:New Designs Of Canada Goose Chilliwack Bombers From DoudouneCanadienneGoosePasCher.fr 2Health News:What to Know When Seeking Drug Addiction Help 2Health News:What to Know When Seeking Drug Addiction Help 3
... OXFORD, England, July 13 International medical,communications ... the Year at the Communique Awards in London ... by an independent panel of,communications experts, who assess ... for healthcare clients, along with business strategy,client retention, ...
... Gentiva Health Services, Inc. (Nasdaq: GTIV ), a ... scheduled a conference call and web cast on Thursday, July 30, 2009, ... ended June 28, 2009. Gentiva plans to issue its financial news release ... , The conference call is open to investment analysts ...
... July 13 Sunesis Pharmaceuticals, Inc. (Nasdaq: ... and commercialization of new oncology therapeutics for the treatment ... has received a $1.5 million milestone payment from Biogen ... of a Raf kinase inhibitor development candidate for the ...
... New data pooled from four large, "real world" ... VIII (rFVIII-FS) reduced bleeding and provided data regarding ... mild-to-severe hemophilia A. Additionally, rates of inhibitor formation ... untreated patients. The data were presented at the ...
... , SUNNYVALE, Calif., July 13 Cepheid (Nasdaq: CPHD ... & Drug Administration (FDA) to market its Xpert(R) C. difficile ... of the bacterium that causes Clostridium difficile infection (CDI). ... for CDI to deliver both rapid turnaround and a high degree ...
... , PORT WASHINGTON, N.Y., July 13 ... of the American Medical Association has granted a CPT Category ... (TM) (MCG) system. MCG is the World,s first Internet based, ... for interactive online diagnosis. The MCG is intended as ...
Cached Medicine News:Health News:Gentiva(R) Health Services Schedules Second Quarter Earnings Call and Web Cast for Thursday, July 30, 2009 2Health News:Gentiva(R) Health Services Schedules Second Quarter Earnings Call and Web Cast for Thursday, July 30, 2009 3Health News:Gentiva(R) Health Services Schedules Second Quarter Earnings Call and Web Cast for Thursday, July 30, 2009 4Health News:Sunesis Pharmaceuticals Receives Milestone Payment From Biogen Idec 2Health News:Analysis of Four Large Post-Marketing Surveillance Studies Describe Clinical Effects of Sucrose-Formulated Recombinant Factor VIII 2Health News:Analysis of Four Large Post-Marketing Surveillance Studies Describe Clinical Effects of Sucrose-Formulated Recombinant Factor VIII 3Health News:Analysis of Four Large Post-Marketing Surveillance Studies Describe Clinical Effects of Sucrose-Formulated Recombinant Factor VIII 4Health News:Analysis of Four Large Post-Marketing Surveillance Studies Describe Clinical Effects of Sucrose-Formulated Recombinant Factor VIII 5Health News:Cepheid Receives FDA Clearance for First On-Demand Molecular Diagnostic Test for Clostridium difficile Infection 2Health News:Cepheid Receives FDA Clearance for First On-Demand Molecular Diagnostic Test for Clostridium difficile Infection 3Health News:Cepheid Receives FDA Clearance for First On-Demand Molecular Diagnostic Test for Clostridium difficile Infection 4Health News:Cepheid Receives FDA Clearance for First On-Demand Molecular Diagnostic Test for Clostridium difficile Infection 5Health News:AMA Grants New Category III CPT Code to Premier Heart's Multifunction CardioGram(TM) (MCG) 2
(Date:8/29/2014)... 29, 2014 Research and Markets ... Cancer Therapeutics Market & Pipeline Insight 2014" report ... developed to prevent and eradicate the prevalence of cancer ... are confined to low specificity, safety and large number ... for a better solution. It has been discovered that ...
(Date:8/29/2014)... 29, 2014 Research and Markets ... Development Trend Forecast of Pharmaceutical Equipment Market in China, ... Research and Development Trend Forecast of Pharmaceutical Equipment Market ... China,s pharmaceutical equipment industry in ... competition landscape, and business performance of domestic major enterprises, ...
(Date:8/29/2014)... WASHINGTON , Aug. 29, 2014 Diseases ... a generation ago are returning. Measles was declared ... cases in 2014 as of August 15—the highest incidence ... public health department declared whooping cough a problem ... children are getting sick and dying from these preventable ...
Breaking Medicine Technology:Global Peptide Cancer Therapeutics Market & Pipeline Insight 2014 2Research and Development Trend Forecast of Pharmaceutical Equipment Market in China, 2014-2018 2Vaccines at the Crossroads: Outbreaks On the Rise Across America 2Vaccines at the Crossroads: Outbreaks On the Rise Across America 3
... Calif., July 26, 2011 Epitomics, Inc., a ... based on its groundbreaking Rabbit Monoclonal (RabMAb®) technology, ... novel cancer-related antibodies that were developed through a ... Cancer Research. The goal of this partnership is ...
... 26, 2011 Bacterin International Holdings, Inc. ... the development of revolutionary bone graft material and anti-infective coatings ... August 11, at 4:30 p.m. Eastern time to discuss results ... will be issued in a press release after the close ...
Cached Medicine Technology:Epitomics Releases New Antibodies Developed With the National Cancer Institute's Center for Cancer Research 2Bacterin Sets Second Quarter 2011 Conference Call for Thursday, August 11, 2011 at 4:30 p.m. ET 2
... DXC-390 color video camera is a 3 CCD ... and industrial imaging. It has high resolution of ... 62dB. It is a c-mount with a high ... HAD technology that greatly improves camera sensitivity while ...
Sony DSR-20MD is the right choice If you need digital recording capability. It accepts both s-video and composite inputs....
The TRIstar II is a highly developed 3-chip video camera for endoscopic applications. Superior image quality and outstanding colour reproduction meets professional requirements....
... Oxylab pO2 probes feature ... of seconds for real-time monitoring ... with Oxylab LDFTM, measurements of ... can be obtained from the ...
Medicine Products: