Navigation Links
First genetic mutations linked to atopic dermatitis identified in African-American children
Date:11/11/2013

PHILADELPHIA - Two specific genetic variations in people of African descent are responsible for persistent atopic dermatitis (AD), an itchy, inflammatory form of the skin disorder eczema. A new report by researchers in the Perelman School of Medicine at the University of Pennsylvania found that loss-of-function mutations to Filaggrin-2 (FLG2), a gene that creates a protein responsible for retaining moisture and protecting the skin from environmental irritants, were associated with atopic dermatitis in African American children. The study, the first report to deduce the mechanism responsible for the persistent form of the condition in African American children, was published in the Journal of Allergy and Clinical Immunology.

Nearly half of people with atopic dermatitis in the United States are African-American children. Previous studies have shown than those of African descent do not usually carry a mutation to the filaggrin gene (FLG) that has been associated with the risk of onset and persistence of AD in those of European and Asian ancestry.

"This finding helps confirm that skin barrier proteins are important in Atopic Dermatitis for people of all ancestries," said lead study author David Margolis, MD, PhD, professor of Dermatology and Epidemiology. "It could also lead to a way to determine which children are most likely to have persistent flare ups throughout their lives."

The team evaluated DNA from 299 African American children, none of whom had experienced skin free of symptoms of AD while not on medication in the previous 6 months. Within the group, researchers discovered that children with either one of two FLG2 mutations - rs12568784 or rs16833974 - were more than 50 percent more likely to have persistent AD than those without the mutations.

Future research will work to better understand mutations of FLG2 and determine if they result in functional changes to the FLG2 protein. In addition, the team is continuing research into mechanisms that may turn off the immune response to irritants that pass through the dysfunctional skin barrier and incite the inflammatory response seen in AD.


'/>"/>

Contact: Kim Menard
kim.menard@uphs.upenn.edu
215-662-6183
University of Pennsylvania School of Medicine
Source:Eurekalert

Related medicine news :

1. Salar Joins Medical Informatics Experts to Judge AMIA’s First Ever Student Design Challenge: Reinventing Clinical Documentation
2. Center for Hispanic Leadership to Launch First-Ever Preventive Care Online Educational Portal for U.S. Hispanics on December 2nd
3. Families, Businesses & Special Needs Children Rally to Support America's Special Kidz (A.S.K.)'s First Fundraiser
4. North Shore-LIJ Epilepsy Center is Among the First in US and the First in New York Metro Area to Offer Combined Minimally-Invasive Surgical Procedures
5. Experts recommend universal diabetes testing for pregnant women at first prenatal visit
6. The MORE Project to Host First Annual World Day of Giving November 30, 2013
7. Safety Jackpot Launches Nation’s First Online, Electronic Scratch-card Safety Recognition System; Jackpot Up to One Million
8. SweetCheeks Products Goes ‘Thigh Tech’ with First Anti-Cellulite Mat with Immediate Results for at Home Use
9. Sinsational Smile Becomes First and Only Certified Eco-Friendly Whitening System in the World
10. ForCPR.com Launches a New Website Directory of First Aid, AED and CPR Training Instructors
11. CS Caregiver University Announces Its First Phase of Inductive Training for the Month of October
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... York, NY (PRWEB) , ... October 13, 2017 , ... ... influential people in business to advocate for action towards gender equality at their inaugural ... views from around the globe, and reached a social audience of over 3 million. ...
(Date:10/13/2017)... , ... October 13, 2017 , ... “The Journey: From ... every danger possible to save lost souls in the Philippines. “The Journey: From the ... is a dedicated teacher of the Bible. She has taught all ages and currently ...
(Date:10/12/2017)... ... 2017 , ... The company has developed a suite of ... authorities worldwide. From Children’s to Adults 50+, every formula has been developed by ... , These products are also: Gluten Free, Non-GMO, Vegan, Soy Free, Non-Dairy*, Preservative ...
(Date:10/12/2017)... ... October 12, 2017 , ... Dr. Parsa Mohebi, the Los ... article to the newly revamped Cosmetic Town journal section, featuring articles ... procedure known as Follicular Unit Extraction (FUE). , Dr. Mohebi says ...
(Date:10/12/2017)... ... October 12, 2017 , ... Health Literacy Innovations ... literacy software tool, and the Cancer Patient Education Network (CPEN), an independent professional ... announce a new strategic alliance. , As CPEN’s strategic partner, HLI will ...
Breaking Medicine News(10 mins):
(Date:10/5/2017)... , Oct. 5, 2017  In response to ... Oral and Maxillofacial Surgeons (AAOMS) released prescribing recommendations ... to be used as a first-line therapy to ... Recognizing the value ... White Paper "Opioid Prescribing: Acute and Postoperative Pain ...
(Date:10/2/2017)... 2017  Eli Lilly and Company (NYSE: ... third quarter of 2017 on Tuesday, October 24, 2017. ... day with the investment community and media to further ... call will begin at 9 a.m. Eastern time. Investors, ... webcast of the conference call through a link that ...
(Date:9/28/2017)... Sept. 28, 2017 Cohen Veterans Bioscience and ... use of wearable and home sensors for real-time monitoring ... Signal Foundation, a nonprofit organization focused on disruptive health ... an affordable analytical system to record and integrate behavioral, ... ...
Breaking Medicine Technology: