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First genetic link discovered to difficult-to-diagnose breast cancer sub-type
Date:4/17/2014

erent screening tests can be offered to those at high risk, as well as finding new treatments for lobular cancer."

Dr Rebecca Roylance, Clinical Senior Lecturer at Queen Mary University of London, said:

"We know invasive lobular breast cancers can behave differently to other breast cancer types, as well as be more difficult to diagnose both of which led us to believe there may be different genetic factors in their development. It is really exciting that our theories based on clinical observations have been confirmed by the identification of specific genetic changes in patients with invasive lobular breast cancer. The big challenge now is for these changes to be confirmed and for this information to be used for the benefit of patients."

Baroness Delyth Morgan, Chief Executive, Breast Cancer Campaign said:

"These results demonstrate just how vital it is to bring researchers together to collaborate in order to unlock the answers around genetics and risk for all sub-types of breast cancer. This could be the first step in assessing who is at risk of developing this type of breast cancer that is so hard to diagnose.

"Breast Cancer Campaign is now funding the study's co-author Dr Elinor Sawyer for a further three years to understand what the new genetic variant found in this study could be doing within cells to increase breast cancer risk. Ultimately Dr Sawyer's work could improve the diagnosis and survival for women with this subtype of breast cancer."


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Contact: Henry French
henry.french@icr.ac.uk
44-207-153-5582
Institute of Cancer Research
Source:Eurekalert

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