Navigation Links
First evidence that obesity gene is risk factor for melanoma
Date:3/4/2013

The research shows that people with particular variations in a stretch of DNA within the FTO gene, called intron 8, could be at greater risk of developing melanoma.

Variations in a different part of the FTO gene, called intron 1, are already known to be the most important genetic risk factor for obesity and overeating. These variants are linked to Body Mass Index (BMI) a measure of a person's shape based on their weight and height. Having a high BMI can increase the risk of various diseases including type 2 diabetes, kidney disease, womb (endometrial) cancer and more.

But this research is the first to reveal that the gene affects a disease melanoma which isn't linked to obesity and BMI.

The results, published in Nature Genetics, suggest that FTO has a more wide-ranging role than previously suspected, with different sections of the gene being involved in various diseases.

Study author, Dr Mark Iles, Cancer Research UK scientist at the University of Leeds, said: "This is the first time to our knowledge that this major obesity gene, already linked to multiple illnesses, has been linked to melanoma. This raises the question whether future research will reveal that the gene has a role in even more diseases?

"When scientists have tried to understand how the FTO gene behaves, so far they've only examined its role in metabolism and appetite. But it's now clear we don't know enough about what this intriguing gene does.

"This reveals a hot new lead for research into both obesity-related illnesses and skin cancer."

The researchers examined tumour samples in more than 13,000 melanoma patients and almost 60,000 unaffected people from around the world.

Malignant melanoma is the fifth most common cancer in the UK with around 12,800 new cases and around 2,200 deaths each year.

Dr Julie Sharp, Cancer Research UK's senior science information manager, said: "These are fascinating ear
'/>"/>

Contact: Rachel Barson
r.barson@leeds.ac.uk
01-133-432-060
University of Leeds
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Researchers describe first functional HIV cure in an infant
2. Zoloft Lawsuit News: Bernstein Liebhard LLP Notes New Pretrial Order in Federal Zoloft Litigation Establishing Tentative Date for First Bellwether Trial
3. Geoff Neupert, StrongFirst Master Kettlebell Instructor, Releases New Video Detailing How To Make Seemingly Unlimited Progress With Only One Kettlebell
4. Federal NuvaRing Blood-Clotting Lawsuits Report: Resource4thePeople Updates Consumers with News That First Bellwether Trial Rescheduled to July
5. U.N. Secretary-General Appoints Ray Chambers as His First Special Envoy for the Financing of the Health-Related Millennium Development Goals
6. Geoff Neupert, StrongFirst Master Kettlebell Instructor, Releases New Video Showing the Best Upper Body Exercises to Use in Traditional Kettlebell Workouts
7. NYC Chiropractor Will Soon be the First Chiropractor in New York to Offer ISCS 2.0 Non Surgical Spinal Decompression
8. Educational First Steps Hosts Early Childhood Education Conference and Symposium for Over 500 Early Childhood Professionals
9. The Triangle’s First Orthopaedic Ambulatory Surgery Center Officially Opens in Brier Creek
10. $3.35 Million Awarded in First Transvaginal Mesh Trial Verdict: Prompts McDonaldWorley.com Support Expansion
11. OHSU scientists first to grow liver stem cells in culture, demonstrate therapeutic benefit
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2014)... Hopkins University School of Medicine researchers have been awarded ... diabetes, Novo Nordisk announced this month. Of the 110 ... Obesity Biologics Science Forum Program, only four projects were ... researchers. They are Jonathan Powell, M.D., Ph.D.; G. William ... Jonathan Powell, a professor of oncology, will use his ...
(Date:4/18/2014)... French . ... regenerative medicine. A team led by Ludwik Leibler from ... and Didier Letourneur from the Laboratoire Recherche Vasculaire Translationnelle ... that the principle of adhesion by aqueous solutions of ... organs and tissues. This easy-to-use gluing method has been ...
(Date:4/17/2014)... have identified new pain relief targets that could ... BBSRC-funded researchers at King,s College London made the ... in the periphery of the body. , Dr ... identifying mechanisms underlying pain generation and our findings ... side effects." , One potential side effect of ...
(Date:4/17/2014)... 17, 2014) Two recent papers by a ... colleagues may help scientists develop treatments or vaccines ... Japanese encephalitis and other disease-causing flaviviruses. , Jeffrey ... molecular genetics at the School of Medicine and ... Medical Institute, and colleagues recently published articles in ...
(Date:4/17/2014)... Doctors who treat patients with a severe and ... an agonizing treatment decision. , The drug sirolimus ... relieve shortness of breath. But some patients eventually ... potentially fatal complications following transplantation. , "It,s a ... director of Loyola University Medical Center,s LAM Clinic ...
Breaking Medicine News(10 mins):Health News:Innovative strategy to facilitate organ repair 2Health News:Innovative strategy to facilitate organ repair 3Health News:New pain relief targets discovered 2Health News:CU researchers discover target for treating dengue fever 2Health News:Patients with rare lung disease face agonizing treatment dilemma 2Health News:Patients with rare lung disease face agonizing treatment dilemma 3
... BRUNSWICK, N.J., Dec. 8 Savient Pharmaceuticals, Inc. (Nasdaq: ... Pharmaceuticals will be presenting at the upcoming 27th Annual J.P. Morgan ... presentation is scheduled to begin on Wednesday, January 14, 2009 at ... Westin St. Francis Hotel in San Francisco, CAJanuary 11-15, 2009. , ...
... Haemonetics announced today that Dr. Jonathan White will ... President of Haemonetics, effective December 8, 2008. In this ... of the next generation of products to complement Haemonetics, blood ... Brad Nutter, Haemonetics, Chairman and CEO, said, "As the global ...
... of the two-story,$35-millionHenry Ford II (West) Pavilion expansion project ... to 40 new private rooms complete,with wireless Internet access, ... to stay overnight. , ... investment in the Henry Ford,Hospital Campus. It will house ...
... Dec. 8 With its acclaimed debut in ... paper,patient medical records by bringing the process into ... far beyond basic record-keeping, allowing,subscribers to take charge ... their,records to use under their own centralized control ...
... Dec. 8 Triple-S,Management Corporation (NYSE: GTS ... announced that it has converted seven million issued and,outstanding ... in,conjunction with the expiration of the lockup agreements signed ... the Company,s initial public offering. It is,expected that the ...
... New Year,s is the most popular,time to try quitting smoking, ... that time resume smoking in less than one week.(1) ... of a New Year,s resolution,and may be well on their ... that smokers who use the 21 mg NicoDerm(R) CQ(R) nicotine ...
Cached Medicine News:Health News:Savient Pharmaceuticals to Present at the 27th Annual J.P. Morgan Healthcare Conference on January 14th 2Health News:Dr. Jonathan White Joins Haemonetics as Head of Research and Development 2Health News:$35 Million Henry Ford II Pavilion Expansion to Open 2Health News:$35 Million Henry Ford II Pavilion Expansion to Open 3Health News:$35 Million Henry Ford II Pavilion Expansion to Open 4Health News:MyHealthArchive.com's New Features -- A Quantum Leap in Using Health Information to Promote Your Health 2Health News:MyHealthArchive.com's New Features -- A Quantum Leap in Using Health Information to Promote Your Health 3Health News:MyHealthArchive.com's New Features -- A Quantum Leap in Using Health Information to Promote Your Health 4Health News:Triple-S Management Corporation Announces Conversion of Class A Shares and Commencement of Class B Stock Repurchase Program 2Health News:New Research May Encourage Smokers to Jump-Start Their New Year's Resolution to Quit Smoking 2Health News:New Research May Encourage Smokers to Jump-Start Their New Year's Resolution to Quit Smoking 3Health News:New Research May Encourage Smokers to Jump-Start Their New Year's Resolution to Quit Smoking 4
(Date:1/15/2014)... The Cadence Fitness & Health Center has been certified ... Association, a non-profit organization assisting medically integrated health and ... Fitness & Health Center is the only certified fitness ... Chicagoland area. "The certification means the Cadence ...
(Date:1/15/2014)... NEW YORK , Jan. 15, 2014 ... research report is available in its catalogue: ... - India Drug Forecast and Market Analysis ... PharmaPoint: Atopic Dermatitis - India ...
(Date:1/15/2014)... NEW YORK , Jan. 15, ... new market research report is available ... Global Markets and Technologies for ... on Routes of Administration ...
Breaking Medicine Technology:Cadence Fitness & Health Center Certified as Medical Fitness Facility 2Cadence Fitness & Health Center Certified as Medical Fitness Facility 3PharmaPoint: Atopic Dermatitis - India Drug Forecast and Market Analysis to 2022 2PharmaPoint: Atopic Dermatitis - India Drug Forecast and Market Analysis to 2022 3PharmaPoint: Atopic Dermatitis - India Drug Forecast and Market Analysis to 2022 4PharmaPoint: Atopic Dermatitis - India Drug Forecast and Market Analysis to 2022 5Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 2Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 3Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 4Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 5Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 6Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 7Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 8Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 9Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 10Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 11Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 12Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 13Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 14Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 15Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 16
... Annual Meeting -, SAN FRANCISCO and EMERYVILLE, ... ) today announced results on the role of ... cancer and,osteoporosis. The data, which were presented at ... new regulatory elements are essential,for the differentiation of ...
... June 16 SuperGen Inc.,(Nasdaq: SUPG ... discovery, rapid,development and commercialization of therapies for ... the 13th Congress of the,European Hematology Association ... kinase inhibitor, prevents tumor cell proliferation in,vivo ...
Cached Medicine Technology:Bionovo Discovers New Estrogen Regulatory Elements for Breast Cancer and Osteoporosis Drugs 2Bionovo Discovers New Estrogen Regulatory Elements for Breast Cancer and Osteoporosis Drugs 3SuperGen's JAK2 Inhibitor, SGI-1252, Inhibits in Vivo Tumor Cell Proliferation 2
... chairs with concave seats and standard-sized ... options like seats, backrests, armrests, and ... are recommended for the following environments: ... control, health care and office. • ...
... chairs with concave seats and ... • Select options like seats, ... glides. • BTT/1P chairs are ... industry, education, laboratory, clean room, ...
... Basic ergonomic chairs with ... with lumbar support • Select ... and casters and glides. • ... the following environments: industry, education, ...
... with concave seats and large backrests ... like seats, backrests, armrests, and casters ... Series for top performance in a ... laboratory, clean room, static control, health ...
Medicine Products: