Navigation Links
First-degree relatives of patients with bicuspid aortic valve should be screened
Date:6/10/2009

Bicuspid Aortic Valve (BAV), a condition in which patients' aortic valves have just two leaflets instead of the normal three, is the most common cardiac anomaly, affecting up to two percent of the general population. The defect can result in calcification deposits on the heart valve, leakage of the valve and may results in a feeling of tightness in the chest as well as shortness of breath. The condition is easily diagnosed; often physicians can hear a "click" or a murmur when they listen to a BAV patient's heart with a stethoscope.

Studies have shown that BAV is likely genetic, although the gene has not been identified, and in some families, incidence of this defect could run as high as 20 percent.

A new study, published in the Journal of the American College of Cardiology, suggests that nearly a third of first-degree relatives (siblings, children or parents) of BAV patients are likely to have enlarged aortas, a potentially serious condition that can only be detected by undergoing transthoracic echocardiograms. This was found even in the absence of any abnormalities of the heart valve itself.

According to the study, 32 percent of first-degree relatives with no heart valve abnormality had significantly larger aortas that expected for age, gender and body size as compared to no enlargement seen in control patients. Also, the study found that the aortas of the first-degree relatives had abnormal stiffness similar to the patients with congenital bicuspid valve. Generally, when aortas are 50 millimeters in diameter, surgery is recommended in order to prevent a rupture of the aorta.

"If you know that a relative does have bicuspid aortic valve, then you know that you should be screened," said study author Kirsten Tolstrup, MD, assistant director of the Cardiac Noninvasive Laboratory at the Cedars-Sinai Heart Institute. "BAV appears to be a genetic condition that has many different manifestations, so we will be studying the genes."

Kirsten Tolstup, MD, assistant director of the Cardiac Noninvasive Laboratory at the Cedars-Sinai Heart Institute, is available to discuss the study's findings and provide additional details.

This study, conducted among 54 patients with bicuspid aortic valve and 48 first-degree relatives of those patients as well as 45 matched controls found:

  • 32 percent of apparently healthy first-degree relatives have enlarged aortas
  • 53 percent of BAV patients had enlarged aortas
  • 9.4 percent of first-degree relatives had BAV

The findings suggest that patients with bicuspid aortic valve and their first-degree relatives should have a screening echocardiogram to be evaluated for dilated aorta and bicuspid aortic valve.


'/>"/>

Contact: Sandy Van
sandy@prpacific.com
808-526-170-880-088-02397
Cedars-Sinai Medical Center
Source:Eurekalert

Related medicine news :

1. Amyloid Beta Level in Serum Predicts Risk for Vascular Disease in First-Degree Relatives of Alzheimer's Patients
2. Kids Living With Relatives Have Fewer Problems Than Those in Foster Homes
3. Patients relatives are ignored by the health system and suffer emotional stress
4. Relatives who decline organ donations face conflict and guilt
5. Relatives of Parkinsons Patients at Higher Psychiatric Risk
6. Females avoid incest by causing male relatives to leave home
7. Patients Say Costs Determining Factor in Their Treatment Decisions
8. Jazz Pharmaceuticals to Present Data From First Phase III Study of Sodium Oxybate in Patients With Fibromyalgia
9. TUG Procedure by Texas Health Dallas Cardiologist Offers Hope to Millions of Patients
10. Physiological response may explain why some severely obese patients overeat
11. Kidney Community Launches Health Care Campaign to Improve Survival Rates of First-Year Dialysis Patients in Iowa
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/21/2017)... ... 21, 2017 , ... The New England Center for Children® (NECC®), a global ... Yie-Hsin Hung to the Board of Directors. , “The New England Center for ... is an invaluable addition to our team,” said Vincent Strully, Jr., President and CEO ...
(Date:9/21/2017)... ... September 21, 2017 , ... A new addiction ... at a time when Virginia faces an opioid epidemic. , Last ... increase of 38 percent from 2015, underscoring the need for additional addiction treatment ...
(Date:9/21/2017)... ... 21, 2017 , ... Coffey Agencies, a full service insurance ... is embarking on an extended charity drive to encourage local residents to engage ... US Breast Cancer statistics show that over a quarter million new cases of ...
(Date:9/20/2017)... ... September 20, 2017 , ... FirstAlign ( ... with the latest Artificial Intelligence (AI) thinking, announced today the launch of its ... access to essential information that offers a more comprehensive understanding of the organization’s ...
(Date:9/20/2017)... ... September 20, 2017 , ... Renal ... for people who have kidney disease. The theme “Describe a positive decision that ... Entrants needed to meet only one qualification— to have been diagnosed with ...
Breaking Medicine News(10 mins):
(Date:9/5/2017)... announced another milestone in their continued growth and success of the company.  Xyntek ... customer engagements regionally.  ... located at 318 West Adams Street, Suite 1528, Chicago, IL ... Xyntek's recently opened Midwest office will support ... In addition to Xyntek,s ...
(Date:9/1/2017)... , Sept. 1, 2017  Explorers Like Us ( ... America,s greatest aural experiences — and deliver these experiences as ... to help people feel and heal better. ... While nothing beats a walk, ... refresh your mind, Life Environments™ is the next best thing ...
(Date:8/28/2017)... 28, 2017 Hill-Rom Holdings, Inc. (NYSE: HRC), will ... September 11, 2017, in New York . ... is scheduled to present at 11:05 a.m. Eastern Time. ... http://ir.hill-rom.com/events.cfm . A recorded replay will be available one ... 10, 2017. About ...
Breaking Medicine Technology: