Navigation Links
First comprehensive DNA study of mast cell leukemia uncovers clues that could improve therapy
Date:12/16/2011

Cold Spring Harbor, N.Y. Cancer researchers at Cold Spring Harbor Laboratory (CSHL) have carried out the first comprehensive study of the changes seen in the DNA of a patient with mast cell leukemia (MCL), an extremely aggressive subtype of acute myeloid leukemia (AML) with a very poor prognosis.

Their genomic survey has helped identify two previously unknown mutations that could directly influence patient response to currently available therapeutic drugs.

The details uncovered by the study not only suggest a diagnostic improvement and an alternative treatment strategy for MCL, but could also serve as a springboard for novel diagnostic and therapeutic approaches for other cancers such as lymphoma.

"This is incredibly exciting because we've gone from knowing very little about the genetics of MCL to uncovering information that could directly benefit patients diagnosed with MCL," says Research Investigator Mona Spector, Ph.D., who led the team's efforts.

The study, which appears online in the journal Leukemia on December 16, is a collaboration between cancer researchers at CSHL and clinicians led by Steven L. Allen, MD, FACP, associate chief of hematology at North Shore-LIJ's Monter Cancer Center and associate investigator at The Feinstein Institute for Medical Research. "This collaboration between the North Shore-LIJ Health System and CSHL allows us to increase medical knowledge and make innovative discoveries that may lead to new treatments for patients who are living with AML," says Allen.

Made possible in large part by funding from the Don Monti Memorial Research Foundation, "the goal of this collaboration was to sequence patient DNA to find information about individual cancers that could be used to improve or design patient-specific treatment strategies," explains CSHL Adjunct Professor and HHMI Investigator Scott Lowe, Ph.D.

In this study, the CSHL scientists used two approaches to identify
'/>"/>

Contact: Hema Bashyam
bashyam@cshl.edu
516-367-6822
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Medical Training School, Pima Medical Institute Offering First Bachelor's Degree Program
2. Retired Military Brass Support First Ladys Call to Reduce Child Obesity, Improve Nutrition
3. NASBE Supports First Lady Michelle Obama in Fight Against Childhood Obesity
4. PolicyLink CEO Angela Glover Blackwell Released the Following Statement on First Lady Michelle Obamas Childhood Obesity Initiative
5. MSU launches first anti-counterfeiting research program
6. AMA Joins First Lady in Fight Against Childhood Obesity
7. National Wildlife Federation Says Outdoor Time for Kids Can Help First Lady Achieve Her “Let's Move” Goal
8. First blinded study of venous insufficiency prevalence in MS shows promising results
9. Akron Institute of Herzing University Launches Its First Bachelors Degree Programs to Prepare Students for Even Greater Success in Business, Health Care and IT
10. First Gene Variants Linked to Stuttering Discovered
11. FAB-HOMES™ Presents First Passive House Collection
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/26/2015)... In this episode of SCI TV ... discusses her study that searched for commonalities in the ... and Field. Shadle wanted to explore the key factors, ... athletes’ success and helped win the Olympic gold. The ... critical to peak athletic performance but to any major ...
(Date:2/26/2015)... Aspen, Colorado (PRWEB) February 26, 2015 ... scale, millions are looking for deeper meaning, more substantial ... the question – how do I live a life ... its 10th round of Younger Next Year Total ... are revealed. This program boasts unbelievable results and jump-starts ...
(Date:2/26/2015)... 2015 The report segments the ... of care, end user, accessory, and region. The ... of the European patient handling equipment market, by ... to grow at the highest CAGR in the ... http://www.marketsandmarkets.com/Market-Reports/european-patient-handling-equipment-market-109569718.html , On the basis of ...
(Date:2/26/2015)... February 26, 2015 “In the last ... monitored the evolution of one of the newest hair ... ARTAS system offers a machinery that facilitates the ... the patient’s scalp,” said Dr. Parsa Mohebi. , Although ... the speed at which the device extracted these grafts ...
(Date:2/26/2015)... 26, 2015 When Cosmetic Town launched ... vision that included, what will soon be, the cornerstone ... information. The plethora of insight that will be accessible ... the Editorial Team has maintained during its existence. Users ... articles on treatments by visiting the Cosmetic Town Journal’s ...
Breaking Medicine News(10 mins):Health News:Anne Shadle and Controlling the Olympic Moment on SCI TV 2Health News:Anne Shadle and Controlling the Olympic Moment on SCI TV 3Health News:The Aspen Club on Actively Aging: Telling a New Story on Aging 2Health News:European Patient Handling Equipment Market Hit to $5,150.2 Million by 2019 - New Resaerch Report by MarketsanMarkets 2Health News:European Patient Handling Equipment Market Hit to $5,150.2 Million by 2019 - New Resaerch Report by MarketsanMarkets 3Health News:Newest Technology now Available at Parsa Mohebi Hair Restoration 2Health News:Cosmetic Town has now Recreated Itself by Adding New Features 2
... By Amanda Gardner HealthDay Reporter , WEDNESDAY, Jan. ... have been around, there have been die-hard opponents convinced that ... of "vaccine phobia" has perhaps never been expressed more vehemently ... insist is tied to autism. Even after the retraction ...
... News) -- Scientists have pinpointed two gene variants that protect ... The findings are detailed in two studies that appear online ... Hepatology . The ability to identify patients with the ... ensure that antiviral therapy is completed and the hepatitis C ...
... Reinberg HealthDay Reporter , WEDNESDAY, Jan. 26 ... to a rehabilitation center in Houston Wednesday morning after ... Tuesday night, another step in her remarkable recovery from ... at Memorial Hermann Texas Medical Center determined that she ...
... FAIRFAX, Va.The Journal of Vascular and Interventional ... Society of Interventional Radiologyannounced several major changes for ... this minimally invasive medical specialty and its lead ... focuses on critical and cutting-edge medical, minimally invasive, ...
... responses identified as factors in the development of Alzheimer,s disease ... South Florida,s Department of Psychiatry and the Center of Excellence ... online in the Journal of Neuroscience ( http://www.jneurosci.org/ ... surface of the brain,s microglia cells, cells that support the ...
... A first of its kind surgical quality improvement program for ... care that can be targeted for quality improvement efforts to ... of the American College of Surgeons National Surgical Quality Improvement ... the January issue of the Journal of the American ...
Cached Medicine News:Health News:Fear of Vaccines Has a Long, Persistent History 2Health News:Fear of Vaccines Has a Long, Persistent History 3Health News:Fear of Vaccines Has a Long, Persistent History 4Health News:Rep. Giffords Moved to Rehab Facility 2Health News:Rep. Giffords Moved to Rehab Facility 3Health News:Journal of Vascular and Interventional Radiology debuts new look, reflects global impact 2Health News:Journal of Vascular and Interventional Radiology debuts new look, reflects global impact 3Health News:Stimulating the brain's immune response may provide treatment for Alzheimer's disease 2Health News:First pediatric surgical quality program shows potential to measure children's outcomes 2
(Date:2/26/2015)... , Feb. 26, 2015  AbbVie (NYSE: ... abstracts of studies in its neuroscience and oncology ... the 67 th American Academy of Neurology ... , from April 18-25. The accepted abstracts feature ... in addition to investigational treatments in AbbVie,s pipeline. ...
(Date:2/26/2015)... -- Today the National Safety Council released a ... effects of pain medications , debunking ... Oxycontin, are safer options than over-the-counter pain relievers. ... on heroin and cocaine combined," said Deborah A.P. ... medications are marketed as the Cadillac option for treating ...
(Date:2/26/2015)... 2015  IRIDEX Corporation (NASDAQ: IRIX ) today ... year 2014 financial results after the market closes on ... the Company will host a conference call with the investment ... Thursday, March 5, 2015 to discuss the results of ... may access the live conference call via telephone by dialing ...
Breaking Medicine Technology:AbbVie's Ongoing Research in Neuroscience and Oncology will be Featured at the 2015 American Academy of Neurology Annual Meeting 2AbbVie's Ongoing Research in Neuroscience and Oncology will be Featured at the 2015 American Academy of Neurology Annual Meeting 3AbbVie's Ongoing Research in Neuroscience and Oncology will be Featured at the 2015 American Academy of Neurology Annual Meeting 4AbbVie's Ongoing Research in Neuroscience and Oncology will be Featured at the 2015 American Academy of Neurology Annual Meeting 5AbbVie's Ongoing Research in Neuroscience and Oncology will be Featured at the 2015 American Academy of Neurology Annual Meeting 6AbbVie's Ongoing Research in Neuroscience and Oncology will be Featured at the 2015 American Academy of Neurology Annual Meeting 7National Safety Council: Opioid prescription painkillers have hidden, deadly side effects 2IRIDEX Announces Fourth Quarter and Full Year 2014 Conference Call and Release Date 2
... IMMULITE 1000 immunoassay system features an ... robust hardware and excellent assay performance. ... and accommodates onboard dilutions, positive sample ... Worldwide, IMMULITE 1000 (and its predecessor, ...
... Immunoassay Analyzer that fits in any lab environment. ... 16 X 21 inches and weighs approximately 60 ... office laboratories, work stations for small hospitals, STAT ... a dedicated system for specialty testing. With a ...
... ECi brings true automation and continuous ... Highly sensitive assays for thyroid, anemia, ... metabolism testing are currently available, with ... Vitros ECi can simultaneously process 60 ...
... Therapeutic Drug Monitoring Market in 1981 with ... use today, this system uses technology known ... serum drug concentration in a patient. Therapeutic ... diseases, often exhibit a narrow therapeutic range ...
Medicine Products: