Navigation Links
First-born babies' higher asthma and allergy rates due to pregnancy conditions
Date:5/20/2008

ATS 2008, TORONTOFirst-born children are at higher risk of developing asthma and allergy because of different conditions they experience in the uterus, according to new research from the Isle of Wight in the United Kingdom, which will be presented at the American Thoracic Societys 2008 International Conference in Toronto on Wednesday, May 21.

In order to determine whether the higher risk of asthma and allergy in first-born children is the result of a prenatal process of post-natal factors, researchers investigated whether birth order affected several immune markers that are set at birth, including a variation in the DNA of the IL-13 gene, which is linked to allergic development.

They recruited more than 1,200 newborns form the Isle of Wight and ascertained their birth order, then sampled their cord blood IgE, an indicator of allergic development, and conducted skin prick tests at ages four and 10. This is the first study to test whether the effect of genes involved in the development of asthma and allergy differs between first- and later-born children, said Wilfried Karmaus, M.D., M.P.H., of the University of South Carolina.

They found that among first-borns, the IL-13 gene variant was associated with a statistically significant higher relative risk of having increased cord-blood IgE, an indication of increased allergic response. This higher risk seemed to persist in older children; at four and ten the children with increased cord blood IgE were also more likely to have a positive skin prick test. Such associations were not found in children who were not first-born.

We were not surprised that birth order had an effect on the development of the immune system, but were surprised that this interaction persisted at least through age ten, said Dr. Karmaus.

This gene-birth order effect is indicative that genes act differently in first-born children. Our findings add to the evidence that allergic reactions are programmed during pregnancy and then effect the disease in later life, he added. This finding may partially account for the increasing prevalence of asthma and allergies in children in the last 30 years, primarily seen in the western world, as developed nations birthrates continue to decline.

It may also indicate that there are ways to reduce the chances of first-borns developing asthma and allergy by changing the conditions in the uterus. If we could produce pregnancy conditions for first-born children that are comparable to later-born children, we may be able to prevent 20 to 30 percent of all cases of asthma and allergy, Dr. Karmaus concluded. Better understanding the mechanism involved in prenatal priming [of immune development] may offer new and exciting avenues of intervention.


'/>"/>

Contact: Keely Savioe
ksavoie@thoracic.org
212-315-8620
American Thoracic Society
Source:Eurekalert

Related medicine news :

1. Mothers prenatal stress predisposes their babies to asthma and allergy
2. ALL: More Dead Babies Found in Michigan Dumpsters
3. Mothers Pass Dangerous Toxins to Babies Through Breast Milk
4. New treatment could reduce chronic lung disease in premature babies
5. March for Babies a Success With Help From Equal Health
6. Breast-Feeding While on Seizure Meds Doesnt Harm Babies
7. Eli Manning Leads March for Babies in Manhattan
8. Humboldt Storage & Moving to Partner with March for Babies
9. March For Babies Has Celebrity Support -- Now It Needs Yours
10. Very Premature Babies Show Raised Risk for Autism
11. Lung damage in babies with congenital heart disease under study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2017)... RICHEY, Fla. (PRWEB) , ... April 24, 2017 ... ... and Prevention (CDC), rising prescription opioid overdose deaths now claim the lives of ... slashed its civil case filings against drug manufacturers, distributors, pharmacies and prescribers by ...
(Date:4/24/2017)... ... April 24, 2017 , ... MAP Health Management announced ... in people with addiction who are served by MAP’s patient engagement ecosystem. Lief ... that monitors heart and breath rates to identify anxiety levels and can provide ...
(Date:4/24/2017)... ... April 24, 2017 , ... Pitavastatin, a relatively new statin, ... not known to have significant interactions with antiretroviral therapy (ART). Among people ... and dampen inflammation in the bloodstream. , While lowering cholesterol and dampening inflammation ...
(Date:4/24/2017)... (PRWEB) , ... April 24, 2017 , ... Come to ... Hotel, 4200 Jim Walter Blvd, for an educational and exciting 2-day program. , ... our staff hearing this before they approach patients” about the course entitled Ain't Misbehavin': ...
(Date:4/24/2017)... (PRWEB) , ... April 24, 2017 , ... Donna Parker, ... but she has not found any of them to be very practical. She wanted ... slowly and easily make changes in their health. It prompted her in writing “ ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... , April 19, 2017  Novartis today ... the National Heart, Lung, and Blood Institute (NHLBI) ... that 58% of patients with treatment-naïve severe aplastic ... when treated with eltrombopag at the initiation of ... The study evaluated three sequential treatment groups, or ...
(Date:4/18/2017)... 2017  Cardinal Health (NYSE: CAH ) ... earnings per share (EPS) guidance and providing a preliminary ... conjunction with this morning,s announcement of the planned acquisition ... Insufficiency businesses. Cardinal Health now believes that ... at the bottom of its previous guidance range of ...
(Date:4/18/2017)... DALLAS , April 18, 2017 Viverae ... proud to announce the integration of IBM ® ... platform to deliver targeted communications for a personalized experience. ... meaningful actions on their health in real time. The ... that matter most to members, wherever they are in ...
Breaking Medicine Technology: