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First Global Atrial Fibrillation Registry, RecordAF, Shows Rhythm-Control Strategy With Current Therapies Achieves Improved Disease Control but not Clinical Outcomes
Date:11/15/2009

, Wynnewood, PA, USA, joint-lead investigator. "We now know that rate-control is not an easier or better treatment strategy than rhythm-control and there is a strong argument to persist with a rhythm-control strategy."

"The incidence of atrial fibrillation is increasing rapidly and becoming a greater burden on our practices. Research such as the RecordAF registry provides a unique insight into factors that influence therapeutic success. This is very important data for physicians who manage patients with atrial fibrillation," said Prof. Eric Prystowsky, St Vincent Hospital and Health Center Program, Indianapolis, IN, USA, joint-lead investigator.

RecordAF is supported by an unrestricted educational grant from sanofi-aventis.

About RecordAF registry

The RecordAF survey recruited 5,604 patients with recent onset atrial fibrillation from 21 countries spanning North and South America, Europe and Asia (5,171 patients - 92.3 percent were evaluable after 12-month follow-up). They were followed-up for a period of one year. The primary outcomes of the study were therapeutic success and clinical outcomes associated with rhythm- and rate-control strategies. Therapeutic success required that therapeutic strategy was unchanged, without clinical events; maintenance of sinus rhythm was required in the rhythm control group and heart rate less than or equal to 80 beats per minute in the rate control group.

532 physicians involved in the registry were randomly selected from an initial representative and exhaustive global list of office- and hospital-based cardiologists. Patients aged greater than or equal to 18 years were considered for enrolment if they presented with AF or a history of AF, diagnosed by standard electrocardiogram (ECG) or ECG Holter monitoring and if they were eligible for pharmacological treatment by rhythm- or rate-control agents. Three visits took place at baseline, 6 months (plus or m
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SOURCE RecordAF registry
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