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First Dutch Patients Treated With the Percutaneous MitraClip(R) System
Date:2/12/2009

MENLO PARK, Calif., Feb. 12 /PRNewswire/ -- Evalve, Inc., the leader in the development of devices for the percutaneous repair of cardiac valves, announced today that the first series of patients have been successfully treated with the MitraClip(R) system at the St. Antonius Hospital, Nieuwegein, Utrecht, Netherlands. The MitraClip(R) system is the only medical device commercially available in the European Union which provides a non-surgical mitral valve repair option for patients suffering from the effects of mitral regurgitation (MR).

Mitral regurgitation is the most common type of heart valve insufficiency in Europe and the United States, affecting millions of people worldwide. In the vast majority of patients, the MR is untreated, requiring the heart to work harder and ultimately leading to heart failure.

The first patients in the Netherlands were treated by the team led by J. Van der Heyden, M.D., assisted by B.J.W.M. Rensing, M.D., PhD.; F.D. Eefting, M.D.; W. Jaarsma, M.D., PhD.; and A. Yilmaz, M.D.

"The MitraClip(R) therapy provides a valuable alternative for those patients who are not good candidates for surgery," said Dr. Van der Heyden, department of interventional cardiology. Dr. Yilmaz, department of cardiothoracic and cardiovascular surgery added, "Until now heart failure patients with associated functional MR had no therapeutic options except medical management when surgery was not considered a good option. We believe the MitraClip(R) system will play a key role for these patients."

Evalve initiated commercial sales of the MitraClip(R) system in Europe under the CE Mark in September 2008. The company is employing a direct sales strategy and is taking a disciplined and measured approach to the initial commercial roll out. The company has worked closely with hospitals to deliver high quality training programs in preparation for the first series of implants. The Mit
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SOURCE Evalve, Inc.
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