Navigation Links
First Complete Mapping of the Alzheimer’s Genome Underway
Date:5/9/2013

Boston (PRWEB) May 09, 2013

The goal of the research project led by Dr. Rudolph Tanzi at Massachusetts General Hospital and funded through collaboration between Cure Alzheimer’s Fund (CAF) and the National Institute of Mental Health (NIMH) is to complete the identification of genes affecting risk for Alzheimer’s disease. The Whole Genome Sequencing (WGS) process will go beyond previously used techniques to allow researchers to understand the genetic switches controlling the Alzheimer’s genes and how they are triggered by other genes and by environmental inputs.

Cure Alzheimer’s Fund has already committed $5.4 million and NIMH $4 million. Additional funds to complete the project will be raised privately. Over the next several months, the study will obtain the complete genomic sequences of more than 1500 subjects in families that have Alzheimer’s. It will then compare the human genome sequences from family members with and without Alzheimer’s disease to identify precisely all of the variations in our genomic DNA that influence risk for Alzheimer’s.

“This research is searching for genetic factors that influence risk for getting the disease and affect brain pathology,” said Dr. Rudy Tanzi, professor at MGH and Harvard Medical School and leader of the WGS project. “We are taking advantage of cutting edge technology to discover exactly how our genes determine susceptibility to Alzheimer’s disease. We will then use this knowledge to guide novel drug discovery efforts.”

Joining with Cure Alzheimer’s Fund to achieve this objective, the National Institutes of Mental Health (NIMH), a part of the National Institutes of Health, has awarded $4 million to the Tanzi laboratory, specifically to support the analysis of the data. Additional funds required to complete the project within the next three years will be raised privately.

“This is a perfect example of an innovative and productive public private partnership as well as the value of leveraging private funds into a much stronger overall effort made possible with public money,” said Jeff Morby, chairman and co-founder of Cure Alzheimer’s Fund. “The data from the WGS initiative will increase the speed of development of therapies, both to prevent the disease and arrest its progress. We are most grateful to the NIMH for partnering with us in this pioneering effort.”

About Cure Alzheimer’s Fund

In nine years, with $20 million invested in research, Cure Alzheimer’s Fund has a strong track record in funding novel approaches to understanding the causes of Alzheimer’s disease and the biological processes that drive the pathology. Cure Alzheimer’s Fund has supported 72 projects in 51 laboratories of leading Alzheimer’s researchers in the US and abroad. Cure Alzheimer’s Fund is a 501c3 public charity and seeks no financial gain for its founders, donors or researchers. The Founders and Board members pay all expenses of the Foundation so that all contributions from others go directly to research.

Read the full story at http://www.prweb.com/releases/2013/5/prweb10710760.htm.


'/>"/>
Source: PRWeb
Copyright©2012 Vocus, Inc.
All rights reserved

Related medicine news :

1. First targeted nanomedicine to enter human clinical studies
2. First contact: Early intervention key in diagnosis and treatment of serious mental illness
3. Donor Kidney Re-Used in Second Patient After Failing in First
4. Many Who First Misuse Prescription Pills Get Them From Friends, Family: Report
5. First-of-its-kind Menopause Map helps women navigate treatment
6. First recipients of AcademyHealths Presidential Scholarship announced
7. Kessler Foundation researchers present at first International Congress on Cognition in MS
8. Whos the Dad? First-Trimester Blood Test May Tell
9. AGA releases first independently developed ABIM-approved Practice Improvement Module in GI
10. Dr. Yael Mosse will receive first Nachman Award in Pediatric Oncology at national conference
11. First study investigating possible link between sunscreen ingredient and endometriosis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... June 27, 2016 , ... A revolution ... the emergency ambulance transport experience for the millions of people who require these ... disrupted the taxi industry through the use of technology. Now, SmartEMS has put ...
(Date:6/26/2016)... ... 2016 , ... On June 10-11, 2016, A Forever Recovery, a holistic treatment ... Longest Breakfast Table in Battle Creek, MI, where the rehabilitation facility is located. This ... of the world’s leading providers of cereal and other breakfast foods. Its residents often ...
(Date:6/26/2016)... ... June 26, 2016 , ... Brent Kasmer, a legally blind and certified personal trainer is helping ... fitness app. The fitness app plans to fix the two major problems leading the fitness ... size fits all type program , They don’t eliminate all the reasons people ...
(Date:6/25/2016)... ... June 25, 2016 , ... Austin residents seeking Mohs surgery services, can now ... and to Dr. Russell Peckham for medical and surgical dermatology. , Dr. Dorsey brings ... The selective fellowship in Mohs Micrographic Surgery completed by Dr. Dorsey was under the ...
(Date:6/25/2016)... Lewisville, TX (PRWEB) , ... June 25, 2016 , ... ... in the United States, named Dr. Sesan Ogunleye, as the Medical Director of its ... be the facility Medical Director of our new Mesquite location,” said Dr. James M. ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 Bracket , a ... its next generation clinical outcomes platform, Bracket eCOA (SM) ... on June 26 – 30, 2016 in Philadelphia ... electronic Clinical Outcome Assessment product of its kind to fully ... Bracket eCOA 6.0 is a flexible platform for ...
(Date:6/23/2016)... June 23, 2016  Astellas today announced the establishment of Astellas Farma Colombia (AFC), a new affiliate with operations ... Latin America . ... ... ... ...
(Date:6/23/2016)... The vast majority of dialysis patients currently ... are usually 3 times a week, with treatment times ... time, equipment preparation and wait time.  This regimen can ... patients who are elderly and frail.  Many elderly dialysis ... centers for some duration of time. Residents ...
Breaking Medicine Technology: