Navigation Links
First Adult Injection in US of Dotarem® (gadoterate meglumine) Performed at Winthrop-University Hospital in New York
Date:9/5/2013

drug therapy. No age-related dosage adjustment is necessary.

8.6 Renal Impairment
No DOTAREM dosage adjustment is recommended for patients with renal impairment. Gadoterate meglumine can be removed from the body by hemodialysis [see Warnings and Precautions (5.1) and Clinical Pharmacology (12.3)].

10 OVERDOSAGE
DOTAREM administered to healthy volunteers and to patients at cumulative doses up to 0.3 mmol/kg was tolerated in a manner similar to lower doses. Adverse reactions to overdosage with DOTAREM have not been reported. Gadoterate meglumine can be removed from the body by hemodialysis [See Clinical Pharmacology (12.3)].

13 NONCLINICAL TOXICOLOGY

13.1 Carcinogenesis, Mutagenesis, Impairment of Fertility
Long-term animal studies have not been performed to evaluate the carcinogenic potential of gadoterate meglumine.
Gadoterate meglumine did not demonstrate mutagenic potential in in vitro bacterial reverse mutation assays (Ames test) using Salmonella typhimurium, in an in vitro chromosome aberration assay in Chinese hamster ovary cells, in an in vitro gene mutation assay in Chinese hamster lung cells, nor in an in vivo mouse micronucleus assay.
No impairment of male or female fertility and reproductive performance was observed in rats after intravenous administration of gadoterate meglumine at the maximum tested dose of 10 mmol/kg/day (16 times the maximum human dose based on surface area), given during more than 9 weeks in males and more than 4 weeks in females. Sperm counts and sperm motility were not adversely affected by treatment with the drug.

13.2 Animal Toxicology and/or Pharmacology
Local intolerance reactions, including moderate irritation associated with infiltration of inflammatory cells were observed after perivenous injection in rabbits suggesting the possibility of local irritation if the contrast medium leaks around the veins in a clinical setting [see Warnin
'/>"/>

Source: PRWeb
Copyright©2012 Vocus, Inc.
All rights reserved

Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14

Related medicine news :

1. Team Third Law BJJ Makes History with First Ever Husband-Wife Double Gold
2. C8 Lawsuit Lawyers at Wright & Schulte LLC Applaud Scheduling of First Trials in Multidistrict Litigation Established for Federal DuPont C8 Lawsuits
3. Cardiology Center in Nevada First to Have New Critical Care Test Equipment
4. Nation’s First Robotic Single Incision (via Belly Button) Hernia Repair, Performed in an Outpatient Setting at K and B Surgical Center
5. Pro Dissertation launches first of its kind statistical research package
6. Dr. Kovanda Among First to Offer Sientra Implants
7. Plastic Surgeon Finally Releasing First Solo Music Artist Song in September and Several Charities Await the Results
8. RAGEWorks Announces First Team 3 Center to Open in November 1st, As Safe Harbor to Help Men Work Out Rage and Anger Issues
9. First Bellwether Trial in Multidistrict Litigation for DePuy Orthopaedics Inc.’s All-Metal Hip Implant to Commence on September 9 in Ohio’s Northern District, Reports Parker Waichman LLP
10. Mayoral Dermatology is the First in Florida to Introduce the New INFINI Radiofrequency System for Skin Rejuvenation
11. Consuming alcohol before first pregnancy linked with increased risk of BBD & breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2015)... ... ... like Toppik , Eau Thermale Avene and Bliss are now available on ... required to qualify for free standard shipping,” said Jennifer Ramirez, the public relations manager. ... the item’s selling price.” , With competitive pricing in the e-commerce market for beauty ...
(Date:8/29/2015)... ... ... popular television program VOICES IN AMERICA, hosted by legendary star of the stage and ... segment to the subject of diabetes. Diabetes is a debilitating health condition that is ... advancements in medical science may prove to be a significant breakthrough that sufferers have ...
(Date:8/28/2015)... ... August 28, 2015 , ... Approximately 2,000 ... Zoo to celebrate children helping children, a thank you to the many creative ... have contributed to the United Methodist initiative to end malaria deaths. , The ...
(Date:8/28/2015)... ... August 28, 2015 , ... ... the FDA’s Position and Best Practices for Compliance, **Presented by FDAnews and ... workshop, chaired by internationally renowned expert Fubin Wu, has been specifically designed ...
(Date:8/28/2015)... ... 28, 2015 , ... Saint Petersburg, FL —Pocket Protein™, a ... carbs, sugar, gluten, lactose or caffeine in a convenient 2 oz. pouch that ... Editor’s Choice Awards. , Five consumer packaged goods (CPG) products were selected by ...
Breaking Medicine News(10 mins):Health News:TheBeautyPlace.com Discounts Shipping on Select Brands 2Health News:Saturday’s United Methodist Event at Columbus Zoo Celebrates Imagine No Malaria 2Health News:Saturday’s United Methodist Event at Columbus Zoo Celebrates Imagine No Malaria 3Health News:FDAnews Announces — Software and Cybersecurity Risk Management for Medical Devices: Understanding the FDA’s Position and Best Practices for Compliance, Oct. 14-15 2Health News:FDAnews Announces — Software and Cybersecurity Risk Management for Medical Devices: Understanding the FDA’s Position and Best Practices for Compliance, Oct. 14-15 3Health News:FDAnews Announces — Software and Cybersecurity Risk Management for Medical Devices: Understanding the FDA’s Position and Best Practices for Compliance, Oct. 14-15 4Health News:FDAnews Announces — Software and Cybersecurity Risk Management for Medical Devices: Understanding the FDA’s Position and Best Practices for Compliance, Oct. 14-15 5Health News:Pocket Protein™ Named 2015 CPG Editor’s Choice Award Finalist by Informa’s SupplySide 2Health News:Pocket Protein™ Named 2015 CPG Editor’s Choice Award Finalist by Informa’s SupplySide 3
... of Leeds have found a mechanism to prevent a ... ,Dr Lezanne Ooi, a postdoctoral researcher in ... progression of cardiac hypertrophy can be halted by increasing ... a significant discovery because whilst the symptoms can be ...
... church of "consequences" if they vote in favour of overturning a ... the ruling Labor Party in the New South Wales state parliament ... how to vote from Sydney Catholic Archbishop George Pell. ... I'm going to do so by saving a lot of lives, ...
... study at Cincinnati Children's Hospital Medical Center, pediatricians now ... with chronic diseases like Crohn's, juvenile arthritis and ... are at increased risk for bone mass deficiencies, fracture ... is a huge demand for this information among clinicians ...
... GAINESVILLE, Fla. University of Florida researchers report the ... cutting the flow of blood .The talc stimulates ... magic bullet for treating metastatic lung cancer. The UF ... for a cancer largely considered incurable. ,Talcum ...
... they are moving closer to understanding why the most ... to drug treatment in the past three decades. They ... in yeast, a protozoan gene that contributes to such ... a two-year period is believed to be the largest ...
... Chinese President Hu Jintao and U.N. Secretary-General Ban Ki-moon ... (G-8) Summit on Thursday, besides giving India's viewpoint ... climate change. ,An External Affairs Ministry background ... of the world's population, it emits only four per ...
Cached Medicine News:Health News:Breakthrough for Treatment of Fatal Heart Condition 2Health News:Australian Catholics Rebel Over Stem Cell Vote Warning 2Health News:A Pratical Tool to Detect Bone Mass Deficiencies in Children With Chronic Diseases 2Health News:A Pratical Tool to Detect Bone Mass Deficiencies in Children With Chronic Diseases 3Health News:A Pratical Tool to Detect Bone Mass Deficiencies in Children With Chronic Diseases 4Health News:Talcum Powder Curbs Lung Tumor Risk 2Health News:Talcum Powder Curbs Lung Tumor Risk 3Health News:New Insights into Antimalarial Drug Resistance 2Health News:New Insights into Antimalarial Drug Resistance 3Health News:New Insights into Antimalarial Drug Resistance 4Health News:Manmohan Singh to Meet UN Chief, Discuss Climate Change 2
(Date:8/28/2015)... Calif. , Aug. 28, 2015  CytomX Therapeutics, ... treatment of cancer, today announced the filing of a ... and Exchange Commission (SEC) relating to a proposed initial ... shares to be offered and the price range for ... to list its common stock under the symbol "CTMX" ...
(Date:8/28/2015)... DUBLIN , Aug. 28, 2015 ... announced the addition of the "Investigation Report on ... Developed by Roche under the trade name ... in the world. In Feb.26, 2010, it was approved ... injections available in China all ...
(Date:8/28/2015)... 2015  Today, in final recognition of the Centers ... Week, 1-800 Contacts is sharing how to keep lens ... wearers who do not properly care for their lens ... Most contact lens wearers understand the ... lens case is sometimes overlooked.  When proper steps to ...
Breaking Medicine Technology:CytomX Files Registration Statement for Proposed Initial Public Offering 2Investigation Report on China's Bevacizumab Market 2015-2019 21-800 Contacts Shares Tips on How to Clean Lens Cases 2
... 11, 2012 PLC Systems Inc. (OTCBB: PLCSF), a ... it will demonstrate its innovative product, RenalGuard ® , ... of Percutaneous Cardiovascular Interventions (EAPCI).  More than 11,000 clinicians ... to attend this event in Paris, France from May ...
... SOUTH BEND, Ind., May 11, 2012  Heraeus Kulzer, ... announced that it has launched a new light ... Venus Pearl is indicated for adhesively bonded, tooth-colored ... to its remarkably soft consistency, this new universal ...
Cached Medicine Technology:PLC to Demonstrate RenalGuard® at EuroPCR 2012 2PLC to Demonstrate RenalGuard® at EuroPCR 2012 3Heraeus Launches Remarkably Smooth Venus® Pearl Composite 2Heraeus Launches Remarkably Smooth Venus® Pearl Composite 3
Indications For Usage: ,Bypass upper airway obstructions, provide long term ventilation, support and/or manage tracheal/bronchial secretions....
... The permanent flexible tube extension ... the neck flange helps keep ... chin, and stoma, enhancing patient ... ,Bivona® FlexTend™ tracheostomy tubes improve ...
... TTS™ tracheostomy tubes are available in both neonatal ... like an uncuffed tube, but it has a ... the shaft of the tube. , ,TTS™ ... tube with the insurance of a cuff, if ...
Portex® pediatric tracheostomy tubes offer a choice in both form and fit. , ,The anatomical shape of the tube shaft along with the caudal angle of the 15 mm connector provide comfort and security...
Medicine Products: