Navigation Links
Firefly genes allow testing of new therapy against lymphoma
Date:12/19/2007

COLUMBUS, Ohio Researchers here have figured out a way to use a firefly gene to let them see just how effective a new drug combination actually is against some forms of cancer and its serious complication.

The new study looked at ATLL, adult T-cell lymphoma and leukemia, a form of cancer where it is particularly hard to gauge the disease's progress, and where the patients' prognosis is generally poor. There is now no widely effective therapy available to treat this disease successfully.

In doing so, the researchers developed what they hope will be the first animal model for the disease that includes a severe bone depletion called humoral hypercalcemia of malignancy (HHM), a condition that can affect four out of every five ATLL patients and shorten their lives.

The study is published in the online edition of the journal Cancer Research.

These ATLL tumors secrete proteins that also cause the bones in these patients to weaken and resorb, explained Thomas Rosol, professor of veterinary biosciences and dean of the College of Veterinary Medicine at Ohio State University.

When that happens, the amount of calcium in the blood can build up to toxic levels. So killing the cancer cells in these patients is only half the battle, he says. We have to stop the resorption of bone and the release of calcium that the cancer causes.

Earlier tissue culture studies on a new anticancer drug, PS-341, showed promise in attacking the cancer cells but before now, an effective animal model wasn't available for researchers to use that included HHM's calcium buildup.

Rosol and his team turned to a combination of PS-341 and zoledronic acid, a form of bisphosphonate that is widely used now to combat the bone loss of osteoporosis and other diseases.

They would then test the two drugs, separately and combined, in a group of specialized mice that had been injected with ATLL tumor cells.

We ca
'/>"/>

Contact: Thomas Rosol
Thomas.Rosol@cvm.osu.edu
614-688-8749
Ohio State University  
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Pathway links inflammation, angiogenesis and breast cancer
2. Traffic Fumes Plus Genes Boosts Kids Asthma Risk
3. New Database to Help Speed Search for Bipolar Disorder Genes
4. Is Perfect Pitch All in the Genes?
5. Discovery suggests location of genes for breast density, a strong risk factor for breast cancer
6. Genes Boost Risk for Rheumatoid Arthritis, Lupus
7. The genes involved in rheumatoid arthritis identified
8. If you think cancer genes are simple, you dont know JAK
9. Test for lung cancer looks for discomforting quiet among protective genes
10. Hushed Genes Might Mean Higher Lung Cancer Risk
11. EURYI project to understand how the brain wires during embryogenesis
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Firefly genes allow testing of new therapy against lymphoma
(Date:8/4/2015)... ... August 04, 2015 , ... Many men are confused ... subject, Renew Man™ is standing up as a voice of authority for men seeking ... healthy aging industry with special experience and expertise in the safe and effective treatment ...
(Date:8/4/2015)... ... 2015 , ... Buckeye Health Plan is reminding parents to ... covered for members under the Healthchek program . , “Many schools have ... immunizations may not be allowed to attend when school begins in August,” said ...
(Date:8/4/2015)... ... August 04, 2015 , ... SanusEO, the healthcare industry innovator ... executive leadership team as Senior Vice President of Sales and Marketing. Mr. McCalley ... global markets with a special emphasis on the healthcare industry. , Today, patients ...
(Date:8/4/2015)... (PRWEB) , ... August 04, 2015 , ... T.E.N., an ... for vendor participating in The ISE® Lions’ Den and Jungle Lounge 2015, which will ... in Las Vegas. , During the event, eight emerging security vendors, known as “Gazelles,” ...
(Date:8/4/2015)... ... August 04, 2015 , ... ... finds the North America IT reseller channel will grow at least 6 percent ... of their 2014 pace and greater than their OEM/vendor partners. , The ...
Breaking Medicine News(10 mins):Health News:New Video from Renew Man™ Raises Awareness of the Right Way to Correct Low Testosterone 2Health News:New Video from Renew Man™ Raises Awareness of the Right Way to Correct Low Testosterone 3Health News:Buckeye Health Plan Reminds Parents to Keep Immunizations In Mind As School Year Kicks Off 2Health News:SanusEO Hires Healthcare Technology Executive Bruce McCalley As Senior Vice President of Sales & Marketing 2Health News:SanusEO Hires Healthcare Technology Executive Bruce McCalley As Senior Vice President of Sales & Marketing 3Health News:T.E.N. Releases Pitch Schedule for The ISE® Lions Den & Jungle Lounge 2015 2Health News:T.E.N. Releases Pitch Schedule for The ISE® Lions Den & Jungle Lounge 2015 3Health News:T.E.N. Releases Pitch Schedule for The ISE® Lions Den & Jungle Lounge 2015 4Health News:The 2112 Group Forecasts North America IT Channel to Grow At Least 6% in 2015 2Health News:The 2112 Group Forecasts North America IT Channel to Grow At Least 6% in 2015 3
... Merck is in trouble again. The Federal Drug Administration of U.S ... was pulled out of the market due to safety reasons. ... same class of drugs as Vioxx ,was voted out 20-1 ... Vioxx from the market in September 2004 after research showed that ...
... can be increasingly used to improve patient care. In a recent ... around 2,250 babies in US alone who succumb to sudden infant ... assistant at the University of Texas has come up with a ... , ,Hung Cao, along with his friends developed a device ...
... Fiorillo noticed that her daughter Bianca could not seem to ... She seemed slower at doing things compared to the other ... on diagnoses it was found that she has CMT, Charcot-Marie-Tooth ... and her brother Tony too suffered from it. ...
... therapy for coronary artery disease is four times more likely ... same medical history. ,Historically, studies have shown ... men, but it has remained unclear how much less effective ... pharmacist and adjunct clinical instructor at the University of Michigan ...
... A former official of the Mets, a leading baseball team ... federal court in San Francisco to distributing// performance-enhancing drugs to ... a decade. ,Kirk Radomski, 37, who had worked ... admitted to selling banned drugs, including anabolic steroids, amphetamines and ...
... may be as important to your health as the food ... toxins that might soon become// as important a risk factor ... ,This class of toxins, called advanced glycation end ... of grilled, fried, or broiled animal products, such as meats ...
Cached Medicine News:Health News:Arcoxia Slammed –Nothing Better Than Vioxx Says FD 2Health News:RFID Use can Avoid Sudden Infant Death Syndrome 2Health News:Cure for CMT 2Health News:Aspirin Therapy for Heart Disease Found More Effective for Men Than Women 2Health News:Aspirin Therapy for Heart Disease Found More Effective for Men Than Women 3Health News:Former Official Confesses He Had Sold Steroids to Leading Baseball Players 2Health News:Food Preparation may Play a Bigger Role in Chronic Disease 2Health News:Food Preparation may Play a Bigger Role in Chronic Disease 3Health News:Food Preparation may Play a Bigger Role in Chronic Disease 4
(Date:8/3/2015)... ReportsnReports.com adds Global Medical ... forecasts as well as Global Medical Simulation Market ... collection of its library. Complete 2015 ... spread across 164 pages, talking about 7 major ... is now available at http://www.reportsnreports.com/reports/407046-global-medical-simulation-industry-report-2015.html . ...
(Date:8/3/2015)... , Aug. 3, 2015 OmniSeq, LLC ... Institute to the OmniSeq SM Genomic Network.  ... Cancer Institute (RPCI) and announced it was making ... a physician-driven, collaborative approach to genomic diagnostics that ... Cancer Institute is a rapidly expanding, multidisciplinary cancer ...
(Date:8/3/2015)... Aug. 3, 2015 Ortho Clinical Diagnostics (OCD) ... named Chief Corporate Brand and Communications Officer, effective immediately. ... team, Bouryal will lead the company,s worldwide corporate brand ... transition to an independent company by adding sites in ... and Chief Executive Officer Dr. Martin Madaus . ...
Breaking Medicine Technology:Medical Simulation Market to see 14% CAGR to 2019 2Medical Simulation Market to see 14% CAGR to 2019 3Medical Simulation Market to see 14% CAGR to 2019 4Medical Simulation Market to see 14% CAGR to 2019 5Medical Simulation Market to see 14% CAGR to 2019 6OmniSeq Adds Wilmot Cancer Institute to its Collaboration-Based Treatment Network 2OmniSeq Adds Wilmot Cancer Institute to its Collaboration-Based Treatment Network 3Ortho Clinical Diagnostics Appoints Kristie Bouryal Chief Corporate Brand and Communications Officer 2
... adjusted for perfect focus where it's needed ... This, along with Keeler's wide angle light ... the patient's pupil size, you will see ... Lithium-ion technology provides a longer life battery ...
... ophthalmoscopes are individually adjusted for perfect focus ... not on paper. This, along with Keeler's ... ensures that whatever the patient's pupil size, ... field of view. Lithium-ion technology provides a ...
The Beta 200S combines Heine's patented aspherical optics (U.S. Pat. 4.963.014) and a single-step Rekoss disk with a range of 36 to +38 dpt. to provide perfectly-focused images even in cases of high ...
A full function instrument at an economical price....
Medicine Products: