Navigation Links
Firefly genes allow testing of new therapy against lymphoma
Date:12/19/2007

COLUMBUS, Ohio Researchers here have figured out a way to use a firefly gene to let them see just how effective a new drug combination actually is against some forms of cancer and its serious complication.

The new study looked at ATLL, adult T-cell lymphoma and leukemia, a form of cancer where it is particularly hard to gauge the disease's progress, and where the patients' prognosis is generally poor. There is now no widely effective therapy available to treat this disease successfully.

In doing so, the researchers developed what they hope will be the first animal model for the disease that includes a severe bone depletion called humoral hypercalcemia of malignancy (HHM), a condition that can affect four out of every five ATLL patients and shorten their lives.

The study is published in the online edition of the journal Cancer Research.

These ATLL tumors secrete proteins that also cause the bones in these patients to weaken and resorb, explained Thomas Rosol, professor of veterinary biosciences and dean of the College of Veterinary Medicine at Ohio State University.

When that happens, the amount of calcium in the blood can build up to toxic levels. So killing the cancer cells in these patients is only half the battle, he says. We have to stop the resorption of bone and the release of calcium that the cancer causes.

Earlier tissue culture studies on a new anticancer drug, PS-341, showed promise in attacking the cancer cells but before now, an effective animal model wasn't available for researchers to use that included HHM's calcium buildup.

Rosol and his team turned to a combination of PS-341 and zoledronic acid, a form of bisphosphonate that is widely used now to combat the bone loss of osteoporosis and other diseases.

They would then test the two drugs, separately and combined, in a group of specialized mice that had been injected with ATLL tumor cells.

We ca
'/>"/>

Contact: Thomas Rosol
Thomas.Rosol@cvm.osu.edu
614-688-8749
Ohio State University  
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Pathway links inflammation, angiogenesis and breast cancer
2. Traffic Fumes Plus Genes Boosts Kids Asthma Risk
3. New Database to Help Speed Search for Bipolar Disorder Genes
4. Is Perfect Pitch All in the Genes?
5. Discovery suggests location of genes for breast density, a strong risk factor for breast cancer
6. Genes Boost Risk for Rheumatoid Arthritis, Lupus
7. The genes involved in rheumatoid arthritis identified
8. If you think cancer genes are simple, you dont know JAK
9. Test for lung cancer looks for discomforting quiet among protective genes
10. Hushed Genes Might Mean Higher Lung Cancer Risk
11. EURYI project to understand how the brain wires during embryogenesis
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Firefly genes allow testing of new therapy against lymphoma
(Date:11/24/2014)... UK (PRWEB) November 24, 2014 ... Massaggi , London's pre-eminent pain-relief service and massage ... Emmett Sports Massage (ESM). This newest sports ... , The key difference between traditional sports massage ... to access the body's very own "reset button,” ...
(Date:11/24/2014)... 2014 The Holiday Inn Westbury - ... and Children's Association to donate various items consisting ... and other such items.The Association's program is aimed toward ... living in nursing homes, assisted living facilities and nursing ... well being of seniors throughout the Long Island area. ...
(Date:11/24/2014)... 24, 2014 The typical American diet ... wrong ingredients. Consistently consuming a diet high in calories ... of excess fat that typically accumulate around the internal ... its ugly head in the form of love handles, ... make the decision to rid themselves of the burden ...
(Date:11/24/2014)... November 24, 2014 Gersowitz Libo & Korek, ... has received national Tier recognition in the 2015 Edition of ... tiered ranking signals a unique combination of quality law practice ... to receive this honor and especially grateful to our clients ... honor and ranking possible,” said Jeff S. Korek, senior partner ...
(Date:11/23/2014)... TX (PRWEB) November 24, 2014 ... Review, H2, 2014" provides data on the Aspergillosis ... and data relating to the clinical trials on ... numbers and their recruitment status as per the ... databook offers a preliminary coverage of disease clinical ...
Breaking Medicine News(10 mins):Health News:Sports Massage in London by Massaggi Presents New Technique to Reset Muscles, Rapidly Eliminate Pain 2Health News:Sports Massage in London by Massaggi Presents New Technique to Reset Muscles, Rapidly Eliminate Pain 3Health News:The Holiday Inn Westbury - Long Island gives back to the local Long Island community, and also goes beyond borders to assist those in need during the 2014 Holiday Season 2Health News:The Holiday Inn Westbury - Long Island gives back to the local Long Island community, and also goes beyond borders to assist those in need during the 2014 Holiday Season 3Health News:Ketogenic Diet is the Perfect Solution for Diet Doc Patients Who Want to Learn How to Lose Weight over the Holidays 2Health News:Ketogenic Diet is the Perfect Solution for Diet Doc Patients Who Want to Learn How to Lose Weight over the Holidays 3Health News:Ketogenic Diet is the Perfect Solution for Diet Doc Patients Who Want to Learn How to Lose Weight over the Holidays 4Health News:U.S. News-Best Lawyers “Best Law Firms” Names Gersowitz Libo & Korek P.C. a 2015 Tier 1 Ranking Firm 2Health News:Aspergillosis Pipeline and Clinical Trials Market (Compnies and Drugs) Review H2 2014 Report at ReportsnReports.com 2Health News:Aspergillosis Pipeline and Clinical Trials Market (Compnies and Drugs) Review H2 2014 Report at ReportsnReports.com 3Health News:Aspergillosis Pipeline and Clinical Trials Market (Compnies and Drugs) Review H2 2014 Report at ReportsnReports.com 4
... , National Poll Finds Voters ... WASHINGTON , Feb. 10 Raising Iowa ... in $65.3 million in new annual revenue to help ... lives, according to a national report released today by a coalition ...
... Poll Finds Voters Prefer Tobacco Tax to Other Tax Increases, Budget ... Raising Texas ,s cigarette tax by $1 per ... revenue to help close the state,s budget shortfall, while also reducing ... by a coalition of public health organizations. , (Logo: http://www.newscom.com/cgi-bin/prnh/20080918/CFTFKLOGO ...
... Veteran Affairs is rolling out treatments nationwide as fast ... patients, there are still significant barriers to veterans getting ... published in the latest issue of the Journal ... and Afghanistan war veterans sought treatment for the first ...
... , ... weight loss shakes and nutritional products supplier, announces their monthly "Biggest Losers" contest to ... , ... February 10, 2010 -- MyDietShopz.com , online weight loss shakes, protein bars, and ...
... ... and award-winning educator, has released a new book with a foreword by Will Smith to ... child to achieve their greatest potential. , ... (PRWEB) February 10, 2010 -- The Immortality of Influence: Building the Best Minds ...
... , , SAN DIEGO , Feb. 10 ... dreams are attainable.  Back in the third quarter of 2006, 62% of ... achieving their personal dreams.  Now 55% of Americans feel this way.  On ... chance or it is impossible for them to achieve their dreams – ...
Cached Medicine News:Health News:New Report: $1 Cigarette Tax Increase Would Raise $65.3 Million for Iowa and Cut Youth Smoking 2Health News:New Report: $1 Cigarette Tax Increase Would Raise $65.3 Million for Iowa and Cut Youth Smoking 3Health News:New Report: $1 Cigarette Tax Increase Would Raise $418.8 Million for Texas and Cut Youth Smoking 2Health News:New Report: $1 Cigarette Tax Increase Would Raise $418.8 Million for Texas and Cut Youth Smoking 3Health News:Many veterans not getting enough treatment for PTSD 2Health News:MyDietShopz.com Announces Biggest Losers Contest - Share Your Story To Inspire Others 2Health News:Groundbreaking Principal and Contributor on Dr. Oz Show Releases His Latest Book on How We Can Influence the Lives of Children 2Health News:Luth Research's IndicatorEDG(TM) Study Finds Americans' Hopes of Achieving Their Dreams Are Fading 2Health News:Luth Research's IndicatorEDG(TM) Study Finds Americans' Hopes of Achieving Their Dreams Are Fading 3Health News:Luth Research's IndicatorEDG(TM) Study Finds Americans' Hopes of Achieving Their Dreams Are Fading 4
(Date:11/23/2014)... 2014 Anthera Pharmaceuticals, Inc. (Nasdaq: ... , President and Chief Executive Officer, will present a ... Conference. Anthera will present at 4:30PM ... in New York City . ... is a biopharmaceutical company focused on developing and commercializing ...
(Date:11/22/2014)... , Nov. 21, 2014  CytoSorbents Corporation ... its European Union approved CytoSorb® cytokine adsorber to ... awarded the Beacon of Light Award at last ... Dr. Phillip Chan , ... an honor to be recognized by the New ...
(Date:11/22/2014)... -- MEDITE Group acquired by CytoCore, Inc. (OTCBB: CYOE) on ... quarter sales ended September 30, 2014 of $8.7 million ... months ended September 2014 and a $38,000 loss for the ... quarter is usually a seasonable weak period due to the ... many countries worldwide, we are proud to announce record sales ...
Breaking Medicine Technology:Anthera Pharmaceuticals to Present at Annual Piper Jaffray Healthcare Conference 2CytoSorbents Wins Beacon of Light Award 2CytoSorbents Wins Beacon of Light Award 3CytoSorbents Wins Beacon of Light Award 4CytoCore Inc. / MEDITE Cancer Diagnostics, Inc. Reports Record YTD and 3rd Quarter Sales 2CytoCore Inc. / MEDITE Cancer Diagnostics, Inc. Reports Record YTD and 3rd Quarter Sales 3
Cushing Little Joker periosteal elevators, solid handle, blade width 1/4" (6 mm), length 7 1/2" (191 mm)....
Ohl periosteal elevators....
Miller Collburn periosteal elevators....
Williger periosteal elevators....
Medicine Products: