Navigation Links
Fireflies' glow helps UT Southwestern researchers track cancer drug's effectiveness
Date:5/28/2008

DALLAS May 29, 2008 The gene that allows fireflies to flash is helping researchers track the effectiveness of anti-cancer drugs over time.

UT Southwestern Medical Center researchers are among the first to show that a technique called bioluminescence imaging (BLI) can be used to determine the effectiveness of cancer drugs that choke off a tumors blood supply.

The technique requires a substrate called luciferin to be added to the bloodstream, which carries it to cells throughout the body. When luciferin reaches cells that have been altered to carry the firefly gene, those cells emit light.

Some cancer drugs, however, work by cutting off the blood supply to tumor cells. Given that luciferin is delivered via the vasculature, the researchers set out to determine the kinetics of luciferin delivery and whether BLI techniques could be used to gauge the effectiveness of drugs that destroy blood vessels that feed tumors.

They tested their theory in mice bearing human breast-cancer tumors. Before being introduced to the animals, the tumor cells had been transfected with the firefly gene, which becomes part of the cells as they divide and grow just like genetically modified, herbicide-resistant food crops.

For the study, researchers used BLI to monitor light emissions from tumors following administration of the luciferin. While the mice didnt visibly glow, the researchers used special light-detecting equipment to observe strong correlations between the amount of light emitted and the size of the tumor as it grew. Detected light emission, however, was severely reduced after the vascular-disrupting drug was administered.

What weve done is offer proof-of-concept that BLI may be an effective and cheaper method to assess drug development and effectiveness, said Dr. Ralph Mason, professor of radiology, director of the UT Southwestern Cancer Imaging Center and senior author of the study. The technique is not intende
'/>"/>

Contact: Kristen Holland Shear
kristen.hollandshear@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Monitoring blood flow helps improve prostate biopsies, Jefferson researchers report
2. U.S. Web Site Helps Consumers Compare Hospitals
3. New Anticoagulation Management Software Helps Clinics Enhance Efficiency and Improve Patient Safety
4. Nutritionist to the Stars Helps to Launch European Liquid Appetite Controller
5. Protein Helps ID Thyroid Cancer Nodules
6. Blood Test Helps Docs Assess Breast Cancer Treatment
7. New Supplement Helps Americans Eat Less Every Day
8. New Presidential $1 Coin Helps Highlight National Stroke Awareness Month This May
9. Salient Corporations Performance Management Solution Helps NY State Counties Identify Medicaid Fraud, Waste, and Abuse
10. Web Site Helps Patients Prepare for Hospital Stay
11. Computer Program Helps Drug Abusers Stay Clean
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Fireflies' glow helps UT Southwestern researchers track cancer drug's effectiveness
(Date:11/27/2014)... Recently, DressVe , the well-known trendy young women’s clothing ... valid during Nov. 29 – Dec. 3 2014. In the ... up to 90% off. In addition, free delivery is provided ... http://www.dressve.com/ , Dresses that combine trendy styles and ... somebody’s personality and figure. The designers of DressVe.com know this ...
(Date:11/27/2014)... November 28, 2014 Cyber Monday cannot ... Turks & Caicos. This boutique resort, ranked #1 ... announcing a few highly sought out openings before Christmas ... they are offering every seventh night complimentary if booked ... is having a January 2015 promotion where every fourth ...
(Date:11/27/2014)... November 27, 2014 Luciana Lagana ... be part of Omadox, a feature film that received 9 ... award for best ensemble cast. It is also an official ... great start to a successful cinematic career for James Noel, ... movies. If you enjoy experimental mystery, filmed in glorious black ...
(Date:11/27/2014)... "As a nurse I see patients every day ... said an inventor from Whiting, N.J. "I put my ... prevent leakage and keep them dry and comfortable." , ... prevents stains on pants, skirts and bottoms, which saves ... the individual has time to get to the bathroom. ...
(Date:11/27/2014)... -- Thanksgiving meals can pose a challenge for people ... says. Many traditional Thanksgiving dishes -- such as ... gluten-free, but "when it comes to pies, stuffing, gravy, ... Anca Safta, director of the Gluten and Allergic Digestive ... North Carolina, said in a center news release. ...
Breaking Medicine News(10 mins):Health News:DressVe.com Introduces Its 2014 Special Monday Sales To The Global Customers 2Health News:The Tuscany on Grace Bay, Top-Rated TripAdvisor Resort in the Turks & Caicos Islands, Offers Special Pre-Christmas & January 2015 Promotions! 2Health News:Luciana Lagana and Gregory Graham Join the Award-Winning Cast of the Black-and-White Experimental Mystery Feature Film Omadox. 2Health News:Luciana Lagana and Gregory Graham Join the Award-Winning Cast of the Black-and-White Experimental Mystery Feature Film Omadox. 3Health News:Expert Shares Gluten-Free Thanksgiving Tips 2
... This release is available in French ... Granada researchers have proven that melatonin a natural hormone ... without reducing the intake of food, improves blood lipid profile ... cholesterol. Melatonin is found in small quantities in some ...
... The first World Congress of Pediatric Urology was held in ... most successful international congregation of pediatric urologists ever assembled. As ... and the Journal of Pediatric Urology have ... The vitality of clinical and basic pediatric urology research ...
... 28 (HealthDay News) -- Women are much more likely than ... imaging test called coronary angiography, a new study has found. ... to enhance images of the heart,s blood vessels and chambers. ... narrow, damaging the organ, explained Dr. Javier Neyra, an internal ...
... WEDNESDAY, April 27 (HealthDay News) -- If you suffer a heart ... than having one at any other time of day, a Spanish ... between 6 a.m. and noon, it is likely to damage about ... the afternoon or evening, the researchers added. "It is well-known ...
... study reports that the health-related quality of life (HRQOL) for ... without this condition. Both physical and mental health are affected ... as the number of those diagnosed continues to climb. Details ... & Research , a journal published by Wiley-Blackwell on behalf ...
... heart attack are likely to be more seriously affected if the ... in Heart journal. Heart attacks that occur between ... area of dead tissue (infarct) caused by the attack, which is ... of the day., , It is well established that a person,s ...
Cached Medicine News:Health News:Melatonin might help in controlling weight gain and preventing heart diseases associated with obesity 2Health News:Success of First World Congress of Pediatric Urology underscores increasing importance of specialty 2Health News:Women's Kidneys May Be at Higher Risk After Heart Test 2Health News:Morning Heart Attacks Cause More Damage, Study Finds 2Health News:Morning Heart Attacks Cause More Damage, Study Finds 3Health News:Adults with arthritis suffer with poorer health related quality of life 2Health News:Heart attacks are more serious if they occur at certain times of the day 2
(Date:11/26/2014)... , Nov. 26, 2014  Cohen, Placitella & ... of investors who purchased Nymox Pharmaceutical Corporation ("Nymox" ... the period from January 31, 2011 through November ... Nymox and certain of its officers and directors ... violation of Sections 10(b) and 20(a) of the ...
(Date:11/26/2014)... VIEJO, Calif. , Nov. 26, 2014 /PRNewswire/ ... announced that the U.S. Food and Drug Administration ... its New Drug Application (NDA) for AVP-825. AVP-825 ... low-dose sumatriptan powder delivered intranasally utilizing a novel ... the Complete Response letter, and consistent with the ...
(Date:11/26/2014)... , Nov. 26, 2014  BioScrip ® , Inc. (NASDAQ: ... President and Chief Executive Officer, will present at the Bank of ... , , , Date: , , , Wednesday, December 3, ... p.m. EST , , , , Location: , , , ... About BioScrip, Inc. BioScrip, Inc. is ...
Breaking Medicine Technology:Cohen, Placitella & Roth, PC Investigating Nymox Pharmaceutical Corporation for Failing to Disclose Material Information 2Cohen, Placitella & Roth, PC Investigating Nymox Pharmaceutical Corporation for Failing to Disclose Material Information 3Avanir Pharmaceuticals Receives Complete Response Letter (CRL) from FDA on AVP-825 NDA 2Avanir Pharmaceuticals Receives Complete Response Letter (CRL) from FDA on AVP-825 NDA 3Avanir Pharmaceuticals Receives Complete Response Letter (CRL) from FDA on AVP-825 NDA 4
... designed specifically for a wide range of ... (POCT) and Physician Office Labs (POL) to ... basic blood chemistry control for verification of ... A1c. This control is compatible with popular ...
SPOT RT KE and RT SE digital camera lines provide maximum performance in a mid-line scientific camera system....
... S8 AutoSet Vantage is ResMeds premium APAP ... algorithm responds to the patients pressure needs ... devices are available with fully integrated humidification ... which save clinicians and patients time by ...
... In the fast-paced world of echo ... make a real difference in your ability ... developed Xcelera Echo Lab Management, a unique ... providing the tools your department needs to ...
Medicine Products: