Navigation Links
Finnish researchers discovered a new anticancer compound
Date:5/21/2014

A team of research scientists from VTT Technical Research Centre of Finland, the University of Turku and the University of Eastern Finland has discovered a previously unknown Cent-1 molecule that kills cancer cells. Their research also shows that new cancer drug candidates can be identified faster and at lower cost by using computer-assisted and cell-based screening of compounds.

The objective of the research project led by Marko Kallio, Principal Scientist at VTT, was to accelerate the drug development process by identifying new compounds that would possess similar binding properties and cellular phenotype , but a different chemical structure, as the selected drugs in clinical use or investigational compounds in development.

The scientists combined computer-based screening and cell-based assays to create a method that can significantly accelerate drug discovery and thereby lower development costs. It is highly likely that the new compounds identified using this method have not yet been patented.

The research team conducted a computer-assisted screening of 65,000 compounds and cell-based assays on the 150 highest scoring hit compounds, before identifying the Cent-1 molecule. The Cent-1 molecule kills cancer cells through a mechanism similar to that of the template drug Rigosertib that is currently under commercial development. However, since the chemical structure of the Cent-1 compound differs from Rigosertib, there are no major obstacles to further development.

What makes the study also significant is evidence that Rigosertib did not inhibit its reported target genes; there is reason to believe that the drug has a different mechanism of action at molecular level than anticipated. This drug discovery related study was published in the Molecular Cancer Therapeutics in April 2014.

Development of new drugs is an expensive and time-consuming process. It usually takes around 10󈝻 years to complete and costs several hundreds of m
'/>"/>

Contact: Marko Kallio
marko.kallio@vtt.fi
358-207-222-810
VTT Technical Research Centre of Finland
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Finnish team of researchers finds a mutation in a tumor of the jaw
2. Finnish research to revolutionise indications for knee surgery
3. Supermodel mouse reveals mechanisms that regulate metabolism, researchers find
4. Detroit Lions help rebuild city with innovative gridiron giving, U-M researchers say
5. Researchers examine intersection of aging, chronic disease
6. Researchers propose treating prison population to fight US hepatitis C epidemic
7. Researchers ID changes that may occur in neural circuits due to cocaine addiction
8. Researchers identify genetic marker linked to OCD
9. Mount Sinai researchers identify changes that may occur in neural circuits due to addiction
10. UTHealth CCTS Biobank continues to innovate allocation of resources for researchers
11. Three Nova Southeastern University researchers receive patents
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... In its comprehensive analysis of medical ... Claim Review division have recently identified out-of-network and medical ... savings are achieved on behalf of employer-clients. , ... in savings to Argus each year, with a total ... by Tom Doney, Cypress president and CEO, these in-depth ...
(Date:12/17/2014)... Mamaroneck, NY (PRWEB) December 17, 2014 ... man who recently brought videos of MIT economist and ... and best-selling author James O’Keefe conducted the interview, which ... “Rich” stated that there was intentional mislabeling in the ... agenda in the bill: A two-hundred-and-fifty billion dollar per ...
(Date:12/17/2014)... Dec. 16, 2014 (HealthDay News) -- Expectant parents should ... and Drug Administration recommends. Use of ultrasound imaging ... is not entirely risk-free, the agency warns. ... harm due to ultrasound imaging and heartbeat monitors, prudent ... is important," Shahram Vaezy, an FDA biomedical engineer, said ...
(Date:12/17/2014)... HealthDay Reporter TUESDAY, Dec. 16, ... approaching, a new study reveals that states that routinely perform ... drivers on their roads. The finding suggests that states ... to deter inebriated revelers from getting behind the wheel in ... passed regarding drinking and driving," said study lead author James ...
(Date:12/15/2014)... OR (PRWEB) December 15, 2014 A ... by United States women as impacting skin health and ... “Four C’s of skin care.” Water and health advocate ... in a recent article describing the survey and the ... every item in every category discussed would benefit from ...
Breaking Medicine News(10 mins):Health News:Out-of-Network & Medical Necessity Reviews among Top Ways TPA Identifies Significant Medical Claim Savings 2Health News:Project Veritas: James O’Keefe Interviews the Man Who Discovered Jonathan Gruber Videos 2Health News:FDA Warns Against Fetal 'Keepsake' Videos 2Health News:Enforcement of Drunk Driving Laws Makes Roads Safer, Study Finds 2Health News:Enforcement of Drunk Driving Laws Makes Roads Safer, Study Finds 3Health News:Water and health advocate Sharon Kleyne adds a “W” for fresh water to “four C’s of skin care” 2Health News:Water and health advocate Sharon Kleyne adds a “W” for fresh water to “four C’s of skin care” 3
... incidence of Alzheimer's disease nationwide, both the New York ... passed a resolution aimed at raising awareness of the ... this brain disorder. ,The resolution declared November ... 2007 as Memory Screening Day in New York State. ...
... export of herbal products and medicines has the potential to ... with the creation of exclusive export promotion zones (EPZ) ... exports can be accelerated with the setting up of EPZs ... a rate of over 25 percent in countries like the ...
... at the 61st Annual Meeting of the Society ... Corporation, announced the worldwide launch of the Cordis ... in angioplasty procedures for patients with carotid and ... unique high-pressure expansion and low profile .014 inch ...
... among asylum seekers in Denmark has proportionally tripled since 2001 ... a study published Thursday . ,Sixty-seven asylum seekers ... percent of the total -- tried to end their lives ... to Help Refugees said. ,That contrasted with the ...
... Titan, a TATA company, is in negotiations with Prof Vijay ... to the University of Arkansas, to start production of ... deal is yet to be finalized. ,Varadan holds ... and Neuro- Electronics, Sensors and Systems; High Density Electronics Center ...
... Project (MVP) today released new data on the performance ... suggesting that the new vaccine-- expected to sell initially ... effective in protecting African children and their communities than ... ,MVP, a partnership between the World Health ...
Cached Medicine News:Health News:New York Legislature Highlights for Awareness of Alzheimer's Disease 2Health News:New York Legislature Highlights for Awareness of Alzheimer's Disease 3Health News:Export of Herbal Products to Reach Rs.120 Billion by 2012: Study 2Health News:New Balloon Catheter Available Worldwide for Carotid and Renal Angioplasty 2Health News:Titan may Produce Glucose Watches Soon 2Health News:Improved Meningitis Vaccine for Africa Expected to End Deadly Scourge 2Health News:Improved Meningitis Vaccine for Africa Expected to End Deadly Scourge 3
(Date:12/15/2014)... and HERZLIYA PITUACH, Israel , ... (NASDAQ: IMNP ) announced today that its Board ... Board succeeding Dr. Daniel Teper who continues as ... member of Immune,s Board of Directors since 2013. ... am delighted to represent the interest of shareholders and to ...
(Date:12/15/2014)... N.Y. , Dec. 15, 2014 As ... SPL (Structured Product Labeling) markup language standard, content teams ... understanding and skills to work with the standard. Starting ... series of three webinars on the benefits and the ... one-hour webinars will be facilitated by Howard Shatz ...
(Date:12/14/2014)... 2014  ChartSpan, a consumer platform for patients managing ... iPad medical app in the United States ... ChartSpan is an iPhone and iPad ... and send electronic healthcare records. The product was built ... of waiting for the healthcare system to deliver on ...
Breaking Medicine Technology:Immune Pharmaceuticals Elects Daniel Kazado as New Chairman of the Board. 2Immune Pharmaceuticals Elects Daniel Kazado as New Chairman of the Board. 3Immune Pharmaceuticals Elects Daniel Kazado as New Chairman of the Board. 4Data Conversion Laboratory Helping Life Sciences Content Producers Understand the Impact and Benefits of Structured Product Labeling 2Data Conversion Laboratory Helping Life Sciences Content Producers Understand the Impact and Benefits of Structured Product Labeling 3ChartSpan Becomes The Most Downloaded Medical App in America 2ChartSpan Becomes The Most Downloaded Medical App in America 3
... ST. LOUIS, March 14, 2011 Members served by Express ... pharmacy benefits account on their smart phones using a new ... Members can download the Express Rx app from ... including those on BlackBerry devices, can access the mobile-optimized website ...
... Streamline Health Solutions, Inc. (Nasdaq: STRM ... for hospitals, announced today that Rick Leach has been ... March 14, 2011. With more than 20 years of ... an extensive background in developing and marketing healthcare information ...
Cached Medicine Technology:New Application Offers Express Scripts Members Convenient Account Access Across a Broad Range of Mobile Phone Platforms 2Streamline Health Appoints Rick Leach as Senior Vice President and Chief Marketing Officer 2Streamline Health Appoints Rick Leach as Senior Vice President and Chief Marketing Officer 3Streamline Health Appoints Rick Leach as Senior Vice President and Chief Marketing Officer 4
... Forms strong flexible gels for ... clarifier: mixture of wide range ... water 10 mg/mL, clear, faintly ... molecular biology MP: 90 °C ...
Inquire...
Inquire...
... Melt), A low temperature agarose for ... , Optimal for in-gel restriction digestion/ligation and ... very manageable clear gel that provides excellent ... approximately 65°C and remains fluid at 37°C ...
Medicine Products: