Navigation Links
Findings point to molecular 'Achilles heel' for half of breast cancer tumors
Date:1/15/2008

Washington, D.C. − Researchers at Lombardi Comprehensive Cancer Center at Georgetown University Medical Center have shown why a protein known as cyclin D1 may be the Achilles heel for breast tumors that are estrogen receptor positive (ER+) − which is the most common type of breast cancer.

In the December 10th online edition of the journal Oncogene, investigators say the findings support testing an experimental class of drugs that aim to inhibit the cyclin D1 protein in women with ER+ breast cancers. These agents are currently being tested in this disease as well as in many other types of cancer, the researchers say, and the study provides additional molecular support for their use in breast cancer.

Everyone knows that cyclin D1 is a huge player in breast cancer, but no one has shown what happens when cyclin D1 is absent at the same time that the estrogen receptor is being over-expressed on tumors. Now we know the answers, and we hope these insights help further our understanding and treatment of breast cancer, said the studys lead author, Maria Silvina Frech, Ph.D., who is currently a postdoctoral researcher at the National Cancer Institute but who worked on the study at Georgetown.

These findings give insight into how drugs that indirectly inhibit cyclin D1 function, either those in testing or ones to be developed, might help a significant number of women with breast cancer, said Priscilla Furth, M.D., a professor at the Lombardi Comprehensive Cancer Center who is the studys senior investigator.

Cyclin D1 belongs to a family of cyclin genes whose proteins regulate cyclin-dependent kinases (CDKs), which in turn control cell division. CDKs are the main facilitators of cell proliferation cycle. Over-production of the Cyclin D1 protein or amplification (extra copies) of the gene have been observed in a number of cancers, and this study continued a body of research in Furths lab that has examined the relationship be
'/>"/>

Contact: Becky Wexler
rjw43@georgetown.edu
202-687-5100
Georgetown University Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Researchers challenge previous findings regarding widely used asthma treatment
2. Statement From the Consumer Healthcare Products Association on the SAMHSA Findings on Cough Medicine Abuse
3. Chemoprevention, naturally: Findings on plant-derived cancer medicines
4. 2007 Life Sciences Compensation Findings Disclosed www.compstudy.com
5. Video: BSP Pharma Inc. Announces Groundbreaking Findings from The Australian Centre for Complementary Medicine Education and Research Joint Health Clinical Study
6. Key findings for all veterans seen in depression and suicide study
7. The Organic Trade Association Hails Preliminary Research Findings Showing Nutritional Benefits of Organic Products
8. Chair of U.S. Preventive Services Task Force Pledges to Recommend Re-evaluation of Recent Glaucoma Findings
9. Incidental findings found when radiologists take a broader look at renal MRA
10. Health psychologists discuss latest research findings
11. Scientists, physicians present latest findings in personalized cancer treatment and prevention
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/26/2014)... 2014 Parker & Sons, Inc. ... in heating, cooling and plumbing contractor services throughout ... services in 2014 with regard to air-conditioning systems. ... is known for its incredibly hot summers. Working ... intricacies and details of a wide variety of ...
(Date:12/25/2014)... 2014 The click strand ... strength and durability. Today, the business announces a ... valid until Jan. 30, 2015. , Click strand ... hardwood. BambooFlooringChina.com is a well-known brand in the ... to find a reliable bamboo flooring supplier. , ...
(Date:12/25/2014)... 2014 Product liability lawsuits filed in ... ( http://www.consumerinjurylawyers.com/DePuy/ ) continue to move forward in federal ... issued in the U.S. District Court, Northern District of ... open conference on January 7, 2015, at the Paul ... West Palm Beach, Florida. The Conference is scheduled to ...
(Date:12/25/2014)... Recently, Dylan Queen, a famous online company supplying ... of discounted prom dresses, most of which are priced ... the company, the promotion is valid until Jan. 22, ... the UK market. , The prom dresses in this ... styles: A-line strapless, empire strapless chiffon, one shoulder, floor-length, ...
(Date:12/25/2014)... sells many bamboo products and the business is famous ... announces big discounts on its bamboo mats , which ... the world’s leader in bamboo flooring. According to the ... 2015. , The bamboo mats are made from well-treated ... the bamboo strips for the mats are boiled and ...
Breaking Medicine News(10 mins):Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 2Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 3Health News:BambooFlooringChina.com: click strand woven bamboo flooring promotion valid until Jan. 30, 2015. 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 3Health News:Dylan Queen: Cheap Prom Dresses for the UK Market 2Health News:Various Styles of Bamboo Mats in Many Colors from BambooFlooringChina.com 2
... 25, 2010) -- Fasten your seatbelt. Get that flu ... light when you,re not in the room. Save money for ... and attitudes that social marketing can seek to influence. When ... world gather next month for the 20th Anniversary Social Marketing ...
... Annual Program will help ... ... of countless heroes who have sacrificed and given so that we are able to live our ... and barbeque,s, we want to bring honor to those who have sacrificed and are surviving,” said ...
... ... health information for mental health and chemical dependence agencies using a wide variety of ... ... LLC ( www.ClinicTracker.com ) and Canvas ( www.GoCanvas.com ) today announced today a ...
... ... Online Pharmacies Compared to U.S. Pharmacy Drug Prices , ... White Plains, New York (PRWEB) -- In stark contrast to ... from abroad have decreased over the past 18 months according to analyses by PharmacyChecker.com ...
... seem to benefit the most, study finds, , TUESDAY, ... protect against the onset of Alzheimer,s disease among otherwise ... who don,t smoke appear to gain the most benefit ... the University of Valencia, the Valencia government and the ...
... ... people understand and tackle their health risks , ... Southfield, MI (Vocus) May 25, 2010 -- U.S. Preventive ... advance the company’s national preventive health agenda. , ,Under the contract, Summit Health ...
Cached Medicine News:Health News:Social marketing changes with times to promote social change 2Health News:Social marketing changes with times to promote social change 3Health News:BuyDirectUSA.com Launches 'Operation Honor a Veteran' 2Health News:Mobile Clinic Management EMR for Patient Health Information Launched by JAG Products and Canvas Partnership 2Health News:Mobile Clinic Management EMR for Patient Health Information Launched by JAG Products and Canvas Partnership 3Health News:Mobile Clinic Management EMR for Patient Health Information Launched by JAG Products and Canvas Partnership 4Health News:PharmacyChecker.com Reports Decrease in Brand Name Drug Prices From Canadian and Other International Online Pharmacies 2Health News:PharmacyChecker.com Reports Decrease in Brand Name Drug Prices From Canadian and Other International Online Pharmacies 3Health News:Moderate Drinking May Protect Brain From Alzheimer's 2Health News:Summit Health, U.S. Preventive Medicine Agree to Continue Worksite Screening Partnership 2Health News:Summit Health, U.S. Preventive Medicine Agree to Continue Worksite Screening Partnership 3
(Date:12/24/2014)... PRINCETON, N.J. , Dec. 24, 2014 /PRNewswire/ ... Company), a late-stage biopharmaceutical company developing products that ... inflammation, oncology and biodefense, announced today that on ... registered public offering. The Company raised ... offering and intends to use the net proceeds ...
(Date:12/24/2014)... , Dec. 24, 2014  Diplomat Pharmacy, Inc. (NYSE: ... pharmacy, is proud to announce Jennifer Hagerman , ... Diplomat, will take office as the president of the ... induction ceremony will take place Feb. 28, 2015, at ... held at the Renaissance Center in Detroit, ...
(Date:12/24/2014)... 23, 2014 PuraMed BioScience®, Inc., (OTC Pink: ... medicinal and healthcare products, announced it received the initial ... hemp-based, advanced headache relief product, for planned distribution to ... Colorado , Washington State , ... the MigraPure H Advanced headache relief gel formulation completed, ...
Breaking Medicine Technology:Soligenix Announces Closing of Public Offering of Units 2Soligenix Announces Closing of Public Offering of Units 3Diplomat's senior director of education and quality to be inducted as 2015 president of the Michigan Pharmacists Association 2Diplomat's senior director of education and quality to be inducted as 2015 president of the Michigan Pharmacists Association 3PuraMed BioScience Nears Final Stages Needed for Distribution of MigraPure H 2PuraMed BioScience Nears Final Stages Needed for Distribution of MigraPure H 3
... Survey Underscores Impact of Disease on Work Status ... today at Digestive Disease Week(R) 2007 (DDW), from,long-term ... 1,& 2) show that subjects with moderately to ... REMICADE(R),(infliximab) in the blinded phase of the trials ...
... 2007 - Synta,Pharmaceuticals Corp., (NASDAQ: SNTA) a ... small,molecule drugs to treat severe medical conditions, ... the Phase 2b clinical,trial in metastatic melanoma ... will be presented at the annual meeting ...
Cached Medicine Technology:Long-Term Extension of Ulcerative Colitis Study Shows Remicade,Responders Maintained Improvement Through Two Years of Follow-Up 2Long-Term Extension of Ulcerative Colitis Study Shows Remicade,Responders Maintained Improvement Through Two Years of Follow-Up 3Long-Term Extension of Ulcerative Colitis Study Shows Remicade,Responders Maintained Improvement Through Two Years of Follow-Up 4Long-Term Extension of Ulcerative Colitis Study Shows Remicade,Responders Maintained Improvement Through Two Years of Follow-Up 5Long-Term Extension of Ulcerative Colitis Study Shows Remicade,Responders Maintained Improvement Through Two Years of Follow-Up 6Long-Term Extension of Ulcerative Colitis Study Shows Remicade,Responders Maintained Improvement Through Two Years of Follow-Up 7Long-Term Extension of Ulcerative Colitis Study Shows Remicade,Responders Maintained Improvement Through Two Years of Follow-Up 8Long-Term Extension of Ulcerative Colitis Study Shows Remicade,Responders Maintained Improvement Through Two Years of Follow-Up 9Synta Oncology Candidate STA-4783 Clinical Trial Results to Be,Presented at the ASCO Annual Meeting 2Synta Oncology Candidate STA-4783 Clinical Trial Results to Be,Presented at the ASCO Annual Meeting 3
... Lyoplant is a new biological ... A pure collagen implant, lyoplant ... three months, replacing implant material ... Its natural structure minimizes suture ...
The Bovie IDS Series are the latest electrosurgical generators with fully digital implementation....
Aaron 1250 is a multipurpose electrosurgical generator with monopolar and bi-polar functions....
European bipolar foot activated forceps....
Medicine Products: