Navigation Links
Findings on HIV-Resistant Sex Workers May Help Vaccine Efforts
Date:2/16/2012

THURSDAY, Feb. 16 (HealthDay News) -- In studying how HIV is transmitted, researchers have discovered that some African sex workers are naturally resistant to the virus, a finding that could influence prevention efforts.

These women are protected by an unusually weak inflammatory response in their vaginas, the scientists noted.

"In this part of the world, women represent over 60 percent of HIV cases, and this proportion continues to increase," Dr. Michel Roger, of the University of Montreal Hospital Centre and its microbiology and immunology department, in a news release. "Studying women who are naturally resistant to the virus enables researchers to identify interesting information in terms of developing vaccinations or microbid gels that could prevent transmission of HIV."

The researchers followed women from Benin and Zimbabwe over the course of 15 years. They found that when some of these women are exposed to HIV, the immune-system cells in their vaginas produced fewer inflammatory molecules than the cells in women infected with the virus.

Although these molecules are usually helpful by activating lymphocyte T-cells that destroy viruses, HIV actually uses these T-cells to invade people's bodies, the researchers said.

"Fewer T-cells means fewer target cells available for the virus to use," Roger explained.

The researchers also found the women's immune response in their vaginas -- where the virus entered their body -- was different from their body's response once the virus was in their bloodstream. The study concluded that a better way to stop the spread of HIV would be to block the virus from entering the body, rather than fight it once it had already invaded.

"AIDS vaccination research has entirely focused on the bloodstream and this approach has been a failure," Roger said. "Our research shows that the immune response is different at the site of the infection, and that we should turn to the entry points in order to find a means for blocking the virus."

The researchers said that the body's mucus membranes would be protected through a through a nasal-spray vaccine.

They added that more research is needed to fully understand the immune response in the vagina and determine if women's DNA plays a role in natural HIV resistance.

The results were recently published in the journal PLoS ONE.

More information

The U.S. Centers for Disease Control and Prevention provides more information on HIV and AIDS.

-- Mary Elizabeth Dallas

SOURCE: University of Montreal, news release, Feb. 13, 2012.


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Georgetown Lombardi researchers present new findings on head & neck cancers
2. Van Andel Research Institute findings provide more complete picture of kidney cancer
3. UK researchers present findings from Kentucky breast cancer patients with disease relapse
4. Scar findings could lead to new therapies, Stanford researchers say
5. Society for Integrative Oncology releases findings presented at annual meeting
6. Many radiologists disagree on management of incidental findings, study finds
7. New findings could lower risk of suicide in men with prostate cancer
8. Virginia Commonwealth University findings may help explain high blood pressure in pregnancy
9. UC Berkeley findings offer new clues into the addicted brain
10. New findings contradict dominant theory in Alzheimers disease
11. Python Findings Shed Light on Human Heart Health
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Findings on HIV-Resistant Sex Workers May Help Vaccine Efforts
(Date:6/26/2016)... (PRWEB) , ... June 26, 2016 , ... On June ... sponsor of the 2016 Cereal Festival and World’s Longest Breakfast Table in Battle Creek, ... of the city’s history as home to some of the world’s leading providers of ...
(Date:6/25/2016)... ... 25, 2016 , ... Experts from the American Institutes for ... Meeting June 26-28, 2016, at the Hynes Convention Center in Boston. , AIR ... care planning, healthcare costs and patient and family engagement. , AIR researchers will ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern Californian, Dr. ... his M.D from the David Geffen School of Medicine at UCLA. He trained in ... to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he ...
(Date:6/24/2016)... ... 2016 , ... Those who have experienced traumatic events may suffer from a ... such as drug or alcohol abuse, as a coping mechanism. To avoid this pain ... following a traumatic event. , Trauma sufferers tend to feel a range of emotions, ...
(Date:6/24/2016)... ... June 24, 2016 , ... Dr. Amanda Cheng, an ... Cheng has extensive experience with all areas of orthodontics, including robotic Suresmile technology, ... , Micro-osteoperforation is a revolutionary adjunct to orthodontic treatment. It can be ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... , June 27, 2016  VMS Rehab Systems, Inc. ... will take whatever measures required to build a strong ... which is currently listed on the OTC Markets-pink current ... Chairman and CEO, "We are seeing an anomaly in ... understand, not only by the Company, but shareholders and ...
(Date:6/24/2016)... 24, 2016   Bay Area Lyme Foundation ... Dean Center for Tick Borne Illness , Harvard ... MIT Hacking Medicine, University of California, Berkeley, and ... the five finalists of Lyme Innovation , ... than 100 scientists, clinicians, researchers, entrepreneurs, and investors ...
(Date:6/24/2016)... and SAN CLEMENTE, Calif. , June 24, 2016 ... mobile pulmonary function testing company, is now able to perform sophisticated ... by ndd Medical Technologies , Inc. Patients ... hospital-based labs.  Thanks to ndd,s EasyOne PRO ® , ARL patients ... get any needed testing done in the comfort of her own ...
Breaking Medicine Technology: