Navigation Links
Findings in epilepsy gene in animals may guide treatment directions for infants
Date:6/1/2009

sulted in overexcited brain cells and seizures in the mice. The seizures resembled human infantile spasms. Equally exciting to the researchers, these mice had another brain wave abnormality similar to that found in children with infantile spasms--an abnormal background EEG.

"This is the first genetic model of a developmental epilepsy, and even more importantly, it was generated by mutating the same gene that can be found mutated in humans with infantile spasms," said Golden. In an unexpected development, the researchers found that half of the female mice carrying the mutation also developed seizures. Because the mutation occurs on the X chromosome, it was expected that male mice would have seizures, which was true, and that all the females would be unaffected carriers, which was not the case.

This discovery prompted the researchers to take a closer look at human families with an infantile spasms patient. They found that the patients' mothers (14 women) had experienced normal development. But of the patients' nine other relativessisters, aunts and a cousinsix had neurological problems, including four with epilepsy. The neurological problems included varying degrees of mental retardation or other learning disabilities. These findings, said Golden, will immediately change the evaluation and testing of women with mental retardation and epilepsy, particularly in families with other affected individuals.

This new finding will also assist genetic counselors in advising parents who already have a child with an Arx mutation and are contemplating having another child.

Going forward, Golden said, this new animal model provides an important tool: an opportunity to begin testing drugs in the mice to identify potential treatments for children. "We can screen existing drugs to see if they are effective against this type of epilepsy," said Golden, adding that understanding the biological mechanism by which infantile spasms develop may also lead
'/>"/>

Contact: John Ascenzi
Ascenzi@email.chop.edu
267-426-6055
Children's Hospital of Philadelphia
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Pitt melanoma researchers present novel findings at ASCO
2. Statement by American Legacy Foundation(R): Findings of Decades of Massive Fraud by Tobacco Industry Upheld in U.S. Court of Appeals
3. HIMSS Analytics and NetMotion Wireless Release Study Findings on Key Challenges for Wireless Healthcare Deployments
4. New Research Finds Recession Has Greater Impact on Health of Parents than Children with Specific Findings on Hispanics
5. New Research Finds Recession Has Greater Impact on Health of Parents than Children With Specific Findings on African Americans
6. Stanford Center on Longevity Releases New Findings About Voter Attitudes on Health Care Reform
7. KLRI Releases 3rd Annual Report On Years Top Longevity Research Findings
8. Swine flu: Early findings about pandemic potential reported in new study
9. Research Findings on Nine GlaxoSmithKline Cancer Compounds to be Presented at ASCO 2009
10. VetCentric Releases Findings of Pet Owner Survey
11. Stanford Issues Findings from Cognitive and Brain Experts Urging Consumer Caution on Memory Fitness Products
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2014)... Search Engine Optimization is needed ... of search engines and get more audience and ... compared many Linux hosting suppliers and announced that ... most recommended Linux hosting suppliers for webmasters from ... buy high quality Linux hosting (including VPS and ...
(Date:8/22/2014)... 2014 Deep Research Report on ... in-depth research report on the Glucose Meter market. ... Glucose Meter definition, classification, application, and industry chain ... covers the international market analysis, including domestic market ... environment & economic situation analysis. The report on ...
(Date:8/22/2014)... 23, 2014 Recently, Skmen.com, an experienced ... of 2014 bohemian dresses in its online store. Moreover, ... prices, up to 28% off. All the international clients ... August 31, 2014. , The company’s professional online ... to show worldwide customers more the latest information about ...
(Date:8/22/2014)... August 22, 2014 AWeber, one ... that currently helps more than 120,000 small businesses ... the attention of Shane Michaels, prompting an investigative review. ... element for any online marketing campaign, despite what some ... the marketing world,” reports Michaels. “AWeber is a great ...
(Date:8/22/2014)... Vegas, NV (PRWEB) August 22, 2014 ... content that is written by marketing experts for marketers ... affiliate links has caught the attention of Shane Michaels, ... involved with Internet marketing in any way knows that ... failure in the industry,” reports Michaels. “But even though ...
Breaking Medicine News(10 mins):Health News:Top10BestSEOHosting.com Announces Best Cheap Hosting Suppliers Of This Summer 2Health News:Glucose Meter Industry Global (Europe, Asia, NA, ROW) Analysis Now Available at ReportsnReports.com 2Health News:Glucose Meter Industry Global (Europe, Asia, NA, ROW) Analysis Now Available at ReportsnReports.com 3Health News:Cheap Bohemian Dresses Unveiled by Experienced Supplier Skmen.com 2Health News:AWeber: Review Exposes Affordable Provider of Opt-In Email Marketing Services 2Health News:My Writers: Review Exposes Online Source for Quality Marketing Content 2
... just more but sicker residents, , THURSDAY, Dec. 31 (HealthDay ... nation,s health-care system is not prepared to deal with the ... baby-boom generation are about to turn 65. And in the ... 65 will double, according to a report on the elder ...
... , MISSION, Kan., Dec. 31 President Obama signed the bill ... With this extension, employers must act quickly to fulfill their notice ... COBRAGuard Inc. is offering a free Webinar on Wednesday, Jan. 6 ... Get it Right the First Time - Your Action Plan for ...
... , NASHVILLE, Tenn., Dec. 31 Emdeon (NYSE: ... cycle management solutions, today announced that it will make a presentation ... be held from January 11 to 14, 2010 in San Francisco, ... at 4:00 p.m. Eastern time/1:00 p.m. Pacific time on Thursday, January ...
... ... and Marketing. , ... (PRWEB) December 31, 2009 -- Bradley Kirkland, President of Stone Soup Technology (SST), has hired ... her a wealth of experience in consultative sales and will work with all potential and ...
... incentive to kick the habit? Just in time for ... age 80, smoking continues to increase one,s risk for age-related ... over 65. The American Journal of ... "The take-home message is that it,s never too late to ...
... , , Blood Supply Prioritized ... YORK, Dec. 30 New York Blood Center (NYBC) serving ... calls upon the community to please donate blood today. ... 2009, coupled with unusually high demand from regional hospitals, have ...
Cached Medicine News:Health News:As U.S. Ages, Health Care May Need to Change 2Health News:As U.S. Ages, Health Care May Need to Change 3Health News:COBRAGuard Offers Free Action Plan Webinar to Assist Employers with COBRA Subsidy Extension 2Health News:COBRAGuard Offers Free Action Plan Webinar to Assist Employers with COBRA Subsidy Extension 3Health News:Emdeon to Present at the 28th Annual J.P. Morgan Healthcare Conference 2Health News:Stone Soup Technology Hires Former Scoop Magazine Publisher Melanie Feltman 2Health News:It's never too late to quit smoking and save your vision 2Health News:Rh-Negative Blood Donors Needed Now 2Health News:Rh-Negative Blood Donors Needed Now 3
(Date:8/21/2014)... 2014  Decision Resources Group finds that, for ... Brazil and Mexico ... prescribe long-acting beta-agonist (LABA)- and long-acting muscarinic antagonist ... current severe cost/coverage constraints. Therefore, new brands of ... launch in these countries—which will considerably expand the ...
(Date:8/21/2014)... , Aug. 21, 2014 /PRNewswire-iReach/ -- ScriptPro ... Alliance (HITRUST) under its Common Security Framework (CSF). ... Security and Privacy Manager, "We appreciate this rigorous, ... of commitment that this certification signifies. Our business ... ABOUT THE CSF CERTIFICATION PROCESS: ScriptPro,s internal ...
(Date:8/21/2014)... BreedIT Corp., (OTCQB: BRDT) ... worldwide license holder and distributor of highly sophisticated ... today is pleased to announce the formation of ... a leading Israeli medical Cannabis breeder. ... breeds of medical Cannabis to meet the requests ...
Breaking Medicine Technology:Novel Fixed-Dose Combinations for COPD in Brazil and Mexico Will Compete With Well-Established Therapies in an Environment Dominated by Aggressive Cost-Control Mechanisms 2Novel Fixed-Dose Combinations for COPD in Brazil and Mexico Will Compete With Well-Established Therapies in an Environment Dominated by Aggressive Cost-Control Mechanisms 3ScriptPro Achieves HITRUST Certification 2BreedIT Ltd. and Seach Ltd. Form KanaboSeed to Develop New Medical Cannabis Varieties 2BreedIT Ltd. and Seach Ltd. Form KanaboSeed to Develop New Medical Cannabis Varieties 3BreedIT Ltd. and Seach Ltd. Form KanaboSeed to Develop New Medical Cannabis Varieties 4
... India, and MISSISSAUGA, Ontario, April 1, 2011 Promius ... RDY ), and Valeant Pharmaceuticals International, Inc. ... announced that they have signed a collaboration agreement for ... Pharma will make an upfront payment and pay future ...
... CINCINNATI, April 1, 2011 CarePoint Partners, one of ... in the United States, launched a food drive today ... the less fortunate in the communities where it operates. ... conducted throughout the month of April. CarePoint Partners is ...
Cached Medicine Technology:Promius Pharma and Valeant Form Collaboration to Market Cloderm® Cream in the United States 2Promius Pharma and Valeant Form Collaboration to Market Cloderm® Cream in the United States 3Promius Pharma and Valeant Form Collaboration to Market Cloderm® Cream in the United States 4CarePoint Partners Kicks Off Food Drive to Help Fight Hunger in Twenty-One Local Communities 2
Titanium. Straight shafts with 6 mm platform and Pierse tips. Flat serrated handle with dull finish....
0.5 mm, 1 x 2 teeth set at 45 degrees. Serrated handle with polished finish....
5 mm tying platform, serrated cross action handle with polished finish. Teeth: 0.10 mm, 1 x 2 set at 90 degrees....
0.12 mm, 1 x 2 teeth. Serrated handle with polished finish....
Medicine Products: