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Findings could lead to a blood test for lung cancer
Date:5/12/2011

ns of miRNAs that distinguished tumors with faster growth rates and that correlated with poor disease-free survival.

Then Croce and his colleagues analyzed blood samples that had been collected more than a year before the individual's lung cancer was detected by spiral CT. They discovered a signature of 15 miRNAs that could identify 18 of 20 individuals whose cancer was later detected by spiral CT.

To verify that finding, they applied the signature to a second set of blood samples collected during a similar but unrelated lung-cancer trial. Here, the signature correctly identified 12 of 15 patients whose lung tumors were detected more than a year later by spiral CT. The researchers estimated that the signature were detectable in blood up to 28 months prior to spiral CT detection.

The researchers also found miRNA signatures in the blood that were associated with the following:

  • Lung-cancer diagnosis a signature identified 16 of 19 patients with lung cancer in set one, and 12 of 16 patients in set two.
  • Poor prognosis a signature identified five of five patients with poor prognosis in set one; four of five in set two.
  • Good prognosis a signature identified five of 15 patients in set one, and five of 11 patients in set two.

"Our goal was to identify biomarkers that could predict tumor development and prognosis to improve lung-cancer diagnosis and treatment," Croce says. "Overall, these findings strengthen the observation that circulating miRNA in plasma is detectable well before clinical disease detection by spiral CT, indicating the possibility of identifying high-risk patients on the basis of miRNA profiling."


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Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Medical Center
Source:Eurekalert

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