Navigation Links
Findings could lead to a blood test for lung cancer
Date:5/12/2011

ns of miRNAs that distinguished tumors with faster growth rates and that correlated with poor disease-free survival.

Then Croce and his colleagues analyzed blood samples that had been collected more than a year before the individual's lung cancer was detected by spiral CT. They discovered a signature of 15 miRNAs that could identify 18 of 20 individuals whose cancer was later detected by spiral CT.

To verify that finding, they applied the signature to a second set of blood samples collected during a similar but unrelated lung-cancer trial. Here, the signature correctly identified 12 of 15 patients whose lung tumors were detected more than a year later by spiral CT. The researchers estimated that the signature were detectable in blood up to 28 months prior to spiral CT detection.

The researchers also found miRNA signatures in the blood that were associated with the following:

  • Lung-cancer diagnosis a signature identified 16 of 19 patients with lung cancer in set one, and 12 of 16 patients in set two.
  • Poor prognosis a signature identified five of five patients with poor prognosis in set one; four of five in set two.
  • Good prognosis a signature identified five of 15 patients in set one, and five of 11 patients in set two.

"Our goal was to identify biomarkers that could predict tumor development and prognosis to improve lung-cancer diagnosis and treatment," Croce says. "Overall, these findings strengthen the observation that circulating miRNA in plasma is detectable well before clinical disease detection by spiral CT, indicating the possibility of identifying high-risk patients on the basis of miRNA profiling."


'/>"/>

Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
2. Researchers Who Discovered First Genes for Stuttering will Present Findings to the National Stuttering Association
3. VARI findings may help patients with deadly kidney cancer
4. UMass Lowell researchers findings suggest new ways to diagnose and treat Alzheimers
5. Research findings expected to ease treatment of low neutrophil counts in cancer patients
6. Cedars-Sinai Heart Institute physicians present findings at ACC scientific meeting
7. Research findings underscore needed action to safeguard lungs of young cancer survivors
8. Those with allergic asthma face double trouble during flu season, UT Southwestern findings suggest
9. Findings suggest optimal dose
10. VARI findings could help diagnose and treat liver cancer
11. Brain MRI in children: Incidental findings yield disclosure dilemmas for doctors, patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/22/2014)... Lexington, Kentucky (PRWEB) October 22, 2014 ... an agreement that will change the current location of ... Road to South Limestone across from the University of ... be a state-of-the-art ambulatory care center, owned and operated ... meet the orthopaedic needs of children and their families ...
(Date:10/22/2014)... With the Affordable Care Act (ACA) open enrollment ... Institutes for Research (AIR) finds that three out of four ... but 42 percent say they are not likely or only ... for coverage. , The AIR survey found wide gaps in ... calculate correctly how much they owe for a routine doctor’s ...
(Date:10/22/2014)... (PRWEB) October 22, 2014 Healthcare ... completing their continuing education at home or on-the-go ... access to 20 brand new, premium Seminar-on-Demand CE ... catalog of over 2,000 hours of ... customize their educational experience. With such a diverse ...
(Date:10/22/2014)... Mission Viejo, CA (PRWEB) October 22, 2014 ... that Jay Cormier, Sr. Vice President of Sales, will ... at the upcoming Meetings Technology Expo on October 28, ... will also be hosting a booth as well as ... on how Lintelus Meeting can create a more engaging ...
(Date:10/22/2014)... HealthDay Reporter , TUESDAY, Oct. 21, ... length may be showing a genetic propensity for obesity as ... have been linked to increased body fat, but the same ... muscle, the researchers said. At 1 year, kids with ... and 3, however, these genes were linked to excessive weight ...
Breaking Medicine News(10 mins):Health News:Shriners Hospitals for Children - Lexington Announces Plan to Build New $47 Million Facility 2Health News:Shriners Hospitals for Children - Lexington Announces Plan to Build New $47 Million Facility 3Health News:Many Americans Fail to Ask Basic Questions Before Signing Up for Health Insurance, National Survey Finds 2Health News:Many Americans Fail to Ask Basic Questions Before Signing Up for Health Insurance, National Survey Finds 3Health News:Many Americans Fail to Ask Basic Questions Before Signing Up for Health Insurance, National Survey Finds 4Health News:Top Provider of Continuing Education at Home Releases 20 New Online Courses 2Health News:Jay Cormier, Sr. Vice President of Sales for Lintelus, Speaks about Event Technology Integration at Meetings Technology Expo in NYC 2Health News:Tall, Heavy 1-Year-Olds May Be at Risk for Obesity Later, Study Finds 2
... study conducted by researchers say it is a misconception ... older or housebound people.// ,Researchers examined 150 ... levels of vitamin D. Among the participants, all African-American, ... D deficiencies, as were all patients younger than 30. ...
... A pitch-black room may be the healthiest environment for your ... at night // may put children at risk for ... to disrupt the circadian rhythm and suppress the production of ... been shown to protect DNA from oxidative damage. Once damaged, ...
... study shows sinusitis in asthma patients tends to be ... suggest patients // can have dramatic improvement in symptoms ... is used. ,In the study patients with asthma ... polyps, olfactory dysfunction, and nasal congestion compared to patients ...
... new study shows moderate consumption of alcohol may cut ... arteries.// Researchers evaluated 225 men after they had undergone ... open blocked arteries with a stent. Less traumatic than ... cause inflammation resulting in renarrowing of the artery, usually ...
... study researchers say the antidepressant duloxetine, also known ... fibromyalgia in women . Duloxetine works by stopping ... of the brain’s neurotransmitters that are linked to ... that is characterized by body pain, muscle tenderness, ...
... cluster of risk factors known as metabolic syndrome is ... risk factors. // ,Metabolic syndrome has been ... coronary heart disease. Metabolic syndrome includes looking at factors ... has two different definitions including one by the National ...
Cached Medicine News:
(Date:10/22/2014)... -- CryoLife, Inc. (NYSE: CRY ), a leading ... and vascular surgery, announced today that James Patrick ... been elected to the Company,s Board of Directors, effective ... , Executive Chairman of CryoLife, stated, "Since joining the Company ... leader who is well positioned to maximize CryoLife,s potential. ...
(Date:10/22/2014)... 21, 2014  Early symptoms of diabetic eye ... but new technology, coupled with yearly, comprehensive eye ... earlier detection of eye diseases, including those associated ... If left untreated, these diseases can potentially lead ... Recently, optometric researchers have deployed a new ...
(Date:10/22/2014)... -- InVivo Therapeutics Holdings Corp. (OTCQB: NVIV) based in ... cord injury (SCI) treatment with their novel Neuro-Spinal Scaffold. ... regrowth in the spinal cord area when cells are ... polymer, the scaffold ultimately breaks down to water and ... NVIV has recently attracted significant investor attention with the ...
Breaking Medicine Technology:Pat Mackin Joins CryoLife Board of Directors 2Pat Mackin Joins CryoLife Board of Directors 3Technology Advancements Enhance Early Detection of Eye Diseases Associated with Diabetes 2Technology Advancements Enhance Early Detection of Eye Diseases Associated with Diabetes 3InVivo Therapeutics Analyst Coverage Initiated: Analyst Report by BrokerBank Securities, Inc. 2InVivo Therapeutics Analyst Coverage Initiated: Analyst Report by BrokerBank Securities, Inc. 3
... multichannel pipettes speed up ... into microplates, with super ... volumes. The improved ergonomic ... multichannels, combined with super ...
... Hamilton is precision, ergonomics, and value!, ... with soft non-slip, contoured handle , Finer ... spring action , Stress-free tip ejection with ... for easy decontamination and sterilization without the ...
... The Finnpipette Digital Multichannel, with ... lighter work of routine laboratory ... these advanced features: Soft-touch tip ... volume pipetting (0.5-10ul models), Entire ...
... Research pro Electronic Pipette is ideal for ... Its easy-to-follow display, ergonomically-placed operating buttons, and ... reverse pipetting and diluting make this a ... functions of a manual pipette without any ...
Medicine Products: