Navigation Links
Finding will improve accuracy of cancer diagnosis
Date:4/29/2009

Grand Rapids, Mich. (April 27, 2009) Van Andel Research Institute (VARI) investigators working in collaboration with Cleveland Clinic researchers have determined that two types of kidney tumors previously thought to be different diseases are actually variations of the same disease. This finding will help doctors to more accurately diagnose the disease in patients, and demonstrates the importance of using molecular data to diagnose cancer in general.

Because adult cystic nephroma (CN) and mixed epithelial and stromal tumors (MEST) produce tumors of differing appearance that include different types of cells, traditionally they have been diagnosed as different diseases. The Cleveland Clinic-VARI study, published recently in The American Journal of Surgical Pathology, demonstrates through molecular analysis that the two types of cancer are variations of the same disease.

"Cancer is often diagnosed by the appearance of the tumor and the types of cells it is made up of," said VARI Distinguished Scientific Investigator Bin Tean Teh, M.D., Ph.D., one of the authors of the study, "but molecular information can allow us to make the determination that two tumors of dissimilar appearance and cell type are, in fact, the same disease. This has important implications for the diagnosis of cancer in general."

Both CN and MEST primarily affect middle-aged females. The primary difference between the two is the appearance of the tumors. Researchers compared tissues of CN tumors and MEST to other kidney tumors and normal kidney tissue at the molecular level and found several pieces of evidence that indicated that CN and MEST are the same type of kidney cancer.

"The more data we have, the more we can understand cancer; the more we understand, the better equipped we are to fight it," said Teh.

"CN and MEST had long been considered as two different entities. Yet some recent studies also suggested they may be the same entity with varying morphology. Such discrepancy caused confusion and frustration among pathologists and urologists. Our study provided by far the most convincing molecular evidence that the two are genetically very similar and should be considered as the same disease entity," said Cleveland Clinic Anatomic and Clinical Pathologist Ming Zhou, M.D., Ph.D., lead author of the study. "This study is an example of how practicing surgical pathologists could use the molecular tool to improve their diagnostic capability and impact patient care."


'/>"/>

Contact: Joe Gavan
616-234-5390
Van Andel Research Institute
Source:Eurekalert

Related medicine news :

1. Many Parents Share Genetic Test Findings With Kids
2. New Alzheimers findings: High stress and genetic risk factor lead to increased memory decline
3. New MRI finding sheds light on multiple sclerosis disease progressio
4. High and mighty: first common height gene identified by researchers behind obesity gene finding
5. Scientists, physicians present latest findings in personalized cancer treatment and prevention
6. Health psychologists discuss latest research findings
7. Incidental findings found when radiologists take a broader look at renal MRA
8. First significant genetic finding in severe PMS, or PMDD
9. Chair of U.S. Preventive Services Task Force Pledges to Recommend Re-evaluation of Recent Glaucoma Findings
10. The Organic Trade Association Hails Preliminary Research Findings Showing Nutritional Benefits of Organic Products
11. Key findings for all veterans seen in depression and suicide study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... ... 2016 , ... June 19, 2016 is World Sickle Cell Observance Day. In ... benefits of holistic treatments, Serenity Recovery Center of Marne, Michigan, has issued ... Sickle Cell Disease (SCD) is a disorder of the red blood cells, which can ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Pulmonary Hypertension ... that it will receive two significant new grants to support its work to ... its 25th anniversary by recognizing patients, medical professionals and scientists for their work ...
(Date:6/24/2016)... ... June 24, 2016 , ... Dr. Amanda Cheng, an ... Cheng has extensive experience with all areas of orthodontics, including robotic Suresmile technology, ... , Micro-osteoperforation is a revolutionary adjunct to orthodontic treatment. It can be ...
(Date:6/24/2016)... ... 2016 , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief Products, join The ... raise to $12 an hour by 2020 and then adjusting it yearly to increase at ... the minimum wage, assure the wage floor does not erode again, and make future increases ...
(Date:6/24/2016)... ... June 24, 2016 , ... EB Medicine presented its ... Emergency Medicine conference in Ponte Vedra Beach, FL. The awards honor the outstanding ... Medicine Practice and Pediatric Emergency Medicine Practice. , “With this award, we ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 ... CAPR ), a biotechnology company focused on ... today announced that patient enrollment in its ongoing ... Duchenne) has exceeded 50% of its 24-patient target. ... in the third quarter of 2016, and to ...
(Date:6/23/2016)... BOGOTA, Colombia , June 23, 2016  Astellas today announced the establishment of Astellas Farma Colombia (AFC), ... company,s second affiliate in Latin America . ... ... Colombia ... ...
(Date:6/23/2016)... 23, 2016  Experian Health, the healthcare ... the patient payment and care experience, today ... products and services that will enhance the ... offerings. These award-winning solutions will enable healthcare ... compliant in an ever-changing environment and redefine ...
Breaking Medicine Technology: