Navigation Links
Finding the Achilles' Heel of ovarian tumor growth
Date:6/19/2014

A team of scientists, led by principal investigator David D. Schlaepfer, PhD, professor in the Department of Reproductive Medicine at the University of California, San Diego School of Medicine report that small molecule inhibitors to a protein called focal adhesion kinase (FAK) selectively prevent the growth of ovarian cancer cells as tumor spheroids.

The findings come in a pair of studies published online this week in the journals Gynecologic Oncology and Molecular Cancer Therapeutics.

Ovarian cancer is a leading cause of female cancer death in the United States. On average, more than 21,000 women are diagnosed with ovarian cancer each year and 14,270 die. Many women achieve remission, but cancer recurrence rates exceed 75 percent, prompting the need for new treatments.

"Ovarian cancer spreads within a women's peritoneal space through a unique mechanism that involves the survival of small clusters of tumor cells termed spheroids," said Schlaepfer. "Our studies show that FAK signaling functions at the center of a tumor cell survival signaling network."

In the first study, published in Gynecologic Oncology, first author Nina Shah, MD, a gynecological oncology fellow in the Department of Reproductive Medicine, found that ovarian tumor cells with low levels of a tumor suppressor protein, called merlin, displayed heightened sensitivity to FAK inhibitor growth cessation.

"With FAK inhibitor clinical trials already testing a similar linkage in mesothelioma (a rare cancer that affects the protective lining of many internal organs), our results support the hypothesis that protein biomarkers such as merlin may identify those patients who may best respond to FAK inhibitor therapy," said Schlaepfer.

In the second study in Molecular Cancer Therapeutics, first author Isabelle Tancioni PhD, an assistant project scientist at UC San Diego Moores Cancer Center discovered that a network of signals generated by
'/>"/>

Contact: Scott LaFee
slafee@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. New findings in breast cancer
2. Kessler Foundation scientists present cognitive research findings at MS dual symposium
3. Researchers present new findings for novel pancreatic cancer vaccine
4. Mayo Clinic urologists present findings at American Urological Association Annual Meeting
5. Finding ways to feed pigs for less
6. Once-Banned Bird Flu Study Yields Sobering Findings
7. Columbus Allergist Dr. Summit Shah Discusses Recent Findings on Food Allergies and Exercise-Induced Anaphylaxis
8. Finding brings scientists 1 step closer to Parkinsons drug
9. Relief for Migraine Sufferers as The Life House Offers New Findings, Free Consults
10. New findings by GW researcher break tanning misconceptions: There is no such thing as a safe tan
11. MRI findings shed light on multiple sclerosis
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Finding the Achilles' Heel of ovarian tumor growth
(Date:8/29/2015)... ... August 29, 2015 , ... ProDrop Particles includes over 40 ... contains 15 seconds of unique footage that users can shrink and stretch in the ... and more. Users can customize color, brightness, scale, speed, range, and flare attributes with ...
(Date:8/29/2015)... ... August 29, 2015 , ... Vascular Health ... and sell Arterosil and Arterosil HP, and that all claims and counterclaims have ... Health Sciences, LLC (VHS) in the United States District Court for the Southern ...
(Date:8/28/2015)... ... August 28, 2015 , ... Approximately 2,000 ... Zoo to celebrate children helping children, a thank you to the many creative ... have contributed to the United Methodist initiative to end malaria deaths. , The ...
(Date:8/28/2015)... ... , ... For Dallas, the time is nearing for the annual Heart Walk, ... , The American Heart Association hosts their well-known Heart Walk to raise money in ... difference can be made. Walkers can participate in the cause and someone can also ...
(Date:8/28/2015)... ... August 28, 2015 , ... On May 30th, 2015, Best Drug Rehabilitation, ... the “Music With A Mission” benefit concert in Mendon, IL. Held in the Show ... money to support music education programs in the underfunded local school districts of Mendon ...
Breaking Medicine News(10 mins):Health News:FCPX Effects Developer, Pixel Film Studios, Releases ProDrop Particles. 2Health News:Saturday’s United Methodist Event at Columbus Zoo Celebrates Imagine No Malaria 2Health News:Saturday’s United Methodist Event at Columbus Zoo Celebrates Imagine No Malaria 3Health News:North Central Surgical Center’s Subsidiary Participates in Walk 2Health News:New Video Released on "Music With A Mission" Benefit Concert Headlining Artist Cadillac Three & Best Drug Rehabilitation 2
... July 12 Volunteers and staff of the,American Heart ... Michael E. DeBakey, who died yesterday at the age ... cardiovascular medicine and is,personally responsible for developing the field ... American Heart Association.,"He single-handedly started surgery of the aorta, ...
... Care for Military, Vets, All Americans, WASHINGTON, July ... joined with national leaders in offering,condolences to the family ... medical pioneer with long ties to the Department,of Veterans ... DeBakey,s skills as a surgeon and manager, along with ...
... meets with President Sirleaf while part of Mercy Ships Crew ... ... Recently returned from a week-long international humanitarian mission to support Mercy ... upcoming NFL training camp with an additional sense of purpose knowing ...
... VNUS(R) Medical,Technologies, Inc. (Nasdaq: VNUS ), a ... of venous reflux disease, announced,today the resignation of Kathleen ... served on VNUS, Board of Directors since April 1997 ... that funded the company during,its start-up activities. There are ...
... assessment tool, SNPs made no difference, study finds , , ... predicting one,s chances of developing breast cancer do not ... some genetic markers for the disease, a new report ... (SNPs) that indicate a small but statistically significant increase ...
... $850 million in cuts, WASHINGTON, July 11 ... important benefits and pay more out of,pocket for ... Medicare,Advantage plan altogether under legislation approved this week ... would cut nearly $14 billion from the,Medicare Advantage ...
Cached Medicine News:Health News:American Heart Association Saddened by Death of Surgical Pioneer Michael E. DeBakey 2Health News:Redskins' Draft Pick Malcolm Kelly Energized By Trip To Mercy Ship In Liberia 2Health News:Redskins' Draft Pick Malcolm Kelly Energized By Trip To Mercy Ship In Liberia 3Health News:VNUS Medical Technologies, Inc. Announces Board of Director Resignation 2Health News:Recent Genetic Discoveries Don't Improve Prediction of Breast Cancer 2Health News:Pennsylvania Seniors' Medicare Advantage Benefits at Risk 2
(Date:8/28/2015)... DUBLIN , Aug. 28, 2015  Perrigo Company ... that it has completed the acquisition of leading OTC ... at €200 million. The transaction is a clear demonstration ... the Company,s leading European distribution network spanning 36 countries.  ... Joseph C. Papa commented, "We are excited to ...
(Date:8/28/2015)... , August 28, 2015 The ... Livestock (Pork/Swine, Poultry, Ruminant, and Aquaculture), & by Region ( ... Asia-Pacific , and Rest of the World) ... The global market for Eubiotics was valued at USD 4.62 ... Billion by 2020, at a CAGR of 7.4% from 2015 ...
(Date:8/27/2015)... 2015  The Academy of Managed Care Pharmacy ... (FDA,s) draft guidance and proposed rule that calls ... bear a nonproprietary name with an FDA-designated suffix. ... decision from the FDA on the naming issue ... urging the agency to use the same nonproprietary ...
Breaking Medicine Technology:Perrigo Completes Acquisition of Leading Portfolio of OTC Brands from GSK 2Perrigo Completes Acquisition of Leading Portfolio of OTC Brands from GSK 3Perrigo Completes Acquisition of Leading Portfolio of OTC Brands from GSK 4Eubiotics Market Worth 7.05 Billion USD by 2020 2Eubiotics Market Worth 7.05 Billion USD by 2020 3Eubiotics Market Worth 7.05 Billion USD by 2020 4Eubiotics Market Worth 7.05 Billion USD by 2020 5AMCP Is Disappointed in FDA's Draft Guidance and Proposed Rule Calling for Suffix on Nonproprietary Names of Biological Products 2
... Inc., announced today that it has successfully completed a ... Capital on behalf of the MPM Bio IV NVS ... reserves by entering into an agreement with Novartis International ... option to acquire Aires following the successful completion of ...
... Colorectal cancer (CRC) are two words that most people ... 50,000 Americans every year, the disease takes their life. Colorectal ... figure that may dramatically decrease if Americans are regularly screened ... one of the most curable cancers. The U.S. ...
Cached Medicine Technology:Aires Pharmaceuticals, Inc. Completes $20M Equity Financing and Signs an Option Agreement with a Major Pharmaceutical Company 2New Screening Approach FIT to Fight Colorectal Cancer in the U.S. 2New Screening Approach FIT to Fight Colorectal Cancer in the U.S. 3New Screening Approach FIT to Fight Colorectal Cancer in the U.S. 4New Screening Approach FIT to Fight Colorectal Cancer in the U.S. 5
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: