Navigation Links
Finding of long-sought drug target structure may expedite drug discovery
Date:3/15/2011

body at its smallest components, we can learn how to improve whole-body health."

A receptor is a protein that receives and sends signals to other molecules. The three-dimensional structure of the solved receptor also contains an agonist a chemical command signal from outside the cell in this case, an adenosine molecule. Similar to the function of a telephone receiver, the receptor acts as a sensor, picking up the message from the agonist and transmitting its information, which begins processes inside the cell.

The researchers discovered that a previously known agonist molecule would bind to its receptor target in a way that stabilizes the protein for crystallization. Once crystallized, the structure can be seen by bombarding it with X-rays. The agonist solidifies the protein by connecting to multiple parts of the receptor with its molecular arms, in the process initiating the function of the entire structure. This adenosine receptor, called A2A, counteracts inflammation and responds to organs in distress. It belongs to the G-protein coupled receptor family, which is involved in processes necessary for many drugs currently in use to take effect. These findings may lead to new drugs for many diseases.

The research was also supported by the National Cancer Institute and the National Institute of General Medical Sciences, both components of the NIH.

"Long-term NIH technology investments in structural biology, including the Protein Structure Initiative, have brought diverse teams of investigators together and yielded powerful methods like the ones used in this study," said NIGMS Director Dr. Jeremy M. Berg. "Receptors must undergo substantial changes in shape in order to function, and revealing these molecular dances in such great detail is an impressive accomplishment."


'/>"/>

Contact: Amy Reiter
NIDDKMedia@mail.nih.gov
301-496-3583
NIH/National Institute of Diabetes and Digestive and Kidney Diseases
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. New findings on drug tolerance in TB suggest ideas for shorter cures
2. Latest findings of Dartmouth HIV/AIDS study could turn treatment on its head
3. Research provides new findings on drug delivery with nanoparticles
4. SMFM highlights significance of spina bifida research findings
5. Most Guidelines for Infectious Diseases Dont Come From Clinical Trial Findings
6. International research team reports major findings in prevention and treatment of blood clots
7. VCU findings may help explain some major clinical symptoms of preeclampsia
8. Addiction research: Key findings every month
9. Surprise finding: Pancreatic cancers progress to lethal stage slowly
10. New Finding Suggests Safe Surgical Margins When Removing Breast Cancers
11. $4.37 million NCI grant accelerates recent laboratory finding in Ewings sarcoma
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Finding of long-sought drug target structure may expedite drug discovery
(Date:12/24/2014)... nearly 20 years, June Cotner has been the go-to ... life's rites of passage. Here, she joins forces with ... Toasts: The Perfect Words to Celebrate Every Occasion , ... and containing many original toasts written just for this ... contains sayings famous and profound, suitable and sentimental. Covering ...
(Date:12/24/2014)... December 24, 2014 “ Relax Melodies ... monthly AppWatch, which features the latest and coolest mobile ... Tropeano, a mobile technology expert and host of NewsWatch, ... this application soothes users so they can fall asleep. ... of adults say they have some sort of difficulty ...
(Date:12/24/2014)... As 2014 draws to a close, ... time and money into a new or tankless water ... in tankless and eco-friendly products or service. Greenstar urges ... in 2015 to research “green” and environmentally friendly options ... Services specializes in eco-friendly and environmentally conscious products ...
(Date:12/24/2014)... 24, 2014 Dr. Ronald Receveur, a ... experience placing dental implants in a day, ... effects of overusing teeth-whitening treatments. , In his ... , Dr. Receveur writes that overusing teeth-whitening treatments can ... damage to enamel. , “Because teeth-whitening treatments ...
(Date:12/24/2014)... Kathleen Doheny HealthDay Reporter ... steady diet of fast food might hurt your child in ... ate fast food in fifth grade lagged behind by eighth ... more than 8,500 U.S. students. "The largest effects were ... food," said study leader Kelly Purtell, assistant professor of human ...
Breaking Medicine News(10 mins):Health News:An Application to Help with Insomnia was Featured on NewsWatch Television on December 19, 2014 2Health News:Greenstar Home Services Offers Tankless Water Heater Advice to Local Homeowners 2Health News:New Albany Dentist Weighs In On New Trend of Overbleaching Teeth 2Health News:New Albany Dentist Weighs In On New Trend of Overbleaching Teeth 3Health News:Can Fast Food Hinder Learning in Kids? 2
... in French . Montreal, September 1, 2009 ... bacteria from the skin of the fruit, holds great promise ... the International Journal of Obesity , was conducted by ... the Universit de Moncton who tested the effects of biotransformed ...
... , , CHICAGO, Sept. 1 ... launched a new online video series, called " Living Positive By ... and AIDS education initiative. The Living Positive By Design ... to encourage thoughtful conversations about HIV and AIDS, to confront HIV ...
... , SEARCY, Ark., Sept. 1 Fourteen ... this year,s National Day of Encouragement with the first ever "7 ... The tour will launch September 5 in San Francisco and conclude ... and commemoration of the third annual National Day of Encouragement in ...
... , WASHINGTON, Sept. 1 The ... Tobacco-Free Kids: , , (Logo: http://www.newscom.com/cgi-bin/prnh/20080918/CFTFKLOGO ) ... Tobacco Company, Lorillard Inc. and other tobacco manufacturers that they have ... legislation is not unexpected. The lawsuit, filed in the federal court ...
... , CINCINNATI, Sept. 1 ... physician office-based patient-education programs has announced that SIGVARIS, the ... expanding to the Skin Care Network to broaden their ... office is an ideal place to increase the awareness ...
... MILFORD, Mass., Sept. 1 Waters Corporation (NYSE: ... Division of the American Chemical Society presented Prof. John R. ... Achievements by a Young Analytical Scientist. Through a ... the combined use of hydrogen-deuterium (H/D) exchange technology ...
Cached Medicine News:Health News:Biotransformed blueberry juice fights fat and diabetes 2Health News:Video: 'Project Runway' Designer Launches New Online Video Series to Educate About Living with HIV and AIDS and Help Combat HIV Stigma 2Health News:Video: 'Project Runway' Designer Launches New Online Video Series to Educate About Living with HIV and AIDS and Help Combat HIV Stigma 3Health News:'7 Days Across America' Campaign Honors Teens Making a Difference in Their Communities 2Health News:'7 Days Across America' Campaign Honors Teens Making a Difference in Their Communities 3Health News:'7 Days Across America' Campaign Honors Teens Making a Difference in Their Communities 4Health News:RJR, Other Tobacco Companies Go to Court to Evade Regulation by FDA 2Health News:SIGVARIS USA Extends Educational Efforts in Healthy Advice's Skin Care Network 2Health News:SIGVARIS USA Extends Educational Efforts in Healthy Advice's Skin Care Network 3Health News:American Chemical Society Awards John R. Engen for Scientific Achievements 2Health News:American Chemical Society Awards John R. Engen for Scientific Achievements 3
(Date:12/24/2014)...   Assurex Health, a personalized medicine company ... for behavioral health and chronic pain conditions, today ... equity financing from new and existing investors, according ... Chief Executive Officer. The financing will ... Health,s GeneSight ®  products.  GeneSight,s patented ...
(Date:12/24/2014)... Dec. 23, 2014 Tianyin Pharmaceutical Co., ... specializes in patented biopharmaceutical, modernized traditional Chinese medicine ... today announced that the Company achieved the Public ... Practice (GMP) certificate of TPI,s Qionglai Facility (QLF) ... The public notice period is a significant procedure ...
(Date:12/24/2014)... CHAPEL HILL, N.C. , Dec. 23, 2014 /PRNewswire/ ... marketplace success. As the key link between the medical ... will grow even more in the coming years as ... relationships. According to research by benchmarking ... and MSLs can gain an important edge is by ...
Breaking Medicine Technology:Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 2Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 3Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 4TPI QLF Achieved Public Notice Status of GMP Certification 2TPI QLF Achieved Public Notice Status of GMP Certification 3Role of Medical Science Liaisons Evolving in Medical Device Sector 2
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: