Navigation Links
Finding of genetic region controlling cardiovascular sensitivity to anesthetic propofol

Researchers at The Medical College of Wisconsin in Milwaukee have identified the genetic region in rats responsible for cardiovascular collapse during anesthesia. While it is well known that people have different cardiovascular sensitivity to anesthesia causing some to collapse even when low doses are administered, the mechanism responsible for this susceptibility is not clear.

"By identifying a genetic susceptibility for cardiovascular collapse to low dose propofol, our findings may provide a key to better understand the underlying cause of the mysterious death of Michael Jackson," says Richard Roman, Ph.D., co author, professor of physiology and director of the Kidney Disease Center at the College.

The study was published in the September 2009, issue of the Journal of Pharmacology and Experimental Therapeutics with an editorial commentary.

To find the genetic mechanism that causes this reaction, researchers at the Medical College led by Thomas A. Stekiel, M.D., and Anna Stadnicka, Ph.D., both associate professors of anesthesiology, administered the anesthetic propofol to a strain of rat (Dah S) that is very sensitive to anesthetics versus Brown Norway (BN) rats that are quite resistant. Through extensive genetic analysis, they were able to determine that a small region on chromosome 13 contained the genetic switch responsible for the difference in the response of these strains to anesthesia. This region also contains the renin gene, an important blood pressure controller.

"The next step is to identify the exact gene and see if it is also responsible for cardiovascular collapse with propofol in humans," says Carol Moreno Quinn, M.D., Ph.D., co-author at the Medical College's Human and Molecular Genetics Center at the College. "We can then test which persons with this gene would be sensitive to anesthesia and prevent deaths and accidents due to cardiovascular collapse in the operating room."

The findings support earlier work by the researchers showing that propofol has greater impact on vascular smooth muscle in the hypertensive salt-sensitive Dahl rats compared to the normotensive Brown Norway rats, and that chromosome 13-associted genes are responsible for variable responses to propofol.

The Dahl salt-sensitive strain develops severe hypertension when fed a high-salt diet. This salt-sensitive characteristic is similar to what is often seen in African Americans with high blood pressure. This Dahl rat model is used to better understand the causes and mechanisms behind the development of high blood pressure and cardiovascular disease in this population.


Contact: Toranj Marphetia
Medical College of Wisconsin

Related medicine news :

1. Many Parents Share Genetic Test Findings With Kids
2. New Alzheimers findings: High stress and genetic risk factor lead to increased memory decline
3. New MRI finding sheds light on multiple sclerosis disease progressio
4. High and mighty: first common height gene identified by researchers behind obesity gene finding
5. Scientists, physicians present latest findings in personalized cancer treatment and prevention
6. Health psychologists discuss latest research findings
7. Incidental findings found when radiologists take a broader look at renal MRA
8. First significant genetic finding in severe PMS, or PMDD
9. Chair of U.S. Preventive Services Task Force Pledges to Recommend Re-evaluation of Recent Glaucoma Findings
10. The Organic Trade Association Hails Preliminary Research Findings Showing Nutritional Benefits of Organic Products
11. Key findings for all veterans seen in depression and suicide study
Post Your Comments:
(Date:11/24/2015)... ... November 25, 2015 , ... ... solutions for drugs, biologics, consumer health and global clinical supply services, today announced ... upcoming Clinical Trial Supply East Asia Conference, to be held at the InterContinental ...
(Date:11/24/2015)... (PRWEB) , ... November 24, 2015 , ... ... that the organization will waive paid entry and parking fees at several of ... and Monument Mountain in Great Barrington in support of REI’s Black Friday #OptOutside ...
(Date:11/24/2015)... ... 24, 2015 , ... The American Association of Poison Control ... centers through donations on Tuesday, Dec. 1, 2015. Since 2012, the Tuesday following ... people to collaborate in improving their local communities and help give back in ...
(Date:11/24/2015)... ... ... , LLC launched their Pro Vest, the latest version of their widely popular weight loss ... 10 hours. , The campaign, which will continue to run through Saturday, ... , The PRO Vest provides consumers with a less expensive, one-size fits all comfort option, ...
(Date:11/24/2015)... San Diego, CA (PRWEB) , ... November 24, ... ... and the Silver&Fit® Exercise and Healthy Aging Program have announced ... provider referral service. , “American Specialty Health Fitness is proud to have the ...
Breaking Medicine News(10 mins):
(Date:11/24/2015)... The uptake of recently approved and pipeline premium ... of market growth to 2021, says GBI Research ... products for Type 1 Diabetes Mellitus (T1DM), will be a key driver ... . --> The uptake of recently approved and pipeline ... driver of market growth to 2021, says GBI Research ...
(Date:11/24/2015)... , UAE, November 24, 2015   ... and dietician deliver s advice and ...   More than 50% of ... to keep themselves healthy according to the DHA   femMED ... in the UAE    Dubai residents are not ...
(Date:11/24/2015)... Mich. , Nov. 24, 2015  Freudenberg Medical has ... rapid HIV testing outside of medical facilities. ... access to medical care is sparse. Nevertheless, prompt diagnosis is ... further spread of the virus. With the help of a ... go from village to village in affected areas and perform ...
Breaking Medicine Technology: