Navigation Links
Finding of genetic region controlling cardiovascular sensitivity to anesthetic propofol
Date:9/10/2009

Researchers at The Medical College of Wisconsin in Milwaukee have identified the genetic region in rats responsible for cardiovascular collapse during anesthesia. While it is well known that people have different cardiovascular sensitivity to anesthesia causing some to collapse even when low doses are administered, the mechanism responsible for this susceptibility is not clear.

"By identifying a genetic susceptibility for cardiovascular collapse to low dose propofol, our findings may provide a key to better understand the underlying cause of the mysterious death of Michael Jackson," says Richard Roman, Ph.D., co author, professor of physiology and director of the Kidney Disease Center at the College.

The study was published in the September 2009, issue of the Journal of Pharmacology and Experimental Therapeutics with an editorial commentary.

To find the genetic mechanism that causes this reaction, researchers at the Medical College led by Thomas A. Stekiel, M.D., and Anna Stadnicka, Ph.D., both associate professors of anesthesiology, administered the anesthetic propofol to a strain of rat (Dah S) that is very sensitive to anesthetics versus Brown Norway (BN) rats that are quite resistant. Through extensive genetic analysis, they were able to determine that a small region on chromosome 13 contained the genetic switch responsible for the difference in the response of these strains to anesthesia. This region also contains the renin gene, an important blood pressure controller.

"The next step is to identify the exact gene and see if it is also responsible for cardiovascular collapse with propofol in humans," says Carol Moreno Quinn, M.D., Ph.D., co-author at the Medical College's Human and Molecular Genetics Center at the College. "We can then test which persons with this gene would be sensitive to anesthesia and prevent deaths and accidents due to cardiovascular collapse in the operating room."

The findings support earlier work by the researchers showing that propofol has greater impact on vascular smooth muscle in the hypertensive salt-sensitive Dahl rats compared to the normotensive Brown Norway rats, and that chromosome 13-associted genes are responsible for variable responses to propofol.

The Dahl salt-sensitive strain develops severe hypertension when fed a high-salt diet. This salt-sensitive characteristic is similar to what is often seen in African Americans with high blood pressure. This Dahl rat model is used to better understand the causes and mechanisms behind the development of high blood pressure and cardiovascular disease in this population.


'/>"/>

Contact: Toranj Marphetia
toranj@mcw.edu
414-955-4744
Medical College of Wisconsin
Source:Eurekalert

Related medicine news :

1. Many Parents Share Genetic Test Findings With Kids
2. New Alzheimers findings: High stress and genetic risk factor lead to increased memory decline
3. New MRI finding sheds light on multiple sclerosis disease progressio
4. High and mighty: first common height gene identified by researchers behind obesity gene finding
5. Scientists, physicians present latest findings in personalized cancer treatment and prevention
6. Health psychologists discuss latest research findings
7. Incidental findings found when radiologists take a broader look at renal MRA
8. First significant genetic finding in severe PMS, or PMDD
9. Chair of U.S. Preventive Services Task Force Pledges to Recommend Re-evaluation of Recent Glaucoma Findings
10. The Organic Trade Association Hails Preliminary Research Findings Showing Nutritional Benefits of Organic Products
11. Key findings for all veterans seen in depression and suicide study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/5/2016)... ... May 05, 2016 , ... Sun Health registered ... the organization’s successful Care Transitions program at the 9th Annual Orthopedic ... “Minimizing Costs in the Post-Acute Environment Through Effective Transitions of Care.” , Major ...
(Date:5/5/2016)... Diego, CA (PRWEB) , ... May 05, 2016 , ... ... travel nursing firm, is encouraging people all over the United States to thank a ... May 12, Aya Healthcare will donate $5 to the American Red Cross of San ...
(Date:5/5/2016)... Ohio (PRWEB) , ... May 05, 2016 , ... United ... Cycle. , Clark brings more than 15 years of experience within the healthcare ... from a successful career as the Director of Patient Financial Services at Spectrum Health. ...
(Date:5/5/2016)... ... May 05, 2016 , ... ... for iOS and Android devices. VisualDx is the first point of care ... support across general medicine. The system speeds diagnosis, therapy decisions and patient ...
(Date:5/5/2016)... (PRWEB) , ... May 05, 2016 , ... With May flowers, summer is just around ... it means a welcome respite from school and the ability to play all day and ... for their children or watch the little tykes themselves. Summer also means trips to the ...
Breaking Medicine News(10 mins):
(Date:5/5/2016)... , May 5, 2016 /PRNewswire/ ... announced the addition of the  "Europe ... - 2016"  report to their offering.  ... ) , ,The latest research ... Highlights - 2016, provides comprehensive insights ...
(Date:5/4/2016)... , May 4, 2016  It,s time for an upgrade. There are many ... a brilliant 3.5 inch LCD, the illustrious DVMAXX HD  offers unparalleled connectivity and ... well as a world class manufacturer of innovative technology.  Photo - ... ... ...
(Date:5/4/2016)... , May 4, 2016 ... completion of an alternative public offering (APO). This was ... operating company, Valeritas, Inc. and a private placement of ... at $5.00 per share. Under the terms ... 3, 2016, Valeritas Holdings, Inc. will trade on the ...
Breaking Medicine Technology: