Navigation Links
Finding of genetic region controlling cardiovascular sensitivity to anesthetic propofol
Date:9/10/2009

Researchers at The Medical College of Wisconsin in Milwaukee have identified the genetic region in rats responsible for cardiovascular collapse during anesthesia. While it is well known that people have different cardiovascular sensitivity to anesthesia causing some to collapse even when low doses are administered, the mechanism responsible for this susceptibility is not clear.

"By identifying a genetic susceptibility for cardiovascular collapse to low dose propofol, our findings may provide a key to better understand the underlying cause of the mysterious death of Michael Jackson," says Richard Roman, Ph.D., co author, professor of physiology and director of the Kidney Disease Center at the College.

The study was published in the September 2009, issue of the Journal of Pharmacology and Experimental Therapeutics with an editorial commentary.

To find the genetic mechanism that causes this reaction, researchers at the Medical College led by Thomas A. Stekiel, M.D., and Anna Stadnicka, Ph.D., both associate professors of anesthesiology, administered the anesthetic propofol to a strain of rat (Dah S) that is very sensitive to anesthetics versus Brown Norway (BN) rats that are quite resistant. Through extensive genetic analysis, they were able to determine that a small region on chromosome 13 contained the genetic switch responsible for the difference in the response of these strains to anesthesia. This region also contains the renin gene, an important blood pressure controller.

"The next step is to identify the exact gene and see if it is also responsible for cardiovascular collapse with propofol in humans," says Carol Moreno Quinn, M.D., Ph.D., co-author at the Medical College's Human and Molecular Genetics Center at the College. "We can then test which persons with this gene would be sensitive to anesthesia and prevent deaths and accidents due to cardiovascular collapse in the operating room."

The findings support earlier work b
'/>"/>

Contact: Toranj Marphetia
toranj@mcw.edu
414-955-4744
Medical College of Wisconsin
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Many Parents Share Genetic Test Findings With Kids
2. New Alzheimers findings: High stress and genetic risk factor lead to increased memory decline
3. New MRI finding sheds light on multiple sclerosis disease progressio
4. High and mighty: first common height gene identified by researchers behind obesity gene finding
5. Scientists, physicians present latest findings in personalized cancer treatment and prevention
6. Health psychologists discuss latest research findings
7. Incidental findings found when radiologists take a broader look at renal MRA
8. First significant genetic finding in severe PMS, or PMDD
9. Chair of U.S. Preventive Services Task Force Pledges to Recommend Re-evaluation of Recent Glaucoma Findings
10. The Organic Trade Association Hails Preliminary Research Findings Showing Nutritional Benefits of Organic Products
11. Key findings for all veterans seen in depression and suicide study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2014)... ways that cells are regulated, scientists at Rockefeller University ... more likely to metastasize. , What,s more, the protein ... two other proteins that are normally linked to neurodegeneration, ... have unexpected ties. , The study, which appears ... points to the possibility of new cancer therapies that ...
(Date:7/9/2014)... of stromal support cells and immune cells and ... in the development of diseases could open new ... was the conclusion of a review article by scientists ... Nature . , Prof. Peter Carmeliet: "Consider the ... of cancer cells has been examined in minute detail ...
(Date:7/9/2014)... have found that fecal transplantation is effective and safe ... This is the result of a study led by ... Women,s Gastrointestinal Medicine at The Women,s Medicine Collaborative. The ... advance of print in the American Journal of ... C. diff , has increased to epidemic proportions over ...
(Date:7/9/2014)... Researchers from The Miriam Hospital have found that ... are also depressed have difficulty sticking to a ... true for women, and screening and brief treatment ... treatment. The study and its findings are published ... , Chronic obstructive pulmonary disease is a common ...
(Date:7/9/2014)... French . ... teens, including brain structure and function, personality, life experiences and ... on to develop binge drinking within the next two years. ... such as life events and a family history of drug ... or not the child had had a single drink at ...
Breaking Medicine News(10 mins):Health News:Protein pushes breast cancer cells to metastasize 2Health News:Protein pushes breast cancer cells to metastasize 3Health News:Wake-up call for more research into cell metabolism 2Health News:Women's Medicine Collaborative examines safety of fecal transplant to treat C. difficile 2Health News:Miriam Hospital study examines effect of depressed mood on pulmonary rehab completion 2Health News:What drives a child to abuse alcohol? 2
... Reports of a study reports that married women is having ... men or unmarried women and the report finds out that ... compared to married women. // , ,Catherine Mercer, ... said. "That is, within a relationship, people who were less ...
... health as it induces lot of alterations in the metabolism ... of colorectal tumours, while drinking in moderation lowers the risk, ... was conducted by Joseph C. Anderson, M.D. and colleagues at ... patients were subject to a survey of drinking habits and ...
... high but critics are more concerned with the availability of ... available to the developing and under developed countries//. ... anytime, due to current global conditions, as there are serious ... continue people have started stock piling and storing stocks of ...
... above may have a sedentary lifestyle if they perceive that their ... earlier studies that fewer than 40 percent of adults aged 65 ... years of independent life., ,A new UCLA study found that ... one can do at an advanced age — were the most ...
... University have said they are trying to develop an ... against lung cancer//. , ,Experiments with mice have ... still needed before the new therapy could be used ... ,"In fact it's a paradox," said research scientist Christian ...
... 27: Union Health Minister Anbumani Ramadoss today fired another salvo at ... country. He said: "influence of mafias over such a regulatory body ... MCI is an autonomous body and the government has no say ... in its functioning. , ,He said a cleansing process ...
Cached Medicine News:Health News:Alcohol Consumption A Threat To Colorectal Tumours 2Health News:Flu Vaccine Can Be Used To Treat Lung Cancer 2
(Date:1/15/2014)... As health officials across the Midwest warn against the widespread ... Michigan will offer free diagnostic testing for ... to administer tests and, in some cases, fill the matching ... the study. The Grand Rapids, Mich. ...
(Date:1/15/2014)... 15, 2014 Shire plc (LSE: SHP, NASDAQ: ... Fair Trading (OFT) approval condition to the announced tender offer for ... As a result of the waiver, the transaction is ... the tender offer on January 24, 2014 following the currently scheduled ...
(Date:1/15/2014)... 2014 Tegra Medical is very pleased to announce the ... new Chief Executive Officer.  Mark was promoted from his current ... the company,s four facilities in Massachusetts , ... joined Tegra Medical in 2012 with 20+ years of broad-based ...
Breaking Medicine Technology:Meijer Pharmacy Offers Free Flu, Strep Testing as Influenza Cases Rise Across the Midwest 2Meijer Pharmacy Offers Free Flu, Strep Testing as Influenza Cases Rise Across the Midwest 3Shire Waives OFT Condition Relating to the Acquisition of ViroPharma Inc. 2Shire Waives OFT Condition Relating to the Acquisition of ViroPharma Inc. 3Tegra Medical Appoints New Chief Executive Officer 2Tegra Medical Appoints New Chief Executive Officer 3
... Oct. 16 AngioGenex Inc. (OTC,Bulletin Board: AGGX.OB) ... molecules that are potent inhibitors of the Id ... filing of this patent,constitute major milestones in the ... Dr. Richard Salvador, President and CEO, and the,former ...
... Oct. 16 When eighty-six-year-old,Keith Hora went to see ... University of Newcastle in Australia, he was told he ... been diagnosed with stage III melanoma, one,of the most ... had multiple melanoma reoccurrences in the previously treated,area of ...
Cached Medicine Technology:AngioGenex Files Patent on First Small Molecule Id-Inhibitors for the Treatment of Cancer 2Recipient of Melanoma Drug in Development Celebrates Two Cancer-Free Years 2
Inorganic phosphorus (UV method) reagent is for the quantitative determination of inorganic phosphorus in human serum....
For the quantitative determination of Inorganic Phosphorus in serum. Linearity: 12.0 mg/dl....
For the kinetic quantitative determination of g-Glutamyl Transferase in serum for manual and/or automated procedures....
Intended for the quantitative determination of gammaglutamyl transferase activity in serum or plasma. Single vial, dry powder reagent. Readily soluble at room temperature. Reaction: Kinetic. Waveleng...
Medicine Products: