Navigation Links
Finding molecular targets of an HIV drug used in cancer therapy
Date:4/28/2011

Researchers at the University of California, San Diego and Hunter College of the City University of New York (CUNY) have identified potential human molecular targets of the anti-HIV drug Nelfinavir, which may explain why the drug is also effective as a cancer therapy. Their study will be published in the online edition of PLoS Computational Biology on April 28.

Nelfinivir is a protease inhibitor that prevents replication of the HIV virus, but it has also been found to have a positive effect on a number of solid tumor types, and is currently in clinical trial as a cancer therapy. However, the mechanism of how the drug worked in humans was not clear.

The researchers discovered that Nelfinavir may interact with multiple human protein kinases enzymes that modify other proteins and regulate the majority of cellular pathways. Protein kinases comprise approximately 2 percent of the human genome, and are important anti-cancer drug targets.

Surprisingly, the interactions between Nelfinavir and kinases are much weaker than those from more specific, rationally designed drugs, said Philip Bourne, PhD, professor of pharmacology at UC San Diego Skaggs School of Pharmacy and Pharmaceutical Sciences. Bourne and colleagues suggest that it is the collective effect of these weak interactions that leads to the clinical efficacy of Nelfinavir.

The research team Li Xie, PhD, from UC San Diego, Thomas Evangelidis, a former graduate student in Bourne's lab, now at the University of Manchester, and research scientist Lei Xie, PhD, now an associate professor at Hunter College, CUNY combined a wide array of computational techniques to investigate the molecular mechanisms underlying Nelfinavir's observed anti-cancer effect.

While drug molecules are designed to bind to targeted proteins in order to achieve a therapeutic effect, small drug molecules can attach to off-target proteins with similar binding sites. The result may
'/>"/>

Contact: Debra Kain
ddkain@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert

Page: 1 2

Related medicine news :

1. OHSU expert co-authors study finding treatment for rare lung disease
2. Ovarian cancer finding may be a win-win for at-risk women who wish to have a family
3. Researchers present new findings on cancer and gene therapy
4. UPCI, Pitt researchers present findings of cancer studies at AACR 102nd Annual Meeting
5. Surprising finding from smoke inhalation study
6. Finding of long-sought drug target structure may expedite drug discovery
7. New findings on drug tolerance in TB suggest ideas for shorter cures
8. Latest findings of Dartmouth HIV/AIDS study could turn treatment on its head
9. Research provides new findings on drug delivery with nanoparticles
10. SMFM highlights significance of spina bifida research findings
11. Most Guidelines for Infectious Diseases Dont Come From Clinical Trial Findings
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/1/2015)... ... , ... Lume Wellness creators Alex, Robert, and Sam have announced update 3.0.1 ... , The app is designed to track various metrics of wellness, including physical ... personal health and use this information for positive behavior modification. Lume Wellness keeps track ...
(Date:7/31/2015)... ... July 31, 2015 , ... Ticket Down is a reputable source of authentic ... Grand Garden Arena. Fans of every genre of music will have an act they ... first day of the festival, the following artists will perform: Sam Smith, Coldplay, Kenny ...
(Date:7/31/2015)... ... ... Aesthetics is New York’s only Thermage skin tightening pinnacle and black diamond award winner ... reduction in New York. Due to its unparalleled level of experience for these ... travel to New York to get their non-surgical skin tightening and body shaping procedures ...
(Date:7/31/2015)... ... July 31, 2015 , ... There’s no better way to enjoy ... comes time to cook the next meal, making July the most appropriate to be ... grilling tips and recipes. , Make the next cookout different than the ones in ...
(Date:7/31/2015)... ... July 31, 2015 , ... Ticket Down is a reliable source ... to catch a new and refreshing show on Broadway, look no further than Hamilton. ... an Obie Award, Outer Critics Circle Award, Drama Desk Award, Lucille Lortel Award, and ...
Breaking Medicine News(10 mins):Health News:Lume Wellness Launches Health and Fitness Tracker iPhone App 2Health News:Cheap 2015 iHeartRadio Music Festival Tickets in Las Vegas at MGM Grand Garden Arena: Ticket Down Slashes Ticket Prices on the iHeart Radio Music Festival in Vegas 2Health News:Cheap 2015 iHeartRadio Music Festival Tickets in Las Vegas at MGM Grand Garden Arena: Ticket Down Slashes Ticket Prices on the iHeart Radio Music Festival in Vegas 3Health News:King Kullen Honors National Hot Dog and Blueberry Month 2Health News:King Kullen Honors National Hot Dog and Blueberry Month 3Health News:Cheap Hamilton Tickets at Richard Rodgers Theatre: Ticket Down Slashes Ticket Prices for Hamilton in New York City at the Richard Rodgers Theatre 2Health News:Cheap Hamilton Tickets at Richard Rodgers Theatre: Ticket Down Slashes Ticket Prices for Hamilton in New York City at the Richard Rodgers Theatre 3Health News:Cheap Hamilton Tickets at Richard Rodgers Theatre: Ticket Down Slashes Ticket Prices for Hamilton in New York City at the Richard Rodgers Theatre 4Health News:Cheap Hamilton Tickets at Richard Rodgers Theatre: Ticket Down Slashes Ticket Prices for Hamilton in New York City at the Richard Rodgers Theatre 5Health News:Cheap Hamilton Tickets at Richard Rodgers Theatre: Ticket Down Slashes Ticket Prices for Hamilton in New York City at the Richard Rodgers Theatre 6Health News:Cheap Hamilton Tickets at Richard Rodgers Theatre: Ticket Down Slashes Ticket Prices for Hamilton in New York City at the Richard Rodgers Theatre 7
... Services Now Taking Part, WASHINGTON, Nov. 7 ... easier, quicker access to their veterans,benefits due to ... offer,streamlined disability evaluations that will reach 19 military,installations, ... Veterans Affairs (VA) announced today the expansion,of the ...
... Keryx Biopharmaceuticals,Inc. (Nasdaq: KERX ) will hold a ... EST to discuss the third quarter 2008 financial results.,Michael ... Company, will,host the call. Keryx will announce its financial ... issued prior to the call., In order to ...
... (Nasdaq:DCGN) scientists and independent researchers at the American Heart ... Orleans Convention Center from November 8 to12 are expected ... risk of heart attack, or atrial fibrillation and stroke, ... basis of the deCODE MI and deCODE AF tests. ...
... Pa., Nov. 7 InfoLogix, Inc. (Nasdaq:,IFLG), a ... asset tracking solutions for the healthcare and commercial,industries, ... ended,September 30, 2008 after close of market on ... David Gulian and Chief Financial,Officer Jay Roberts will ...
... 7 As the clock runs out on,the Bush ... crucial international health program, the Global Fund to Fight ... meeting of the Fund,s Board in India,where they have ... to demand dramatic cut backs in grants for health,programs ...
... Pa., Nov. 7 Two state officials,traveling the state ... in the commonwealth brought their tour to Bedford, Blair ... Dennis Wolff and acting Health,Secretary Everette James is part ... initiative, which is a comprehensive plan to address,food safety ...
Cached Medicine News:Health News:VA Announces Expansion of Disability Evaluation System Pilot 2Health News:Keryx Biopharmaceuticals, Inc. to Hold Conference Call on Third Quarter 2008 Financial Results on Tuesday, November 11, at 8:30 A.M. EST 2Health News:Presentations at AHA expand on clinical utility of deCODE's DNA-based tests 2Health News:Presentations at AHA expand on clinical utility of deCODE's DNA-based tests 3Health News:Presentations at AHA expand on clinical utility of deCODE's DNA-based tests 4Health News:InfoLogix to Report Third Quarter Financial Results on November 10, 2008 2Health News:Obama Could Inherit Weaker Global Health Fund 2Health News:Rendell Cabinet Secretaries Address Food Safety Concerns During Central PA Tour 2
(Date:7/31/2015)... More than 1,500 substance abuse prevention and treatment specialists ... Indianapolis Aug. 2-6 for Community Anti-Drug Coalitions ... The week-long training, held at the JW Marriott, will ... biggest public health challenges – youth drug use. ... intensive training opportunity, offering more than 70 half-day and ...
(Date:7/31/2015)... BOSTON , July 31, 2015  Boston ... children benefiting from 3D printing of their anatomy ... had life-threatening cerebrovascular malformations (abnormalities in the brain,s ... Reporting online today in the Journal ... use of 3D printing and synthetic resins to ...
(Date:7/31/2015)... Pa. , July 31, 2015 ... fully integrated specialty pharmaceutical company focused on developing, ... the closing of its previously announced underwritten public ... at a public offering price of $11.25 per ... offering included 1,000,000 shares issued upon the exercise ...
Breaking Medicine Technology:Community Leaders From Across The Country Head To Indianapolis For CADCA 2015 Mid-Year Training Institute Aug. 2-6 23D Printing Helps Doctors Rehearse Complex Brain Procedures 23D Printing Helps Doctors Rehearse Complex Brain Procedures 33D Printing Helps Doctors Rehearse Complex Brain Procedures 4Egalet Announces Closing of Public Offering of Common Stock and Exercise in Full of Underwriters' Option to Purchase Additional Shares 2Egalet Announces Closing of Public Offering of Common Stock and Exercise in Full of Underwriters' Option to Purchase Additional Shares 3Egalet Announces Closing of Public Offering of Common Stock and Exercise in Full of Underwriters' Option to Purchase Additional Shares 4
... National Pharmaceutical Council,s Board of Directors today announced that it ... Care Business Unit at Pfizer Inc, to serve as Chairman ... variety of senior roles at Pfizer, which she joined in ... President/General Manager of the Customer Business Unit and Commercial Operations ...
... VirtualScopics, Inc. (Nasdaq: VSCP ), a leading provider ... before the market opens on Thursday, November 12, 2009 ... The company will host a conference call that morning ... Chief Executive Officer, Jeff Markin, and Chief Business and ...
Cached Medicine Technology:National Pharmaceutical Council Board of Directors Elects Pfizer's Marie-Caroline Sainpy as Chairman 2VirtualScopics Schedules Third Quarter 2009 Earnings Announcement 2
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: