Navigation Links
Finding may explain anti-cancer activity of thiazole antibiotics
Date:8/11/2009

University of Illinois at Chicago College of Medicine researchers have discovered how some recently approved drugs act against cancer cells. The finding may lead to a more effectively targeted anti-cancer strategy.

In a new study reported in the journal PLoS ONE online, UIC researchers show how a class of drugs inhibits a protein called FoxM1 and suggest that the drugs' ability to inhibit FoxM1 may account for their anti-cancer activity.

FoxM1 is one of the most highly over-produced proteins in cancer cells and is believed to play an important role is causing cells to become cancerous. Because production of the protein is not usually switched on in non-dividing cells, the protein may present a promising target for anti-cancer treatments.

Andrei Gartel, UIC associate professor of molecular genetics, and his colleagues had previously shown that antibiotics called thiazoles kill cancer cells and inhibit FoxM1. When they went on to investigate whether the antibiotics attacked other proteins involved in cancer, they got a surprising result.

"We found that these thiazole antibiotics actually stabilized other cancer-causing proteins," Gartel said.

It was an unexpected hint suggesting that thiazole antibiotics may act as inhibitors of the proteasome, a molecular complex that acts as a trash collector in cells, degrading old proteins that the cell has marked for destruction. This inhibition of the proteasome was confirmed in later experiments, Gartel said.

Recently, a number of proteasome inhibitors have shown promise against cancer, but no one understands why they have anti-cancer effects.

"We decided to see if these proteasome inhibitors, including Velcade, were, like our antibiotics, targeting FoxM1," he said.

The researchers found that the proteasome inhibitors did inhibit FoxM1 and that they also caused cells to self-destruct in the same concentrations.

It's possible, Gartel suggested, that by using thiazole antibiotics in combination with well-known proteasome inhibitors, "we may see a synergy that allows us to markedly reduce the dose of any one of these drugs and still effectively kill the cancer cells."


'/>"/>

Contact: Jeanne Galatzer-Levy
jgala@uic.edu
312-996-1583
University of Illinois at Chicago
Source:Eurekalert

Related medicine news :

1. Many Parents Share Genetic Test Findings With Kids
2. New Alzheimers findings: High stress and genetic risk factor lead to increased memory decline
3. New MRI finding sheds light on multiple sclerosis disease progressio
4. High and mighty: first common height gene identified by researchers behind obesity gene finding
5. Scientists, physicians present latest findings in personalized cancer treatment and prevention
6. Health psychologists discuss latest research findings
7. Incidental findings found when radiologists take a broader look at renal MRA
8. First significant genetic finding in severe PMS, or PMDD
9. Chair of U.S. Preventive Services Task Force Pledges to Recommend Re-evaluation of Recent Glaucoma Findings
10. The Organic Trade Association Hails Preliminary Research Findings Showing Nutritional Benefits of Organic Products
11. Key findings for all veterans seen in depression and suicide study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/22/2017)... ... February 22, 2017 , ... Using the power of the ... simple online checklist. Over a period of just 24 months, thousands of individuals interested ... online checklist called T.A.D. , “The internet is not getting quieter. In fact it’s ...
(Date:2/22/2017)... (PRWEB) , ... February 22, 2017 , ... ANGLESTRONG ... Kurt Angle, is now available on the App Store and Google ... mobile apps for the addiction and recovery industry, partnered with Angle to build ANGLESTRONG. ...
(Date:2/22/2017)... ... February 22, 2017 , ... Becker’s Spine Review, ... is featuring Michigan neurosurgeon Jay Jagannathan, M.D., as a “Spine Surgeon to Know.” ... of neurosurgeons in Michigan performing minimally invasive back surgery that often results in ...
(Date:2/22/2017)... , ... February 22, 2017 , ... A product of ... seem to derive a heart-protective benefit from eating soy foods, while others do not, ... men who are able to produce equol—a substance made by some types of “good” ...
(Date:2/22/2017)... ... 2017 , ... Forty-five percent of American respondents feel that ... or friends have also commented about their poor hearing. However, only 13 percent ... reason, suggested by 89 percent of American respondents, is that they don’t want ...
Breaking Medicine News(10 mins):
(Date:2/22/2017)... Summary Provides understanding and ... entered into by the worlds leading healthcare companies. ... Description The Global Atherosclerosis Partnering Terms and ... to partnering deals and agreements entered into by ... Trends in partnering deals - Top deals ...
(Date:2/22/2017)... Summary Provides understanding and access ... entered into by the worlds leading healthcare companies. ... The Global Motor Neurone Disease Partnering Terms and Agreements ... deals and agreements entered into by the world,s leading ... - Top deals by value - Deals ...
(Date:2/22/2017)... 2017 The top three ... Olympus Corporation, Nikon Corporation, and Leica Microsystems. Collectively ... the overall market in 2015. The oligopolistic market ... result-oriented research and development activities and mergers and ... on expanding their business to emerging economies as ...
Breaking Medicine Technology: