Navigation Links
Finding clues for nerve cell repair
Date:6/3/2008

A new study at the Montreal Neurological Institute at McGill University identifies a key mechanism for the normal development of motor nerve cells (motor neurons) - cells that control muscles. This finding is crucial to understanding and treating a range of conditions involving nerve cell loss or damage, from spinal cord injury to neurodegenerative diseases such as ALS, also known as Lou Gehrig's disease.

Nerve cell regeneration is a complex process. Not only do nerve cells have to regenerate, but just as importantly, their specific and individual connections need to be regenerated also. The study, published recently in the Proceedings of the National Academy of Sciences, provides invaluable insight into these vital processes by understanding the mechanisms involved in normal development of selected types of spinal cord motor nerve cells.

Motor neurons are highly specialized. They have distinct characteristics and connect to specific muscle types in specific regions of the body. "These highly targeted nerve cell-to-muscle connections are determined in part by specific patterns of gene expression during embryonic development. More specifically, certain genes are expressed which tell the neuron what its properties will be, where to settle and which particular muscle to connect with," says Dr. Stefano Stifani, neuroscientist at the Montreal Neurological Institute and lead investigator in the study.

When nerve cells develop they require characteristic patterns of gene expression in order to become motor neurons or another type of nerve cell called interneurons. Dr. Stifani and colleagues show that during development, motor nerve cells have to express certain genes that continually suppress interneuron developmental characteristics.

"We have identified a key factor, called Runx1, which controls the correct development of motor neurons in the upper part of the spinal cord. Runx1, a factor that controls gene expression, helps motor neurons to maintain their status by regulating the expression of specific genes. In doing so, it might also help motor neurons find their target muscles."

Understanding the normal development and the highly specialized nature of nerve cells has important implications for understanding diseased or damaged nerve cells. For example, in ALS, the motor nerve cells that are involved in swallowing and controlling the tongue are often the first to degenerate. Knowing the specific patterns of gene expression of different motor nerve cells may help to explain why certain motor neurons are more susceptible to degeneration and help identify new targets for treatments.


'/>"/>

Contact: Sandra McPherson
sandra.mcpherson@mcgill.ca
514-398-1902
Montreal Neurological Institute and Hospital
Source:Eurekalert

Related medicine news :

1. Many Parents Share Genetic Test Findings With Kids
2. New Alzheimers findings: High stress and genetic risk factor lead to increased memory decline
3. New MRI finding sheds light on multiple sclerosis disease progressio
4. High and mighty: first common height gene identified by researchers behind obesity gene finding
5. Scientists, physicians present latest findings in personalized cancer treatment and prevention
6. Health psychologists discuss latest research findings
7. Incidental findings found when radiologists take a broader look at renal MRA
8. First significant genetic finding in severe PMS, or PMDD
9. Chair of U.S. Preventive Services Task Force Pledges to Recommend Re-evaluation of Recent Glaucoma Findings
10. The Organic Trade Association Hails Preliminary Research Findings Showing Nutritional Benefits of Organic Products
11. Key findings for all veterans seen in depression and suicide study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... , ... October 13, 2017 , ... PurhealthRX , ... Oil utilizing Purzorb™ technology. Applying the Purzorb™process to full spectrum CBD oil will revolutionize ... providing a CBD form that can be easily incorporated into liquid products, while reducing ...
(Date:10/13/2017)... OBISPO, Calif. (PRWEB) , ... October 13, 2017 , ... ... or dementia. However, many long-term care insurance companies have a waiver for care if ... the 90-day elimination period, when the family pays for care, is often waived, so ...
(Date:10/13/2017)... ... , ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh, has ... least understood books in the Holy Scriptures, Revelation. The Book of Revelation paints a ... centuries. Many have tossed it off as mere rubbish, but Yisrayl Hawkins says that ...
(Date:10/13/2017)... ... October 13, 2017 , ... “America On The Brink”: the ... “America On The Brink” is the creation of published author, William Nowers. Captain ... As a WWII veteran, he spent thirty years in the Navy. Following his ...
(Date:10/12/2017)... ... October 12, 2017 , ... The ... demand of today’s consumer and regulatory authorities worldwide. From Children’s to Adults 50+, ... to meet the highest standard. , These products are also: Gluten Free, ...
Breaking Medicine News(10 mins):
(Date:9/27/2017)... Sept. 27, 2017  DarioHealth Corp. (NASDAQ: DRIO), a leading global digital ... its MyDario product is expected to appear on The Dr. Oz Show ... Oz Show airs in your area: http://www.doctoroz.com/page/where-watch-dr-oz-show ... The nine-time Emmy award-winning, The Dr. Oz Show kicked off ... The segment features ...
(Date:9/23/2017)... -- Janssen Biotech, Inc. (Janssen) announced today that it ... Food and Drug Administration (FDA) for the Biologics License ... of moderately to severely active rheumatoid arthritis (RA). The ... to further evaluate the safety of sirukumab in the ... "We are disappointed by ...
(Date:9/19/2017)... 2017 HistoSonics, Inc., a venture-backed medical device company developing a non-invasive, robotically assisted, ... three leadership team developments today:   ... ... Tom Tefft ... Veteran medical device executive Josh Stopek , PhD, who has ...
Breaking Medicine Technology: