Navigation Links
Finding cancer 'cold spots' can help minimize radiotherapy side-effects
Date:4/30/2010

Fine-tuning radiotherapy to take into account which parts of a patient's tumor are growing fastest could improve control of cancer while subjecting patients to lower doses of radiation, Dutch researchers reported today at the 2nd European Lung Cancer Conference.

"The only problem in radiotherapy is minimizing the side-effects," says lead researcher Dr Christian Siedschlag from the Dutch Cancer Institute. "If one could hit the tumor with arbitrarily high doses without having to worry about complications, all tumor cells could be killed with 100 percent certainty. Unfortunately this is not the case, therefore one must take every chance to administer no more dose than is absolutely necessary."

With this in mind, the Dutch researchers investigated whether some areas in a tumor might not need to be irradiated, thereby decreasing the overall dose and minimizing damage while achieving the same therapeutic effect.

The tool they used to do this is a form of positron emission tomography scanning called FDG PET. PET scans measure the glucose metabolism of a tumor by injecting 'radioactive sugar' and measuring where the radioactivity (and hence the sugar) is absorbed in the body.

Tumors have an increased metabolism compared to normal tissue, which makes them show up well on PET scans. In most cases, lung tumors are visible on PET scans as a bright sphere, with the highest intensity in the middle.

"Sometimes, though, the shape of the tumor on a PET scan is more irregular, for instance donut-shaped with a 'cold spot' in the middle or boomerang-shaped with a 'cold spot' (or 'cold area') on one side," Dr Siedschlag explains. "The underlying question that motivated this study was: can we give less radiation dose to these cold spots? If it turned out that these cold areas show less signal on a PET scan because there are less active tumor cells, then the answer would be yes. However, it could also have been that the radioactive sugar doesn't reach the cold spots for other reasons."

At the ELCC meeting, the group reports preliminary results showing that indeed in most cases the cold spots consist of dead tumor cells. In 7 out of 61 patients they saw cold spots on PET scans. Surgical examination showed that in five cases, these spots were in fact dead cells.

"By decreasing the doses given to the cold spots, one might be able to increase the dose given to the rest of the tumor, while keeping the normal tissue dose constant. Or one could keep the dose given to the rest of the tumor constant, which would lead to less side-effects with an identical therapeutic result."


'/>"/>

Contact: Vanessa Pavinato
media@esmo.org
European Society for Medical Oncology
Source:Eurekalert

Related medicine news :

1. New Finding Could Mark Shift in Alzheimers Research
2. Scientists Report Key Finding in Breast Cancer Research
3. Research findings underscore needed action to safeguard lungs of young cancer survivors
4. Finding Good Migraine Care a Headache for the Uninsured
5. ACS Webinar features tips for finding and building a career in public policy and chemical industry
6. Cosmetic and Plastic Surgery Web Site Announces Improvements to the Patient Process of Finding Cosmetic Doctors in Their Area
7. Cedars-Sinai Heart Institute physicians present findings at ACC scientific meeting
8. Research findings expected to ease treatment of low neutrophil counts in cancer patients
9. MatchMySport.com Aims to Reduce Obesity Levels Through Sports Participation by Finding Sports Partners/Players/Teams
10. UMass Lowell researchers findings suggest new ways to diagnose and treat Alzheimers
11. VARI findings may help patients with deadly kidney cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/22/2017)... ... 22, 2017 , ... A cylindrical “pipeline” used for treating ... reach ones, according to the results of a clinical trial announced Wednesday. , ... Ricardo A. Hanel, MD, PhD, neurovascular surgeon with Baptist Health and Lyerly Neurosurgery ...
(Date:2/22/2017)... ... 22, 2017 , ... Using the power of the internet, IdrisArkette.com has managed ... a period of just 24 months, thousands of individuals interested in a medical procedure ... , “The internet is not getting quieter. In fact it’s becoming noisier by the ...
(Date:2/22/2017)... (PRWEB) , ... February 22, 2017 , ... ... of issues related to spine practices, is featuring Michigan neurosurgeon Jay Jagannathan, M.D., ... as one of a small number of neurosurgeons in Michigan performing minimally invasive ...
(Date:2/22/2017)... ... February 22, 2017 , ... Forty-five ... of those report that family members or friends have also commented about their ... hearing loss wear hearing aids. One reason, suggested by 89 percent of American ...
(Date:2/22/2017)... ... ... Social media marketing is transitioning from a singular person activity to a ... into this insight and more in its latest episode of its Brains Over Brawn ... with social media strategist and partner of the digital firm Med|Ed Digital Jessica Columbo. ...
Breaking Medicine News(10 mins):
(Date:2/22/2017)... Feb. 22, 2017 The Senior Care Pharmacy ... Senate and House of Representatives that will curtail the ... (PBMs) -- from extracting retroactive direct and indirect remuneration ... (LTC) pharmacies and the Medicare program. S. ... (R-WV) and Jon Tester (D-MT), and House ...
(Date:2/22/2017)... DUBLIN , Feb 22, 2017 Research ... Devices Market Analysis & Trends - Industry Forecast to 2025" report ... The ... of around 5.2% over the next decade to reach approximately $2.1 billion ... estimates and forecasts for all the given segments on global as well ...
(Date:2/22/2017)... 2017 Henry Schein Medical today announced ... with Rijuven, which develops innovative digital medical devices, ... practitioners. CardioSleeve is a stethoscope ... sound signals, transmits real-time data to any smartphone ... to help physicians provide diagnostic interpretation of a ...
Breaking Medicine Technology: