Navigation Links
Finding cancer 'cold spots' can help minimize radiotherapy side-effects
Date:4/30/2010

Fine-tuning radiotherapy to take into account which parts of a patient's tumor are growing fastest could improve control of cancer while subjecting patients to lower doses of radiation, Dutch researchers reported today at the 2nd European Lung Cancer Conference.

"The only problem in radiotherapy is minimizing the side-effects," says lead researcher Dr Christian Siedschlag from the Dutch Cancer Institute. "If one could hit the tumor with arbitrarily high doses without having to worry about complications, all tumor cells could be killed with 100 percent certainty. Unfortunately this is not the case, therefore one must take every chance to administer no more dose than is absolutely necessary."

With this in mind, the Dutch researchers investigated whether some areas in a tumor might not need to be irradiated, thereby decreasing the overall dose and minimizing damage while achieving the same therapeutic effect.

The tool they used to do this is a form of positron emission tomography scanning called FDG PET. PET scans measure the glucose metabolism of a tumor by injecting 'radioactive sugar' and measuring where the radioactivity (and hence the sugar) is absorbed in the body.

Tumors have an increased metabolism compared to normal tissue, which makes them show up well on PET scans. In most cases, lung tumors are visible on PET scans as a bright sphere, with the highest intensity in the middle.

"Sometimes, though, the shape of the tumor on a PET scan is more irregular, for instance donut-shaped with a 'cold spot' in the middle or boomerang-shaped with a 'cold spot' (or 'cold area') on one side," Dr Siedschlag explains. "The underlying question that motivated this study was: can we give less radiation dose to these cold spots? If it turned out that these cold areas show less signal on a PET scan because there are less active tumor cells, then the answer would be yes. However, it could also have been that the radioactive sugar doesn't reach the cold spots for other reasons."

At the ELCC meeting, the group reports preliminary results showing that indeed in most cases the cold spots consist of dead tumor cells. In 7 out of 61 patients they saw cold spots on PET scans. Surgical examination showed that in five cases, these spots were in fact dead cells.

"By decreasing the doses given to the cold spots, one might be able to increase the dose given to the rest of the tumor, while keeping the normal tissue dose constant. Or one could keep the dose given to the rest of the tumor constant, which would lead to less side-effects with an identical therapeutic result."


'/>"/>

Contact: Vanessa Pavinato
media@esmo.org
European Society for Medical Oncology
Source:Eurekalert

Related medicine news :

1. New Finding Could Mark Shift in Alzheimers Research
2. Scientists Report Key Finding in Breast Cancer Research
3. Research findings underscore needed action to safeguard lungs of young cancer survivors
4. Finding Good Migraine Care a Headache for the Uninsured
5. ACS Webinar features tips for finding and building a career in public policy and chemical industry
6. Cosmetic and Plastic Surgery Web Site Announces Improvements to the Patient Process of Finding Cosmetic Doctors in Their Area
7. Cedars-Sinai Heart Institute physicians present findings at ACC scientific meeting
8. Research findings expected to ease treatment of low neutrophil counts in cancer patients
9. MatchMySport.com Aims to Reduce Obesity Levels Through Sports Participation by Finding Sports Partners/Players/Teams
10. UMass Lowell researchers findings suggest new ways to diagnose and treat Alzheimers
11. VARI findings may help patients with deadly kidney cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/27/2017)... ... July 27, 2017 , ... Trusted dentist, speaker and ... sleep apnea in Wayne, NJ to receive custom treatment at his practice ... apnea with the use of custom-crafted oral appliances. Highly-trained in using the latest ...
(Date:7/27/2017)... Viejo, CA (PRWEB) , ... July 27, 2017 , ... ... Cut Pro X . This Final Cut Pro X exclusive features transitions that contain ... and add rotation to the transition using intuitive drop-down menus. TransPanel Volume 4 makes ...
(Date:7/27/2017)... ... 2017 , ... SSCI, a division of Albany Molecular Research, ... representing a milestone achievement. , As an industry-leading provider of ... served as expert and fact witnesses to assist our clients to perform infringement ...
(Date:7/27/2017)... ... July 27, 2017 , ... MAP Health Management, ... year’s Fierce Innovation Awards: Healthcare Edition 2017, an awards program from the publisher ... Population Health Management/Patient Engagement Solutions. , MAP was selected as a finalist ...
(Date:7/27/2017)... ... July 27, 2017 , ... ... 2012-2016, will keynote Day 2 of the HIMSS Healthcare Security Forum, the nation’s ... the Sheraton Boston Hotel, Sept. 11-13, 2017. , Daniel will deliver his keynote, ...
Breaking Medicine News(10 mins):
(Date:7/26/2017)... Sancilio Pharmaceuticals Company, Inc. (SPCI) today announced ... Altemia TM , an oral therapy for pediatric patients ... (SCD). The SCOT Trial, is a double-blind, placebo-controlled, dose-finding, ... Altemia TM in pediatric patients aged 5-17 years ... "The completion of ...
(Date:7/24/2017)... IBM (NYSE: IBM ) has been recognized ... Arrays (SSA) for the fourth year in a row. 1 ... "Vendors in the Leaders quadrant have the highest scores for ... in the Leaders quadrant has the market share, credibility, and ... new technologies. These vendors demonstrate a clear understanding of market ...
(Date:7/21/2017)... 21, 2017  Endo International plc (NASDAQ: ... review of its manufacturing network, the Company will be ... in Huntsville, Alabama . The closure ... the next 12 to 18 months. The ... volumes of commoditized products and these restructuring actions are ...
Breaking Medicine Technology: