Navigation Links
Finding brings scientists 1 step closer to Parkinson's drug
Date:6/27/2012

Grand Rapids, Mich. (June 27, 2012) Van Andel Institute announces that researchers at Lund University in Sweden have published a study detailing how Parkinson's disease spreads through the brain. Experiments in rat models uncover a process previously used to explain mad cow disease, in which misfolded proteins travel from sick to healthy cells. This model has never before been identified so clearly in a living organism, and the breakthrough brings researchers one step closer to a disease-modifying drug for Parkinson's.

"Parkinson's is the second most common neurodegenerative disorder after Alzheimer's disease," said Patrik Brundin M.D., Ph.D., Jay Van Andel Endowed Chair in Parkinson's Research at Van Andel Research Institute (VARI), Head of the Neuronal Survival Unit at Lund University and senior author of the study. "A major unmet medical need is a therapy that slows disease progression. We aim to better understand how Parkinson's pathology progresses and thereby uncover novel molecular targets for disease-modifying treatments."

Previous research demonstrates that a misfolded protein known as alpha-synuclein protein gradually appears in healthy young neurons transplanted to the brains of Parkinson's patients. This discovery gave rise to the group's hypothesis of cell-to-cell protein transfer, which has since been demonstrated in laboratory experiments.

In the current study, published this week in the PLoS ONE, researchers for the first time were able to follow events in the recipient cell as it accepts the diseased protein by allowing it to pass its outer cell membrane. The experiments also show how the transferred proteins attract proteins in the host cell leading to abnormal folding or "clumping" inside the cells.

"This is a cellular process likely to lead to the disease process as Parkinson's progresses, and it spreads to an increasing number of brain regions as the patient gets sicker," said Elodie Angot, Ph.D., of Lu
'/>"/>

Contact: Tim Hawkins
tim.hawkins@vai.org
616-234-5519
Van Andel Research Institute
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New findings in breast cancer
2. Kessler Foundation scientists present cognitive research findings at MS dual symposium
3. Researchers present new findings for novel pancreatic cancer vaccine
4. Mayo Clinic urologists present findings at American Urological Association Annual Meeting
5. Finding ways to feed pigs for less
6. Once-Banned Bird Flu Study Yields Sobering Findings
7. Columbus Allergist Dr. Summit Shah Discusses Recent Findings on Food Allergies and Exercise-Induced Anaphylaxis
8. Scientists solving the mystery of human consciousness
9. Scientists uncover multiple faces of deadly breast cancer
10. Scientists identify major source of cells defense against oxidative stress
11. Scientists tailor cell surface targeting system to hit organelle ZIP codes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/30/2014)... Acne is a common problem millions of American cope ... than a daily nuisance, for some, it can have a crippling ... even lead to dramatic mood swings and depression. , Those ... up their skin. In some cases, that can make the problem ... error, those on a quest for clearer skin can now view ...
(Date:8/30/2014)... New York, New York (PRWEB) August 30, 2014 ... and other incretin mimetic claims continue to move forward ... a statement issued by AstraZeneca PLC on July 31, ... have been named in 409 product liability claims that ... cancer. Court documents indicate that many of these claims ...
(Date:8/30/2014)... HealthDay Reporter FRIDAY, Aug. 29, ... on for broken bones or other orthopedic trauma shops around ... Less-educated patients and patients who had used narcotic painkillers ... said study lead author Dr. Brent Morris, a shoulder and ... suggests that doctors aren,t talking to one another about the ...
(Date:8/30/2014)... 30, 2014 "My wife suffered neck, ... car accident," said one of two inventors from Bethel, ... her shoulder and neck area. She tried other pillows ... and pressure, assisting in comfort and providing extra sleep." ... CRADLE to support the head, neck and back comfortably. ...
(Date:8/30/2014)... August 30, 2014 "My niece developed ... that, at any moment, her fever might get worse," ... keep me well aware of how she was doing, ... TEMP ALARM to continuously monitor a child's temperature. The ... fever. This ensures that prompt medical care can be ...
Breaking Medicine News(10 mins):Health News:Acne Treatment Reviews Added to Popular Treatment Website 2Health News:Byetta Lawsuits Move Forward, as Bernstein Liebhard LLP Notes Settlements in More than 80 Cases 2Health News:Byetta Lawsuits Move Forward, as Bernstein Liebhard LLP Notes Settlements in More than 80 Cases 3Health News:'Doctor-Shopping' for Painkillers Common After Broken-Bone Surgery, Study Finds 2Health News:'Doctor-Shopping' for Painkillers Common After Broken-Bone Surgery, Study Finds 3
... , , , ... (Hologic or the Company) (Nasdaq: HOLX ), a ... systems and surgical products dedicated to serving the healthcare needs ... (FDA) cleared the Company,s 510K application for the MammoSite((R)) ML ...
... , NEW YORK, Sept. 5 Reporter Jim ... 5, 2009) Mr. Rutenberg accused me of making false statements, but ... statements are true. Mr. Rutenberg is the one writing falsehoods. ... are not what,s needed. The focus should be on the health ...
... ... of Hissey Kientz, LLP is warning consumers to immediately stop ... prior to a colonoscopy. In December 2008 the Food and Drug Administration ... the FDA’s warnings about the dangers of Phospho-soda and Fleet’s recall of ...
... ... winners of the 2009 research grants. This year,s grantees will explore such important ... opioids enhance migraine pain. , ... (PRWEB) September 5, 2009 -- The Migraine Research Foundation (MRF), the only ...
... WASHINGTON, Sept. 4 The California Nurses ... of Medicine for recommending strong patient safety protections for ... ongoing H1N1/swine flu pandemic--and calls on the Centers for ... , "America,s registered nurses have significant ...
... dual parents for child,s success , SATURDAY, Sept. 5 (HealthDay ... one- or two-parent household -- may help a child succeed ... findings, by an Ohio State University professor, challenge the conventional ... single parent marrying or moving in with a partner may ...
Cached Medicine News:Health News:FDA Clears Hologic's MammoSite(R) ML Radiation Therapy System for the Treatment of Early-Stage Breast Cancer 2Health News:FDA Clears Hologic's MammoSite(R) ML Radiation Therapy System for the Treatment of Early-Stage Breast Cancer 3Health News:FDA Clears Hologic's MammoSite(R) ML Radiation Therapy System for the Treatment of Early-Stage Breast Cancer 4Health News:Betsy McCaughey Addresses New York Times: Charges of Falsehoods But No Evidence 2Health News:Betsy McCaughey Addresses New York Times: Charges of Falsehoods But No Evidence 3Health News:Hissey Kientz LLP Urges Patients To Heed FDA Warning About Phospho-soda Products 2Health News:Hissey Kientz LLP Urges Patients To Heed FDA Warning About Phospho-soda Products 3Health News:Hissey Kientz LLP Urges Patients To Heed FDA Warning About Phospho-soda Products 4Health News:Migraine Research Foundation Announces Winners of 2009 Research Grants 2Health News:Migraine Research Foundation Announces Winners of 2009 Research Grants 3Health News:Migraine Research Foundation Announces Winners of 2009 Research Grants 4Health News:America's Registered Nurses Applaud New Institute of Medicine H1N1/Swine Flu Safety Recommendations -- and Call on CDC to Maintain Stringent Safety Guidelines 2Health News:Single Parents May Do as Well as Two: Study 2
(Date:8/29/2014)... -- Does your doctor know what you,re smoking?  Chances are, ... to the over 112,000 currently registered patients under ... other roughly 20,300+ active physicians listed with the Colorado Dept ... even though a poll in February 2014 showed 51% of ... it. "With marijuana legalization underway, every doctor ...
(Date:8/29/2014)... Md. , Aug. 29, 2014  United Therapeutics ... the U.S. District Court for the District of ... favor in the company,s case against Sandoz, Inc. regarding ... Peter Sheridan ruled that U.S. Patent No. ... and enjoined Sandoz from marketing its generic product until ...
(Date:8/29/2014)... , August 29, 2014 ... Market by Product & Services (Equipment, Reagent, Primer, ... Application (Diagnostics, PCR, QPCR, Gene Synthesis, NGS, DNA, ... MarketsandMarkets, the global Oligonucleotide Synthesis Market is expected ... Million in 2014, growing at a CAGR of ...
Breaking Medicine Technology:Medical Rules Marijuana Sales in Colorado But Most Doctors Still in the Dark 2Medical Rules Marijuana Sales in Colorado But Most Doctors Still in the Dark 3Medical Rules Marijuana Sales in Colorado But Most Doctors Still in the Dark 4District Court Decision Received In Remodulin Patent Case 2Oligonucleotide Synthesis Market Worth $1,712.1 Million by 2019 2Oligonucleotide Synthesis Market Worth $1,712.1 Million by 2019 3Oligonucleotide Synthesis Market Worth $1,712.1 Million by 2019 4
1000 L, Racked, Pre-sterilized, 100 tips/rack Recommended for 500 and 1000 L pipettes....
300 L, Racked, Filtered, Pre-sterilized, 96 tips/rack Recommended for 250 and 300 L pipettes....
Diamond Filter Tips play a critical role in preventing aerosol-borne contamination. Also available sterilized (no need to autoclave) and certified free of detectable RNase, DNase, DNA, RNA, and prote...
... Eliminate aerosol contamination, which ... in PCR. Hydrophobic, nonwicking ... air can pass through ... in contrast to tips ...
Medicine Products: