Navigation Links
Finding antitumor T cells in a patient's own cancer
Date:11/13/2013

Patients with tumors that contain increased numbers of T lymphocytes generally survive longer than those with tumors without T-cell involvement, suggesting that T cells with potent antitumor function naturally exist in cancer and control tumor progression. With the exception of melanoma, it has been difficult to identify and isolate the tumor-reactive T cells from common cancers, however, the ability to do so could be used to fight a patient's own cancer.

In a paper recently published in Clinical Cancer Research, investigators in the lab of Daniel Powell, PhD, at the Perelman School of Medicine, University of Pennsylvania, demonstrated for the first time that a T cell activation molecule can be used as a biomarker to identify rare antitumor T cells in human cancers. The molecule, CD137, is a protein that is not normally found on the surface of resting T cells but its expression is induced when the T cell is activated.

In their work, Powell and colleagues developed a rapid system to accurately isolate these cells directly from human tumor tissue. TILs, short for tumor-infiltrating lymphocytes are white blood cells that have left the bloodstream and migrated into tumor tissue. They took human tumor samples that contained TILs, disrupted them to single cell suspensions, and cultured the mix of tumor cells and TILs overnight. The next morning they selectively captured the TILs that expressed the CD137 molecule.

In a test tube-based experiment, the team showed that the isolated CD137 T cells recognize cancers cells taken from the same patient. The T cells recognize proteins (called antigens, immunologically) presented by the tumor cells as small peptides derived from inside the cell.

After isolating the CD137 cells from other non-reactive TILs and tumor cells, they theoretically could be given back to the patient as a concentrated dose of their own tumor-fighting cells. To model this, the team injected cancer cells in combina
'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Da Vinci Robot Lawsuit News: Bernstein Liebhard LLP Notes FDA Finding that Robotic Surgery Complications Linked to da Vinci Robot Doubled in Past Year
2. Volunteers join scientists in finding out who gets rid of cow dung
3. Patheon to Present Multiple Scientific Findings at AAPS Annual Meeting and Exposition
4. The Khalili Center for Bariatric Care Seconds the Findings of The New England Journal of Medicine: Surgical Skills Are Essential
5. SweatGuru Launches in San Francisco, New York and Los Angeles to Make Finding a Workout Easy
6. Startup Businesses Are Finding Competitive Equipment Leasing and Financing at LeaseQ as Local Banks and Leading Institutions Fail to Support Entrepreneurs
7. Statement from Special Envoy Ray Chambers on the Findings of the WHO Global Tuberculosis Report 2013
8. Just in Time for Halloween—MyClassifiedAds.net Shares Six Successful Tricks to Finding Fruitful Treats Using Newspaper Ads
9. Aging expert Colin Milner addresses United Nations' findings by offering "Nine Principles" for improving society's response to population aging
10. Voices Against Brain Cancer Discusses Recent Finding By Johns Hopkins Researchers Concerning Brain Tumor Treatments
11. Penn Medicine researcher unveils findings on 2 new weapons against thyroid cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Finding antitumor T cells in a patient's own cancer
(Date:4/23/2014)... donors was safe and effective in treating patients ... difficile , according to a new pilot study ... available online. Known as fecal microbiota transplantation, the ... colonoscope or a nasogastric tube. The findings suggest ... readily available to patients. , A growing concern, ...
(Date:4/23/2014)... University researcher is looking to give exercise enthusiasts the ... latest research shows that a cyber buddy can help. ... for Health Journal , is the first to indicate ... motivator during exercise, a software-generated partner also can be ... isn,t real can still motivate people to give greater ...
(Date:4/23/2014)... that targets an important brain receptor has a dramatic ... relapse behavior, a University at Buffalo animal study has ... may be a novel lead compound for treating cocaine ... research was published as an online preview article in ... the compound, RO5263397, severely blunted a broad range of ...
(Date:4/23/2014)... The American Gastroenterological Association (AGA) Research Foundation ... Scholars. The AGA Research Scholar Awards program, launched ... and productive research careers in digestive diseases. This ... additional year allowing for three consecutive years of ... faculty who are paving the way for promising ...
(Date:4/23/2014)... researcher from the Cancer Science Institute of Singapore (CSI ... the cancer specific stem cell which causes gastric cancer. ... drugs for the treatment of this disease and other ... Dr Chan Shing Leng, Research Assistant Professor at CSI ... variant of a cell surface protein, CD44v8-10, marks gastric ...
Breaking Medicine News(10 mins):Health News:Pilot study suggests ways to widen access to fecal transplants for C. diff infections 2Health News:Cyber buddy is better than 'no buddy' 2Health News:Novel compound halts cocaine addiction and relapse behaviors 2Health News:AGA announces 2014 Class of AGA Research Scholars 2Health News:Scientists identify cancer specific cell for potential treatment of gastric cancer 2Health News:Scientists identify cancer specific cell for potential treatment of gastric cancer 3
... Shoulder Patients Benefit from Personalized AttentionDENVER, April 7 ... specialist at Western Orthopaedics, specializes in a spectrum ... technique called shoulder resurfacing to a reversed shoulder ... improves range of motion. According to the American ...
... ZixCorp,s email encryption services DALLAS, April 7 ... the leader in email encryption services, today announced ... signed a three-year contract for the company,s email ... policies to ensure the secure handling of confidential ...
... National Physical Laboratory (NPL) has developed the first sensor ... of bubbles in a liquid when a high frequency ... ensure that their instruments are properly disinfected before they ... annual Outstanding Ultrasonics Product award from the Ultrasonic Industry ...
... CITY, Mo., April 7 ... celebrates World Health Day by changing lives around ... Multimedia News Release, go to: http://www.prnewswire.com/mnr/childreninternational/37664/ (Photo: ... report, 1,735 teens in 11 countries around the ...
... 7 TeamStaff, Inc. (Nasdaq: TSTF ... administrative staffing services, today announced that its government ... has been awarded an Information Technology ("IT") Schedule ... General Services Administration (GSA). The contract is ...
... focus on medical home opportunities, solutions at April 28 ... to center stage in the current political and economic ... the patient and primary care health care provider at ... Washington, DC for a working meeting to advance the ...
Cached Medicine News:Health News:Western Orthopaedics in Denver Blends Innovative Techniques to Provide a Spectrum of Shoulder Care 2Health News:Western Orthopaedics in Denver Blends Innovative Techniques to Provide a Spectrum of Shoulder Care 3Health News:Zix Corporation Selected by Houston Healthcare for Email Encryption Service 2Health News:I'm forever imploding bubbles 2Health News:Photos: Report Shows Youth Health Educators Reach More Poor Teens with a Message of Living Healthy Lives! 2Health News:General Services Administration Awards Information Technology Schedule Contract to TeamStaff's Government Staffing Subsidiary 2Health News:General Services Administration Awards Information Technology Schedule Contract to TeamStaff's Government Staffing Subsidiary 3Health News:Patient-Centered Primary Care Collaborative Stakeholders Convene in Washington, DC for Working Meeting 2Health News:Patient-Centered Primary Care Collaborative Stakeholders Convene in Washington, DC for Working Meeting 3
(Date:1/15/2014)... , Jan. 15, 2014 Reportlinker.com ... is available in its catalogue: ... – Worldwide Analysis http://www.reportlinker.com/p01957812/Insulin-Pump-Market--Forecast-–-Worldwide-Analysis.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Medical_Equipment_and_Supply ... Analysis Insulin Pumps ...
(Date:1/15/2014)... 15, 2014 Reportlinker.com announces that ... available in its catalogue: ... for Advanced Drug Delivery Systems -- ... http://www.reportlinker.com/p01941928/Global-Markets-and-Technologies-for-Advanced-Drug-Delivery-Systems----Focus-on-Routes-of-Administration.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Drug_Delivery_Technology ...
(Date:1/14/2014)... (Nasdaq: LMNX ) today announced that it expects ... Monday, February 3, 2014. A press release announcing the results ... (Logo: http://photos.prnewswire.com/prnh/20100104/LUMINEXLOGO ) Management will ... financial results for the fourth quarter and twelve months ended ...
Breaking Medicine Technology:Insulin Pump Market & Forecast - Worldwide Analysis 2Insulin Pump Market & Forecast - Worldwide Analysis 3Insulin Pump Market & Forecast - Worldwide Analysis 4Insulin Pump Market & Forecast - Worldwide Analysis 5Insulin Pump Market & Forecast - Worldwide Analysis 6Insulin Pump Market & Forecast - Worldwide Analysis 7Insulin Pump Market & Forecast - Worldwide Analysis 8Insulin Pump Market & Forecast - Worldwide Analysis 9Insulin Pump Market & Forecast - Worldwide Analysis 10Insulin Pump Market & Forecast - Worldwide Analysis 11Insulin Pump Market & Forecast - Worldwide Analysis 12Insulin Pump Market & Forecast - Worldwide Analysis 13Insulin Pump Market & Forecast - Worldwide Analysis 14Insulin Pump Market & Forecast - Worldwide Analysis 15Insulin Pump Market & Forecast - Worldwide Analysis 16Insulin Pump Market & Forecast - Worldwide Analysis 17Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 2Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 3Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 4Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 5Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 6Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 7Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 8Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 9Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 10Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 11Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 12Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 13Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 14Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 15Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 16Luminex Corporation Fourth Quarter Earnings Release Scheduled for February 3, 2014 2Luminex Corporation Fourth Quarter Earnings Release Scheduled for February 3, 2014 3
... Scotland, and BEDMINSTER, N.J., June 22, 2011 ... Kyowa Hakko Kirin Co. Ltd., and an international specialty ... from the U.S. Food and Drug Administration (FDA) for ... moderate to severe pain associated with chronic anal fissures. ...
... Ambrx Inc. today announced that Ho Cho, Ph.D., the ... the company,s antibody drug conjugate (ADC) programs at five ... from recent xenograft studies comparing Ambrx ADCs with those ... has been clinically validated as safe and efficacious for ...
Cached Medicine Technology:ProStrakan Receives FDA Approval for Rectiv™ for the Treatment of Moderate to Severe Pain Associated With Chronic Anal Fissures 2ProStrakan Receives FDA Approval for Rectiv™ for the Treatment of Moderate to Severe Pain Associated With Chronic Anal Fissures 3Ambrx to Present Data from Antibody Drug Conjugate Program at Upcoming Scientific Conferences 2
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: