Navigation Links
Finding antitumor T cells in a patient's own cancer
Date:11/13/2013

Patients with tumors that contain increased numbers of T lymphocytes generally survive longer than those with tumors without T-cell involvement, suggesting that T cells with potent antitumor function naturally exist in cancer and control tumor progression. With the exception of melanoma, it has been difficult to identify and isolate the tumor-reactive T cells from common cancers, however, the ability to do so could be used to fight a patient's own cancer.

In a paper recently published in Clinical Cancer Research, investigators in the lab of Daniel Powell, PhD, at the Perelman School of Medicine, University of Pennsylvania, demonstrated for the first time that a T cell activation molecule can be used as a biomarker to identify rare antitumor T cells in human cancers. The molecule, CD137, is a protein that is not normally found on the surface of resting T cells but its expression is induced when the T cell is activated.

In their work, Powell and colleagues developed a rapid system to accurately isolate these cells directly from human tumor tissue. TILs, short for tumor-infiltrating lymphocytes are white blood cells that have left the bloodstream and migrated into tumor tissue. They took human tumor samples that contained TILs, disrupted them to single cell suspensions, and cultured the mix of tumor cells and TILs overnight. The next morning they selectively captured the TILs that expressed the CD137 molecule.

In a test tube-based experiment, the team showed that the isolated CD137 T cells recognize cancers cells taken from the same patient. The T cells recognize proteins (called antigens, immunologically) presented by the tumor cells as small peptides derived from inside the cell.

After isolating the CD137 cells from other non-reactive TILs and tumor cells, they theoretically could be given back to the patient as a concentrated dose of their own tumor-fighting cells. To model this, the team injected cancer cells in combination with the CD137 TILs into immune-deficient mice. The CD137 TILs actively controlled tumor progression, while TILs that did not express CD137 from the same patient had no impact on tumor growth.

Giving large numbers of patients' tumor-reactive T cells back to the same patient can lead to cancer eradication in melanoma, but investigators have had a hard time doing the same for other cancers. However, Powell and colleagues showed that their new approach can be used in a variety of cancers, including melanoma and ovarian cancer, which suggests this promising therapy can now be widely applied.

This field has a growing enthusiasm for T-cell therapy, says Powell. The initial findings are encouraging and have produced additional questions to be answered: How do CD137 cells control tumor growth? In what other cancers do similar tumor-reactive T cells exist? How can we identify, expand, and use them? How can we use this new knowledge to shorten the time to make TILs for clinical trials? Powell and colleagues are working diligently to address these questions and move the current approach forward.


'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert  

Related medicine news :

1. Da Vinci Robot Lawsuit News: Bernstein Liebhard LLP Notes FDA Finding that Robotic Surgery Complications Linked to da Vinci Robot Doubled in Past Year
2. Volunteers join scientists in finding out who gets rid of cow dung
3. Patheon to Present Multiple Scientific Findings at AAPS Annual Meeting and Exposition
4. The Khalili Center for Bariatric Care Seconds the Findings of The New England Journal of Medicine: Surgical Skills Are Essential
5. SweatGuru Launches in San Francisco, New York and Los Angeles to Make Finding a Workout Easy
6. Startup Businesses Are Finding Competitive Equipment Leasing and Financing at LeaseQ as Local Banks and Leading Institutions Fail to Support Entrepreneurs
7. Statement from Special Envoy Ray Chambers on the Findings of the WHO Global Tuberculosis Report 2013
8. Just in Time for Halloween—MyClassifiedAds.net Shares Six Successful Tricks to Finding Fruitful Treats Using Newspaper Ads
9. Aging expert Colin Milner addresses United Nations' findings by offering "Nine Principles" for improving society's response to population aging
10. Voices Against Brain Cancer Discusses Recent Finding By Johns Hopkins Researchers Concerning Brain Tumor Treatments
11. Penn Medicine researcher unveils findings on 2 new weapons against thyroid cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Finding antitumor T cells in a patient's own cancer
(Date:3/25/2017)... , ... March 25, 2017 , ... Getting earned media ... public relations partner. , All through the year, Garden Media aims to provide ... working with key influencers and pitching client’s key messages to gain coveted ...
(Date:3/24/2017)... ... March 24, 2017 , ... Infectious disease ... hospitals in the United States, it’s a threat that is constantly changing and ... infection prevention and offers strategies for the healthcare community to help decrease the ...
(Date:3/24/2017)... (PRWEB) , ... March 24, 2017 , ... The iaedp ... and other medical professionals caring for those suffering from the full spectrum of disordered ... 800, as eating disorders professionals from nearly all 50 states and several countries converged ...
(Date:3/24/2017)... ... 24, 2017 , ... Northridge dentists, Dr. Michel ... sleep apnea and TMJ at their office. TMJ, or temporomandibular joint disorder, has ... type, is increasingly being treated at dental offices with newly developed procedures and ...
(Date:3/24/2017)... ... March 24, 2017 , ... ... of enhancements, upgrading their training and leads programs. , In February, 2017, Empower ... elite sales agents, Performance Partners is designed to teach how to maximize their ...
Breaking Medicine News(10 mins):
(Date:3/24/2017)... FinancialBuzz.com News Commentary   ... Medical cannabis products around the world are projected to gain popularity. A ... market will reach a value of USD 55.8 billion by 2025. ... growing industry. By the end of 2016, 28 states have now laws ... conservative states like Arkansas and North ...
(Date:3/24/2017)... -- Global Ampoules Market report provides a ... and industry chain structure. The Ampoules market analysis is ... landscape analysis, and major regions, development status. ... Complete ... 10 company profiles and 183 tables and figures is ...
(Date:3/24/2017)... , March 24, 2017  Eli Lilly and ... plans to invest $850 million in its U.S. ... across its U.S. enterprise, including research laboratories, manufacturing ... are being driven by demand for Lilly products, ... medicines in development targeting cancer, pain, diabetes and ...
Breaking Medicine Technology: