Navigation Links
Finding Points to Possible Blood Test for Brain Tumors
Date:11/17/2008

brain. When Skog analyzed the protein and RNA content of these microvesicles (also called exosomes) in the blood samples of glioblastoma patients, he found that he could obtain a sort of molecular snapshot of the tumor.

"By analyzing the RNA in these serum exosomes, we could determine the mutational profile in the tumor without doing a biopsy," explained Skog. "So, this is an enabling technology to look at what's going on inside the tumor at a given moment."

Like all cancers, glioblastoma cells often contain dozens of mutations. One of these, called EGFRvIII, is a mutation in the gene for a growth factor receptor called EGFR. Skog first screened 30 glioblastoma biopsies for the presence of EGFRvIII; he found it in 14 samples. When he examined blood samples from the same patients, he was able to detect the mutation in 7 samples, including two corresponding to biopsy samples that had come back negative for EGFRvIII.

That particular observation made quite an impression on Fisher. "They were really good at showing that a lot of the tumors that expressed [EGFRvIII], they were able to find it in these microvesicles in the blood, and you go, 'wow'," he said. "And then, even on top of that, they found a few tumors where they weren't able to find it, but we know that EGFRvIII is very specific to glioblastoma in a patient like this, and they were able to find it in the blood but not in the tumor, and you go, 'Hot darn, that's just incredible'."

It may therefore one day be possible to test blood samples from glioblastoma patients to monitor patient progress, check for recurrence, and make individualized treatment decisions. For instance, said Breakefield, one current chemotherapeutic is a monoclonal antibody that specifically targets the EGFRvIII mutation. "Obviously, those people would respond better to this if they had that mutation," she said.

More remotely, it may one day be possible to run early screens for the occurr
'/>"/>

Copyright©2008 ScoutNews,LLC.
All rights reserved  

Page: 1 2 3 4

Related medicine news :

1. First Family Will Have Tough Time Finding Hypoallergenic Dog
2. Best Practice Database Provides Key Findings for Biopharma Product Launch Evaluation
3. Medicaid Health Plans of America Congratulates President-Elect Barack Obama on His Historic Victory and Pledges Its Full Cooperation on Finding Solutions to the Nations Health Care Challenges
4. Tibotec presents interim findings for TMC435, an investigational genotype 1 hepatitis C treatment
5. NABP Findings Underscore Dangers of Purchasing Prescription Medicine Online and From Foreign Sources
6. New National Public Opinion Survey Reveals Important Findings on Oral Health Care Perceptions
7. LegalView Reintroduces its Medical Malpractice Information Portal with Updated Links to Finding Immediate Legal Assistance
8. New findings may improve treatment of inherited breast cancer
9. Curemark CEO Presents Autism Findings at Prestigious Neurobiology Conference at Oxford
10. Post-marketing studies finding adverse events in drugs used in children
11. Endoscopic ultrasound highly accurate in evaluating ambiguous radiographic findings of the pancreas
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Finding Points to Possible Blood Test for Brain Tumors
(Date:4/1/2015)... 01, 2015 eMindful , the ... of its executive team with the addition of veteran ... , In his new role, Suissa is ... interface across the business and consumer portals. He also ... the company’s online community. His hiring was a ...
(Date:4/1/2015)... April 01, 2015 When annoying or ... waiting days or weeks for an appointment with a ... and next day appointments haven’t been possible within dermatology. ... Dermatology’s offices have noticed demand for this level of ... realize how important relief or answers to dermatological issues ...
(Date:4/1/2015)... (PRWEB) April 01, 2015 EB ... Practice, Pediatric Emergency Medicine Practice, and Hospital Medicine ... partnered with AgileMD to provide the content from ... in a mobile application format available on iPhones, ... “Our collaboration with AgileMD to develop mobile applications ...
(Date:4/1/2015)... 2015 On May 1, 2015, the ... Educational Institute in Albany, New York . This year’s ... nursing and feature an address by Helen R. Connors, PhD, ... University of Kansas School of Nursing and Center for Healthcare ... sponsored by the Excelsior College School of Nursing, Kinsinger ...
(Date:4/1/2015)... 2015 It is the meat that has ... now found wrapped around other foods, infused into cocktails and ... meat candy, the gateway meat for vegetarians and the perfect ... North American Meat Institute (NAMI) has developed a new ... of a bacon processing plant and companion brochure ...
Breaking Medicine News(10 mins):Health News:Addressing The Growing Demand for Interactive, Internet Mindfulness Programs, eMindful Expands Leadership Team With Top Digital Marketing Executive 2Health News:Addressing The Growing Demand for Interactive, Internet Mindfulness Programs, eMindful Expands Leadership Team With Top Digital Marketing Executive 3Health News:Dermatology Associates of Wisconsin and Forefront Dermatology Answers Patients' Needs With Unmatched Availability In Sheboygan and Sheboygan Falls 2Health News:EB Medicine Partners With AgileMD on Mobile Application for Emergency Medicine Clinicians 2Health News:EB Medicine Partners With AgileMD on Mobile Application for Emergency Medicine Clinicians 3Health News:Excelsior College School of Nursing Educational Institute to Influence Nursing Empowerment 2Health News:Excelsior College School of Nursing Educational Institute to Influence Nursing Empowerment 3Health News:New Ultimate Guide to Bacon Video Provides Inside Look at How Bacon is Made 2
... a chronic disease – myositis -- will speak to congressional ... of the staff// hearing them on this day – designated ... with this little-known and poorly understood disease. Internationally-known male model ... close personal friend, who is prominent in Europe and has ...
... the Mayo Clinic has found that injecting an anesthetic at ... ,Men with abnormal digital rectal exams or elevated prostate-specific antigen ... prostate biopsies done. ,Nearly 16% pf the patients suffer a ... to a new study presented at the annual meeting of ...
... a new study at the Mayo Clinic, there is a ... bilateral ovariectomy ; surgical removal of both// ovaries, and not ... be published in the October 1 issue of The Lancet ... increase in death rates due to all causes in this ...
... that in addition to previously known symptoms of fatigue, ... older adults, there// also exists a relationship between ... supports the notion that mild anemia may be an ... adults," says Paulo Chaves, M.D., P.h.D., an assistant professor ...
... will soon get calorie-rich and varied midday meals.// ... state were being served 'khichdi' six times a week and ... menu drab. ,"Now the government has chalked out ... and even an occasional serving of dry fruit," said B.M. ...
... by JIPMER employees continues into the eighth day today, but ... up for duty. The employees are protesting// against the decision ... ,The striking employees said that the Cabinet must ... temporary paramedical staff to tide over the crisis. JIPMER Director ...
Cached Medicine News:Health News:Ovary removal linked with Early Death in Younger Women 2Health News:Ovary removal linked with Early Death in Younger Women 3Health News:Anemia Affects Both Body and Mind 2
(Date:4/1/2015)... April 1, 2015 International Isotopes Inc. (OTCQB: ... year ended December 31, 2014.  The Company reports a ... loss, and positive cash flow for the year ended ... in 2014 was approximately $7.5 million compared to approximately ... approximately 10%.  With the exception of the radiological services ...
(Date:4/1/2015)... , April 1, 2015 ... Report on Global Azithromycin Industry and 2015 ... Industry reports added to Pharmaceutical category in ... the report introduces Azithromycin basic information, including ... overview, policy analysis, and news analysis, etc. ...
(Date:4/1/2015)... -- Oramed Pharmaceuticals Inc. (NASDAQ: ORMP ... on the development of oral drug delivery systems, announced ... Glucose Clamp Study. The study will be performed at ... San Antonio and University Health System,s ... Ralph DeFronzo . The glucose clamp is ...
Breaking Medicine Technology:International Isotopes Inc. Announces 2014 Year End Financial Results 2International Isotopes Inc. Announces 2014 Year End Financial Results 3International Isotopes Inc. Announces 2014 Year End Financial Results 4International Isotopes Inc. Announces 2014 Year End Financial Results 5International Isotopes Inc. Announces 2014 Year End Financial Results 6International Isotopes Inc. Announces 2014 Year End Financial Results 7Azithromycin Market & Polypeptide Drug Industry - Global Research Reports 2Azithromycin Market & Polypeptide Drug Industry - Global Research Reports 3Azithromycin Market & Polypeptide Drug Industry - Global Research Reports 4Azithromycin Market & Polypeptide Drug Industry - Global Research Reports 5Oramed Enrolls First Patient in its Glucose Clamp Study for Oral Insulin 2Oramed Enrolls First Patient in its Glucose Clamp Study for Oral Insulin 3
... YORK, July 19, 2011 Reportlinker.com announces ... available in its catalogue: ... http://www.reportlinker.com/p0574348/European-Medical-Displays-Markets.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Medical_Imaging This research ... market in terms of the challenges faced ...
... drug companies face a number of obstacles to commercialize ... (FDA) and GMP compliance, to distribution agreements and the ... must be coordinated.  Those issues have just become easier ... VPCI have entered into a joint association.  The collaboration ...
Cached Medicine Technology:European Medical Displays Markets 2European Medical Displays Markets 3European Medical Displays Markets 4Spanish Drug Companies Have New Support Option for the U.S. Market 2
... insertion of Alcon Acrylic, Chiron/Iolab LI-41 and Pharmacia ... are taller and thinner, maximizing the surface area ... migration during loading and insertion, and makes it ... folded lens optic. The special direct-acting jaws release ...
Autoref / Ker N vision K 5001 has auto fogging, wide view window, near vision reading. Clear 5.6 Inch color monitor. Data screen function. SE Value display function. Quick printer with automatic cutt...
KR-8000 Supra is capable of obtaining perfectly accurate keratometry and/or refraction measurements through pupils as narrow as 2.0 mm....
... the child-friendly, portable autorefractor that tests ... It can perform objective refraction from ... away even through glasses and contact ... sounds engage the patient throughout the ...
Medicine Products: