Navigation Links
Finding May Lead to Vaccine for Traveler's Diarrhea

Researchers discover key clues to bacteria's structure,,,,

WEDNESDAY, June 10 (HealthDay News) -- Montezuma's revenge, also known as traveler's diarrhea, can ruin a vacation.

Now, researchers have figured out how the bacteria responsible for the illness -- enterotoxigenic Escherichia coli, or ETEC -- are able to make you so miserable.

The bacteria use surface "pili" or "fimbriae" to attach, or bind, to the intestinal epithelia of the host. These fibers, which are needed for ETEC infection to take place in the intestines, exit the bacterium through a pore on the bacterial surface, the researchers explained in a news release from the Boston University School of Medicine.

"Atomic resolution detail of the proteins in the fibers and analysis of genetic variability among different clinical strains were combined to show that each bacterial strain presents a different outer surface of the major protein while preserving the protein components that are buried within the fiber," the study's senior author, Esther Bullitt, an associate professor in the department of physiology and biophysics at Boston University School of Medicine, said in the news release.

"Because of this, the antibodies produced against ETEC during one episode of infection are often not protective against later infections by other strains," she added.

Developing a cross-protective vaccine will require a strategy that focuses on use of the tip protein as an antigen, according to the study, which is published in this week's issue of the Proceedings of the National Academy of Sciences.

"The structural findings reported here have bearing on research to help guide vaccine development," the researchers said in the news release.

ETEC bacteria cause the largest number of community-acquired cases of childhood diarrhea in the developing world and are the most common culprit in traveler's diarrhea, according to the World Health Organization.

ETEC bacteria are transmitted by food or water contaminated with animal or human feces. Infection occurs when a person eats food or drinks water or ice contaminated with ETEC bacteria.

Infection with ETEC can cause profuse watery diarrhea and abdominal cramping. Fever, nausea with or without vomiting, chills, loss of appetite, headache, muscle aches and bloating can also occur but are less common.

The illness develops one to three days after exposure and usually lasts three to four days, although some infections last more than a week, but it is rarely life-threatening.

More information

The U.S. Centers for Disease Control and Prevention has more on enterotoxigenic Escherichia coli.

-- Jennifer Thomas

SOURCE: Boston University School of Medicine, news release, June 8, 2009

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Many Parents Share Genetic Test Findings With Kids
2. New Alzheimers findings: High stress and genetic risk factor lead to increased memory decline
3. New MRI finding sheds light on multiple sclerosis disease progressio
4. High and mighty: first common height gene identified by researchers behind obesity gene finding
5. Scientists, physicians present latest findings in personalized cancer treatment and prevention
6. Health psychologists discuss latest research findings
7. Incidental findings found when radiologists take a broader look at renal MRA
8. First significant genetic finding in severe PMS, or PMDD
9. Chair of U.S. Preventive Services Task Force Pledges to Recommend Re-evaluation of Recent Glaucoma Findings
10. The Organic Trade Association Hails Preliminary Research Findings Showing Nutritional Benefits of Organic Products
11. Key findings for all veterans seen in depression and suicide study
Post Your Comments:
Related Image:
Finding May Lead to Vaccine for Traveler's Diarrhea
(Date:11/24/2015)... , ... November 24, 2015 , ... DMG Productions announced ... Begley Jr., airing first quarter 2016 via Discovery Channel. Dates and show times TBA. ... Province, and is in the business of producing and supplying medical marijuana pursuant to ...
(Date:11/24/2015)... (PRWEB) , ... November 24, 2015 , ... ... LENR HHT Bolier Reactor System. Brillouin is the developer of renewable energy technologies ... low energy nuclear reactions (“LENR”), announced today that its WET™ and HHT™ Boiler ...
(Date:11/24/2015)... ... 2015 , ... American Family Care (AFC), the nation’s leading provider of urgent ... located in Metro Atlanta’s North Point Mall. The clinic is designed to test the ... is scheduled to operate through Dec. 24. , Holiday Pop-Up Clinic , Official Opening ...
(Date:11/24/2015)... ... November 24, 2015 , ... ... been designated an Aetna Institute of Quality® Bariatric Surgery Facility for treating individuals ... and cost of health care services available to its members to help them ...
(Date:11/24/2015)... ... ... Bibliomotion is thrilled to announce the launch of UNCONVENTIONAL LEADERSHIP: ... Nancy M. Schlichting, Chief Executive Officer of Henry Ford Health System (November 24, ... patients and their families, shaped my desire to improve the system of care. I ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)... , Nov. 25, 2015 Research and ... the "Membranes Market - Global Forecast to 2020" ... Asia-Pacific , accounting for 37.21% of the total ... Asia-Pacific region is projected to growth ... growth has been attributed primarily to the fast growing ...
(Date:11/25/2015)... 2015 --> ... Lizenz für das Patent über eine neue Hepatitis-B-Behandlung, welches ... innehaben, an Enyo Pharma vergeben haben. Im ... gerufenen und von Edelris gemeinsam mit seinen Partnern Inserm ... für HBV identifiziert, und es wurden neue Inhaltsstoffe entdeckt, ...
(Date:11/25/2015)... DUBLIN , November 25, 2015 ... has announced the addition of the  ... 2015-2019"  report to their offering.  ... announced the addition of the  "Global ...  report to their offering.  ...
Breaking Medicine Technology: