Navigation Links
Finding May Lead to Vaccine for Traveler's Diarrhea
Date:6/10/2009

Researchers discover key clues to bacteria's structure,,,,

WEDNESDAY, June 10 (HealthDay News) -- Montezuma's revenge, also known as traveler's diarrhea, can ruin a vacation.

Now, researchers have figured out how the bacteria responsible for the illness -- enterotoxigenic Escherichia coli, or ETEC -- are able to make you so miserable.

The bacteria use surface "pili" or "fimbriae" to attach, or bind, to the intestinal epithelia of the host. These fibers, which are needed for ETEC infection to take place in the intestines, exit the bacterium through a pore on the bacterial surface, the researchers explained in a news release from the Boston University School of Medicine.

"Atomic resolution detail of the proteins in the fibers and analysis of genetic variability among different clinical strains were combined to show that each bacterial strain presents a different outer surface of the major protein while preserving the protein components that are buried within the fiber," the study's senior author, Esther Bullitt, an associate professor in the department of physiology and biophysics at Boston University School of Medicine, said in the news release.

"Because of this, the antibodies produced against ETEC during one episode of infection are often not protective against later infections by other strains," she added.

Developing a cross-protective vaccine will require a strategy that focuses on use of the tip protein as an antigen, according to the study, which is published in this week's issue of the Proceedings of the National Academy of Sciences.

"The structural findings reported here have bearing on research to help guide vaccine development," the researchers said in the news release.

ETEC bacteria cause the largest number of community-acquired cases of childhood diarrhea in the developing world and are the most common culprit in traveler's diarrhea, according to the World Health Organization.

ETEC bacteria are transmitted by food or water contaminated with animal or human feces. Infection occurs when a person eats food or drinks water or ice contaminated with ETEC bacteria.

Infection with ETEC can cause profuse watery diarrhea and abdominal cramping. Fever, nausea with or without vomiting, chills, loss of appetite, headache, muscle aches and bloating can also occur but are less common.

The illness develops one to three days after exposure and usually lasts three to four days, although some infections last more than a week, but it is rarely life-threatening.

More information

The U.S. Centers for Disease Control and Prevention has more on enterotoxigenic Escherichia coli.



-- Jennifer Thomas



SOURCE: Boston University School of Medicine, news release, June 8, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Many Parents Share Genetic Test Findings With Kids
2. New Alzheimers findings: High stress and genetic risk factor lead to increased memory decline
3. New MRI finding sheds light on multiple sclerosis disease progressio
4. High and mighty: first common height gene identified by researchers behind obesity gene finding
5. Scientists, physicians present latest findings in personalized cancer treatment and prevention
6. Health psychologists discuss latest research findings
7. Incidental findings found when radiologists take a broader look at renal MRA
8. First significant genetic finding in severe PMS, or PMDD
9. Chair of U.S. Preventive Services Task Force Pledges to Recommend Re-evaluation of Recent Glaucoma Findings
10. The Organic Trade Association Hails Preliminary Research Findings Showing Nutritional Benefits of Organic Products
11. Key findings for all veterans seen in depression and suicide study
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Finding May Lead to Vaccine for Traveler's Diarrhea
(Date:3/28/2017)... ... ... Usually, the impending arrival of warmer weather means the gleeful banishment of ... chin, this means more anxiety than elation. The cosmetic dermatology experts at Cosmetic Laser ... chin is undesirable,” Dr. Goldman said, “but it seems doubly so when the fat ...
(Date:3/28/2017)... ... March 28, 2017 , ... ... release of two biometric time and attendance tracking products: the new NCheck Cloud ... NCheck Cloud Bio Attendance uses biometric face recognition to enable users to check ...
(Date:3/28/2017)... ... ... Columbus OH. Dr. Justin Harper, Founder of Juvly Aesthetics in Ohio and New ... sit on the 2017 National Advisory Board for Allergan’s Facial Aesthetics National Advisory Board., ... the clinic from a small start-up to number 78 in the country based on ...
(Date:3/28/2017)... ... March 28, 2017 , ... The Lice ... Atlantic City March 13-16, was a busy spot this year. Liz Solovay and ... strategies for preventing outbreaks among camp communities during the upcoming 2017 camping season. ...
(Date:3/28/2017)... ... March 28, 2017 , ... Nurse practitioners ... as their value increases in the healthcare workforce, according to a survey recently ... boards, career fairs, and candidate leads to healthcare employers of physicians and advanced ...
Breaking Medicine News(10 mins):
(Date:3/28/2017)... Israel , March 28, 2017 Emosis ... This new business entity, Emosis Ltd, headquartered in Tel ... of novel assays complementing the mother company existing technology platform and ... and sales development of Emosis kits. ... This strategic move starts building Emosis international footprint. ...
(Date:3/28/2017)... 2017  AcelRx Pharmaceuticals, Inc. (Nasdaq: ACRX), a ... commercialization of innovative therapies for the treatment of ... Agency (EMA) has notified the company that the ... Application (MAA) has passed validation, and that the ... MAA for ARX-04 (known as DSUVIA™ in the ...
(Date:3/28/2017)... Mass. , March 28, 2017 ... company developing innovative therapeutics that address significant unmet ... a patent from the Japan Patent Office (JPO) ... connective tissue growth factor (CTGF) for the treatment ... limited to skin fibrosis and proliferative retinopathy (Japanese ...
Breaking Medicine Technology: