Navigation Links
Finding May Lead to Vaccine for Traveler's Diarrhea
Date:6/10/2009

Researchers discover key clues to bacteria's structure,,,,

WEDNESDAY, June 10 (HealthDay News) -- Montezuma's revenge, also known as traveler's diarrhea, can ruin a vacation.

Now, researchers have figured out how the bacteria responsible for the illness -- enterotoxigenic Escherichia coli, or ETEC -- are able to make you so miserable.

The bacteria use surface "pili" or "fimbriae" to attach, or bind, to the intestinal epithelia of the host. These fibers, which are needed for ETEC infection to take place in the intestines, exit the bacterium through a pore on the bacterial surface, the researchers explained in a news release from the Boston University School of Medicine.

"Atomic resolution detail of the proteins in the fibers and analysis of genetic variability among different clinical strains were combined to show that each bacterial strain presents a different outer surface of the major protein while preserving the protein components that are buried within the fiber," the study's senior author, Esther Bullitt, an associate professor in the department of physiology and biophysics at Boston University School of Medicine, said in the news release.

"Because of this, the antibodies produced against ETEC during one episode of infection are often not protective against later infections by other strains," she added.

Developing a cross-protective vaccine will require a strategy that focuses on use of the tip protein as an antigen, according to the study, which is published in this week's issue of the Proceedings of the National Academy of Sciences.

"The structural findings reported here have bearing on research to help guide vaccine development," the researchers said in the news release.

ETEC bacteria cause the largest number of community-acquired cases of childhood diarrhea in the developing world and are the most common culprit in traveler's diarrhea, according to the World Health Organization.

ETEC bacteria are transmitted by food or water contaminated with animal or human feces. Infection occurs when a person eats food or drinks water or ice contaminated with ETEC bacteria.

Infection with ETEC can cause profuse watery diarrhea and abdominal cramping. Fever, nausea with or without vomiting, chills, loss of appetite, headache, muscle aches and bloating can also occur but are less common.

The illness develops one to three days after exposure and usually lasts three to four days, although some infections last more than a week, but it is rarely life-threatening.

More information

The U.S. Centers for Disease Control and Prevention has more on enterotoxigenic Escherichia coli.



-- Jennifer Thomas



SOURCE: Boston University School of Medicine, news release, June 8, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Many Parents Share Genetic Test Findings With Kids
2. New Alzheimers findings: High stress and genetic risk factor lead to increased memory decline
3. New MRI finding sheds light on multiple sclerosis disease progressio
4. High and mighty: first common height gene identified by researchers behind obesity gene finding
5. Scientists, physicians present latest findings in personalized cancer treatment and prevention
6. Health psychologists discuss latest research findings
7. Incidental findings found when radiologists take a broader look at renal MRA
8. First significant genetic finding in severe PMS, or PMDD
9. Chair of U.S. Preventive Services Task Force Pledges to Recommend Re-evaluation of Recent Glaucoma Findings
10. The Organic Trade Association Hails Preliminary Research Findings Showing Nutritional Benefits of Organic Products
11. Key findings for all veterans seen in depression and suicide study
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Finding May Lead to Vaccine for Traveler's Diarrhea
(Date:7/24/2017)... TX (PRWEB) , ... July 24, 2017 , ... ... student scholarship will be awarded for the fall semester to a deserving student. ... Emergency Centers Spring 2017 scholarship was awarded to Mariana Castillo who is a nursing ...
(Date:7/24/2017)... ... 2017 , ... BayMark Health Services has been awarded four ... State Targeted Response to the Opioid Crisis program. The funding, awarded by ... of a hub and spoke model for opioid treatment in California. The federal ...
(Date:7/24/2017)... ... July 24, 2017 , ... A four alarm ... construction site and threatened numerous homes and businesses nearby, causing some 700 individuals ... NBCLosAngeles.com. Los Angeles Area consulting firm Fire Protection Group, Inc. notes that the ...
(Date:7/24/2017)... ... July 24, 2017 , ... The International Essential Tremor Foundation (IETF) will host ... tremor (ET). The seminar will take place on Saturday, Aug. 26 at the Embassy ... program will run from 9 a.m. to 12 p.m., with check-in beginning at 8 ...
(Date:7/24/2017)... ... July 24, 2017 , ... Axiad IDS , a leading provider ... partnered with WALLIX to expand its solution to help government contractors more ... a number of ways to address the authentication requirements within NIST SP800-171, but ...
Breaking Medicine News(10 mins):
(Date:7/15/2017)... Enterin Inc., a Philadelphia -based biotechnology company ... the completion of a $12.7 million Series A financing round. ... as the participation of existing investors. ... of New Ventures III and our current investors, and view ... of our platform technology to transform the course of PD ...
(Date:7/13/2017)... , July 13, 2017  New York City-based market research ... markets should be aware of.  From new products to new ... detailed in a recently completed study, Potential Pipeline Disruptors ... 1.  Age-Driven Growth - True ... been aware of the impact the growing population and, to ...
(Date:7/11/2017)... Md. , July 11, 2017  The global ... estimated revenues of approximately $394.1 million in 2016.  Although ... trend of solid growth, in particular as a result ... clinical practice, and the recent introduction of a significant ... need for less-invasive testing of tumor biomarkers to guide ...
Breaking Medicine Technology: