Navigation Links
Finding May Lead to New Drugs for Urinary Infections
Date:2/20/2009

Researchers seek way to destroy bad, not good, E. coli,,

FRIDAY, Feb. 20 (HealthDay News) -- Potential targets for new drugs to fight the bacteria that cause many urinary tract infections have been identified by U.S. researchers.

Two molecules called yersiniabactin and salmochelin enable E. coli to steal iron from their hosts, which makes it easier for the bacteria to survive and reproduce. Identifying the two molecules -- called siderophores -- could help lead to the development of antibiotics that target pathogenic E. coli strains without harming beneficial bacteria in the gut.

The findings appear in the Feb. 20 issue of PLoS Pathogens.

"When we treat an infection with antibiotics, it's like dropping a bomb -- nearly everything gets wiped out, regardless of whether it's helpful or harmful. We'd like to find ways to target the bad bacteria and leave the good bacteria alone, and these siderophores are a great lead in that direction," study author Jeff Henderson, of the Center for Women's Infectious Disease Research at Washington University School of Medicine in St. Louis, said in a Public Library of Science news release.

The E. coli bacteria that cause urinary tract infections might come from the human gut, where several strains of the bacteria reside. But it's believed that other strains help aid digestion and block other infectious organisms.

For their study, Henderson and his colleagues used a method called metabolomics to study the differences between disease-causing and friendly E. coli strains. Metabolomics involves analyzing all the chemicals produced by a cell, including growth signals, toxins and waste products.

"This allows us to look at the end products of many genes working together," senior study author Scott Hultgren explained in the news release. "We assess what all the various assembly lines are producing and which products disease-causing bacteria prefer to make, such as certain siderophores."

Drugs that block or disrupt the activity of the proteins that make siderophores could be one way to fight disease-causing bacteria. Another approach is what the researchers call a "Trojan horse" strategy.

"To steal iron, siderophores have to be sent out from the cell, bind to the iron and then be taken back into the cell," Henderson said. "If we can design an antibiotic that looks like a siderophore, we might be able to trick only disease-causing bacteria into taking up the drug while leaving other bacteria alone."

More information

The U.S. National Institute of Diabetes and Digestive and Kidney Diseases has more about urinary tract infections.



-- Robert Preidt



SOURCE: Public Library of Science, news release, Feb. 19, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. JAMA article contends earlier study overstated validity of findings on bisphenol A
2. Findings raise new questions about evolution of hormones in mammals
3. Center for the Study of Traumatic Encephalopathy announces new findings
4. New findings on old kidneys could enhance transplants, Stanford study shows
5. Wynonna Judd Reveals Her alli(R), Her Story for Finding a Healthier Lifestyle
6. New findings shed light on why smokers struggle to quit
7. Bionovo to Present Recent Findings of BN108, its Anticancer Agent, at the 31st Annual San Antonio Breast Cancer Symposium
8. Finding Grace on a Less Traveled Road: A Cancer Doctor Reflects on Living and Dying
9. Breast cancer in men: Mammography and sonography findings
10. Initial Survey Findings on Diabetes Awareness Released by PatientAssistance.com
11. Finding Points to Possible Blood Test for Brain Tumors
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Finding May Lead to New Drugs for Urinary Infections
(Date:10/13/2017)... LUIS OBISPO, Calif. (PRWEB) , ... October 13, 2017 , ... ... Alzheimer’s or dementia. However, many long-term care insurance companies have a waiver for care ... is the 90-day elimination period, when the family pays for care, is often waived, ...
(Date:10/13/2017)... Texas (PRWEB) , ... October 13, 2017 , ... Yisrayl ... this week that explains one of the most popular and least understood books in ... like cryptic and puzzling descriptions that have baffled scholars for centuries. Many have tossed ...
(Date:10/13/2017)... ... October 13, 2017 , ... “America On The Brink”: the Christian history of ... Brink” is the creation of published author, William Nowers. Captain Nowers and his ... veteran, he spent thirty years in the Navy. Following his career as a ...
(Date:10/12/2017)... WAUSAU, Wis. (PRWEB) , ... October 12, 2017 ... ... formulated standard products to meet the demand of today’s consumer and regulatory authorities ... team of probiotic experts and tested to meet the highest standard. , ...
(Date:10/12/2017)... ... October 12, 2017 , ... Information ... we intend to develop to enable prevention of a major side effect of ... loss, especially in pediatric patients. For cisplatin, hearing loss is FDA listed on-label ...
Breaking Medicine News(10 mins):
(Date:9/28/2017)... -- Cohen Veterans Bioscience and Early Signal Foundation announce ... home sensors for real-time monitoring of patients with trauma-related ... organization focused on disruptive health solutions for rare disorders ... to record and integrate behavioral, cognitive, physiological and contextual ... ...
(Date:9/25/2017)... 25, 2017  EpiVax, Inc., a leader in ... immune-engineering today announced the launch of EpiVax Oncology ... personalized therapeutic cancer vaccines. EpiVax has provided $500,000 ... to enabling technologies to the new precision immunotherapy ... EpiVax Oncology as Chief Executive Officer. Gad brings ...
(Date:9/19/2017)... , Sept. 19, 2017 HistoSonics, Inc., a venture-backed medical device company developing ... of targeted tissues, announced three leadership team developments today:   ... ... ... Veteran medical device executive Josh Stopek ...
Breaking Medicine Technology: