Navigation Links
Finding May Allow Some Women to Stop Blood Thinners
Date:8/25/2008

It details risk factors for recurrent blood clots

MONDAY, Aug. 25 (HealthDay News) -- A new study identifies some women -- but not men -- who might be able to stop taking blood-thinning medication for the clotting condition called venous thromboembolism.

Current guidelines call for indefinite use of a clot-preventing drug, most often warfarin (Coumadin), for many people with the condition. But researchers report that they've identified a group of traits in women that indicate a very low risk of recurrent clots, so that medication might not be necessary after a few months.

The study, published in the Aug. 26 issue of the Canadian Medical Association Journal, found no such indicators of low risk in men with the condition.

The finding applies to what Dr. Marc A. Rodger, a senior scientist at the Ottawa Hearth Research Institute, who led the study, called "out-of-the-blue" venous thrombosis, with no obvious cause of clots in the legs, arms or lungs. In cases where there is a known cause, such as surgery, the risk of a recurrent clot is low and anti-clotting therapy is routinely stopped after a matter of months.

Rodger and his colleagues studied 69 potential predictive factors in more than 600 men and women who had stopped taking an anticoagulant after a first venous thromboembolism. They singled out four of those factors: discoloration, redness or swelling of a leg; high levels of a blood clotting marker, D-dimer; obesity, marked by a body mass index of 30 or higher; and being 65 or older.

Women who had one or none of those factors had a 1.6 percent chance of developing another clot in the next year. Women with two or more had a 14.1 percent one-year risk.

It's a "bit of a mystery" why no predictive factors were found for men, Rodger said. "There are theories about hormonal differences, but none has been proved," he said.

What is known is that while men and women are at equal risk of a first out-of-the-blue venous thrombosis, men are at 1.5 to 2 times the risk of a recurrence, Rodger said. "It's been documented in several studies that men are at increased risk of recurrence," he said.

Between 5 percent and 13 percent of those having recurrent clots die because of them, he added.

Before doctors can start telling women who meet the criterion that they can stop taking Coumadin, Rodger said, "This needs to be validated in a second study which we are currently planning." Those plans call for enrolling 3,000 people in 40 medical centers in Canada, the United States and four other countries.

"The study will take about two years to recruit patients and will have a one-year follow-up, so results are expected in three years," he said.

Dr. Clive Kearon is a professor of medicine at McMaster University's Michael G. DeGroote School of Medicine, in Hamilton, Ontario, Canada, who wrote an accompanying editorial in the journal. "One would be happy to be able to recommend stopping" blood-thinning therapy, he said, because it increases the risk of major bleeding. "The current recommendation is to remain on long-term therapy, but many patients elect not to do it."

Coumadin is a difficult drug to manage, requiring frequent blood tests and even careful dieting, since green, leafy vegetables are rich in vitamin K, which governs blood clotting.

Some doctors might not wait for the three years needed to get confirmation of the finding, Rodger said. "Oftentimes, patients choose not to take an anticoagulant [blood thinner]," he said. "So, a physician might feel more comfortable to allow women with one or fewer of these risk factors to discontinue the medication."

More information

Learn more about venous thrombosis from the U.S. National Library of Medicine.



SOURCES: Marc A. Rodger, M.D., senior scientist, Ottawa Health Research Institute, Ottawa, Ontario, Canada; Clive Kearon, M.D., professor, medicine, McMaster University Michael G. DeGroote School of Medicine, Hamilton, Ontario, Canada; Aug. 26, 2008, Canadian Medical Association Journal


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Many Parents Share Genetic Test Findings With Kids
2. New Alzheimers findings: High stress and genetic risk factor lead to increased memory decline
3. New MRI finding sheds light on multiple sclerosis disease progressio
4. High and mighty: first common height gene identified by researchers behind obesity gene finding
5. Scientists, physicians present latest findings in personalized cancer treatment and prevention
6. Health psychologists discuss latest research findings
7. Incidental findings found when radiologists take a broader look at renal MRA
8. First significant genetic finding in severe PMS, or PMDD
9. Chair of U.S. Preventive Services Task Force Pledges to Recommend Re-evaluation of Recent Glaucoma Findings
10. The Organic Trade Association Hails Preliminary Research Findings Showing Nutritional Benefits of Organic Products
11. Key findings for all veterans seen in depression and suicide study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/11/2016)... Colorado (PRWEB) , ... February 11, 2016 , ... Colorado ... Review as one of 334 spine surgeons to know in 2016 . The ... in the field of spine surgery. , Dr. Corenman understands the importance of ...
(Date:2/11/2016)... ... February 11, 2016 , ... Talix today announced ... , will be presenting at the 2016 HIMSS Annual Conference & Exhibition, taking ... During his session, “ Coding for Care: Using Data Analytics for Risk Adjustment ...
(Date:2/11/2016)... Rock, AR (PRWEB) , ... February 11, 2016 , ... ... in their community by announcing a new fundraiser in support of a local boy ... also hopes the campaign will bring awareness to, and rally support for, all local ...
(Date:2/11/2016)... ... February 11, 2016 , ... Pixel Film Studios brings the spirit of the ... the Christmas edition of the ProDrop series. Pick and choose from 30 unique designs ... spirit of Christmas using ProDrop's wintry generators. ProDrop Christmas is a Final Cut Pro ...
(Date:2/11/2016)... , ... February 11, 2016 , ... ... exhibiting at the American Academy of Dermatology Annual Meeting at the Walter E. ... is to raise awareness for both the condition of hyperhidrosis (excessive sweating) and ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... 11, 2016 Jeffrey Zucker , ... Trials, will present at this year,s Summit for Clinical Operations ... in Miami, FL. Zucker will discuss ... study execution, supporting SCOPE,s "Improving Site Study Activation and Performance" ... Thursday, Feb. 25 at 11:05 a.m. --> ...
(Date:2/11/2016)... , Feb. 11, 2016  Delcath Systems, Inc. ... medical device company focused on oncology with an ... liver cancers, announces the engagement of Lars ... Global Medical Consultant. Dr. Birgerson will provide strategic ... clinical operations team to help ensure timely facilitation ...
(Date:2/11/2016)... REDWOOD CITY, Calif. , Feb. 11, 2016 /PRNewswire/ ... that a podium presentation will be made at the ... Burn and Wound Care Symposium, which is being ... . This international conference covers the latest advancements in ... endorsed by the American Burn Association, Australian-New Zealand Burns ...
Breaking Medicine Technology: