Navigation Links
Finasteride unlikely to induce high grade prostate cancers
Date:9/11/2007

An increase in high-grade prostate cancer among men taking the drug finasteride is likely caused by an increased detection of cancers, and not by the development of more high-grade cancers, according to two studies published online September 11 in the Journal of the National Cancer Institute.

The Prostate Cancer Prevention Trial (PCPT) was the first long-term randomized trial of a possible drug to prevent prostate cancer. The trial showed a nearly 25 percent reduction in prostate cancer incidence among men who took finasteride compared with a placebo. But men taking finasteride had greater rates of high-grade prostate cancer than men taking placebo (6.4 percent vs. 5.1 percent). It is unclear whether finasteride causes more high-grade prostate cancers or simply creates a situation where more high-grade cancers are detected.

Yael Cohen, Ph.D., of Gamida Cell in Jerusalem and colleagues tested their hypothesis that finasteride reduces prostate volume and therefore increases the likelihood of finding high-grade cancer cells in a biopsy. Analyzing data from the PCPT, they investigated the association between high-grade prostate cancer and prostate volume.

Detection of high-grade cancers in the placebo group increased as the prostate size decreased. They found that prostate size in the finasteride group was 25 percent smaller than in the placebo group. Therefore, when the prostate size was taken into consideration, there was not a statistically significant difference between the prevalence of high-grade prostate cancer in the two groups.

If our conclusion that finasteride accelerates the detection of high-grade cancer yet may not promote its development is correct, then the implications regarding the clinical impact of this drug are quite favorable. The occurrence of lower grade tumors of questionable clinical significance would be reduced, and the early detection of more serious tumors would be enhanced, the authors write.

In a second study, M. Scott Lucia, M.D., of the University of Colorado Health Sciences Center in Denver and colleagues investigated whether finasteride changes the appearance of tumor tissue so that lower-grade tumors are diagnosed as high-grade. The researchers examined surgically-removed prostates and high-grade prostate cancer biopsies from men treated with finasteride and a placebo for signs that finasteride affected prostate size, tumor size, or disease stage.

Like Cohen and colleagues, they found that men treated with finasteride had smaller prostate glands. High-grade tumors were not larger in men taking finasteride, but when they were present in surgically-removed prostates, the tumors were more likely to be detected because the prostates were usually smaller. They also found no major differences in tumor features between the two groups, indicating that it is unlikely that low-grade tumors were being classified as high-grade.

Although the evidence does not exclude the possibility that finasteride may have induced high-grade prostate cancer in some men, the analysis of prostatectomies from the PCPT does indicate that the relative increase in high-grade tumors in the finasteride group is less than originally believed. This evidence further suggests that increased detection may have contributed to the finasteride-associated increase in high-grade disease, the authors write.

In an accompanying editorial, Gerald Andriole, M.D., of Washington University School of Medicine in St. Louis, Mo., and colleagues find the evidence from these two studies important and convincing. Taken together, the studiesprovide substantial reassurance that the increased proportion of high-grade cancer on biopsy in PCPT is not likely to be clinically relevant, the editorialists write. Nevertheless it is necessary, they say, to continue research on the effects of finasteride and other similar drugs such as dutasteride on prostate cancer incidence and Gleason score.


'/>"/>

Contact: Liz Savage
jncimedia@oxfordjournals.org
301-841-1287
Journal of the National Cancer Institute
Source:Eurekalert

Related medicine news :

1. Finasteride lowers risk of prostate cancer but increases risk of high-grade tumors
2. Finasteride lowers risk of prostate cancer but increases risk of high-grade tumors
3. Fibroids unlikely to Turn Cancerous
4. Men who takes risk is unlikely to impress women
5. An unlikely contender for speedy surgery recovery: Chewing gum
6. New Gastric Cancer Drug Unlikely to Benefit Kidney Cancer Patients
7. Sharon Unlikely To Regain Consciousness
8. People In Pain Are Unlikely To Seek Medical Help
9. Health Targets To Treat Cancer Patients Unlikely To Be Met
10. Avian Flu Unlikely to Spread Through Water Systems
11. Offenders Unlikely to Seek Help
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is World ... with chronic pain and the benefits of holistic treatments, Serenity Recovery Center ... with Sickle Cell Disease. , Sickle Cell Disease (SCD) is a disorder of the ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Global law ... magazine’s 2016 Legal Elite. The attorneys chosen by their peers for this recognition are ... , Seven Greenberg Traurig Shareholders received special honors as members of this year’s Legal ...
(Date:6/24/2016)... ... , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief Products, join The ‘Business ... to $12 an hour by 2020 and then adjusting it yearly to increase at the ... minimum wage, assure the wage floor does not erode again, and make future increases more ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Haute Beauty ... Barry M. Weintraub as a prominent plastic surgeon and the network’s newest partner. ... and the most handsome men, look naturally attractive. Plastic surgery should be invisible.” ...
(Date:6/24/2016)... ... June 24, 2016 , ... National recruitment firm Slone Partners ... with extensive sequencing and genomics experience, as Vice President of North American Capital Sales ... be responsible for leading the sales team in the commercialization of the HTG EdgeSeq ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 24, 2016 The Academy of Managed Care ... that would allow biopharmaceutical companies to more easily ... make formulary and coverage decisions, a move that addresses ... medicines. The recommendations address restrictions in the ... the drug label, a prohibition that hinders decision makers ...
(Date:6/24/2016)... Mass. , June 24, 2016   Pulmatrix, ... pharmaceutical company developing innovative inhaled drugs, announced today that ... Russell Investments reconstituted its comprehensive set of ... "This is an important milestone for Pulmatrix," ... will increase shareholder awareness of our progress in developing ...
(Date:6/23/2016)... 2016 Any dentist who has made an implant ... process. Many of them do not even offer this as ... high laboratory costs involved. And those who ARE able to ... a high cost that the majority of today,s patients would ... Parsa Zadeh , founder of Dental Evolutions Inc. and inventor ...
Breaking Medicine Technology: