Navigation Links
Fighting sleeping sickness with X-ray lasers
Date:12/21/2012

This press release is available in German.

Using the world's most powerful X-ray free-electron laser, an international team of researchers, including scientists of the Max Planck Institute for Medical Research in Heidelberg, has obtained new insight into the structure of a medicinally important protein that may serve as a blueprint for the development of drugs to fight sleeping sickness. Science magazine have chosen the experimental study as one of the top ten scientific breakthroughs of the year.

Sleeping sickness is caused by the unicellular organism Trypanosoma brucei that is transmitted by tsetse flies. The disease kills about 30,000 people word-wide each year. The currently available drugs against the disease are of limited efficacy and can have severe side effects. Moreover, resistance against them is increasing. A promising drug target is the protein Cathepsin B whose enzymatic activity is vital for the parasite's survival. Inhibitors of Cathepsin B need to be highly specific against the trypanosomal variant because it resembles the human form. The featured work provides detailed insight into the structure of trypanosomal Cathepsin B in a natively inhibited form that might serve as a blueprint for the rational design of drugs. The biologically important form of the protein was obtained by a trick: instead of crystallizing the protein in plastic trays in the lab, it was crystallized in vivo in the cells that produced the protein. This approach provides natively modified proteins, but the crystals obtained are tiny.

The use of the X-ray free-electron laser (FEL) at Stanford was essential for the work. Protein structures are typically determined by exposing crystals of the protein to X-rays. Unfortunately, many of the most interesting proteins, such a membrane proteins, do not form crystals of sufficient size for analysis
'/>"/>

Contact: Dr. Ilme Schlichting
ilme.schlichting@mpimf-heidelberg.mpg.de
49-622-148-6500
Max-Planck-Gesellschaft
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. From a Failed Vaccine, New Insights Into Fighting HIV
2. Doctors Detail High Costs of Fighting Malpractice Claims
3. Soybeans soaked in warm water naturally release key cancer-fighting substance
4. Living longer - variability in infection-fighting genes can be a boon for male survival
5. 2-1-1 could be effective tool in fighting cancer disparities
6. Moffitt researcher, colleagues find success with new immune approach to fighting some cancers
7. Parents Fighting May Have Long-Lasting Effect on Kids
8. Why current strategies for fighting obesity are not working
9. Ordinary chickens may be extraordinary in fighting cancer, says Texas A&M researcher
10. Fighting obesity with thermal imaging
11. Male Ontario students show declines in fighting; females show elevated bullying and mental distress
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Fighting sleeping sickness with X-ray lasers
(Date:10/31/2014)... In the first study of its kind, Rice University ... circuits that cause cancer cells to become metastatic. The ... allows cancer cells to both migrate and form new ... to new drugs that interfere with the genetic switches ... cells and circulating tumor cells -- two of the ...
(Date:10/31/2014)... Daily Gossip writes in its Xtreme Fat Loss review that ... loss program ever developed. It promises to provide users the ... no wonder after all that this has become the most ... and workout fat loss program was created by Joel Marion, ... the author of this fat loss system, the method can ...
(Date:10/31/2014)... With all the preparations families carry out ... may overlook one critical area – the potential for ... performance and even behavior. Typical children’s vision screenings at ... vision problems, and to address this challenge, Dr. Rosenak’s ... The Awesome Eyes Student Vision Program. , The ...
(Date:10/31/2014)... FRIDAY, Oct. 31, 2014 (HealthDay News) -- Sleep apnea may ... as where you parked your car or left your house ... with severe sleep apnea showed that this ability -- called ... eye movement (REM) sleep, even when other stages of sleep ... during which dreams typically occur. "We,ve shown for the ...
(Date:10/31/2014)... say that either they or a family member have ... latest issue of The Gerontological Society of America,s ... which goes on to show that Americans strongly support ... end-of-life health care wishes. , This PP&AR , ... features 12 articles that present new ways of understanding ...
Breaking Medicine News(10 mins):Health News:Decoding the emergence of metastatic cancer stem cells 2Health News:Decoding the emergence of metastatic cancer stem cells 3Health News:Xtreme Fat Loss Diet Review Reveals How to Transform Your Body in 25 Days 2Health News:New School Vision Initiative Announced by Dr. Rosenak’s Optical Options; Program Aims to Help Recognize Unseen Vision Problems That Impact School Success 2Health News:New School Vision Initiative Announced by Dr. Rosenak’s Optical Options; Program Aims to Help Recognize Unseen Vision Problems That Impact School Success 3Health News:Sleep Apnea May Steal Some of Your Memory: Study 2Health News:Advance directives can benefit patients, families, and health care system 2
... the leading cause of disability among adults. As the population ... // and public health toll of this chronic, crippling joint ... early diagnosis, moderate exercise is one of the most effective ... OA of the knee and hip. , ...
... high fat and sugar induces abnormalities in immune systems, which ... liver, according to a study of mice // conducted by ... published in the Oct. issue of the journal Hepatology, found ... more weight, but also developed fatty livers and increased levels ...
... cause of mortality in patients with muscular dystrophy and ... and approximately 70 % of those with Becker muscular ... muscular dystrophy caused by defects in a gene called ... heart failure and premature death. , ,Cardiac symptoms ...
... Stony Brook University's School of Dental Medicine have developed ... and confections and will not promote cavity formation in ... technology, which has been named CaviStat(R), is more effective ... tooth decay. This conclusion was arrived at after testing ...
... of bilateral muscle weakness with areflexia provoked by ... Cataplexy is diagnosed based on clinical interview. Two ... their usefulness has been limited because of length ... ,Used effectively even these screening tests require the ...
... studies that suggested that radiation treatment for prostate cancer ... suppress hormones. // , ,Researchers at Johns Hopkins ... that hormone therapy will not diminish the value of ... and remains undiagnosed and can present late when the ...
Cached Medicine News:Health News:Exercise Can Strenghten Knee Cartilage 2Health News:Hormone Treatment Before Radiation for Prostate Cancer 2
(Date:10/31/2014)... NEW YORK , Oct. 31, 2014  Grammy ... performance to a high-profile audience of philanthropists, athletes, actors, ... Foundation Gala on Wednesday, November 19 at the Mandarin ... . This year,s fundraising event will honor six individuals ... The Orthopaedic Foundation will bestow its highest honor, ...
(Date:10/31/2014)... , Oct. 31, 2014  Australian biopharmaceutical company Specialised ... (nanoparticle albumin-bound paclitaxel) in combination with gemcitabine, will ... patients with metastatic pancreatic cancer from 1 November. ... cancer is the 5 th most common cause ... all cancer deaths, with the lowest 5-year survival of ...
(Date:10/31/2014)... ARBOR, Mich. , Oct. 31, 2014 /PRNewswire/ ... immune modulators to treat autoimmune disease and cancer, ... of novel synthetic RORgamma agonist product candidates will ... Society for Immunotherapy of Cancer (SITC) being held ... & Convention Center, National Harbor, MD.  The poster, ...
Breaking Medicine Technology:10th Anniversary Orthopaedic Foundation Gala Set For Success 2Specialised Therapeutics Australia Announces Breakthrough Cancer Drug Abraxane(R) to be PBS Listed for Metastatic Pancreatic Cancer 2Specialised Therapeutics Australia Announces Breakthrough Cancer Drug Abraxane(R) to be PBS Listed for Metastatic Pancreatic Cancer 3Specialised Therapeutics Australia Announces Breakthrough Cancer Drug Abraxane(R) to be PBS Listed for Metastatic Pancreatic Cancer 4Specialised Therapeutics Australia Announces Breakthrough Cancer Drug Abraxane(R) to be PBS Listed for Metastatic Pancreatic Cancer 5Specialised Therapeutics Australia Announces Breakthrough Cancer Drug Abraxane(R) to be PBS Listed for Metastatic Pancreatic Cancer 6Specialised Therapeutics Australia Announces Breakthrough Cancer Drug Abraxane(R) to be PBS Listed for Metastatic Pancreatic Cancer 7Specialised Therapeutics Australia Announces Breakthrough Cancer Drug Abraxane(R) to be PBS Listed for Metastatic Pancreatic Cancer 8Lycera Announces Presentation of Data on Anti-Tumor Activity of Novel Synthetic RORgamma Agonists at Society for Immunotherapy of Cancer Meeting 2
... (NYSE: BSX ) today announced financial results for the ... for net sales and earnings per share (EPS) for the ... highlights (Sales growth rates are constant currency): , ... EPS of $0.19, both within the Company,s guidance ranges ...
... NEW ORLEANS, Oct. 19 NCPA 111th Annual Convention ... in targeted pharmacy-based patient care services, has announced the ... National Community Pharmacists Association,s annual convention, MirixaEdge enables pharmacists ... of their patients regardless of health plan, employer, or ...
Cached Medicine Technology:Boston Scientific Announces Results for Third Quarter Ended September 30, 2009 2Boston Scientific Announces Results for Third Quarter Ended September 30, 2009 3Boston Scientific Announces Results for Third Quarter Ended September 30, 2009 4Boston Scientific Announces Results for Third Quarter Ended September 30, 2009 5Boston Scientific Announces Results for Third Quarter Ended September 30, 2009 6Boston Scientific Announces Results for Third Quarter Ended September 30, 2009 7Boston Scientific Announces Results for Third Quarter Ended September 30, 2009 8Boston Scientific Announces Results for Third Quarter Ended September 30, 2009 9Boston Scientific Announces Results for Third Quarter Ended September 30, 2009 10Boston Scientific Announces Results for Third Quarter Ended September 30, 2009 11Boston Scientific Announces Results for Third Quarter Ended September 30, 2009 12Boston Scientific Announces Results for Third Quarter Ended September 30, 2009 13Boston Scientific Announces Results for Third Quarter Ended September 30, 2009 14Boston Scientific Announces Results for Third Quarter Ended September 30, 2009 15Boston Scientific Announces Results for Third Quarter Ended September 30, 2009 16Boston Scientific Announces Results for Third Quarter Ended September 30, 2009 17Boston Scientific Announces Results for Third Quarter Ended September 30, 2009 18Boston Scientific Announces Results for Third Quarter Ended September 30, 2009 19Boston Scientific Announces Results for Third Quarter Ended September 30, 2009 20Boston Scientific Announces Results for Third Quarter Ended September 30, 2009 21Boston Scientific Announces Results for Third Quarter Ended September 30, 2009 22Boston Scientific Announces Results for Third Quarter Ended September 30, 2009 23Boston Scientific Announces Results for Third Quarter Ended September 30, 2009 24Boston Scientific Announces Results for Third Quarter Ended September 30, 2009 25Boston Scientific Announces Results for Third Quarter Ended September 30, 2009 26Boston Scientific Announces Results for Third Quarter Ended September 30, 2009 27Boston Scientific Announces Results for Third Quarter Ended September 30, 2009 28Boston Scientific Announces Results for Third Quarter Ended September 30, 2009 29Mirixa Corporation Announces MirixaEdge(SM) 2
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: