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Fighting obesity may be as easy as ATP, says UH researcher
Date:10/22/2007

tantaneous. However, ATP that goes unused eventually gets converted into fat hence the growing obesity epidemic at a time when high-calorie food is plentiful.

The focus of the NIH grant is to develop sensors, based on harmonic generation spectroscopy and related techniques, that detect metabolic activity in mitochondrial complexes. Often considered the powerhouses of cells, mitochondria convert molecules extracted from the food we eat into ATP, the fuel used by the rest of the cell. The mitochondria house enzymes that carry out these steps essential to metabolism.

The NIH-funded project will focus on electrode-based sensors that detect mitochondrial enzymes in action and may lead to development of portable instruments worn by patients for continuous monitoring of resting and active metabolism, as well as other clinical devices. Moreover, studies have shown that mitochondria are often defective in patients suffering from obesity, type-2 diabetes and heart disease. It is hoped the sensors will be able to distinguish normal from dysfunctional mitochondrial activity.

Millers collaborators include William Widger, professor of biology and biochemistry at UH; and Drs. Dale Hamilton and Richard Robbins, endocrinologists in the Department of Medicine at The Methodist Hospital. The NIH award will last through Aug. 31, 2010.

In addition to the NIH project, Miller is focusing on a related project that is part of the TcSUH Biomedical Research Program and is being funded by TcSUH. It focuses more on technologies based on superconducting quantum interference devices (SQUIDs) and related magnetic sensors that measure minute changes in magnetic flux used to detect extremely small changes in magnetic fields, electric currents and voltages. This could lead to clinical instruments designed for early diagnosis of metabolic syndrome and insulin resistance.

Miller envisions that nanoscale probes eventually could be developed
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Contact: Lisa Merkl
lkmerkl@uh.edu
713-743-8192
University of Houston
Source:Eurekalert

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