Navigation Links
Fighting diseases of aging by wasting energy
Date:12/4/2007

By making the skeletal muscles of mice use energy less efficiently, researchers report in the December issue of Cell Metabolism, a publication of Cell Press, that they have delayed the animals deaths and their development of age-related diseases, including vascular disease, obesity, and one form of cancer. Those health benefits, driven by an increased metabolic rate, appear to come without any direct influence on the aging process itself, according to the researchers.

The mitochondria powering the mouse muscles were made inefficient by increasing the activity of so-called uncoupling protein 1 (UCP1). UCP1 disrupts the transfer of electrons from food to oxygen, a process known as mitochondrial respiration, which normally yields the energy transport molecule ATP. Instead, the energy is lost as heat.

When you make the mitochondria inefficient, the muscles burn more calories, a metabolic increase that could be at least a partial substitute for exercise, said Clay Semenkovich of Washington University School of Medicine in St. Louis. There are a couple of ways to treat obesity and related diseases, he continued. You can eat less, but thats unpopular, or you could eat what you want as these animals did and introduce an altered physiology. Its a fundamentally different way of addressing the problem.

Atherosclerosis, diabetes, hypertension, and cancer occur more frequently with increasing age, the researchers explained. These age-related diseases are distinct from the process of aging, a physiological decline that includes decreases in muscle strength, cardiopulmonary function, vision, and hearing as well as wrinkled skin and graying hair. Thus, the researchers added, aging and age-related disease are associated but may not share the same mechanisms.

Given the difficulty of validating strategies to increase life span in humans and the possible dissociation between aging and age-related diseases, the researchers said, identifying a simple intervention affecting several age-related diseases is an attractive approach to decreasing the morbidity of growing old. They suspected that treatments designed to alter the efficiency of mitochondrial respiration might be one way to accomplish this.

Earlier studies had shown that young mice engineered to express modestly increased levels of UCP1 in skeletal muscle had a mildly increased metabolic rate, although they ate and grew normally. The animals muscles otherwise functioned as usual. In the new study, Semenkovichs group used these mice to determine whether respiratory uncoupling in skeletal musclea tissue that adapts to altered heat production and oxygen consumption during exercisecan affect age-related disease.

They found that animals with increased UCP1 only in skeletal muscle lived longer. Altered female animals also developed lymphoma, a type of cancer that originates in white blood cells called lymphocytes, less frequently. In mice genetically predisposed to vascular disease, the increase in UCP1 led to a decline in atherosclerosis in animals fed a western-type high-fat diet. Likewise, mice predisposed to developing diabetes and hypertension were relieved of those ailments by increased UCP1 in skeletal muscle. The uncoupled mice also had less body fat (or adiposity) and higher body temperatures and metabolic rates, among other biochemical changes.

The consequences of excess adiposity disproportionately affect older individuals, the researchers concluded. Excess adiposity can be treated through two simple approaches, decreasing energy intake or increasing energy consumption. Considerable effort is currently being devoted to the development of agents that decrease energy intake in hopes of decreasing adiposity and perhaps age-related disease. Our results indicate that increasing energy consumption in mice has beneficial effects on survival, vascular disease, elevated blood pressure, and diabetes. This intervention does not slow aging but may diminish susceptibility to pathology. Strategies to safely accelerate energy consumption specifically in skeletal muscle could decrease the impact of some common age-related diseases.


'/>"/>

Contact: Cathleen Genova
cgenova@cell.com
617-397-2802
Cell Press
Source:Eurekalert

Related medicine news :

1. Study shines more light on benefit of vitamin D in fighting cancer
2. Cities Say Restaurant Nutrition Information Crucial in Fighting Obesity
3. Elliot Yamin: Fighting Diabetes
4. Their immune cells, fighting your cancer
5. Clean Hands are Key to Fighting Cold, Flu Germs
6. Fighting the Gassy Effects of Good Eating, From the Harvard Health Letter
7. Family Infighting Hurts the Heart
8. The Power of Community in Fighting HIV/AIDS Among Latinos
9. Fighting obesity may be as easy as ATP, says UH researcher
10. Handwashing, Masks Beat Drugs at Fighting Flu
11. Germ-Fighting Inhaler Could Fend Off Bioterror Agents
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/8/2016)... ... February 08, 2016 , ... Stephanie Hebert Insurance Agency, ... of a new charity campaign. As part of their ongoing community involvement program, ... the belief that children deserve a voice, and in the spirit of neighbors ...
(Date:2/8/2016)... ... February 08, 2016 , ... Brenton ... for pouches, bags, and flow wrapped products at WestPack 2015, February 9-11, in ... manufacturers step up to semi-automatic or fully-automatic case packing with a small footprint, ...
(Date:2/8/2016)... ... 08, 2016 , ... Steve Helwig & Associates Insurance & Financial, serving the ... has teamed up with Citizens Opposed to Domestic Abuse in support of its efforts ... all those victimized by the fear of violence in their own homes, donations may ...
(Date:2/8/2016)... ... 2016 , ... Delta Dental of California and its affiliated companies announced today ... Radine, who recently retired as president and CEO of Delta Dental of California and ... the Year , helped lead the effort to raise funds for studies to strengthen ...
(Date:2/8/2016)... ... February 08, 2016 , ... Eating disorders and post-traumatic stress ... women and men with eating disorders report a history of trauma, research suggests ... of an eating disorder. , At the 2016 iaedp Symposium, the workshop, ...
Breaking Medicine News(10 mins):
(Date:2/8/2016)... YORK, Pa. , Feb. 8, 2016  Unilife Corporation ... developer and supplier of injectable drug delivery systems, today announced ... and six months ended December 31, 2015 after market close ... not scheduled a conference call to discuss these financial results.  ... About Unilife Corporation --> About Unilife ...
(Date:2/8/2016)... 8, 2016  Sangamo BioSciences, Inc. (NASDAQ: ... announced that the U.S. Food and Drug Administration ... (IND) application for SB-318, a single treatment strategy ... Type I (MPS I). The SB-318 IND application ... a Phase 1/2 clinical study (SB-318-1502) designed to ...
(Date:2/8/2016)... Feb. 8, 2016  CTI BioPharma Corp. (CTI BioPharma) ... written communication from the U.S. Food and Drug Administration ... placed a partial clinical hold on the clinical studies ... application for pacritinib. This clinical hold impacts part of ... and will also affect planned clinical trials. ...
Breaking Medicine Technology: