Navigation Links
Fighting disease from within the mosquito: New techniques to help halt the spread of disease
Date:4/10/2013

Scientists have revealed a new technique to introduce disease-blocking bacteria into mosquitoes, with promising results that may halt the spread of diseases such as dengue, yellow fever and potentially malaria.

When infected with the bacteria Wolbachia, mosquitoes are unable to spread viruses such as dengue, a disease which kills round 40,000 people each year with no vaccines or specific treatments currently available. There have been around 2,400 cases of dengue infection in Northern Australia in recent years.

However, the bacteria has been difficult to spread within the mosquito population because it reduces the mosquitoes' ability to lay viable eggs.

Now Professor Hoffmann from the University of Melbourne and Professor Michale Turelli from the University of California have shown that by introducing an insecticide resistance gene alongside the Wolbachia bacteria into the mosquito, that the insects pass on the disease-blocking bacteria to other mosquitoes faster. The results are published in the journal Proceedings of the Royal Society B.

This could mean that the spread of disease can be stopped faster, and less infected mosquitoes would need to be released in a disease control program said Professor Ary Hoffmann from the University of Melbourne's Bio21 Institute and Department of Genetics.

"Our results show that Wolbachia-based strategies could hold the key to a cheap and sustainable approach to disease control," Professor Hoffmann said.

Wolbachia bacteria strains live naturally inside up to 70% of all insects and are known to protect them against viral infection. The disease-blocking strain of Wolbachia was first discovered in Australian fruit flies in 1988 by Prof Hoffmann, and trials with collaborators at Monash and James Cook Universities in 2011 showed that Wolbachia-infected mosquitoes were unable to spread the dengue virus.

The approach taken in this new work involves adding a pesticide resistance gene to a newer strain of Wolbachia called wMelPop, which is a strong blocker of dengue and other viruses. Insecticide use is very common in dengue and malaria-prone regions and so this strategy should select for the survival of only the Wolbachia-infected mosquitoes, but then these insects would be unable to pass on a virus to humans.

Prof Hoffmann added that insecticide resistance genes would not spread to the uninfected mosquito populations because a Wolbachia-infected female with a resistance gene will always pass on both the gene and the bacteria to her offspring. Then, when an uninfected female mates with an infected male, the bacterium causes cytoplasmic incompatibility, which leads to the death of embryos.

"So the association between resistance and the infection is maintained, the resistance does not move into the rest of the population, and the strategy can utilize insecticides that are no longer part of active mosquito control programs."


'/>"/>

Contact: Nerissa Hannink
nhannink@unimelb.edu.au
61-430-588-055
University of Melbourne
Source:Eurekalert

Related medicine news :

1. From a Failed Vaccine, New Insights Into Fighting HIV
2. Doctors Detail High Costs of Fighting Malpractice Claims
3. Soybeans soaked in warm water naturally release key cancer-fighting substance
4. Living longer - variability in infection-fighting genes can be a boon for male survival
5. 2-1-1 could be effective tool in fighting cancer disparities
6. Moffitt researcher, colleagues find success with new immune approach to fighting some cancers
7. Parents Fighting May Have Long-Lasting Effect on Kids
8. Why current strategies for fighting obesity are not working
9. Ordinary chickens may be extraordinary in fighting cancer, says Texas A&M researcher
10. Fighting obesity with thermal imaging
11. Male Ontario students show declines in fighting; females show elevated bullying and mental distress
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... ... June 24, 2016 , ... A recent article ... are unfamiliar with. The article goes on to state that individuals are now more ... these less common operations such as calf and cheek reduction. The Los Angeles area ...
(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is World Sickle ... chronic pain and the benefits of holistic treatments, Serenity Recovery Center of ... Sickle Cell Disease. , Sickle Cell Disease (SCD) is a disorder of the red ...
(Date:6/24/2016)... ... 2016 , ... The Pulmonary Hypertension Association (PHA) learned during ... two significant new grants to support its work to advance research and patient ... recognizing patients, medical professionals and scientists for their work in fighting pulmonary hypertension ...
(Date:6/24/2016)... San Francisco, CA (PRWEB) , ... June 24, ... ... at CitiDent, is now offering micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has ... , self-ligating Damon brackets , AcceleDent, and accelerated osteogenic orthodontics. , ...
(Date:6/24/2016)... ... June 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief Products, ... minimum wage raise to $12 an hour by 2020 and then adjusting it yearly to ... value of the minimum wage, assure the wage floor does not erode again, and make ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 23, 2016 Any dentist who has made an ... current process. Many of them do not even offer this ... and high laboratory costs involved. And those who ARE able ... such a high cost that the majority of today,s patients ... Parsa Zadeh , founder of Dental Evolutions Inc. and ...
(Date:6/23/2016)... 23, 2016 Capricor Therapeutics, ... a biotechnology company focused on the discovery, development ... patient enrollment in its ongoing randomized HOPE-Duchenne clinical ... 50% of its 24-patient target. Capricor expects the ... quarter of 2016, and to report top line ...
(Date:6/23/2016)... and BOGOTA, Colombia , June 23, 2016  Astellas today announced the establishment of ... Farma Brasil as the company,s second affiliate in Latin America . ... ... Manager of Astellas Farma Colombia ... ...
Breaking Medicine Technology: