Navigation Links
Fighting disease from within the mosquito: New techniques to help halt the spread of disease
Date:4/10/2013

Scientists have revealed a new technique to introduce disease-blocking bacteria into mosquitoes, with promising results that may halt the spread of diseases such as dengue, yellow fever and potentially malaria.

When infected with the bacteria Wolbachia, mosquitoes are unable to spread viruses such as dengue, a disease which kills round 40,000 people each year with no vaccines or specific treatments currently available. There have been around 2,400 cases of dengue infection in Northern Australia in recent years.

However, the bacteria has been difficult to spread within the mosquito population because it reduces the mosquitoes' ability to lay viable eggs.

Now Professor Hoffmann from the University of Melbourne and Professor Michale Turelli from the University of California have shown that by introducing an insecticide resistance gene alongside the Wolbachia bacteria into the mosquito, that the insects pass on the disease-blocking bacteria to other mosquitoes faster. The results are published in the journal Proceedings of the Royal Society B.

This could mean that the spread of disease can be stopped faster, and less infected mosquitoes would need to be released in a disease control program said Professor Ary Hoffmann from the University of Melbourne's Bio21 Institute and Department of Genetics.

"Our results show that Wolbachia-based strategies could hold the key to a cheap and sustainable approach to disease control," Professor Hoffmann said.

Wolbachia bacteria strains live naturally inside up to 70% of all insects and are known to protect them against viral infection. The disease-blocking strain of Wolbachia was first discovered in Australian fruit flies in 1988 by Prof Hoffmann, and trials with collaborators at Monash and James Cook Universities in 2011 showed that Wolbachia-infected mosquitoes were unable to spread the dengue virus.

The approach taken in this new work involves adding a pesticide resistance gene to a newer strain of Wolbachia called wMelPop, which is a strong blocker of dengue and other viruses. Insecticide use is very common in dengue and malaria-prone regions and so this strategy should select for the survival of only the Wolbachia-infected mosquitoes, but then these insects would be unable to pass on a virus to humans.

Prof Hoffmann added that insecticide resistance genes would not spread to the uninfected mosquito populations because a Wolbachia-infected female with a resistance gene will always pass on both the gene and the bacteria to her offspring. Then, when an uninfected female mates with an infected male, the bacterium causes cytoplasmic incompatibility, which leads to the death of embryos.

"So the association between resistance and the infection is maintained, the resistance does not move into the rest of the population, and the strategy can utilize insecticides that are no longer part of active mosquito control programs."


'/>"/>

Contact: Nerissa Hannink
nhannink@unimelb.edu.au
61-430-588-055
University of Melbourne
Source:Eurekalert

Related medicine news :

1. From a Failed Vaccine, New Insights Into Fighting HIV
2. Doctors Detail High Costs of Fighting Malpractice Claims
3. Soybeans soaked in warm water naturally release key cancer-fighting substance
4. Living longer - variability in infection-fighting genes can be a boon for male survival
5. 2-1-1 could be effective tool in fighting cancer disparities
6. Moffitt researcher, colleagues find success with new immune approach to fighting some cancers
7. Parents Fighting May Have Long-Lasting Effect on Kids
8. Why current strategies for fighting obesity are not working
9. Ordinary chickens may be extraordinary in fighting cancer, says Texas A&M researcher
10. Fighting obesity with thermal imaging
11. Male Ontario students show declines in fighting; females show elevated bullying and mental distress
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/8/2016)... ... February 08, 2016 , ... Steve Helwig & Associates Insurance & Financial, ... enrichment program, has teamed up with Citizens Opposed to Domestic Abuse in support of ... To support all those victimized by the fear of violence in their own homes, ...
(Date:2/8/2016)... , ... February 08, 2016 , ... Remember the old ... , According to Perry A~, author of “Calcium Bentonite Clay” the health benefits ... role in balancing and detoxifying the body. , A former motivational speaker, Perry A~ ...
(Date:2/8/2016)... ... February 08, 2016 , ... ... share this important news! AHCC and the Home Health and Hospice ICD-10 Transition ... designee for official ICD coding guidance and clarifications, to address concerns over the ...
(Date:2/8/2016)... (PRWEB) , ... February 08, 2016 , ... ... (NADL), only four states in the U.S. require dental technicians to be certified ... in the dental industry, NADL created the “What’s In Your Mouth?” campaign to ...
(Date:2/6/2016)... ... February 06, 2016 , ... FOR ... AT AORN SURGICAL CONFERENCE & EXPO , WHAT:     , This conference is ... 5000 perioperative nurses in attendance to study the latest evidence-based recommendations and ...
Breaking Medicine News(10 mins):
(Date:2/8/2016)... , Feb. 8, 2016 In a historic vote among ... plans to construct a medical cannabis cultivation facility and dispensary on tribal ... of New York as a provider for patients in the ... York as a provider for patients in the state,s Medical ... 29% (34) to approve the project and pursue designation from the ...
(Date:2/8/2016)... , Feb. 8, 2016 ... the "Knee Reconstruction Devices Market by Product ... Implants), and Geography (U.S., Canada, Eu-5, Japan, Bric, ... 2020" report to their offering. ... of the "Knee Reconstruction Devices Market by ...
(Date:2/8/2016)... , Feb. 8, 2016  The University of ... announced today that, as part of the development ... of the first hospitals in the U.S. to start ... Muraszko , M.D., U-M,s chair of neurosurgery. ... neurosurgery. --> The BrightMatter technology from ...
Breaking Medicine Technology: