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Fifth Annual AACR Margaret Foti Award presented to Arthur D. Levinson, Ph.D.
Date:3/25/2011

ORLANDO, Fla. Arthur D. Levinson, Ph.D., chairman and former CEO of Genentech Inc., will receive the Fifth Annual American Association for Cancer Research Margaret Foti Award for Leadership and Extraordinary Achievements in Cancer Research at the AACR 102nd Annual Meeting 2011, held April 2-6.

This award recognizes an individual whose leadership and extraordinary achievements in cancer research, or in support of cancer research, have made a major impact on the field.

"Dr. Levinson revolutionized the approach to developing cancer therapeutics, which led to targeted drugs," said Margaret Foti, Ph.D., M.D. (h.c.), chief executive officer of the AACR. "It is because of his scientific insight and inspirational leadership that we have gained advancements in drug development and personalized healthcare, benefitting countless cancer patients."

While working in the Princeton laboratory of Dr. Arnold J. Levine as a graduate student, Levinson identified adenovirus encoded antigens that were required for its tumorigenic ability. As a postdoctoral fellow in the laboratory of Drs. Mike Bishop and Harold Varmus at the University of California, San Francisco, Levinson discovered that the p60-Src protein was a membrane-associated phosphoprotein, and co-discovered it to be a protein kinase. This was the first description of an enzymatic activity to be associated with the product of an oncogene.

Levinson joined Genentech in 1980 as a senior scientist, and conducted research programs on oncogene function and mammalian gene expression. His lab provided formal proof that the src gene product was a tyrosine protein kinase. Other contributions to the research arena consisted of the demonstration that the ras gene product possessed intrinsic GTPase activity, whose activity is directly affected by mutations that activated the oncogenic potential of the gene. He also pioneered the development at Genentech of the first commercially efficient large-s
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Contact: Michele Sharp
Michele.Sharp@aacr.org
267-646-0622
American Association for Cancer Research
Source:Eurekalert

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