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Field guide to the Epstein-Barr virus charts viral paths toward cancer
Date:8/23/2012

onal Biology Program. While analyzing data for the Encyclopedia of DNA Elements (ENCODE) Consortium, a multi-institutional project of the National Human Genome Research Institute to build a comprehensive list of all the ways human cells interact with and regulate their genes, Arvey also collected data related to EBV, which maintains a stable infection in the cells he had studied..

At his urging, the Leslie lab began a collaboration with the Lieberman lab at Wistar, which has studied the virus and its relationship to cancer for over two decades. The project involved studying 700 sets of genetic data from over 50 separate lines of B cells infected with EBV. The Leslie lab took on the work of developing collecting the data, while the Lieberman lab conducted the experimental validation to back up their findings.

"The vast majority of data analyzed in the paper comes from large-scale next-generation sequencing experiments carried out by projects such as ENCODE and HapMap," said Leslie. "Our study depends critically on the unbiased nature of sequencing datasince we could detect transcription factor binding sites and histone modifications along the EBV genome as well as transcripts of viral origin from sequencing experiments in human cellsas well as the availability of large public data sets."

While not affiliated with ENCODE directly, the EBV atlas project benefited greatly from the data generated through the project. According to Leslie, the fact that they could derive such a detailed characterization of the EBV epigenome and transcriptome largely from public data underscores the value of these big data resources.


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Contact: Greg Lester
glester@wistar.org
215-898-3943
The Wistar Institute
Source:Eurekalert  

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