Navigation Links
Fibrous stroma associated with poor prognosis in lung squamous cell carcinoma
Date:9/1/2011

The nature of the connective tissue surrounding lung cancer nests can help predict the aggressiveness of squamous cell carcinoma, according to research published in the September issue of the Journal of Thoracic Oncology, the official publication of the International Association for the Study of Lung Cancer (IASLC).

Non-small cell lung cancer (NSCLC) is the major cause of cancer-related deaths worldwide; its two major subtypes are adenocarcinoma and squamous cell carcinoma (SqCC). Although many reports have described the prognostic markers for adenocarcinoma, less research has been done into prognostic markers for SqCC.

In the study, researchers from Japan's National Cancer Center Hospital East and Keio University found that the prognosis for lung cancer patients with SqCC tumors surrounded by "fibrous stroma" was significantly worse than for patients whose SqCC cells were surrounded by "thin stroma."

Of the 220 patients whose tissue specimens were reviewed, 85 had fibrous stroma -- that is, stroma wider than some cancer nests and intermingled with plump fibroblast and/or collagen fibers -- and 135 had thin stroma, narrower than the cancer nest and composed of thin collagen-fiber lamellae or infiltrative lymphocytes. All had undergone a complete resection for a solitary lesion and were diagnosed as having a pathologic stage I disease. Patients who had received preoperative chemotherapy or preoperative thoracic radiation were excluded.

The 5-year recurrence-free survival rate was 70% for patients with thin stroma and 50% for patients with fibrous stroma. The 5-year overall survival rate was 72.3% for thin stroma cases and 55.5% for those with fibrous stroma.

SqCC tumors surrounded by fibrous stroma showed reduced expression of E-cadherin and increased expression of laminin-5y2 and matrix metalloproteinase-7 (MMP7), proteins that have been found to increase cell motility and invasiveness.

"Elucidating
'/>"/>

Contact: Rene McGaw
renee.mcgaw@ucdenver.edu
303-724-5796
International Association for the Study of Lung Cancer
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Optimal surgical procedure for duodenal gastrointestinal stromal tumors
2. Stroma may provide key to better cancer treatment
3. Jefferson study determines bone marrow stromal stem cells may aid in stroke recovery
4. Certain genetic profiles associated with recurrence-free survival for non-small cell lung cancer
5. Certain pain medications do not appear to be associated with skin cancer risk
6. News brief: ALDH associated with worse overall survival in patients with pancreatic adenocarcinoma
7. New research shows emotional impact of low sexual desire and associated distress
8. Increased HAART coverage associated with 50 percent drop
9. Pretreatment SUV associated with head and neck cancer treatment outcomes, may help decide treatment plans
10. New developments in nanotechnology tackle the 2 biggest problems associated with chemotherapy
11. MedQuist Launches EHR Integration for Dictations Associated with Template-based Clinical Documentation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/2/2015)... ProvidaStaff has announced today that ... division to EDU Healthcare to reflect better ... systems and students nationwide. , “ProvidaStaff has always been ... the country,” said Angela M. Lewis, President of ProvidaStaff. ... and the introduction of EDU Healthcare better aligns our ...
(Date:3/1/2015)... 2015 To help healthcare ... their practices compliantly and profitably, MDreferralPRO and ... The interoperability between a strategic referral ... practice management system is necessary for a ... A referral management and development solution relies ...
(Date:3/1/2015)... Metamora, Michigan (PRWEB) March 01, 2015 ... approved to treat Overactive Bladder (OAB) symptoms, such as a ... adults when another type of medication (anticholinergic) does not work ... different treatment option that takes another approach to targeting the ... BOTOX® works on the nerves and bladder muscle, blocking the ...
(Date:3/1/2015)... March 01, 2015 A federal ... http://www.consumerinjurylawyers.com/wright-profemur-hip-replacement ) scheduled to go to trial in ... a witness to provide testimony regarding the role ... of the Profemur device, Bernstein Liebhard LLP comments. ... Court, Northern District of Iowa on February 25th, ...
(Date:3/1/2015)... ERISAPros is pleased to announce the ... professional staff of its Compliance Department. , Evelyn King, ... University-Mortiz College of Law. Prior to joining ERISAPros, Evelyn ... Fortune 500 companies as well as several privately held ... experiences range from benefit plan design, vendor management, administrative ...
Breaking Medicine News(10 mins):Health News:ProvidaStaff Announces New Name Change to EDU Healthcare for Its Educational Healthcare Division 2Health News:ProvidaStaff Announces New Name Change to EDU Healthcare for Its Educational Healthcare Division 3Health News:Power Up Physician and Patient Referral Management While Qualifying for ARRA Incentives 2Health News:Power Up Physician and Patient Referral Management While Qualifying for ARRA Incentives 3Health News:Power Up Physician and Patient Referral Management While Qualifying for ARRA Incentives 4Health News:Women's Excellence Now Offers BOTOX For Overactive Bladder Treatment 2Health News:Wright Profemur Hip Lawyers at Bernstein Liebhard LLP Comment on Court’s Decision Regarding Testimony Pertaining to Prototype for Profemur Hip Replacement 2Health News:Wright Profemur Hip Lawyers at Bernstein Liebhard LLP Comment on Court’s Decision Regarding Testimony Pertaining to Prototype for Profemur Hip Replacement 3Health News:ERISAPros Recruits Evelyn King, J.D. and Carolyn Roddy, J.D. to its Professional Staff 2
... IT Company Launches into EXACENT,s Virtualized Environment , ... ... grade - on demand virtual data center , is pleased ... , ,HybridChart, a Scottsdale based company, has developed innovative and user-friendly ...
... suggests it might be possible , , THURSDAY, Feb. 19 ... hearing loss in lab animals, a new study shows. ... may be possible to create a pill that protects ... , Two studies found that giving supplements containing antioxidants ...
... Healthcare has always been a vital issue for Americans ... industry -- financial wellness. The two are far more closely ... and AOL Health found that debt stress is a major ... likely to have health problems, 20% more likely to have ...
... for Natural Dentistry - San Diego County,s premiere dental ... revolutionary care program designed to promote whole-body health at ... 19 Most people despise the dentist - the ... lights. It causes many Americans to skip the dentist ...
... experimental therapy using tiny bubbles activated by transcranial ... drug tissue plasminogen activator (tPA) is more effective ... ischemic stroke, according to new research presented at ... San Diego. , The findings, presented by Andrei ...
... Systems and, Romer Labs for use ... Pro analytical software,SUNNYVALE, CA, Feb. 19 /PRNewswire-FirstCall/ - MDS ... discovery and life sciences research, today announced that two ... Beacon Analytical Systems, which focuses on the development and ...
Cached Medicine News:Health News:EXACENT To Provide IT VIirtualization To HybridChart 2Health News:EXACENT To Provide IT VIirtualization To HybridChart 3Health News:A Pill to Prevent Hearing Loss? 2Health News:Recession Spawns Vital New Industry - Financial Wellness 2Health News:Recession Spawns Vital New Industry - Financial Wellness 3Health News:Discover Whole Body Wellness Through a Revolutionary - and Natural - Approach to Dental Care 2Health News:Discover Whole Body Wellness Through a Revolutionary - and Natural - Approach to Dental Care 3Health News:Study shows ultrasound and tPA effective for stroke 2Health News:MDS Analytical Technologies Announces Validation of Two More Kits for High-Throughput Detection of Melamine in Food 2Health News:MDS Analytical Technologies Announces Validation of Two More Kits for High-Throughput Detection of Melamine in Food 3Health News:MDS Analytical Technologies Announces Validation of Two More Kits for High-Throughput Detection of Melamine in Food 4
(Date:3/2/2015)... marzo 2015  SI-BONE, Inc., una società per ... fusione con chirurgia mininvasiva (minimally invasive surgical/MIS) per ... System ® , ha annunciato oggi che oltre ... intero utilizzando oltre 44.000 iFuse Implants.  ... adottata guadagnando consenso con oltre 900 chirurghi che ...
(Date:3/2/2015)... March 2, 2015 Isis Pharmaceuticals, Inc. (NASDAQ: ... $15 million milestone payment from GSK related to advancing the ... familial amyloid polyneuropathy (FAP).  "We are very ... , and plan to report data from the Phase 2/3 ... fifteen months of dosing and are now receiving ISIS-TTR Rx ...
(Date:3/2/2015)... 2, 2015   Lexicon Pharmaceuticals, Inc. (Nasdaq: ... developing breakthrough treatments for human disease, will release its ... Wednesday, March 4, 2015 before the financial markets open.  ... to discuss clinical development progress and financial results for ... 10:00 a.m. Eastern Time on March 4, 2015. ...
Breaking Medicine Technology:SI-BONE, Inc. rivela l'obiettivo di 15.000 interventi con iFuse 2SI-BONE, Inc. rivela l'obiettivo di 15.000 interventi con iFuse 3SI-BONE, Inc. rivela l'obiettivo di 15.000 interventi con iFuse 4Isis Pharmaceuticals Earns $15 Million From GSK for Advancing ISIS-TTR Rx 2Isis Pharmaceuticals Earns $15 Million From GSK for Advancing ISIS-TTR Rx 3Lexicon To Report Fourth Quarter And Year End 2014 Financial Results On March 4, 2015 2
... MORRISVILLE, N.C., Sept. 11 Clinical Logistics is pleased to announce ... Corporation (Gentris), a GLP compliant laboratory, located in Morrisville, North Carolina. ... DNA, RNA, whole blood, FFPE tissue blocks, urine, plasma, serum, saliva, ... storage conditions is available: , , ...
... YORK, Sept. 11 /PRNewswire-FirstCall/ - (OTCBB: GVBP.OB) - GENova ... method for destroying breast cancer cells, using stem cell ... that enables us to identify the protein expression in ... tumors. This ability to identify the molecular markers of ...
Cached Medicine Technology:Clinical Logistics Enters Partnership with Gentris Corporation 2New stem cell identification technology could cure breast cancer 2
... nebulizer system offers an affordable and ... COPD or other respiratory conditions. The ... gives patients the ability to take ... Its unique nebulizer design delivers powerful ...
... The most compact, portable DC powered ... Elite provides the freedom to take ... system is powered by the included ... Adapter and Battery Kit. The integral ...
... The 50 psi MaxiCompressor, the ... to run 24 hours a ... It features a tamper-proof locking ... unintentional increases or decreases in ...
... PulmoStar is a low cost compressor/nebuliser which offers ... the home, health centre or clinic. The SunMist ... and a simple filter change every six months., ... With Disposable Neb, 3 Prong Polarized plug With ...
Medicine Products: