Navigation Links
Fibrous stroma associated with poor prognosis in lung squamous cell carcinoma
Date:9/1/2011

The nature of the connective tissue surrounding lung cancer nests can help predict the aggressiveness of squamous cell carcinoma, according to research published in the September issue of the Journal of Thoracic Oncology, the official publication of the International Association for the Study of Lung Cancer (IASLC).

Non-small cell lung cancer (NSCLC) is the major cause of cancer-related deaths worldwide; its two major subtypes are adenocarcinoma and squamous cell carcinoma (SqCC). Although many reports have described the prognostic markers for adenocarcinoma, less research has been done into prognostic markers for SqCC.

In the study, researchers from Japan's National Cancer Center Hospital East and Keio University found that the prognosis for lung cancer patients with SqCC tumors surrounded by "fibrous stroma" was significantly worse than for patients whose SqCC cells were surrounded by "thin stroma."

Of the 220 patients whose tissue specimens were reviewed, 85 had fibrous stroma -- that is, stroma wider than some cancer nests and intermingled with plump fibroblast and/or collagen fibers -- and 135 had thin stroma, narrower than the cancer nest and composed of thin collagen-fiber lamellae or infiltrative lymphocytes. All had undergone a complete resection for a solitary lesion and were diagnosed as having a pathologic stage I disease. Patients who had received preoperative chemotherapy or preoperative thoracic radiation were excluded.

The 5-year recurrence-free survival rate was 70% for patients with thin stroma and 50% for patients with fibrous stroma. The 5-year overall survival rate was 72.3% for thin stroma cases and 55.5% for those with fibrous stroma.

SqCC tumors surrounded by fibrous stroma showed reduced expression of E-cadherin and increased expression of laminin-5y2 and matrix metalloproteinase-7 (MMP7), proteins that have been found to increase cell motility and invasiveness.

"Elucidating
'/>"/>

Contact: Rene McGaw
renee.mcgaw@ucdenver.edu
303-724-5796
International Association for the Study of Lung Cancer
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Optimal surgical procedure for duodenal gastrointestinal stromal tumors
2. Stroma may provide key to better cancer treatment
3. Jefferson study determines bone marrow stromal stem cells may aid in stroke recovery
4. Certain genetic profiles associated with recurrence-free survival for non-small cell lung cancer
5. Certain pain medications do not appear to be associated with skin cancer risk
6. News brief: ALDH associated with worse overall survival in patients with pancreatic adenocarcinoma
7. New research shows emotional impact of low sexual desire and associated distress
8. Increased HAART coverage associated with 50 percent drop
9. Pretreatment SUV associated with head and neck cancer treatment outcomes, may help decide treatment plans
10. New developments in nanotechnology tackle the 2 biggest problems associated with chemotherapy
11. MedQuist Launches EHR Integration for Dictations Associated with Template-based Clinical Documentation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... 22, 2015 The Incredible Bulk is a ... to increase lean muscle by up to 30lbs in less ... attention of HealthyandFitZone.com’s Stan Stevenson, prompting an investigative review. , ... a step-by-step, scientific diet formula that allows the body to ...
(Date:1/22/2015)... 22, 2015 Blue Cross and Blue Shield ... exemplify what it means to “Live Fearless.” , ... to share their stories about how they or someone they ... others by living in the moment. By telling these types ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 The federal court ... the U.S. District Court, Southern District of West Virginia has ... in that proceeding’s first bellwether trial. In an Order dated ... new trial after finding that C.R. Bard had not proven ...
(Date:1/22/2015)... A new white paper by The Beryl Institute ... long-term care environment as well as provides recommendations for ... “The Power of Person-Centeredness in Long-Term Care: A View ... patient, resident and family experience in long-term care and ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Autocarinsurancebest.com has released ... purchasing a commercial auto insurance policy . , Auto ... their vehicles. It is no longer necessary to call an ... are now available online on a single website: http://autocarinsurancebest.com/ ...
Breaking Medicine News(10 mins):Health News:The Incredible Bulk: Review Examining Ben Pakulski’s Brand New Bulking Muscle Building Diet Program Released 2Health News:Blue Cross and Blue Shield of Minnesota to Showcase “Faces of Fearless” 2Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 2Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 3Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 4Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 3Health News:Commercial Auto Insurance Provides Several Important Features! 2
... were bewildered as about 3,000 people in the steel town were ... first reported in a small group at a slum// cluster in ... Monday. Since then, it has rapidly spread to other parts of ... headache and acute colic pain, said a senior district health official. ...
... draw attention to the issue of self harm. Self-Harm is ... that need support, help and above all, understanding. According to ... know how to help a person who self-harms. ... provoking statistics to the fore - that nearly 41% ...
... U.S. government plans to reimburse funds spent on poor ... Centers// for Medicare and Medicaid Services, told a National ... the states to file reimbursement claims for Medicaid recipients ... D Program. ,It also plans to ...
... itself to tackle a crippling disease which is a very ... be spread by mosquitoes// . This fever has already hit ... France. ,According to the French Health Minister, Bertrand, ... population , and many returning to the mainland from the ...
... of the bird flu scare, the Indian Railways has decided ... and has decided to bring back the chicken on its ... the serving of chickens and eggs in any form from ... ministry said in a statement. "It is now safe to ...
... There is heavy import restrictions due to the bird ... established import restrictions, including Japan and Hong Kong temporarily ... to this development World Health Organization publicly stated that ... to ease consumers' fears and concerns. In its statement, ...
Cached Medicine News:
(Date:1/23/2015)... Jan. 23, 2015 /PRNewswire/-- Harwood Feffer LLP ( www.hfesq.com ) ... of Advaxis, Inc. ("Advaxis" or the "Company") (NASDAQ: ... its fiduciary duties to shareholders. On January ... website reporting that Advaxis had misrepresented the clinical data ...
(Date:1/23/2015)... MERIDIAN, Idaho , Jan. 23, 2015  Now available ... Patent No. 7,849,611) support that prevents ankle sprains by ... a brace, it fits securely around the outside of ... ankle mobility & comfort while still offering protection against ...
(Date:1/23/2015)... LAS VEGAS , Jan. 23, 2015 Cord Blood ... CBAI ) ("CBAI" or the "Company")  filed a Preliminary Proxy ... ( www.sec.gov ) today, and provides an update for shareholders ... authorized shares is requested. Dear Shareholders, ...
Breaking Medicine Technology:Harwood Feffer LLP Announces Investigation of Advaxis, Inc. 2The Armor1 Ankle Roll Guard is the New Breakthrough Solution for Ankle Sprain Prevention! 2Cord Blood America Announces Preliminary Proxy Filing and Details Why a "YES" Vote to Increase Authorized Shares Is Requested 2Cord Blood America Announces Preliminary Proxy Filing and Details Why a "YES" Vote to Increase Authorized Shares Is Requested 3Cord Blood America Announces Preliminary Proxy Filing and Details Why a "YES" Vote to Increase Authorized Shares Is Requested 4
... Oct. 27, 2011 e-Zassi announces an agreement with ... Industry, to promote and provide proprietary decision support software ... UBM Canon,s Qmed , the ... and organizations, will make available to its users and ...
... Surgical facilities are facing unprecedented challenges due to ... with shrinking budgets and lowered staffing levels, has forced ... value when purchasing surgical instruments . A focus ... important as price. Most US-based surgical instrument ...
Cached Medicine Technology:e-Zassi and UBM Canon Partner to Provide Online Medical Device Decision Support Tools at Qmed.com 2e-Zassi and UBM Canon Partner to Provide Online Medical Device Decision Support Tools at Qmed.com 3American-Made Surgical Instruments Meet the High Demands of Surgical Facilities 2
... and 4 metal chest electrodes on ... procedure enabling a patient to easily ... ECG through a simple change of ... per lead and 10 seconds of ...
... IMPACs comprehensive information system designed specifically ... integrate and streamline their diagnostic, management, ... intuitive software solution. Thousands of laboratory ... have proven PowerPaths unique "case-centric model ...
... The Digital-Photo Adapter ... designed optics for the ... technology. In combination with ... this is the best ...
... The CMGS-1 Color Mini-Ganzfeld Stimulator is ... can be integrated with your existing LKC ... with other visual electrodiagnostic test systems. ... is the smallest commercial Ganzfeld to meet ...
Medicine Products: