Navigation Links
Fibrous stroma associated with poor prognosis in lung squamous cell carcinoma
Date:9/1/2011

The nature of the connective tissue surrounding lung cancer nests can help predict the aggressiveness of squamous cell carcinoma, according to research published in the September issue of the Journal of Thoracic Oncology, the official publication of the International Association for the Study of Lung Cancer (IASLC).

Non-small cell lung cancer (NSCLC) is the major cause of cancer-related deaths worldwide; its two major subtypes are adenocarcinoma and squamous cell carcinoma (SqCC). Although many reports have described the prognostic markers for adenocarcinoma, less research has been done into prognostic markers for SqCC.

In the study, researchers from Japan's National Cancer Center Hospital East and Keio University found that the prognosis for lung cancer patients with SqCC tumors surrounded by "fibrous stroma" was significantly worse than for patients whose SqCC cells were surrounded by "thin stroma."

Of the 220 patients whose tissue specimens were reviewed, 85 had fibrous stroma -- that is, stroma wider than some cancer nests and intermingled with plump fibroblast and/or collagen fibers -- and 135 had thin stroma, narrower than the cancer nest and composed of thin collagen-fiber lamellae or infiltrative lymphocytes. All had undergone a complete resection for a solitary lesion and were diagnosed as having a pathologic stage I disease. Patients who had received preoperative chemotherapy or preoperative thoracic radiation were excluded.

The 5-year recurrence-free survival rate was 70% for patients with thin stroma and 50% for patients with fibrous stroma. The 5-year overall survival rate was 72.3% for thin stroma cases and 55.5% for those with fibrous stroma.

SqCC tumors surrounded by fibrous stroma showed reduced expression of E-cadherin and increased expression of laminin-5y2 and matrix metalloproteinase-7 (MMP7), proteins that have been found to increase cell motility and invasiveness.

"Elucidating whether the peritumoral stroma of lung SqCC contributes to cancer progression would be meaningful for the development of treatment targeting the tumor microenvironment and tailored to the histological subtype," researchers wrote.


'/>"/>

Contact: Rene McGaw
renee.mcgaw@ucdenver.edu
303-724-5796
International Association for the Study of Lung Cancer
Source:Eurekalert

Related medicine news :

1. Optimal surgical procedure for duodenal gastrointestinal stromal tumors
2. Stroma may provide key to better cancer treatment
3. Jefferson study determines bone marrow stromal stem cells may aid in stroke recovery
4. Certain genetic profiles associated with recurrence-free survival for non-small cell lung cancer
5. Certain pain medications do not appear to be associated with skin cancer risk
6. News brief: ALDH associated with worse overall survival in patients with pancreatic adenocarcinoma
7. New research shows emotional impact of low sexual desire and associated distress
8. Increased HAART coverage associated with 50 percent drop
9. Pretreatment SUV associated with head and neck cancer treatment outcomes, may help decide treatment plans
10. New developments in nanotechnology tackle the 2 biggest problems associated with chemotherapy
11. MedQuist Launches EHR Integration for Dictations Associated with Template-based Clinical Documentation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... ... Apple Rehab Shelton Lakes , which specializes in the delivery of sub-acute ... of a disaster drill on October 3rd. , Apple Rehab participated with the Shelton ... well as the Connecticut Long Term Care Mutual Aid Plan (LTC-MAP). The LTC-MAP ...
(Date:10/13/2017)... ... October 13, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The ... the most popular and least understood books in the Holy Scriptures, Revelation. The Book ... have baffled scholars for centuries. Many have tossed it off as mere rubbish, but ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... healthcare compliance program management, will showcase a range of technology and learning solutions ... Living (NCAL) Convention and Expo to be held October 14–18, 2017 at the ...
(Date:10/12/2017)... ... ... The American College of Medical Informatics (ACMI) will present the 2017 Morris ... of AMIA’s Annual Symposium in Washington, D.C. AMIA’s Annual Symposium is taking ... in the field of medical informatics, this prestigious award is presented to an individual ...
(Date:10/12/2017)... ... October 12, 2017 , ... Leading pediatric oncology experts at Children’s ... the 49th Congress of the International Society of Paediatric Oncology (SIOP) Oct. ... Center for Cancer and Blood Disorders at Children’s National, and Stephen P. Hunger, ...
Breaking Medicine News(10 mins):
(Date:10/5/2017)... Oct. 5, 2017  In response to the ... and Maxillofacial Surgeons (AAOMS) released prescribing recommendations that ... be used as a first-line therapy to manage ... Recognizing the value and ... Paper "Opioid Prescribing: Acute and Postoperative Pain Management" ...
(Date:10/2/2017)... -- Diplomat Pharmacy, Inc. (NYSE: DPLO ) ... , and named its founder as Diplomat,s chief information ... Tennessee , will operate under Diplomat subsidiary Envoy ... for health care partners to include IT outsourcing, consulting, ... "In an interoperable world, technology delivers comprehensive insight and ...
(Date:10/2/2017)... Oct. 2, 2017 The Rebound mobile app is ... to reverse the tide of prescription drug addiction. The app ... medicine intake and stepping down their dosage in a safe, ... in December 2017; the first 100,000 people to sign up ... http://www.rebound-solution.com/ ...
Breaking Medicine Technology: