Navigation Links
Fibroblasts contribute to melanoma tumor growth, say Moffitt Cancer Center researchers
Date:1/5/2012

TAMPA, Fla. -- Fibroblasts, cells that play a role in the structural framework of tissues, play an apparent role in melanoma tumor growth. Fibroblasts also contribute to melanoma drug resistance and may also facilitate the "flare" response when a tumor's metabolism is enhanced following a patient being removed from a targeted therapy, said researchers at Moffitt Cancer Center in Tampa, Fla.

Alexander R. Anderson, Ph.D., co-director of Integrative Mathematical Oncology at Moffitt, and Moffitt Comprehensive Melanoma Research Center member Keiran S. Smalley, Ph.D., along with colleagues from the Wistar Institute in Philadelphia, investigated the role of fibroblasts in melanoma progression and published their findings in a recent issue of Molecular Pharmaceutics.

"A role for fibroblasts in cancer progression has long been suspected," explained Anderson, who works with mathematical models of cancer to investigate tumor cell- microenvironment interactions. "In this study, we used an integrated mathematical and experimental approach to investigate whether melanoma cells recruit, activate and stimulate fibroblasts to deposit certain proteins known to be pro-survival for melanoma cells."

Fibroblasts are the most common of connective tissues, and they function to synthesize the "extra cellular matrix" of cells and collagen, the structural framework also called "stroma" for tissues.

The researchers knew that fibroblasts were drawn to cancer cells and that they became activated by cancer cells. They also knew that different cancer cell lines have varying capabilities for recruiting and stimulating fibroblasts. An expectation has been that aggressive cancers stimulate fibroblasts more than do less aggressive cancers.

When they investigated the relationship between fibroblasts and tumors using mathematical models, the research team came up with some unexpected findings.

Anderson and Smalley expected the fibroblast-derived "extra cellular matrix" that supports the tumor structure to have "direct effects on tumor behavior." However, once they ran their theoretical models they came up with a number of unexpected conclusions with potentially far-reaching implications about drug resistance and tumor growth.

"Our finding that the fibroblast population might facilitate the "flare response" a period during which a tumor has enhanced metabolism and increases it progression trajectory after patients are removed from targeted therapy was a surprise," said Smalley, whose research aims at developing new therapies for melanoma and getting them into clinical practice.

The researchers knew that a targeted therapy would kill only the tumor population, not the fibroblasts in the tumor structure. However, the finding that fibroblasts contribute to melanoma drug resistance was unexpected.

"Targeted therapies may actually hasten tumor progression when they are stopped due to resistance to the targeted drug," said Smalley. "We found in our models that fibroblasts appear to facilitate the flare response after targeted therapy ends."

Their conclusions about the relationship between fibroblasts and cancer tumors were not predicted or expected, but revealed though the use of mathematical models.

"If these conclusions are confirmed experimentally, we may gain important new insights into how drug resistance can be managed clinically," concluded Anderson.


'/>"/>
Contact: Ferdie De Vega
Ferdinand.DeVega@moffitt.org
813-745-7858
H. Lee Moffitt Cancer Center & Research Institute
Source:Eurekalert

Related medicine news :

1. Football could contribute to strokes in adolescents
2. Sewage treatment plants may contribute to antibiotic resistance problem
3. Low vitamin D levels may contribute to development of Type 2 diabetes
4. Past Trauma May Contribute to Bowel Disorder
5. Common medications can contribute to lower urinary tract symptoms in men
6. Poor gut sense of numbers contributes to persistent math difficulties
7. Sleep loss in early childhood may contribute to the development of ADHD symptoms
8. Cell division abnormality contributes to inflammation in COPD
9. Disruption of nerve cell supply chain may contribute to Parkinsons
10. Severity of hepatitis C and HIV co-infection in mothers contribute to HCV transmission to child
11. MRI may contribute to early detection of Alzheimers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/25/2017)... ... ... Swissray is pleased to announce the release of the ELITE DXA, a new bone ... scan window, which is more than double that of existing bone densitometers. Historically, subjects ... an accurate total body bone density or body composition study. The ELITE DXA ...
(Date:3/24/2017)... ... March 24, 2017 , ... Vighter established its NAEMT ... by providing Prehospital Trauma Life Support (PHTLS) course scholarships to four medics assigned ... education developed in cooperation with the American College of Surgeons to promote critical ...
(Date:3/24/2017)... NY (PRWEB) , ... March 24, 2017 , ... ... scale; from third world countries to hospitals in the United States, it’s a ... conversation on the current obstacles facing infection prevention and offers strategies for the ...
(Date:3/24/2017)... ... March 24, 2017 , ... The Radiology Business Management Association (RBMA) ... awards, now in their 12th year, are among the most prestigious in radiology marketing ... the awards were retooled to recognize achievements in both large budget (over $5,000) and ...
(Date:3/24/2017)... TX (PRWEB) , ... March 24, 2017 , ... ... clinic which can be found at 9618 Huebner Road. The clinic is the group’s ... OCS, Clinic Director, and Dr. Ali Higgins, PT, will provide care from the clinic, ...
Breaking Medicine News(10 mins):
(Date:3/24/2017)... DUBLIN , Mar 24, 2017 Research ... in Drug Discovery and Diagnostics, 2017 - 2035" report to ... The ... current landscape and future outlook of the growing market of deep ... data revolution, deep learning algorithms have emerged as a novel solution ...
(Date:3/24/2017)... 24, 2017 Today Stock-Callers.com have issued ... are: Neovasc Inc. (NASDAQ: NVCN), Hologic Inc. (NASDAQ: HOLX), Edwards ... SSH ). These companies are part of the Healthcare ... Thursday, March 23 rd , 2017, with the NYSE Health ... health care companies in the S&P 500 were down about ...
(Date:3/24/2017)... INDIANAPOLIS , March 24, 2017  Eli ... today announced plans to invest $850 million in ... span facilities across its U.S. enterprise, including research ... The investments are being driven by demand for ... of potential medicines in development targeting cancer, pain, ...
Breaking Medicine Technology: