Navigation Links
Fewer weeks of hormone therapy before radiation reduces side effects in intermediate risk PCa
Date:9/23/2013

Atlanta, September 23, 2013 A shorter course of androgen suppression therapy prior to radiation therapy, when compared to a longer course of androgen suppression therapy, yields favorable outcomes and fewer adverse effects for intermediate-risk prostate cancer patients, according to research presented today at the American Society for Radiation Oncology's (ASTRO) 55th Annual Meeting. The study confirmed a disease-specific-survival (DSS) rate of 95 percent when patients received fewer weeks of neoadjuvant (NEO) total androgen suppression (TAS).

The multi-institutional phase III trial, Radiation Therapy Oncology Group (RTOG) 9910, evaluated 1,490 intermediate-risk prostate cancer (PCa) patients from 152 institutions in the U.S. and Canada. Patients were accrued from 2000 to 2004 and followed for an average of 9 years, and the average age of the men was 71 at the time of accrual. The patients were stratified and randomized into two groups―Group 1 consisted of 752 patients who received eight weeks of NEO TAS, and Group 2 consisted of 738 patients who received 28 weeks of NEO TAS. Both groups then received eight weeks of external beam radiation therapy (RT) and concurrent TAS.

Cumulative incidence was used to estimate and test efficacy for DSS, prostate-specific antigen (PSA) failure, locoregional tumor progression and distant metastasis. Overall survival (OS) rates were estimated via the Kaplan-Meier method and efficacy tested with log rank. There were 30 PCa deaths in Group 1, for a 10-year DSS rate of 95 percent; and 24 PCa deaths in Group 2, for a 10-year DSS rate of 96 percent (no statistical difference). There were 200 additional deaths not attributable to PCa in Group 1 for a 10-year OS rate of 66 percent, and 196 such deaths in Group 2, for a 10-year OS rate of 67 percent. By 10 years, 27 percent of patients had a PSA failure (using the newer RTOG-ASTRO definition of nadir+2), 5 percent had PCa recurrence in the prostate (locoregional) and 6 percent had distant metastasis. Hot flashes and erectile dysfunction were more common in Group 2.

"Sometimes, preliminary research leads us to assume that more treatment is better, but this study serves as a strong cautionary note to put the promising treatment to the test," said Thomas Pisansky, MD, lead author of the study and professor of radiation oncology at the Mayo Clinic in Rochester, Minn. "Overall, both groups had very, very good outcomes, but patients assigned to Group 2 had more side effects from androgen suppression than Group 1, who received only eight weeks of NEO TAS. Now, investigators know the upper boundary of how much androgen suppression is needed in this group of patients. The results have substantial importance because they can alter the research strategy to one in which investigation can now concentrate on ways to simplify the treatment and further reduce side effects."


'/>"/>

Contact: Michelle Kirkwood
michellek@astro.org
703-286-1600
American Society for Radiation Oncology
Source:Eurekalert

Related medicine news :

1. PeopleKeys Develops HR Filtering Tools in Response to Fewer Jobs, Increased Competition in Health Care
2. Twin Cities Home Sales Hit A Hot Summer Pace: 31.4 Percent Fewer Days
3. Longest and largest study of insulin pumps to treat type 1 diabetes in children shows they control blood sugar more effectively and with fewer complications than injections
4. Kwiksure Examines Why Drivers Have Fewer Accidents on Hong Kong Island than in the New Territories
5. Fewer states holding alcohol retailers responsible for harms from illegal service
6. Prostate cancers are fewer, smaller on walnut-enriched diet
7. Fewer Families Struggling to Pay Medical Bills: CDC
8. Healthy lifestyle choices mean fewer memory complaints, poll by UCLA and Gallup finds
9. Integrated stroke care system results in fewer deaths, discharges to long-term care facilities
10. Veterans Disability Appeals See Fewer Decisions in FY2012, Reports Allsup
11. Abutment-Free Sophono Systems Produce Comparable Study Results to Cochlear’s Baha Products, With Fewer Complications
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2017)... Segundo, CA (PRWEB) , ... March 23, 2017 ... ... Verisys FACIS Monthly Monitoring Healthcare products at competitive pricing. Verisys ... source sanctions, Exclusions, Debarments, License restrictions and Disciplinary actions. , “We are delighted ...
(Date:3/23/2017)... ... March 23, 2017 , ... On 2 March 2017, the ... Special Operations Command’s Patriot Award. The award was presented by the USSOCOM Commander, ... Foundation for its significant and enduring support to the command. , Accepting ...
(Date:3/23/2017)... ... , ... News Advisory/Interview Opportunity , After six years of advocacy, testimony and ... for public health and the environment and is calling on the United States to ... overwhelming support of European citizens, the European Union (EU) will, beginning next year, ban ...
(Date:3/23/2017)... ... March 23, 2017 , ... ... HealthiPASS, an innovative patient - centric payment system, to expand its focus on ... in the patient financial experience. , “At Ogden Clinic, we are working ...
(Date:3/23/2017)... , ... March 23, 2017 , ... ... announced the publication of “Profiling protein expression in circulating tumor cells using microfluidic ... describes the use of the Vortex technology to capture CTCs and ...
Breaking Medicine News(10 mins):
(Date:3/22/2017)... , 22 de marzo de 2017   ... líder de soluciones de productos y servicios para ... que ha adquirido EPL Archives, Inc., una organización ... clientes en todo el ciclo de vida de ... una muestra de archivo, almacenamiento de documentos y ...
(Date:3/22/2017)... March 22, 2017 Ampio Pharmaceuticals, Inc. ... of Ampion™, a low molecular weight fraction of ... that it is re-issuing its previous release that was ... disclosures that are required under the NYSE MKT ... these additional disclosures along with the previously disclosed ...
(Date:3/22/2017)... -- New Jersey,s hospitals and ... saved $641 million in healthcare costs between 2012 and ... improvement program. The results reflect five ... of a national initiative from the U.S. Department of ... Hospital Association and its affiliate, the Health Research and ...
Breaking Medicine Technology: